Q08857 (CD36_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Platelet glycoprotein 4

Alternative name(s):
Glycoprotein IIIb
Short name=GPIIIB
PAS IV
PAS-4
Platelet glycoprotein IV
Short name=GPIV
CD_antigen=CD36

Gene names

Name:

Cd36

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport By similarity. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects By similarity. Ref.3
Subunit structure	Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. Ref.3
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the CD36 family.

Ontologies

Keywords
Biological process	Cell adhesion Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic cell clearance Inferred from mutant phenotype PubMed 15647754. Source: MGI cGMP-mediated signaling Inferred from electronic annotation. Source: Compara cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW cell surface receptor signaling pathway Inferred from direct assay PubMed 20978343. Source: BHF-UCL cellular response to bacterial lipopeptide Inferred from mutant phenotype PubMed 15690042. Source: MGI cellular response to hydroperoxide Inferred from mutant phenotype PubMed 20978343. Source: BHF-UCL cellular response to lipopolysaccharide Inferred from mutant phenotype PubMed 16061696. Source: MGI cellular response to lipoteichoic acid Inferred from direct assay PubMed 15690042. Source: MGI cholesterol transport Inferred from mutant phenotype PubMed 12376530. Source: BHF-UCL defense response to Gram-positive bacterium Inferred from mutant phenotype PubMed 15690042PubMed 16061696. Source: MGI lipid storage Inferred from mutant phenotype PubMed 10772654. Source: BHF-UCL lipoprotein transport Inferred from mutant phenotype PubMed 10772654. Source: BHF-UCL long-chain fatty acid import Inferred from electronic annotation. Source: Compara low-density lipoprotein particle clearance Inferred from mutant phenotype PubMed 10772654. Source: BHF-UCL low-density lipoprotein particle mediated signaling Inferred from direct assay PubMed 20978343. Source: BHF-UCL negative regulation of growth of symbiont in host Inferred from mutant phenotype PubMed 15690042PubMed 16061696. Source: MGI negative regulation of transcription factor import into nucleus Inferred from mutant phenotype PubMed 20978343. Source: BHF-UCL negative regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 20978343. Source: BHF-UCL nitric oxide mediated signal transduction Inferred from electronic annotation. Source: Compara phagocytosis, recognition Inferred from direct assay PubMed 16061696. Source: MGI plasma membrane long-chain fatty acid transport Inferred from electronic annotation. Source: Compara positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from mutant phenotype PubMed 16061696. Source: MGI positive regulation of MAPK cascade Inferred from mutant phenotype PubMed 15690042. Source: MGI positive regulation of blood coagulation Inferred from mutant phenotype PubMed 20978343. Source: BHF-UCL positive regulation of blood microparticle formation Inferred from mutant phenotype PubMed 20978343. Source: BHF-UCL positive regulation of cell-matrix adhesion Inferred from electronic annotation. Source: Compara positive regulation of cholesterol storage Inferred from mutant phenotype PubMed 12376530. Source: BHF-UCL positive regulation of interleukin-12 production Inferred from mutant phenotype PubMed 16061696. Source: MGI positive regulation of interleukin-6 production Inferred from mutant phenotype PubMed 16061696. Source: MGI positive regulation of macrophage cytokine production Inferred from mutant phenotype PubMed 16061696. Source: MGI positive regulation of macrophage derived foam cell differentiation Inferred from mutant phenotype PubMed 10772654PubMed 12376530. Source: BHF-UCL positive regulation of peptidyl-tyrosine phosphorylation Inferred from direct assay PubMed 20978343. Source: BHF-UCL positive regulation of phagocytosis, engulfment Inferred from direct assay PubMed 16061696. Source: MGI positive regulation of reactive oxygen species metabolic process Inferred from mutant phenotype PubMed 20978343. Source: BHF-UCL positive regulation of tumor necrosis factor production Inferred from mutant phenotype PubMed 15690042PubMed 16061696. Source: MGI regulation of removal of superoxide radicals Inferred from mutant phenotype PubMed 20978343. Source: BHF-UCL regulation of transcription from RNA polymerase II promoter in response to oxidative stress Inferred by curator PubMed 20978343. Source: BHF-UCL response to stilbenoid Inferred from expression pattern PubMed 17086191. Source: UniProtKB
Cellular_component	Golgi apparatus Inferred from direct assay PubMed 15496455. Source: MGI external side of plasma membrane Inferred from direct assay PubMed 15690042PubMed 16061696. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane raft Inferred from direct assay PubMed 15496455. Source: MGI
Molecular_function	Gram-negative bacterial cell surface binding Inferred from direct assay PubMed 16061696. Source: MGI Gram-positive bacterial cell surface binding Inferred from direct assay PubMed 16061696. Source: MGI high-density lipoprotein particle binding Inferred from direct assay PubMed 14729860. Source: MGI lipid binding Inferred from sequence or structural similarity PubMed 10772654. Source: BHF-UCL lipoteichoic acid receptor activity Inferred from mutant phenotype PubMed 16061696. Source: MGI low-density lipoprotein particle binding Inferred from mutant phenotype PubMed 10772654PubMed 12376530. Source: BHF-UCL low-density lipoprotein receptor activity Inferred from mutant phenotype PubMed 10772654. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 472	471	Platelet glycoprotein 4		PRO_0000144153
Regions
	Topological domain	2 – 7	6	Cytoplasmic Potential
	Transmembrane	8 – 29	22	Helical; Potential
	Topological domain	30 – 439	410	Extracellular Potential
	Transmembrane	440 – 461	22	Helical; Potential
	Topological domain	462 – 472	11	Cytoplasmic Potential
	Region	93 – 120	28	Required for interaction with thrombospondins, THBS1 and THBS2
Amino acid modifications
	Lipidation	3	1	S-palmitoyl cysteine By similarity
	Lipidation	7	1	S-palmitoyl cysteine By similarity
	Lipidation	464	1	S-palmitoyl cysteine By similarity
	Lipidation	466	1	S-palmitoyl cysteine By similarity
	Glycosylation	79	1	N-linked (GlcNAc...) Potential
	Glycosylation	134	1	N-linked (GlcNAc...) Potential
	Glycosylation	205	1	N-linked (GlcNAc...) Potential
	Glycosylation	220	1	N-linked (GlcNAc...) Potential
	Glycosylation	235	1	N-linked (GlcNAc...) Potential
	Glycosylation	247	1	N-linked (GlcNAc...) Potential
	Glycosylation	321	1	N-linked (GlcNAc...) Potential
	Glycosylation	417	1	N-linked (GlcNAc...) Potential
	Disulfide bond	243 ↔ 311		By similarity
	Disulfide bond	272 ↔ 333		By similarity
	Disulfide bond	313 ↔ 322		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q08857 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 80AEABB18206534F	FASTA	472	52,698
	10 20 30 40 50 60 MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DMLIEKTIKR EVVLEEGTTA FKNWVKTGTT 70 80 90 100 110 120 VYRQFWIFDV QNPDDVAKNS SKIKVKQRGP YTYRVRYLAK ENITQDPEDH TVSFVQPNGA 130 140 150 160 170 180 IFEPSLSVGT EDDNFTVLNL AVAAAPHIYQ NSFVQVVLNS LIKKSKSSMF QTRSLKELLW 190 200 210 220 230 240 GYKDPFLSLV PYPISTTVGV FYPYNDTVDG VYKVFNGKDN ISKVAIIESY KGKRNLSYWP 250 260 270 280 290 300 SYCDMINGTD AASFPPFVEK SRTLRFFSSD ICRSIYAVFG SEIDLKGIPV YRFVLPANAF 310 320 330 340 350 360 ASPLQNPDNH CFCTEKVISN NCTSYGVLDI GKCKEGKPVY ISLPHFLHAS PDVSEPIEGL 370 380 390 400 410 420 HPNEDEHRTY LDVEPITGFT LQFAKRLQVN ILVKPARKIE ALKNLKRPYI VPILWLNETG 430 440 450 460 470 TIGDEKAEMF KTQVTGKIKL LGMVEMALLG IGVVMFVAFM ISYCACKSKN GK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CD36 is a receptor for oxidized low density lipoprotein." Endemann G., Stanton L.W., Madden K.S., Bryant C.M., White R.T., Protter A.A. J. Biol. Chem. 268:11811-11816(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Peritoneal macrophage.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland.
[3]	"The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein." Simantov R., Febbraio M., Silverstein R.L. Matrix Biol. 24:27-34(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH THBS2, FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L23108 mRNA. Translation: AAA53028.1. BC010262 mRNA. Translation: AAH10262.1.
IPI	IPI00331214.
PIR	I49590.
RefSeq	NP_001153027.1. NM_001159555.1. NP_001153028.1. NM_001159556.1. NP_001153029.1. NM_001159557.1. NP_001153030.1. NM_001159558.1. NP_031669.3. NM_007643.4.
UniGene	Mm.18628. Mm.406799.
3D structure databases
ProteinModelPortal	Q08857.
ModBase	Search...
Protein family/group databases
TCDB	9.B.39.1.1. long chain fatty acid translocase (lcFAT) family.
Proteomic databases
PaxDb	Q08857.
PRIDE	Q08857.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000082367; ENSMUSP00000080974; ENSMUSG00000002944. ENSMUST00000165232; ENSMUSP00000126300; ENSMUSG00000002944. ENSMUST00000169095; ENSMUSP00000131832; ENSMUSG00000002944. ENSMUST00000170051; ENSMUSP00000133008; ENSMUSG00000002944.
GeneID	12491.
KEGG	mmu:12491.
Organism-specific databases
CTD	948.
MGI	MGI:107899. Cd36.
Phylogenomic databases
eggNOG	NOG257244.
HOGENOM	HOG000252951.
HOVERGEN	HBG002754.
InParanoid	Q08857.
KO	K06259.
OMA	KRNYIVP.
OrthoDB	EOG4KWJT5.
Gene expression databases
ArrayExpress	Q08857.
Bgee	Q08857.
CleanEx	MM_CD36.
Genevestigator	Q08857.
GermOnline	ENSMUSG00000002944. Mus musculus.
Family and domain databases
InterPro	IPR002159. CD36. IPR005428. CD36_antigen. [Graphical view]
PANTHER	PTHR11923. PTHR11923. 1 hit.
Pfam	PF01130. CD36. 1 hit. [Graphical view]
PRINTS	PR01610. CD36ANTIGEN. PR01609. CD36FAMILY.
ProtoNet	Search...
Other
ChiTaRS	CD36. mouse.
NextBio	281412.
SOURCE	Search...

Entry information

Entry name

CD36_MOUSE

Accession

Primary (citable) accession number: Q08857

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program