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Protein

Platelet glycoprotein 4

Gene

Cd36

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides (PubMed:7685021). They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable) (PubMed:19847289, PubMed:20037584, PubMed:23395392). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:17507371, PubMed:18753675, PubMed:21610069). Involved in oral fat perception and preferences (PubMed:16276419). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity) (PubMed:16276419). In taste receptor cells, mediates the induction of an increase in intracellulare calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (PubMed:18162488). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity) (PubMed:23557700). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (PubMed:15748999). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (PubMed:20037584, PubMed:23812099). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:15690042, PubMed:19847289).By similarity1 Publication13 Publications
(Microbial infection) Acts as an accessory receptor for M.tuberculosis lipoprotein LprA, in conjunction with coreceptors TLR2 and TLR1; the lipoprotein acts as an agonist to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling (PubMed:19864601, PubMed:23395392).3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei463 – 4631Critical for TLR4-TLR6 dimerization and signalingBy similarity

GO - Molecular functioni

  • high-density lipoprotein particle binding Source: MGI
  • lipid binding Source: BHF-UCL
  • lipoprotein particle binding Source: MGI
  • lipoteichoic acid receptor activity Source: MGI
  • low-density lipoprotein particle binding Source: BHF-UCL
  • low-density lipoprotein receptor activity Source: BHF-UCL

GO - Biological processi

  • amyloid fibril formation Source: UniProtKB
  • apoptotic cell clearance Source: MGI
  • cell adhesion Source: UniProtKB-KW
  • cell surface receptor signaling pathway Source: BHF-UCL
  • cellular response to bacterial lipopeptide Source: MGI
  • cellular response to diacyl bacterial lipopeptide Source: UniProtKB
  • cellular response to hydroperoxide Source: BHF-UCL
  • cellular response to lipopolysaccharide Source: MGI
  • cellular response to lipoteichoic acid Source: MGI
  • cellular response to low-density lipoprotein particle stimulus Source: UniProtKB
  • cGMP-mediated signaling Source: MGI
  • cholesterol import Source: UniProtKB
  • cholesterol transport Source: BHF-UCL
  • defense response to Gram-positive bacterium Source: MGI
  • immune response Source: InterPro
  • interleukin-1 beta secretion Source: UniProtKB
  • intestinal absorption Source: UniProtKB
  • intestinal cholesterol absorption Source: UniProtKB
  • lipid storage Source: BHF-UCL
  • lipoprotein transport Source: BHF-UCL
  • long-chain fatty acid import Source: UniProtKB
  • low-density lipoprotein particle clearance Source: BHF-UCL
  • low-density lipoprotein particle mediated signaling Source: BHF-UCL
  • negative regulation of gene expression Source: BHF-UCL
  • negative regulation of growth of symbiont in host Source: MGI
  • negative regulation of transcription factor import into nucleus Source: BHF-UCL
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • nitric oxide mediated signal transduction Source: MGI
  • pattern recognition receptor signaling pathway Source: GOC
  • phagocytosis, recognition Source: MGI
  • plasma lipoprotein particle clearance Source: BHF-UCL
  • positive regulation of blood coagulation Source: BHF-UCL
  • positive regulation of blood microparticle formation Source: BHF-UCL
  • positive regulation of cell-matrix adhesion Source: MGI
  • positive regulation of cholesterol storage Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  • positive regulation of interleukin-12 production Source: MGI
  • positive regulation of interleukin-6 production Source: MGI
  • positive regulation of macrophage cytokine production Source: MGI
  • positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  • positive regulation of MAPK cascade Source: MGI
  • positive regulation of NLRP3 inflammasome complex assembly Source: UniProtKB
  • positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  • positive regulation of phagocytosis, engulfment Source: MGI
  • positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
  • positive regulation of tumor necrosis factor production Source: MGI
  • receptor internalization Source: UniProtKB
  • regulation of energy homeostasis Source: UniProtKB
  • regulation of removal of superoxide radicals Source: BHF-UCL
  • regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: BHF-UCL
  • response to fatty acid Source: UniProtKB
  • response to linoleic acid Source: UniProtKB
  • response to lipid Source: UniProtKB
  • response to stilbenoid Source: UniProtKB
  • sensory perception of taste Source: UniProtKB
  • triglyceride transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion, Transport

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-1236973. Cross-presentation of particulate exogenous antigens (phagosomes).
R-MMU-3000471. Scavenging by Class B Receptors.

Protein family/group databases

TCDBi9.B.39.1.1. the long chain fatty acid translocase (lcfat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein 4
Alternative name(s):
Glycoprotein IIIb
Short name:
GPIIIB
PAS IV
PAS-4
Platelet glycoprotein IV
Short name:
GPIV
CD_antigen: CD36
Gene namesi
Name:Cd36
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:107899. Cd36.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 76CytoplasmicSequence analysis
Transmembranei8 – 2922HelicalSequence analysisAdd
BLAST
Topological domaini30 – 439410ExtracellularSequence analysisAdd
BLAST
Transmembranei440 – 46122HelicalSequence analysisAdd
BLAST
Topological domaini462 – 47211CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical part of cell Source: UniProtKB
  • apical plasma membrane Source: UniProtKB-SubCell
  • brush border membrane Source: UniProtKB
  • cell surface Source: BHF-UCL
  • external side of plasma membrane Source: MGI
  • extracellular space Source: MGI
  • Golgi apparatus Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • membrane raft Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

The preference to lipids such linoleic acid is fully abolished in mutant mice as well as the induction of both flux and protein content of pancreatobiliary secretions (PubMed:21901153, PubMed:16276419). Animals with a double knockout of APOE and CD36, fed a Western diet for 12 weeks, exhibit much lower levels of CXCL1, CXCL2 and CCL5 cytokine mRNA expression in the descending aorta and a corresponding decrease in atherosclerotic lesion formation, compared to APOE single knockout mice. Enterocytes from proximal small intestine exhibit reduced uptake of fatty acid and cholesterol. They also show reduced fatty acid incorporation into triglycerides and triglyceride secretion (PubMed:17507371). After oral fat loading, animals have lipoproteins smaller than chylomicron in size in plasma and intestinal lymph (PubMed:18753675).5 Publications

Chemistry

ChEMBLiCHEMBL2176845.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 472471Platelet glycoprotein 4PRO_0000144153Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi3 – 31S-palmitoyl cysteineBy similarity
Lipidationi7 – 71S-palmitoyl cysteineBy similarity
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence analysis
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence analysis
Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence analysis
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence analysis
Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence analysis
Disulfide bondi243 ↔ 311By similarity
Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence analysis
Disulfide bondi272 ↔ 333By similarity
Disulfide bondi313 ↔ 322By similarity
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence analysis
Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence analysis
Lipidationi464 – 4641S-palmitoyl cysteineBy similarity
Lipidationi466 – 4661S-palmitoyl cysteineBy similarity
Cross-linki469 – 469Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubituitin)By similarity
Cross-linki472 – 472Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubituitin)By similarity

Post-translational modificationi

Ubiquitinated at Lys-469 and Lys-472. Ubiquitination is induced by fatty acids such as oleic acid and leads to degradation by the proteasome (PubMed:21610069, PubMed:18353783). Ubiquitination and degradation are inhibited by insulin which blocks the effect of fatty acids (PubMed:18353783).2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Lipoprotein, Palmitate, Ubl conjugation

Proteomic databases

PaxDbiQ08857.
PRIDEiQ08857.

PTM databases

iPTMnetiQ08857.
SwissPalmiQ08857.

Expressioni

Tissue specificityi

Expressed in the apical side of lingual taste bud cells of the circumvallate papillae (PubMed:16276419, PubMed:21901153). Highly expressed in the intestine on the luminal surface of enterocytes. In small intestines expression levels follow a steep decreasing gradient from proximal to distal segments (PubMed:17507371). Expressed in macrophages (PubMed:23395392, PubMed:23812099). Cell surface expression detected in lung alveolar macrophages, dendritic macrophages and lung macrophages (at protein level) (PubMed:19362712).6 Publications

Inductioni

Expressed in a circadian manner in the circumvallate papillae, levels being lower during the dark period. Protein levels decrease in presence of lipids.1 Publication

Gene expression databases

BgeeiQ08857.
CleanExiMM_CD36.
ExpressionAtlasiQ08857. baseline and differential.
GenevisibleiQ08857. MM.

Interactioni

Subunit structurei

Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity (By similarity) (PubMed:15748999). Upon interaction with a ligand, such as oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, rapidly forms a complex with TLR4 and TLR6; the complex is internalized and triggers an inflammatory signal. Through its C-terminus, interacts with PTK2, PXN and LYN, but not with SRC. LYN kinase activity is required for facilitating TLR4-TLR6 heterodimerization and signal initiation (By similarity). Interacts with CD9, CD81, FCER1G, ITGB2 and/or ITGB2; forming a membrane heteromeric complex required for the internalization of CD36 and its ligands (PubMed:23395392).By similarity2 Publications

Protein-protein interaction databases

BioGridi198587. 1 interaction.
IntActiQ08857. 4 interactions.
MINTiMINT-4090233.
STRINGi10090.ENSMUSP00000080974.

Structurei

3D structure databases

ProteinModelPortaliQ08857.
SMRiQ08857. Positions 40-432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 12028Required for interaction with thrombospondins, THBS1 and THBS2Add
BLAST
Regioni460 – 47213Interaction with PTK2, PXN and LYNBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the CD36 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3776. Eukaryota.
ENOG410XS17. LUCA.
HOGENOMiHOG000252951.
HOVERGENiHBG002754.
InParanoidiQ08857.
KOiK06259.
OMAiKDYTIFP.
OrthoDBiEOG79SDWX.
PhylomeDBiQ08857.
TreeFamiTF317925.

Family and domain databases

InterProiIPR005428. CD36/SCARB1/SNMP1.
IPR033076. CD36_chordates.
IPR002159. CD36_fam.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PTHR11923:SF12. PTHR11923:SF12. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08857-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DMLIEKTIKR EVVLEEGTTA
60 70 80 90 100
FKNWVKTGTT VYRQFWIFDV QNPDDVAKNS SKIKVKQRGP YTYRVRYLAK
110 120 130 140 150
ENITQDPEDH TVSFVQPNGA IFEPSLSVGT EDDNFTVLNL AVAAAPHIYQ
160 170 180 190 200
NSFVQVVLNS LIKKSKSSMF QTRSLKELLW GYKDPFLSLV PYPISTTVGV
210 220 230 240 250
FYPYNDTVDG VYKVFNGKDN ISKVAIIESY KGKRNLSYWP SYCDMINGTD
260 270 280 290 300
AASFPPFVEK SRTLRFFSSD ICRSIYAVFG SEIDLKGIPV YRFVLPANAF
310 320 330 340 350
ASPLQNPDNH CFCTEKVISN NCTSYGVLDI GKCKEGKPVY ISLPHFLHAS
360 370 380 390 400
PDVSEPIEGL HPNEDEHRTY LDVEPITGFT LQFAKRLQVN ILVKPARKIE
410 420 430 440 450
ALKNLKRPYI VPILWLNETG TIGDEKAEMF KTQVTGKIKL LGMVEMALLG
460 470
IGVVMFVAFM ISYCACKSKN GK
Length:472
Mass (Da):52,698
Last modified:January 23, 2007 - v2
Checksum:i80AEABB18206534F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23108 mRNA. Translation: AAA53028.1.
BC010262 mRNA. Translation: AAH10262.1.
CCDSiCCDS19100.1.
PIRiI49590.
RefSeqiNP_001153027.1. NM_001159555.1.
NP_001153028.1. NM_001159556.1.
NP_001153029.1. NM_001159557.1.
NP_001153030.1. NM_001159558.1.
NP_031669.3. NM_007643.4.
XP_006535683.1. XM_006535620.2.
XP_006535684.1. XM_006535621.2.
XP_006535685.1. XM_006535622.2.
XP_006535686.1. XM_006535623.2.
XP_006535687.1. XM_006535624.2.
XP_006535688.1. XM_006535625.1.
UniGeneiMm.18628.
Mm.406799.

