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Q08857 (CD36_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Platelet glycoprotein 4
Alternative name(s):
Glycoprotein IIIb
Short name=GPIIIB
PAS IV
PAS-4
Platelet glycoprotein IV
Short name=GPIV
CD_antigen=CD36
Gene names
Name:Cd36
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport By similarity. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects By similarity. Ref.3

Subunit structure

Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. Ref.3

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the CD36 family.

Ontologies

Keywords
   Biological processCell adhesion
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic cell clearance

Inferred from mutant phenotype PubMed 15647754. Source: MGI

cGMP-mediated signaling

Inferred from electronic annotation. Source: Ensembl

cell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

cell surface receptor signaling pathway

Inferred from direct assay PubMed 20978343. Source: BHF-UCL

cellular response to bacterial lipopeptide

Inferred from mutant phenotype PubMed 15690042. Source: MGI

cellular response to hydroperoxide

Inferred from mutant phenotype PubMed 20978343. Source: BHF-UCL

cellular response to lipopolysaccharide

Inferred from mutant phenotype PubMed 16061696. Source: MGI

cellular response to lipoteichoic acid

Inferred from direct assay PubMed 15690042. Source: MGI

cholesterol transport

Inferred from mutant phenotype PubMed 12376530. Source: BHF-UCL

defense response to Gram-positive bacterium

Inferred from mutant phenotype PubMed 15690042PubMed 16061696. Source: MGI

lipid storage

Inferred from mutant phenotype PubMed 10772654. Source: BHF-UCL

lipoprotein transport

Inferred from mutant phenotype PubMed 10772654. Source: BHF-UCL

long-chain fatty acid import

Inferred from electronic annotation. Source: Ensembl

low-density lipoprotein particle clearance

Inferred from mutant phenotype PubMed 10772654. Source: BHF-UCL

low-density lipoprotein particle mediated signaling

Inferred from direct assay PubMed 20978343. Source: BHF-UCL

negative regulation of growth of symbiont in host

Inferred from mutant phenotype PubMed 15690042PubMed 16061696. Source: MGI

negative regulation of transcription factor import into nucleus

Inferred from mutant phenotype PubMed 20978343. Source: BHF-UCL

negative regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 20978343. Source: BHF-UCL

nitric oxide mediated signal transduction

Inferred from electronic annotation. Source: Ensembl

phagocytosis, recognition

Inferred from direct assay PubMed 16061696. Source: MGI

plasma membrane long-chain fatty acid transport

Inferred from electronic annotation. Source: Ensembl

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from mutant phenotype PubMed 16061696. Source: MGI

positive regulation of MAPK cascade

Inferred from mutant phenotype PubMed 15690042. Source: MGI

positive regulation of blood coagulation

Inferred from mutant phenotype PubMed 20978343. Source: BHF-UCL

positive regulation of blood microparticle formation

Inferred from mutant phenotype PubMed 20978343. Source: BHF-UCL

positive regulation of cell-matrix adhesion

Inferred from electronic annotation. Source: Ensembl

positive regulation of cholesterol storage

Inferred from mutant phenotype PubMed 12376530. Source: BHF-UCL

positive regulation of interleukin-12 production

Inferred from mutant phenotype PubMed 16061696. Source: MGI

positive regulation of interleukin-6 production

Inferred from mutant phenotype PubMed 16061696. Source: MGI

positive regulation of macrophage cytokine production

Inferred from mutant phenotype PubMed 16061696. Source: MGI

positive regulation of macrophage derived foam cell differentiation

Inferred from mutant phenotype PubMed 10772654PubMed 12376530. Source: BHF-UCL

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from direct assay PubMed 20978343. Source: BHF-UCL

positive regulation of phagocytosis, engulfment

Inferred from direct assay PubMed 16061696. Source: MGI

positive regulation of reactive oxygen species metabolic process

Inferred from mutant phenotype PubMed 20978343. Source: BHF-UCL

positive regulation of tumor necrosis factor production

Inferred from mutant phenotype PubMed 15690042PubMed 16061696. Source: MGI

regulation of removal of superoxide radicals

Inferred from mutant phenotype PubMed 20978343. Source: BHF-UCL

regulation of transcription from RNA polymerase II promoter in response to oxidative stress

Inferred by curator PubMed 20978343. Source: BHF-UCL

response to stilbenoid

Inferred from expression pattern PubMed 17086191. Source: UniProtKB

   Cellular_componentGolgi apparatus

Inferred from direct assay PubMed 15496455. Source: MGI

external side of plasma membrane

Inferred from direct assay PubMed 15690042PubMed 16061696. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane raft

Inferred from direct assay PubMed 15496455PubMed 23444136. Source: MGI

   Molecular_functionhigh-density lipoprotein particle binding

Inferred from direct assay PubMed 14729860. Source: MGI

lipid binding

Inferred from sequence or structural similarity PubMed 10772654. Source: BHF-UCL

lipoteichoic acid receptor activity

Inferred from mutant phenotype PubMed 16061696. Source: MGI

low-density lipoprotein particle binding

Inferred from mutant phenotype PubMed 10772654PubMed 12376530. Source: BHF-UCL

low-density lipoprotein receptor activity

Inferred from mutant phenotype PubMed 10772654. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 472471Platelet glycoprotein 4
PRO_0000144153

Regions

Topological domain2 – 76Cytoplasmic Potential
Transmembrane8 – 2922Helical; Potential
Topological domain30 – 439410Extracellular Potential
Transmembrane440 – 46122Helical; Potential
Topological domain462 – 47211Cytoplasmic Potential
Region93 – 12028Required for interaction with thrombospondins, THBS1 and THBS2

