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Q08862

- GSTA_RABIT

UniProt

Q08862 - GSTA_RABIT

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Protein

Glutathione S-transferase Yc

Gene
N/A
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91GlutathioneBy similarity
Binding sitei45 – 451GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB

GO - Biological processi

  1. glutathione metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Yc (EC:2.5.1.18)
Alternative name(s):
Alpha II
GST class-alpha
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Chromosome 12

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Glutathione S-transferase YcPRO_0000185799Add
BLAST

Proteomic databases

PRIDEiQ08862.

Expressioni

Tissue specificityi

Liver.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000025810.

Structurei

3D structure databases

ProteinModelPortaliQ08862.
SMRiQ08862. Positions 2-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8381GST N-terminalAdd
BLAST
Domaini85 – 208124GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 552Glutathione bindingBy similarity
Regioni67 – 682Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG266414.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08862-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGKPKLHYF NARGRMESIR WLLTAAGVEF EEKCMKTRED LEKLRKDGVL
60 70 80 90 100
MFQQVPMVEI DGMKLVQTRA IFNYIADKHN LYGKDIKERA LIDMYTEGIV
110 120 130 140 150
DLNELILTRP FLPPEEQEAK LAQIKDKAKN RYFPAFEKVL KSHGQDYLVG
160 170 180 190 200
NKLSKADILL VELLYNVEEL NPGATASFPL LQALKTRISN LPTVKKFLQP
210 220
GSQRNPPDDE KCREEAKIIF H
Length:221
Mass (Da):25,450
Last modified:January 23, 2007 - v2
Checksum:iD475160FE1299219
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74529 mRNA. Translation: AAA31260.1.
PIRiB41031.
RefSeqiNP_001164569.1. NM_001171098.2.
XP_008260973.1. XM_008262751.1.
UniGeneiOcu.1982.

Genome annotation databases

EnsembliENSOCUT00000021072; ENSOCUP00000025810; ENSOCUG00000021171.
GeneIDi100328911.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74529 mRNA. Translation: AAA31260.1 .
PIRi B41031.
RefSeqi NP_001164569.1. NM_001171098.2.
XP_008260973.1. XM_008262751.1.
UniGenei Ocu.1982.

3D structure databases

ProteinModelPortali Q08862.
SMRi Q08862. Positions 2-220.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000025810.

Proteomic databases

PRIDEi Q08862.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSOCUT00000021072 ; ENSOCUP00000025810 ; ENSOCUG00000021171 .
GeneIDi 100328911.

Phylogenomic databases

eggNOGi NOG266414.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115734.
HOVERGENi HBG053749.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01266. GSTRNSFRASEA.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The major alpha-class glutathione S-transferases of rabbit lung and liver. Primary sequences, expression, and regulation."
    Gardlik S.J., Gasser R., Philpot R.M., Serabjit-Singh C.J.
    J. Biol. Chem. 266:19681-19687(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.
    Tissue: Liver.

Entry informationi

Entry nameiGSTA_RABIT
AccessioniPrimary (citable) accession number: Q08862
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3