Genome annotation databases

EnsembliENSMUST00000082367; ENSMUSP00000080974; ENSMUSG00000002944.
ENSMUST00000165232; ENSMUSP00000126300; ENSMUSG00000002944.
ENSMUST00000169095; ENSMUSP00000131832; ENSMUSG00000002944.
ENSMUST00000170051; ENSMUSP00000133008; ENSMUSG00000002944.
ENSMUST00000197890; ENSMUSP00000143061; ENSMUSG00000002944.
GeneIDi12491.
KEGGimmu:12491.
UCSCiuc008wnn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23108 mRNA. Translation: AAA53028.1.
BC010262 mRNA. Translation: AAH10262.1.
CCDSiCCDS19100.1.
PIRiI49590.
RefSeqiNP_001153027.1. NM_001159555.1.
NP_001153028.1. NM_001159556.1.
NP_001153029.1. NM_001159557.1.
NP_001153030.1. NM_001159558.1.
NP_031669.3. NM_007643.4.
XP_006535683.1. XM_006535620.2.
XP_006535684.1. XM_006535621.2.
XP_006535685.1. XM_006535622.2.
XP_006535686.1. XM_006535623.2.
XP_006535687.1. XM_006535624.2.
XP_006535688.1. XM_006535625.1.
UniGeneiMm.18628.
Mm.406799.

3D structure databases

ProteinModelPortaliQ08857.
SMRiQ08857. Positions 40-432.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198587. 1 interaction.
IntActiQ08857. 4 interactions.
MINTiMINT-4090233.
STRINGi10090.ENSMUSP00000080974.

Chemistry

ChEMBLiCHEMBL2176845.

Protein family/group databases

TCDBi9.B.39.1.1. the long chain fatty acid translocase (lcfat) family.

PTM databases

iPTMnetiQ08857.
SwissPalmiQ08857.

Proteomic databases

PaxDbiQ08857.
PRIDEiQ08857.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082367; ENSMUSP00000080974; ENSMUSG00000002944.
ENSMUST00000165232; ENSMUSP00000126300; ENSMUSG00000002944.
ENSMUST00000169095; ENSMUSP00000131832; ENSMUSG00000002944.
ENSMUST00000170051; ENSMUSP00000133008; ENSMUSG00000002944.
ENSMUST00000197890; ENSMUSP00000143061; ENSMUSG00000002944.
GeneIDi12491.
KEGGimmu:12491.
UCSCiuc008wnn.2. mouse.

Organism-specific databases

CTDi948.
MGIiMGI:107899. Cd36.

Phylogenomic databases

eggNOGiKOG3776. Eukaryota.
ENOG410XS17. LUCA.
HOGENOMiHOG000252951.
HOVERGENiHBG002754.
InParanoidiQ08857.
KOiK06259.
OMAiKDYTIFP.
OrthoDBiEOG79SDWX.
PhylomeDBiQ08857.
TreeFamiTF317925.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-1236973. Cross-presentation of particulate exogenous antigens (phagosomes).
R-MMU-3000471. Scavenging by Class B Receptors.

Miscellaneous databases

NextBioi281412.
PROiQ08857.
SOURCEiSearch...

Gene expression databases

BgeeiQ08857.
CleanExiMM_CD36.
ExpressionAtlasiQ08857. baseline and differential.
GenevisibleiQ08857. MM.

Family and domain databases

InterProiIPR005428. CD36/SCARB1/SNMP1.
IPR033076. CD36_chordates.
IPR002159. CD36_fam.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PTHR11923:SF12. PTHR11923:SF12. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CD36 is a receptor for oxidized low density lipoprotein."
    Endemann G., Stanton L.W., Madden K.S., Bryant C.M., White R.T., Protter A.A.
    J. Biol. Chem. 268:11811-11816(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Peritoneal macrophage.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. "CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions."
    Laugerette F., Passilly-Degrace P., Patris B., Niot I., Febbraio M., Montmayeur J.P., Besnard P.
    J. Clin. Invest. 115:3177-3184(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  4. "The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein."
    Simantov R., Febbraio M., Silverstein R.L.
    Matrix Biol. 24:27-34(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH THBS2, FUNCTION.
  5. Cited for: FUNCTION.
  6. "CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine."
    Nassir F., Wilson B., Han X., Gross R.W., Abumrad N.A.
    J. Biol. Chem. 282:19493-19501(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
  7. "The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse."
    Gaillard D., Laugerette F., Darcel N., El-Yassimi A., Passilly-Degrace P., Hichami A., Khan N.A., Montmayeur J.P., Besnard P.
    FASEB J. 22:1458-1468(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake."
    Smith J., Su X., El-Maghrabi R., Stahl P.D., Abumrad N.A.
    J. Biol. Chem. 283:13578-13585(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION.
  9. "TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis."
    Drage M.G., Pecora N.D., Hise A.G., Febbraio M., Silverstein R.L., Golenbock D.T., Boom W.H., Harding C.V.
    Cell. Immunol. 258:29-37(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION (MICROBIAL INFECTION), TISSUE SPECIFICITY.
    Tissue: Macrophage.
  10. "CD36 and TLR interactions in inflammation and phagocytosis: implications for malaria."
    Erdman L.K., Cosio G., Helmers A.J., Gowda D.C., Grinstein S., Kain K.C.
    J. Immunol. 183:6452-6459(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION (MICROBIAL INFECTION).
  11. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  12. "Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2."
    Jimenez-Dalmaroni M.J., Xiao N., Corper A.L., Verdino P., Ainge G.D., Larsen D.S., Painter G.F., Rudd P.M., Dwek R.A., Hoebe K., Beutler B., Wilson I.A.
    PLoS ONE 4:E7411-E7411(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior."
    Silverstein R.L., Febbraio M.
    Sci. Signal. 2:RE3-RE3(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW OF FUNCTION.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  15. "CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer."
    Stewart C.R., Stuart L.M., Wilkinson K., van Gils J.M., Deng J., Halle A., Rayner K.J., Boyer L., Zhong R., Frazier W.A., Lacy-Hulbert A., El Khoury J., Golenbock D.T., Moore K.J.
    Nat. Immunol. 11:155-161(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  16. "Luminal lipid regulates CD36 levels and downstream signaling to stimulate chylomicron synthesis."
    Tran T.T., Poirier H., Clement L., Nassir F., Pelsers M.M., Petit V., Degrace P., Monnot M.C., Glatz J.F., Abumrad N.A., Besnard P., Niot I.
    J. Biol. Chem. 286:25201-25210(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, UBIQUITINATION.
  17. "The lipid-sensor candidates CD36 and GPR120 are differentially regulated by dietary lipids in mouse taste buds: impact on spontaneous fat preference."
    Martin C., Passilly-Degrace P., Gaillard D., Merlin J.F., Chevrot M., Besnard P.
    PLoS ONE 6:E24014-E24014(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE.
  18. "Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization."
    Heit B., Kim H., Cosio G., Castano D., Collins R., Lowell C.A., Kain K.C., Trimble W.S., Grinstein S.
    Dev. Cell 24:372-383(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, FUNCTION (MICROBIAL INFECTION), INTERACTION WITH FCER1G; ITGB1; ITGB2; CD9 AND CD81, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  19. "FAT/CD36: a major regulator of neuronal fatty acid sensing and energy homeostasis in rats and mice."
    Le Foll C., Dunn-Meynell A., Musatov S., Magnan C., Levin B.E.
    Diabetes 62:2709-2716(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  20. "CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation."
    Sheedy F.J., Grebe A., Rayner K.J., Kalantari P., Ramkhelawon B., Carpenter S.B., Becker C.E., Ediriweera H.N., Mullick A.E., Golenbock D.T., Stuart L.M., Latz E., Fitzgerald K.A., Moore K.J.
    Nat. Immunol. 14:812-820(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCD36_MOUSE
AccessioniPrimary (citable) accession number: Q08857
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.