Amino acid modifications

Lipidation31S-palmitoyl cysteine By similarity
Lipidation71S-palmitoyl cysteine By similarity
Lipidation4641S-palmitoyl cysteine By similarity
Lipidation4661S-palmitoyl cysteine By similarity
Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation1341N-linked (GlcNAc...) Potential
Glycosylation2051N-linked (GlcNAc...) Potential
Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation2351N-linked (GlcNAc...) Potential
Glycosylation2471N-linked (GlcNAc...) Potential
Glycosylation3211N-linked (GlcNAc...) Potential
Glycosylation4171N-linked (GlcNAc...) Potential
Disulfide bond243 ↔ 311 By similarity
Disulfide bond272 ↔ 333 By similarity
Disulfide bond313 ↔ 322 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q08857 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 80AEABB18206534F

FASTA47252,698
        10         20         30         40         50         60 
MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DMLIEKTIKR EVVLEEGTTA FKNWVKTGTT 

        70         80         90        100        110        120 
VYRQFWIFDV QNPDDVAKNS SKIKVKQRGP YTYRVRYLAK ENITQDPEDH TVSFVQPNGA 

       130        140        150        160        170        180 
IFEPSLSVGT EDDNFTVLNL AVAAAPHIYQ NSFVQVVLNS LIKKSKSSMF QTRSLKELLW 

       190        200        210        220        230        240 
GYKDPFLSLV PYPISTTVGV FYPYNDTVDG VYKVFNGKDN ISKVAIIESY KGKRNLSYWP 

       250        260        270        280        290        300 
SYCDMINGTD AASFPPFVEK SRTLRFFSSD ICRSIYAVFG SEIDLKGIPV YRFVLPANAF 

       310        320        330        340        350        360 
ASPLQNPDNH CFCTEKVISN NCTSYGVLDI GKCKEGKPVY ISLPHFLHAS PDVSEPIEGL 

       370        380        390        400        410        420 
HPNEDEHRTY LDVEPITGFT LQFAKRLQVN ILVKPARKIE ALKNLKRPYI VPILWLNETG 

       430        440        450        460        470 
TIGDEKAEMF KTQVTGKIKL LGMVEMALLG IGVVMFVAFM ISYCACKSKN GK 

« Hide

References

« Hide 'large scale' references
[1]"CD36 is a receptor for oxidized low density lipoprotein."
Endemann G., Stanton L.W., Madden K.S., Bryant C.M., White R.T., Protter A.A.
J. Biol. Chem. 268:11811-11816(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Peritoneal macrophage.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
[3]"The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein."
Simantov R., Febbraio M., Silverstein R.L.
Matrix Biol. 24:27-34(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH THBS2, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L23108 mRNA. Translation: AAA53028.1.
BC010262 mRNA. Translation: AAH10262.1.
PIRI49590.
RefSeqNP_001153027.1. NM_001159555.1.
NP_001153028.1. NM_001159556.1.
NP_001153029.1. NM_001159557.1.
NP_001153030.1. NM_001159558.1.
NP_031669.3. NM_007643.4.
XP_006535683.1. XM_006535620.1.
XP_006535684.1. XM_006535621.1.
XP_006535685.1. XM_006535622.1.
XP_006535686.1. XM_006535623.1.
XP_006535687.1. XM_006535624.1.
XP_006535688.1. XM_006535625.1.
UniGeneMm.18628.
Mm.406799.

3D structure databases

ProteinModelPortalQ08857.
SMRQ08857. Positions 37-432.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198587. 1 interaction.
IntActQ08857. 3 interactions.
MINTMINT-4090233.

Chemistry

ChEMBLCHEMBL2176845.

Protein family/group databases

TCDB9.B.39.1.1. the long chain fatty acid translocase (lcfat) family.

Proteomic databases

PaxDbQ08857.
PRIDEQ08857.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000082367; ENSMUSP00000080974; ENSMUSG00000002944.
ENSMUST00000165232; ENSMUSP00000126300; ENSMUSG00000002944.
ENSMUST00000169095; ENSMUSP00000131832; ENSMUSG00000002944.
ENSMUST00000170051; ENSMUSP00000133008; ENSMUSG00000002944.
GeneID12491.
KEGGmmu:12491.
UCSCuc008wnn.2. mouse.

Organism-specific databases

CTD948.
MGIMGI:107899. Cd36.

Phylogenomic databases

eggNOGNOG257244.
HOGENOMHOG000252951.
HOVERGENHBG002754.
InParanoidQ08857.
KOK06259.
OMAKRNYIVP.
OrthoDBEOG79SDWX.
TreeFamTF317925.

Enzyme and pathway databases

ReactomeREACT_196573. Binding and Uptake of Ligands by Scavenger Receptors.

Gene expression databases

ArrayExpressQ08857.
BgeeQ08857.
CleanExMM_CD36.
GenevestigatorQ08857.

Family and domain databases

InterProIPR002159. CD36.
IPR005428. CD36_antigen.
[Graphical view]
PANTHERPTHR11923. PTHR11923. 1 hit.
PfamPF01130. CD36. 1 hit.
[Graphical view]
PRINTSPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.
ProtoNetSearch...

Other

ChiTaRSCD36. mouse.
NextBio281412.
PROQ08857.
SOURCESearch...

Entry information

Entry nameCD36_MOUSE
AccessionPrimary (citable) accession number: Q08857
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot