SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q08862

- GSTA_RABIT

UniProt

Q08862 - GSTA_RABIT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glutathione S-transferase Yc
Gene
N/A
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91Glutathione By similarity
Binding sitei45 – 451Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB

GO - Biological processi

  1. glutathione metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Yc (EC:2.5.1.18)
Alternative name(s):
Alpha II
GST class-alpha
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Chromosome 12

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Glutathione S-transferase Yc
PRO_0000185799Add
BLAST

Proteomic databases

PRIDEiQ08862.

Expressioni

Tissue specificityi

Liver.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000025810.

Structurei

3D structure databases

ProteinModelPortaliQ08862.
SMRiQ08862. Positions 2-220.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8381GST N-terminal
Add
BLAST
Domaini85 – 208124GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 552Glutathione binding By similarity
Regioni67 – 682Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.

Phylogenomic databases

eggNOGiNOG266414.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08862-1 [UniParc]FASTAAdd to Basket

« Hide

MAGKPKLHYF NARGRMESIR WLLTAAGVEF EEKCMKTRED LEKLRKDGVL    50
MFQQVPMVEI DGMKLVQTRA IFNYIADKHN LYGKDIKERA LIDMYTEGIV 100
DLNELILTRP FLPPEEQEAK LAQIKDKAKN RYFPAFEKVL KSHGQDYLVG 150
NKLSKADILL VELLYNVEEL NPGATASFPL LQALKTRISN LPTVKKFLQP 200
GSQRNPPDDE KCREEAKIIF H 221
Length:221
Mass (Da):25,450
Last modified:January 23, 2007 - v2
Checksum:iD475160FE1299219
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74529 mRNA. Translation: AAA31260.1.
PIRiB41031.
RefSeqiNP_001164569.1. NM_001171098.2.
UniGeneiOcu.1982.

Genome annotation databases

EnsembliENSOCUT00000021072; ENSOCUP00000025810; ENSOCUG00000021171.
GeneIDi100328911.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74529 mRNA. Translation: AAA31260.1 .
PIRi B41031.
RefSeqi NP_001164569.1. NM_001171098.2.
UniGenei Ocu.1982.

3D structure databases

ProteinModelPortali Q08862.
SMRi Q08862. Positions 2-220.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000025810.

Proteomic databases

PRIDEi Q08862.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSOCUT00000021072 ; ENSOCUP00000025810 ; ENSOCUG00000021171 .
GeneIDi 100328911.

Phylogenomic databases

eggNOGi NOG266414.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115734.
HOVERGENi HBG053749.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01266. GSTRNSFRASEA.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The major alpha-class glutathione S-transferases of rabbit lung and liver. Primary sequences, expression, and regulation."
    Gardlik S.J., Gasser R., Philpot R.M., Serabjit-Singh C.J.
    J. Biol. Chem. 266:19681-19687(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.
    Tissue: Liver.

Entry informationi

Entry nameiGSTA_RABIT
AccessioniPrimary (citable) accession number: Q08862
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi