Cytochrome c oxidase subunit 1 - Rhizobium leguminosarum

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Q08855 (COX1_RHILE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 83. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 1
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I

Gene names

Name:	ctaD
Synonyms:	coxA

Organism

Rhizobium leguminosarum

Taxonomic identifier

384 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length	538 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity	4 ferrocytochrome c + O₂ + 4 H⁺ = 4 ferricytochrome c + 2 H₂O.
Pathway	Energy metabolism; oxidative phosphorylation.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Developmental stage	Free in soil (not as bacteroid).
Sequence similarities	Belongs to the heme-copper respiratory oxidase family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Heme Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	aerobic respiration Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW oxidative phosphorylation Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 538

538

Cytochrome c oxidase subunit 1

PRO_0000183447

Regions

Transmembrane

37 – 57

Helical; Potential

Transmembrane

84 – 104

Helical; Potential

Transmembrane

121 – 141

Helical; Potential

Transmembrane

170 – 190

Helical; Potential

Transmembrane

208 – 228

Helical; Potential

Transmembrane

259 – 279

Helical; Potential

Transmembrane

291 – 311

Helical; Potential

Transmembrane

329 – 349

Helical; Potential

Transmembrane

362 – 382

Helical; Potential

Transmembrane

401 – 421

Helical; Potential

Transmembrane

438 – 458

Helical; Potential

Transmembrane

476 – 496

Helical; Potential

Sites

Metal binding

Iron (heme A axial ligand) Probable

Metal binding

265

Copper B Probable

Metal binding

269

Copper B Probable

Metal binding

314

Copper B Probable

Metal binding

315

Copper B Probable

Metal binding

400

Iron (heme A3 axial ligand) Probable

Metal binding

402

Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link

265 ↔ 269

1'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q08855 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 740C8FE6C902D9BF
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FASTA

538

59,133

        10         20         30         40         50         60 
MATSAAAHGE HAEDHGHDEH AHPTGWRRST NHKDIGTLYL IFAIIAGVIG AAMSLAIRAE 

        70         80         90        100        110        120 
LMYPGVEYFH NTHLYNVFVT SHGVIMIFFM VMPAMIGGFG NWFLPLMIGA PDMAFPRMNN 

       130        140        150        160        170        180 
ISFWLLPASF GLLLMSTFVE GEPGANGAGA GWTMYVPLSS SGHPGPAVDL AIFSLHIAGA 

       190        200        210        220        230        240 
SSILGAINFI TTILNMRAPG MTLHKMPLFA WSVLITAFLL LLSLPVLAGA ITMLLTDRNF 

       250        260        270        280        290        300 
GTTFFAPEGG GDPLLYQHLF WFFGHPEVYI LILPGFGMIS HIISTFSRKP VFGYIGMVYA 

       310        320        330        340        350        360 
MAAIGGLGFV VWAHHMYIVG MDLDTEAYFV SATMIIAVPT GIKIFSWIAT MWGGSIEFAT 

       370        380        390        400        410        420 
PMLWALAFIF LFTVGGVTGV VLANASLDRV LHDTYYVVAH FHYVLSLGAI FAIFAGWYYW 

       430        440        450        460        470        480 
FPKMSGYMYN ETLAEAHFWL IFIGVNLIFF PEHFLGISGM PRRYIDYPDA FAGWNLVSSI 

       490        500        510        520        530 
GSYISGFSVL LFIYCVYDAF AKNVPVGDNP WGAGATTLEW TLPSPPPVHE FEVLPRVE

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References

[1]

"Cytochrome aa3 gene regulation in members of the family Rhizobiaceae: comparison of copper and oxygen effects in Bradyrhizobium japonicum and Rhizobium tropici."
Gabel C., Bittinger M.A., Maier R.J.
Appl. Environ. Microbiol. 60:141-148(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X74341 Genomic DNA. Translation: CAA52388.1.
PIR	S36424.
3D structure databases
ProteinModelPortal	Q08855.
SMR	Q08855. Positions 24-538.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00705.
Family and domain databases
Gene3D	1.20.210.10. 1 hit.
InterPro	IPR000883. Cyt_c_Oxase_su1. IPR023615. Cyt_c_Oxase_su1_BS. IPR023616. Cyt_c_Oxase_su1_dom. IPR014241. Cyt_c_oxidase_su1_bac. [Graphical view]
PANTHER	PTHR10422. PTHR10422. 1 hit.
Pfam	PF00115. COX1. 1 hit. [Graphical view]
PRINTS	PR01165. CYCOXIDASEI.
SUPFAM	SSF81442. COX1. 1 hit.
TIGRFAMs	TIGR02891. CtaD_CoxA. 1 hit.
PROSITE	PS50855. COX1. 1 hit. PS00077. COX1_CUB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX1_RHILE

Accession

Primary (citable) accession number: Q08855

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents