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Q08857

- CD36_MOUSE

UniProt

Q08857 - CD36_MOUSE

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Protein
Platelet glycoprotein 4
Gene
Cd36
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport By similarity. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects By similarity.1 Publication

GO - Molecular functioni

  1. high-density lipoprotein particle binding Source: MGI
  2. lipid binding Source: BHF-UCL
  3. lipoteichoic acid receptor activity Source: MGI
  4. low-density lipoprotein particle binding Source: BHF-UCL
  5. low-density lipoprotein receptor activity Source: BHF-UCL
  6. protein binding Source: UniProtKB

GO - Biological processi

  1. apoptotic cell clearance Source: MGI
  2. cGMP-mediated signaling Source: Ensembl
  3. cell adhesion Source: UniProtKB-KW
  4. cell surface receptor signaling pathway Source: BHF-UCL
  5. cellular response to bacterial lipopeptide Source: MGI
  6. cellular response to hydroperoxide Source: BHF-UCL
  7. cellular response to lipopolysaccharide Source: MGI
  8. cellular response to lipoteichoic acid Source: MGI
  9. cholesterol transport Source: BHF-UCL
  10. defense response to Gram-positive bacterium Source: MGI
  11. lipid storage Source: BHF-UCL
  12. lipoprotein transport Source: BHF-UCL
  13. long-chain fatty acid import Source: Ensembl
  14. low-density lipoprotein particle clearance Source: BHF-UCL
  15. low-density lipoprotein particle mediated signaling Source: BHF-UCL
  16. negative regulation of gene expression Source: BHF-UCL
  17. negative regulation of growth of symbiont in host Source: MGI
  18. negative regulation of transcription factor import into nucleus Source: BHF-UCL
  19. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  20. nitric oxide mediated signal transduction Source: Ensembl
  21. pattern recognition receptor signaling pathway Source: GOC
  22. phagocytosis, recognition Source: MGI
  23. plasma lipoprotein particle clearance Source: BHF-UCL
  24. plasma membrane long-chain fatty acid transport Source: Ensembl
  25. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  26. positive regulation of MAPK cascade Source: MGI
  27. positive regulation of blood coagulation Source: BHF-UCL
  28. positive regulation of blood microparticle formation Source: BHF-UCL
  29. positive regulation of cell-matrix adhesion Source: Ensembl
  30. positive regulation of cholesterol storage Source: BHF-UCL
  31. positive regulation of interleukin-12 production Source: MGI
  32. positive regulation of interleukin-6 production Source: MGI
  33. positive regulation of macrophage cytokine production Source: MGI
  34. positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  35. positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  36. positive regulation of phagocytosis, engulfment Source: MGI
  37. positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
  38. positive regulation of tumor necrosis factor production Source: MGI
  39. receptor-mediated endocytosis Source: GOC
  40. regulation of removal of superoxide radicals Source: BHF-UCL
  41. regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: BHF-UCL
  42. response to stilbenoid Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion, Transport

Enzyme and pathway databases

ReactomeiREACT_196592. Scavenging by Class B Receptors.
REACT_198602. PPARA activates gene expression.
REACT_199093. Cross-presentation of particulate exogenous antigens (phagosomes).

Protein family/group databases

TCDBi9.B.39.1.1. the long chain fatty acid translocase (lcfat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein 4
Alternative name(s):
Glycoprotein IIIb
Short name:
GPIIIB
PAS IV
PAS-4
Platelet glycoprotein IV
Short name:
GPIV
CD_antigen: CD36
Gene namesi
Name:Cd36
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:107899. Cd36.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 76Cytoplasmic Reviewed prediction
Transmembranei8 – 2922Helical; Reviewed prediction
Add
BLAST
Topological domaini30 – 439410Extracellular Reviewed prediction
Add
BLAST
Transmembranei440 – 46122Helical; Reviewed prediction
Add
BLAST
Topological domaini462 – 47211Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: MGI
  2. cell surface Source: BHF-UCL
  3. external side of plasma membrane Source: MGI
  4. integral component of membrane Source: UniProtKB-KW
  5. membrane raft Source: MGI
  6. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 472471Platelet glycoprotein 4
PRO_0000144153Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi3 – 31S-palmitoyl cysteine By similarity
Lipidationi7 – 71S-palmitoyl cysteine By similarity
Glycosylationi79 – 791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi134 – 1341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi205 – 2051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi220 – 2201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi235 – 2351N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi243 ↔ 311 By similarity
Glycosylationi247 – 2471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi272 ↔ 333 By similarity
Disulfide bondi313 ↔ 322 By similarity
Glycosylationi321 – 3211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi417 – 4171N-linked (GlcNAc...) Reviewed prediction
Lipidationi464 – 4641S-palmitoyl cysteine By similarity
Lipidationi466 – 4661S-palmitoyl cysteine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ08857.
PaxDbiQ08857.
PRIDEiQ08857.

Expressioni

Gene expression databases

ArrayExpressiQ08857.
BgeeiQ08857.
CleanExiMM_CD36.
GenevestigatoriQ08857.

Interactioni

Subunit structurei

Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity.1 Publication

Protein-protein interaction databases

BioGridi198587. 1 interaction.
IntActiQ08857. 4 interactions.
MINTiMINT-4090233.

Structurei

3D structure databases

ProteinModelPortaliQ08857.
SMRiQ08857. Positions 37-432.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 12028Required for interaction with thrombospondins, THBS1 and THBS2
Add
BLAST

Sequence similaritiesi

Belongs to the CD36 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257244.
HOGENOMiHOG000252951.
HOVERGENiHBG002754.
InParanoidiQ08857.
KOiK06259.
OMAiKRNYIVP.
OrthoDBiEOG79SDWX.
PhylomeDBiQ08857.
TreeFamiTF317925.

Family and domain databases

InterProiIPR002159. CD36.
IPR005428. CD36_antigen.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08857-1 [UniParc]FASTAAdd to Basket

« Hide

MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DMLIEKTIKR EVVLEEGTTA    50
FKNWVKTGTT VYRQFWIFDV QNPDDVAKNS SKIKVKQRGP YTYRVRYLAK 100
ENITQDPEDH TVSFVQPNGA IFEPSLSVGT EDDNFTVLNL AVAAAPHIYQ 150
NSFVQVVLNS LIKKSKSSMF QTRSLKELLW GYKDPFLSLV PYPISTTVGV 200
FYPYNDTVDG VYKVFNGKDN ISKVAIIESY KGKRNLSYWP SYCDMINGTD 250
AASFPPFVEK SRTLRFFSSD ICRSIYAVFG SEIDLKGIPV YRFVLPANAF 300
ASPLQNPDNH CFCTEKVISN NCTSYGVLDI GKCKEGKPVY ISLPHFLHAS 350
PDVSEPIEGL HPNEDEHRTY LDVEPITGFT LQFAKRLQVN ILVKPARKIE 400
ALKNLKRPYI VPILWLNETG TIGDEKAEMF KTQVTGKIKL LGMVEMALLG 450
IGVVMFVAFM ISYCACKSKN GK 472
Length:472
Mass (Da):52,698
Last modified:January 23, 2007 - v2
Checksum:i80AEABB18206534F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23108 mRNA. Translation: AAA53028.1.
BC010262 mRNA. Translation: AAH10262.1.
CCDSiCCDS19100.1.
PIRiI49590.
RefSeqiNP_001153027.1. NM_001159555.1.
NP_001153028.1. NM_001159556.1.
NP_001153029.1. NM_001159557.1.
NP_001153030.1. NM_001159558.1.
NP_031669.3. NM_007643.4.
XP_006535683.1. XM_006535620.1.
XP_006535684.1. XM_006535621.1.
XP_006535685.1. XM_006535622.1.
XP_006535686.1. XM_006535623.1.
XP_006535687.1. XM_006535624.1.
XP_006535688.1. XM_006535625.1.
UniGeneiMm.18628.
Mm.406799.

Genome annotation databases

EnsembliENSMUST00000082367; ENSMUSP00000080974; ENSMUSG00000002944.
ENSMUST00000165232; ENSMUSP00000126300; ENSMUSG00000002944.
ENSMUST00000169095; ENSMUSP00000131832; ENSMUSG00000002944.
ENSMUST00000170051; ENSMUSP00000133008; ENSMUSG00000002944.
GeneIDi12491.
KEGGimmu:12491.
UCSCiuc008wnn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23108 mRNA. Translation: AAA53028.1 .
BC010262 mRNA. Translation: AAH10262.1 .
CCDSi CCDS19100.1.
PIRi I49590.
RefSeqi NP_001153027.1. NM_001159555.1.
NP_001153028.1. NM_001159556.1.
NP_001153029.1. NM_001159557.1.
NP_001153030.1. NM_001159558.1.
NP_031669.3. NM_007643.4.
XP_006535683.1. XM_006535620.1.
XP_006535684.1. XM_006535621.1.
XP_006535685.1. XM_006535622.1.
XP_006535686.1. XM_006535623.1.
XP_006535687.1. XM_006535624.1.
XP_006535688.1. XM_006535625.1.
UniGenei Mm.18628.
Mm.406799.

3D structure databases

ProteinModelPortali Q08857.
SMRi Q08857. Positions 37-432.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198587. 1 interaction.
IntActi Q08857. 4 interactions.
MINTi MINT-4090233.

Chemistry

ChEMBLi CHEMBL2176845.

Protein family/group databases

TCDBi 9.B.39.1.1. the long chain fatty acid translocase (lcfat) family.

Proteomic databases

MaxQBi Q08857.
PaxDbi Q08857.
PRIDEi Q08857.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082367 ; ENSMUSP00000080974 ; ENSMUSG00000002944 .
ENSMUST00000165232 ; ENSMUSP00000126300 ; ENSMUSG00000002944 .
ENSMUST00000169095 ; ENSMUSP00000131832 ; ENSMUSG00000002944 .
ENSMUST00000170051 ; ENSMUSP00000133008 ; ENSMUSG00000002944 .
GeneIDi 12491.
KEGGi mmu:12491.
UCSCi uc008wnn.2. mouse.

Organism-specific databases

CTDi 948.
MGIi MGI:107899. Cd36.

Phylogenomic databases

eggNOGi NOG257244.
HOGENOMi HOG000252951.
HOVERGENi HBG002754.
InParanoidi Q08857.
KOi K06259.
OMAi KRNYIVP.
OrthoDBi EOG79SDWX.
PhylomeDBi Q08857.
TreeFami TF317925.

Enzyme and pathway databases

Reactomei REACT_196592. Scavenging by Class B Receptors.
REACT_198602. PPARA activates gene expression.
REACT_199093. Cross-presentation of particulate exogenous antigens (phagosomes).

Miscellaneous databases

ChiTaRSi CD36. mouse.
NextBioi 281412.
PROi Q08857.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q08857.
Bgeei Q08857.
CleanExi MM_CD36.
Genevestigatori Q08857.

Family and domain databases

InterProi IPR002159. CD36.
IPR005428. CD36_antigen.
[Graphical view ]
PANTHERi PTHR11923. PTHR11923. 1 hit.
Pfami PF01130. CD36. 1 hit.
[Graphical view ]
PRINTSi PR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CD36 is a receptor for oxidized low density lipoprotein."
    Endemann G., Stanton L.W., Madden K.S., Bryant C.M., White R.T., Protter A.A.
    J. Biol. Chem. 268:11811-11816(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Peritoneal macrophage.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. "The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein."
    Simantov R., Febbraio M., Silverstein R.L.
    Matrix Biol. 24:27-34(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH THBS2, FUNCTION.

Entry informationi

Entry nameiCD36_MOUSE
AccessioniPrimary (citable) accession number: Q08857
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3