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Q08857

- CD36_MOUSE

UniProt

Q08857 - CD36_MOUSE

Protein

Platelet glycoprotein 4

Gene

Cd36

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport By similarity. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects By similarity.By similarity

    GO - Molecular functioni

    1. high-density lipoprotein particle binding Source: MGI
    2. lipid binding Source: BHF-UCL
    3. lipoteichoic acid receptor activity Source: MGI
    4. low-density lipoprotein particle binding Source: BHF-UCL
    5. low-density lipoprotein receptor activity Source: BHF-UCL
    6. protein binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic cell clearance Source: MGI
    2. cell adhesion Source: UniProtKB-KW
    3. cell surface receptor signaling pathway Source: BHF-UCL
    4. cellular response to bacterial lipopeptide Source: MGI
    5. cellular response to hydroperoxide Source: BHF-UCL
    6. cellular response to lipopolysaccharide Source: MGI
    7. cellular response to lipoteichoic acid Source: MGI
    8. cGMP-mediated signaling Source: Ensembl
    9. cholesterol transport Source: BHF-UCL
    10. defense response to Gram-positive bacterium Source: MGI
    11. lipid storage Source: BHF-UCL
    12. lipoprotein transport Source: BHF-UCL
    13. long-chain fatty acid import Source: Ensembl
    14. low-density lipoprotein particle clearance Source: BHF-UCL
    15. low-density lipoprotein particle mediated signaling Source: BHF-UCL
    16. negative regulation of gene expression Source: BHF-UCL
    17. negative regulation of growth of symbiont in host Source: MGI
    18. negative regulation of transcription factor import into nucleus Source: BHF-UCL
    19. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    20. nitric oxide mediated signal transduction Source: Ensembl
    21. pattern recognition receptor signaling pathway Source: GOC
    22. phagocytosis, recognition Source: MGI
    23. plasma lipoprotein particle clearance Source: BHF-UCL
    24. plasma membrane long-chain fatty acid transport Source: Ensembl
    25. positive regulation of blood coagulation Source: BHF-UCL
    26. positive regulation of blood microparticle formation Source: BHF-UCL
    27. positive regulation of cell-matrix adhesion Source: Ensembl
    28. positive regulation of cholesterol storage Source: BHF-UCL
    29. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
    30. positive regulation of interleukin-12 production Source: MGI
    31. positive regulation of interleukin-6 production Source: MGI
    32. positive regulation of macrophage cytokine production Source: MGI
    33. positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
    34. positive regulation of MAPK cascade Source: MGI
    35. positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
    36. positive regulation of phagocytosis, engulfment Source: MGI
    37. positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
    38. positive regulation of tumor necrosis factor production Source: MGI
    39. receptor-mediated endocytosis Source: GOC
    40. regulation of removal of superoxide radicals Source: BHF-UCL
    41. regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: BHF-UCL
    42. response to stilbenoid Source: UniProtKB

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Cell adhesion, Transport

    Enzyme and pathway databases

    ReactomeiREACT_196592. Scavenging by Class B Receptors.
    REACT_198602. PPARA activates gene expression.
    REACT_199093. Cross-presentation of particulate exogenous antigens (phagosomes).

    Protein family/group databases

    TCDBi9.B.39.1.1. the long chain fatty acid translocase (lcfat) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Platelet glycoprotein 4
    Alternative name(s):
    Glycoprotein IIIb
    Short name:
    GPIIIB
    PAS IV
    PAS-4
    Platelet glycoprotein IV
    Short name:
    GPIV
    CD_antigen: CD36
    Gene namesi
    Name:Cd36
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:107899. Cd36.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: BHF-UCL
    2. external side of plasma membrane Source: MGI
    3. Golgi apparatus Source: MGI
    4. integral component of membrane Source: UniProtKB-KW
    5. membrane raft Source: MGI
    6. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 472471Platelet glycoprotein 4PRO_0000144153Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi3 – 31S-palmitoyl cysteineBy similarity
    Lipidationi7 – 71S-palmitoyl cysteineBy similarity
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi243 ↔ 311By similarity
    Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi272 ↔ 333By similarity
    Disulfide bondi313 ↔ 322By similarity
    Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
    Lipidationi464 – 4641S-palmitoyl cysteineBy similarity
    Lipidationi466 – 4661S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiQ08857.
    PaxDbiQ08857.
    PRIDEiQ08857.

    Expressioni

    Gene expression databases

    ArrayExpressiQ08857.
    BgeeiQ08857.
    CleanExiMM_CD36.
    GenevestigatoriQ08857.

    Interactioni

    Subunit structurei

    Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity.1 Publication

    Protein-protein interaction databases

    BioGridi198587. 1 interaction.
    IntActiQ08857. 4 interactions.
    MINTiMINT-4090233.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08857.
    SMRiQ08857. Positions 37-432.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 76CytoplasmicSequence Analysis
    Topological domaini30 – 439410ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini462 – 47211CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2922HelicalSequence AnalysisAdd
    BLAST
    Transmembranei440 – 46122HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni93 – 12028Required for interaction with thrombospondins, THBS1 and THBS2Add
    BLAST

    Sequence similaritiesi

    Belongs to the CD36 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257244.
    HOGENOMiHOG000252951.
    HOVERGENiHBG002754.
    InParanoidiQ08857.
    KOiK06259.
    OMAiKRNYIVP.
    OrthoDBiEOG79SDWX.
    PhylomeDBiQ08857.
    TreeFamiTF317925.

    Family and domain databases

    InterProiIPR002159. CD36.
    IPR005428. CD36_antigen.
    [Graphical view]
    PANTHERiPTHR11923. PTHR11923. 1 hit.
    PfamiPF01130. CD36. 1 hit.
    [Graphical view]
    PRINTSiPR01610. CD36ANTIGEN.
    PR01609. CD36FAMILY.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q08857-1 [UniParc]FASTAAdd to Basket

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    MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DMLIEKTIKR EVVLEEGTTA    50
    FKNWVKTGTT VYRQFWIFDV QNPDDVAKNS SKIKVKQRGP YTYRVRYLAK 100
    ENITQDPEDH TVSFVQPNGA IFEPSLSVGT EDDNFTVLNL AVAAAPHIYQ 150
    NSFVQVVLNS LIKKSKSSMF QTRSLKELLW GYKDPFLSLV PYPISTTVGV 200
    FYPYNDTVDG VYKVFNGKDN ISKVAIIESY KGKRNLSYWP SYCDMINGTD 250
    AASFPPFVEK SRTLRFFSSD ICRSIYAVFG SEIDLKGIPV YRFVLPANAF 300
    ASPLQNPDNH CFCTEKVISN NCTSYGVLDI GKCKEGKPVY ISLPHFLHAS 350
    PDVSEPIEGL HPNEDEHRTY LDVEPITGFT LQFAKRLQVN ILVKPARKIE 400
    ALKNLKRPYI VPILWLNETG TIGDEKAEMF KTQVTGKIKL LGMVEMALLG 450
    IGVVMFVAFM ISYCACKSKN GK 472
    Length:472
    Mass (Da):52,698
    Last modified:January 23, 2007 - v2
    Checksum:i80AEABB18206534F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23108 mRNA. Translation: AAA53028.1.
    BC010262 mRNA. Translation: AAH10262.1.
    CCDSiCCDS19100.1.
    PIRiI49590.
    RefSeqiNP_001153027.1. NM_001159555.1.
    NP_001153028.1. NM_001159556.1.
    NP_001153029.1. NM_001159557.1.
    NP_001153030.1. NM_001159558.1.
    NP_031669.3. NM_007643.4.
    XP_006535683.1. XM_006535620.1.
    XP_006535684.1. XM_006535621.1.
    XP_006535685.1. XM_006535622.1.
    XP_006535686.1. XM_006535623.1.
    XP_006535687.1. XM_006535624.1.
    XP_006535688.1. XM_006535625.1.
    UniGeneiMm.18628.
    Mm.406799.

    Genome annotation databases

    EnsembliENSMUST00000082367; ENSMUSP00000080974; ENSMUSG00000002944.
    ENSMUST00000165232; ENSMUSP00000126300; ENSMUSG00000002944.
    ENSMUST00000169095; ENSMUSP00000131832; ENSMUSG00000002944.
    ENSMUST00000170051; ENSMUSP00000133008; ENSMUSG00000002944.
    GeneIDi12491.
    KEGGimmu:12491.
    UCSCiuc008wnn.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23108 mRNA. Translation: AAA53028.1 .
    BC010262 mRNA. Translation: AAH10262.1 .
    CCDSi CCDS19100.1.
    PIRi I49590.
    RefSeqi NP_001153027.1. NM_001159555.1.
    NP_001153028.1. NM_001159556.1.
    NP_001153029.1. NM_001159557.1.
    NP_001153030.1. NM_001159558.1.
    NP_031669.3. NM_007643.4.
    XP_006535683.1. XM_006535620.1.
    XP_006535684.1. XM_006535621.1.
    XP_006535685.1. XM_006535622.1.
    XP_006535686.1. XM_006535623.1.
    XP_006535687.1. XM_006535624.1.
    XP_006535688.1. XM_006535625.1.
    UniGenei Mm.18628.
    Mm.406799.

    3D structure databases

    ProteinModelPortali Q08857.
    SMRi Q08857. Positions 37-432.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198587. 1 interaction.
    IntActi Q08857. 4 interactions.
    MINTi MINT-4090233.

    Chemistry

    ChEMBLi CHEMBL2176845.

    Protein family/group databases

    TCDBi 9.B.39.1.1. the long chain fatty acid translocase (lcfat) family.

    Proteomic databases

    MaxQBi Q08857.
    PaxDbi Q08857.
    PRIDEi Q08857.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000082367 ; ENSMUSP00000080974 ; ENSMUSG00000002944 .
    ENSMUST00000165232 ; ENSMUSP00000126300 ; ENSMUSG00000002944 .
    ENSMUST00000169095 ; ENSMUSP00000131832 ; ENSMUSG00000002944 .
    ENSMUST00000170051 ; ENSMUSP00000133008 ; ENSMUSG00000002944 .
    GeneIDi 12491.
    KEGGi mmu:12491.
    UCSCi uc008wnn.2. mouse.

    Organism-specific databases

    CTDi 948.
    MGIi MGI:107899. Cd36.

    Phylogenomic databases

    eggNOGi NOG257244.
    HOGENOMi HOG000252951.
    HOVERGENi HBG002754.
    InParanoidi Q08857.
    KOi K06259.
    OMAi KRNYIVP.
    OrthoDBi EOG79SDWX.
    PhylomeDBi Q08857.
    TreeFami TF317925.

    Enzyme and pathway databases

    Reactomei REACT_196592. Scavenging by Class B Receptors.
    REACT_198602. PPARA activates gene expression.
    REACT_199093. Cross-presentation of particulate exogenous antigens (phagosomes).

    Miscellaneous databases

    ChiTaRSi CD36. mouse.
    NextBioi 281412.
    PROi Q08857.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q08857.
    Bgeei Q08857.
    CleanExi MM_CD36.
    Genevestigatori Q08857.

    Family and domain databases

    InterProi IPR002159. CD36.
    IPR005428. CD36_antigen.
    [Graphical view ]
    PANTHERi PTHR11923. PTHR11923. 1 hit.
    Pfami PF01130. CD36. 1 hit.
    [Graphical view ]
    PRINTSi PR01610. CD36ANTIGEN.
    PR01609. CD36FAMILY.
    ProtoNeti Search...

    Publicationsi

    1. "CD36 is a receptor for oxidized low density lipoprotein."
      Endemann G., Stanton L.W., Madden K.S., Bryant C.M., White R.T., Protter A.A.
      J. Biol. Chem. 268:11811-11816(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Peritoneal macrophage.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    3. "The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein."
      Simantov R., Febbraio M., Silverstein R.L.
      Matrix Biol. 24:27-34(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH THBS2, FUNCTION.

    Entry informationi

    Entry nameiCD36_MOUSE
    AccessioniPrimary (citable) accession number: Q08857
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3