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Protein

60 kDa chaperonin

Gene

groL

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Heat shock protein 60
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, hsp60, mopA
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000635372 – 53960 kDa chaperoninAdd BLAST538

Proteomic databases

PRIDEiQ08854.

Expressioni

Inductioni

By heat shock.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ08854.
SMRiQ08854.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08854-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKQLKFSED ARQAMLRGVD QLANAVKVTI GPKGRNVVLD KEFTAPLITN
60 70 80 90 100
DGVTIAKEIE LEDPYENMGA KLVQEVANKT NEIAGDGTTT ATVLAQAMIQ
110 120 130 140 150
EGLKNVTSGA NPVGLRQGID KAVKVAVEAL HENSQKVENK NEIAQVGAIS
160 170 180 190 200
AADEEIGRYI SEATEKVGND GVITIITIEE SNRLNTELEL GMQFDRGYQS
210 220 230 240 250
PYMVTDSDKM VAELERPYIL VTDKKISSFQ DILPLLEQVV QSNRPILIVA
260 270 280 290 300
DEVEGDALTN IVLNRMRGTF TAVAVKAPGF GDRRKAMLED LAILTGAQVI
310 320 330 340 350
TDDLGLDLKD ASIDMLGTAS KVEVTKDNTT VVDGDGDENS IDARVSQLKS
360 370 380 390 400
QIEETESDFD REKLQERLAK LAGGVAVIKV GAASETELKE RKLRIEDALN
410 420 430 440 450
STRAAVEEGI VAGGGTALVN VYQKVSENEA EGDIETGVNI VLKALTAPVR
460 470 480 490 500
QIAENAGLEG SVIVERLKNA EPGVGFNGAT NEWVNMLRRG IVDPTKVTRS
510 520 530
ALQHAASVAA MFLTTEAVVA SIPEKNNDQP NMGGMPGMM
Length:539
Mass (Da):57,854
Last modified:January 23, 2007 - v3
Checksum:i5817237C84F5615E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14711 Genomic DNA. Translation: BAA03533.1.
PIRiJN0601.

Similar proteinsi

Entry informationi

Entry nameiCH60_STAAU
AccessioniPrimary (citable) accession number: Q08854
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 89 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families