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Q08857

- CD36_MOUSE

UniProt

Q08857 - CD36_MOUSE

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Protein

Platelet glycoprotein 4

Gene

Cd36

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport (By similarity). Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4-TLR6, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42 binding, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory signals, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei463 – 4631Critical for TLR4-TLR6 dimerization and signalingBy similarity

GO - Molecular functioni

  1. high-density lipoprotein particle binding Source: MGI
  2. lipid binding Source: BHF-UCL
  3. lipoteichoic acid receptor activity Source: MGI
  4. low-density lipoprotein particle binding Source: BHF-UCL
  5. low-density lipoprotein receptor activity Source: BHF-UCL

GO - Biological processi

  1. apoptotic cell clearance Source: MGI
  2. cell adhesion Source: UniProtKB-KW
  3. cell surface receptor signaling pathway Source: BHF-UCL
  4. cellular response to bacterial lipopeptide Source: MGI
  5. cellular response to hydroperoxide Source: BHF-UCL
  6. cellular response to lipopolysaccharide Source: MGI
  7. cellular response to lipoteichoic acid Source: MGI
  8. cGMP-mediated signaling Source: Ensembl
  9. cholesterol transport Source: BHF-UCL
  10. defense response to Gram-positive bacterium Source: MGI
  11. lipid storage Source: BHF-UCL
  12. lipoprotein transport Source: BHF-UCL
  13. long-chain fatty acid import Source: Ensembl
  14. low-density lipoprotein particle clearance Source: BHF-UCL
  15. low-density lipoprotein particle mediated signaling Source: BHF-UCL
  16. negative regulation of gene expression Source: BHF-UCL
  17. negative regulation of growth of symbiont in host Source: MGI
  18. negative regulation of transcription factor import into nucleus Source: BHF-UCL
  19. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  20. nitric oxide mediated signal transduction Source: Ensembl
  21. pattern recognition receptor signaling pathway Source: GOC
  22. phagocytosis, recognition Source: MGI
  23. plasma lipoprotein particle clearance Source: BHF-UCL
  24. plasma membrane long-chain fatty acid transport Source: Ensembl
  25. positive regulation of blood coagulation Source: BHF-UCL
  26. positive regulation of blood microparticle formation Source: BHF-UCL
  27. positive regulation of cell-matrix adhesion Source: Ensembl
  28. positive regulation of cholesterol storage Source: BHF-UCL
  29. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  30. positive regulation of interleukin-12 production Source: MGI
  31. positive regulation of interleukin-6 production Source: MGI
  32. positive regulation of macrophage cytokine production Source: MGI
  33. positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  34. positive regulation of MAPK cascade Source: MGI
  35. positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  36. positive regulation of phagocytosis, engulfment Source: MGI
  37. positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
  38. positive regulation of tumor necrosis factor production Source: MGI
  39. receptor-mediated endocytosis Source: GOC
  40. regulation of removal of superoxide radicals Source: BHF-UCL
  41. regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: BHF-UCL
  42. response to stilbenoid Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion, Transport

Enzyme and pathway databases

ReactomeiREACT_196592. Scavenging by Class B Receptors.
REACT_198602. PPARA activates gene expression.
REACT_199093. Cross-presentation of particulate exogenous antigens (phagosomes).
REACT_230045. MyD88:Mal cascade initiated on plasma membrane.
REACT_252217. Transcriptional regulation of white adipocyte differentiation.
REACT_254406. Toll Like Receptor TLR6:TLR2 Cascade.

Protein family/group databases

TCDBi9.B.39.1.1. the long chain fatty acid translocase (lcfat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein 4
Alternative name(s):
Glycoprotein IIIb
Short name:
GPIIIB
PAS IV
PAS-4
Platelet glycoprotein IV
Short name:
GPIV
CD_antigen: CD36
Gene namesi
Name:Cd36
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:107899. Cd36.

Subcellular locationi

Cell membrane; Multi-pass membrane protein
Note: Upon ligand-binding, internalized through dynamin-dependent endocytosis.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 76CytoplasmicSequence Analysis
Transmembranei8 – 2922HelicalSequence AnalysisAdd
BLAST
Topological domaini30 – 439410ExtracellularSequence AnalysisAdd
BLAST
Transmembranei440 – 46122HelicalSequence AnalysisAdd
BLAST
Topological domaini462 – 47211CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: BHF-UCL
  2. external side of plasma membrane Source: MGI
  3. extracellular space Source: Ensembl
  4. Golgi apparatus Source: MGI
  5. integral component of membrane Source: UniProtKB-KW
  6. membrane raft Source: MGI
  7. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Animals with a double knockout of APOE and CD36, fed a Western diet for 12 weeks, exhibit much lower levels of CXCL1, CXCL2 and CCL5 cytokine mRNA expression in the descending aorta and a corresponding decrease in atherosclerotic lesion formation, compared to APOE single knockout mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 472471Platelet glycoprotein 4PRO_0000144153Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi3 – 31S-palmitoyl cysteineBy similarity
Lipidationi7 – 71S-palmitoyl cysteineBy similarity
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi243 ↔ 311By similarity
Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi272 ↔ 333By similarity
Disulfide bondi313 ↔ 322By similarity
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
Lipidationi464 – 4641S-palmitoyl cysteineBy similarity
Lipidationi466 – 4661S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ08857.
PaxDbiQ08857.
PRIDEiQ08857.

Expressioni

Gene expression databases

BgeeiQ08857.
CleanExiMM_CD36.
ExpressionAtlasiQ08857. baseline and differential.
GenevestigatoriQ08857.

Interactioni

Subunit structurei

Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. Upon interaction with a ligand, such as oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, rapidly forms a complex with TLR4 and TLR6; the complex is internalized and triggers an inflammatory signal. Through its C-terminus, interacts with PTK2, PXN and LYN, but not with SRC. LYN kinase activity is required for facilitating TLR4-TLR6 heterodimerization and signal initiation.By similarity1 Publication

Protein-protein interaction databases

BioGridi198587. 1 interaction.
IntActiQ08857. 4 interactions.
MINTiMINT-4090233.

Structurei

3D structure databases

ProteinModelPortaliQ08857.
SMRiQ08857. Positions 40-432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 12028Required for interaction with thrombospondins, THBS1 and THBS2Add
BLAST
Regioni460 – 47213Interaction with PTK2, PXN and LYNBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the CD36 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257244.
HOGENOMiHOG000252951.
HOVERGENiHBG002754.
InParanoidiQ08857.
KOiK06259.
OMAiKRNYIVP.
OrthoDBiEOG79SDWX.
PhylomeDBiQ08857.
TreeFamiTF317925.

Family and domain databases

InterProiIPR002159. CD36.
IPR005428. CD36_antigen.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08857-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DMLIEKTIKR EVVLEEGTTA
60 70 80 90 100
FKNWVKTGTT VYRQFWIFDV QNPDDVAKNS SKIKVKQRGP YTYRVRYLAK
110 120 130 140 150
ENITQDPEDH TVSFVQPNGA IFEPSLSVGT EDDNFTVLNL AVAAAPHIYQ
160 170 180 190 200
NSFVQVVLNS LIKKSKSSMF QTRSLKELLW GYKDPFLSLV PYPISTTVGV
210 220 230 240 250
FYPYNDTVDG VYKVFNGKDN ISKVAIIESY KGKRNLSYWP SYCDMINGTD
260 270 280 290 300
AASFPPFVEK SRTLRFFSSD ICRSIYAVFG SEIDLKGIPV YRFVLPANAF
310 320 330 340 350
ASPLQNPDNH CFCTEKVISN NCTSYGVLDI GKCKEGKPVY ISLPHFLHAS
360 370 380 390 400
PDVSEPIEGL HPNEDEHRTY LDVEPITGFT LQFAKRLQVN ILVKPARKIE
410 420 430 440 450
ALKNLKRPYI VPILWLNETG TIGDEKAEMF KTQVTGKIKL LGMVEMALLG
460 470
IGVVMFVAFM ISYCACKSKN GK
Length:472
Mass (Da):52,698
Last modified:January 23, 2007 - v2
Checksum:i80AEABB18206534F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23108 mRNA. Translation: AAA53028.1.
BC010262 mRNA. Translation: AAH10262.1.
CCDSiCCDS19100.1.
PIRiI49590.
RefSeqiNP_001153027.1. NM_001159555.1.
NP_001153028.1. NM_001159556.1.
NP_001153029.1. NM_001159557.1.
NP_001153030.1. NM_001159558.1.
NP_031669.3. NM_007643.4.
XP_006535683.1. XM_006535620.1.
XP_006535684.1. XM_006535621.1.
XP_006535685.1. XM_006535622.1.
XP_006535686.1. XM_006535623.1.
XP_006535687.1. XM_006535624.1.
XP_006535688.1. XM_006535625.1.
UniGeneiMm.18628.
Mm.406799.

Genome annotation databases

EnsembliENSMUST00000082367; ENSMUSP00000080974; ENSMUSG00000002944.
ENSMUST00000165232; ENSMUSP00000126300; ENSMUSG00000002944.
ENSMUST00000169095; ENSMUSP00000131832; ENSMUSG00000002944.
ENSMUST00000170051; ENSMUSP00000133008; ENSMUSG00000002944.
GeneIDi12491.
KEGGimmu:12491.
UCSCiuc008wnn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23108 mRNA. Translation: AAA53028.1 .
BC010262 mRNA. Translation: AAH10262.1 .
CCDSi CCDS19100.1.
PIRi I49590.
RefSeqi NP_001153027.1. NM_001159555.1.
NP_001153028.1. NM_001159556.1.
NP_001153029.1. NM_001159557.1.
NP_001153030.1. NM_001159558.1.
NP_031669.3. NM_007643.4.
XP_006535683.1. XM_006535620.1.
XP_006535684.1. XM_006535621.1.
XP_006535685.1. XM_006535622.1.
XP_006535686.1. XM_006535623.1.
XP_006535687.1. XM_006535624.1.
XP_006535688.1. XM_006535625.1.
UniGenei Mm.18628.
Mm.406799.

3D structure databases

ProteinModelPortali Q08857.
SMRi Q08857. Positions 40-432.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198587. 1 interaction.
IntActi Q08857. 4 interactions.
MINTi MINT-4090233.

Chemistry

ChEMBLi CHEMBL2176845.

Protein family/group databases

TCDBi 9.B.39.1.1. the long chain fatty acid translocase (lcfat) family.

Proteomic databases

MaxQBi Q08857.
PaxDbi Q08857.
PRIDEi Q08857.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082367 ; ENSMUSP00000080974 ; ENSMUSG00000002944 .
ENSMUST00000165232 ; ENSMUSP00000126300 ; ENSMUSG00000002944 .
ENSMUST00000169095 ; ENSMUSP00000131832 ; ENSMUSG00000002944 .
ENSMUST00000170051 ; ENSMUSP00000133008 ; ENSMUSG00000002944 .
GeneIDi 12491.
KEGGi mmu:12491.
UCSCi uc008wnn.2. mouse.

Organism-specific databases

CTDi 948.
MGIi MGI:107899. Cd36.

Phylogenomic databases

eggNOGi NOG257244.
HOGENOMi HOG000252951.
HOVERGENi HBG002754.
InParanoidi Q08857.
KOi K06259.
OMAi KRNYIVP.
OrthoDBi EOG79SDWX.
PhylomeDBi Q08857.
TreeFami TF317925.

Enzyme and pathway databases

Reactomei REACT_196592. Scavenging by Class B Receptors.
REACT_198602. PPARA activates gene expression.
REACT_199093. Cross-presentation of particulate exogenous antigens (phagosomes).
REACT_230045. MyD88:Mal cascade initiated on plasma membrane.
REACT_252217. Transcriptional regulation of white adipocyte differentiation.
REACT_254406. Toll Like Receptor TLR6:TLR2 Cascade.

Miscellaneous databases

NextBioi 281412.
PROi Q08857.
SOURCEi Search...

Gene expression databases

Bgeei Q08857.
CleanExi MM_CD36.
ExpressionAtlasi Q08857. baseline and differential.
Genevestigatori Q08857.

Family and domain databases

InterProi IPR002159. CD36.
IPR005428. CD36_antigen.
[Graphical view ]
PANTHERi PTHR11923. PTHR11923. 1 hit.
Pfami PF01130. CD36. 1 hit.
[Graphical view ]
PRINTSi PR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CD36 is a receptor for oxidized low density lipoprotein."
    Endemann G., Stanton L.W., Madden K.S., Bryant C.M., White R.T., Protter A.A.
    J. Biol. Chem. 268:11811-11816(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Peritoneal macrophage.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. "The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein."
    Simantov R., Febbraio M., Silverstein R.L.
    Matrix Biol. 24:27-34(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH THBS2, FUNCTION.
  4. "CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer."
    Stewart C.R., Stuart L.M., Wilkinson K., van Gils J.M., Deng J., Halle A., Rayner K.J., Boyer L., Zhong R., Frazier W.A., Lacy-Hulbert A., El Khoury J., Golenbock D.T., Moore K.J.
    Nat. Immunol. 11:155-161(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiCD36_MOUSE
AccessioniPrimary (citable) accession number: Q08857
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3