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Q08855

- COX1_RHILE

UniProt

Q08855 - COX1_RHILE

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Protein

Cytochrome c oxidase subunit 1

Gene
ctaD, coxA
Organism
Rhizobium leguminosarum
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi82 – 821Iron (heme A axial ligand) Inferred
Metal bindingi265 – 2651Copper B Inferred
Metal bindingi269 – 2691Copper B Inferred
Metal bindingi314 – 3141Copper B Inferred
Metal bindingi315 – 3151Copper B Inferred
Metal bindingi400 – 4001Iron (heme A3 axial ligand) Inferred
Metal bindingi402 – 4021Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Synonyms:coxA
OrganismiRhizobium leguminosarum
Taxonomic identifieri384 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 5721Helical; Reviewed predictionAdd
BLAST
Transmembranei84 – 10421Helical; Reviewed predictionAdd
BLAST
Transmembranei121 – 14121Helical; Reviewed predictionAdd
BLAST
Transmembranei170 – 19021Helical; Reviewed predictionAdd
BLAST
Transmembranei208 – 22821Helical; Reviewed predictionAdd
BLAST
Transmembranei259 – 27921Helical; Reviewed predictionAdd
BLAST
Transmembranei291 – 31121Helical; Reviewed predictionAdd
BLAST
Transmembranei329 – 34921Helical; Reviewed predictionAdd
BLAST
Transmembranei362 – 38221Helical; Reviewed predictionAdd
BLAST
Transmembranei401 – 42121Helical; Reviewed predictionAdd
BLAST
Transmembranei438 – 45821Helical; Reviewed predictionAdd
BLAST
Transmembranei476 – 49621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Cytochrome c oxidase subunit 1PRO_0000183447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki265 ↔ 2691'-histidyl-3'-tyrosine (His-Tyr) By similarity

Expressioni

Developmental stagei

Free in soil (not as bacteroid).

Structurei

3D structure databases

ProteinModelPortaliQ08855.
SMRiQ08855. Positions 24-538.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08855-1 [UniParc]FASTAAdd to Basket

« Hide

MATSAAAHGE HAEDHGHDEH AHPTGWRRST NHKDIGTLYL IFAIIAGVIG    50
AAMSLAIRAE LMYPGVEYFH NTHLYNVFVT SHGVIMIFFM VMPAMIGGFG 100
NWFLPLMIGA PDMAFPRMNN ISFWLLPASF GLLLMSTFVE GEPGANGAGA 150
GWTMYVPLSS SGHPGPAVDL AIFSLHIAGA SSILGAINFI TTILNMRAPG 200
MTLHKMPLFA WSVLITAFLL LLSLPVLAGA ITMLLTDRNF GTTFFAPEGG 250
GDPLLYQHLF WFFGHPEVYI LILPGFGMIS HIISTFSRKP VFGYIGMVYA 300
MAAIGGLGFV VWAHHMYIVG MDLDTEAYFV SATMIIAVPT GIKIFSWIAT 350
MWGGSIEFAT PMLWALAFIF LFTVGGVTGV VLANASLDRV LHDTYYVVAH 400
FHYVLSLGAI FAIFAGWYYW FPKMSGYMYN ETLAEAHFWL IFIGVNLIFF 450
PEHFLGISGM PRRYIDYPDA FAGWNLVSSI GSYISGFSVL LFIYCVYDAF 500
AKNVPVGDNP WGAGATTLEW TLPSPPPVHE FEVLPRVE 538
Length:538
Mass (Da):59,133
Last modified:February 1, 1996 - v1
Checksum:i740C8FE6C902D9BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74341 Genomic DNA. Translation: CAA52388.1.
PIRiS36424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74341 Genomic DNA. Translation: CAA52388.1 .
PIRi S36424.

3D structure databases

ProteinModelPortali Q08855.
SMRi Q08855. Positions 24-538.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cytochrome aa3 gene regulation in members of the family Rhizobiaceae: comparison of copper and oxygen effects in Bradyrhizobium japonicum and Rhizobium tropici."
    Gabel C., Bittinger M.A., Maier R.J.
    Appl. Environ. Microbiol. 60:141-148(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_RHILE
AccessioniPrimary (citable) accession number: Q08855
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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