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Q08853 (ATC_PLAFK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Calcium-transporting ATPase
EC=3.6.3.8
Alternative name(s):
Calcium pump
Gene names
Name:ATP6
OrganismPlasmodium falciparum (isolate K1 / Thailand)
Taxonomic identifier5839 [NCBI]
Taxonomic lineageEukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania)

Protein attributes

Sequence length1228 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.

Catalytic activity

ATP + H2O + Ca2+[side 1] = ADP + phosphate + Ca2+[side 2].

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]

Ontologies

Keywords
   Biological processCalcium transport
Ion transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Calcium
Magnesium
Nucleotide-binding
   Molecular functionHydrolase
   PTMPhosphoprotein
   Technical term3D-structure
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

calcium-transporting ATPase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12281228Calcium-transporting ATPase
PRO_0000046227

Regions

Topological domain1 – 6363Cytoplasmic Potential
Transmembrane64 – 8118Helical; Potential
Topological domain82 – 9211Extracellular Potential
Transmembrane93 – 11220Helical; Potential
Topological domain113 – 270158Cytoplasmic Potential
Transmembrane271 – 29121Helical; Potential
Topological domain292 – 3009Extracellular Potential
Transmembrane301 – 32121Helical; Potential
Topological domain322 – 974653Cytoplasmic Potential
Transmembrane975 – 99420Helical; Potential
Topological domain995 – 10006Extracellular Potential
Transmembrane1001 – 102121Helical; Potential
Topological domain1022 – 104221Cytoplasmic Potential
Transmembrane1043 – 106725Helical; Potential
Topological domain1068 – 111851Extracellular Potential
Transmembrane1119 – 114022Helical; Potential
Topological domain1141 – 115111Cytoplasmic Potential
Transmembrane1152 – 117221Helical; Potential
Topological domain1173 – 118513Extracellular Potential
Transmembrane1186 – 120621Helical; Potential
Topological domain1207 – 122822Cytoplasmic Potential
Compositional bias457 – 4659Poly-Asn
Compositional bias661 – 67111Poly-Asn

Sites

Active site35814-aspartylphosphate intermediate
Binding site7161ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q08853 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 9A6EA4ABF4684079

FASTA1,228139,415
        10         20         30         40         50         60 
MEEVIKNAHT YDVEDVLKFL DVNKDNGLKN EELDDRRLKY GLNELEVEKK KSIFELILNQ 

        70         80         90        100        110        120 
FDDLLVKILL LAAFISFVLT LLDMKHKKIE ICDFIEPLVI VLILILNAAV GVWQECNAEK 

       130        140        150        160        170        180 
SLEALKELQP TKAKVLRDGK WEIIDSKYLY VGDIIELSVG NKTPADARII KIYSTSLKVE 

       190        200        210        220        230        240 
QSMLTGESCS VDKYAEKMED SYKNCEIQLK KNILFSSTAI VCGRCIAVVI NIGMKTEIGH 

       250        260        270        280        290        300 
IQHAVIESNS EDTQTPLQIK IDLFGQQLSK IIFVICVTVW IINFKHFSDP IHGSFLYGCL 

       310        320        330        340        350        360 
YYFKISVALA VAAIPEGLPA VITTCLALGT RRMVKKNAIV RKLQSVETLG CTTVICSDKT 

       370        380        390        400        410        420 
GTLTTNQMTT TVFHLFRESD SLTEYQLCQK GDTYYFYESS NLTNDIYAGE SSFFNKLKDE 

       430        440        450        460        470        480 
GNVEALTDDG EEGSIDEADP YSDYFSSDSK KMKNDLNNNN NNNNNSSRSG AKRNIPLKEM 

       490        500        510        520        530        540 
KSNENTIISR GSKILEDKIN KYCYSEYDYN FYMCLVNCNE ANIFCNDNSQ IVKKFGDSTE 

       550        560        570        580        590        600 
LALLHFVHNF DILPTFSKNN KMPAEYEKNT TPVQSSNKKD KSPRGINKFF SSKNDNSHIT 

       610        620        630        640        650        660 
STLNENDKNL KNANHSNYTT AQATTNGYEA IGENTFEHGT SFENCFHSKL GNKINTTSTH 

       670        680        690        700        710        720 
NNNNNNNNNS NSVPSECISS WRNECKQIKI IEFTRERKLM SVIVENKKKE IILYCKGAPE 

       730        740        750        760        770        780 
NIIKNCKYYL TKNDIRPLNE TLKNEIHNKI QNMGKRALRT LSFAYKKLSS KDLNIKNTDD 

       790        800        810        820        830        840 
YYKLEQDLIY LGGLGIIDPP RKYVGRAIRL CHMAGIRVFM ITGDNINTAR AIAKEINILN 

       850        860        870        880        890        900 
KNEGDDEKDN YTNNKNTQIC CYNGREFEDF SLEKQKHILK NTPRIVFCRT EPKHKKQIVK 

       910        920        930        940        950        960 
VLKDLGETVA MTGDGVNDAP ALKSADIGIA MGINGTEVAK EASDIVLADD NFNTIVEAIK 

       970        980        990       1000       1010       1020 
EGRCIYNNMK AFIRYLISSN IGEVASIFIT ALLGIPDSLA PVQLLWVNLV TDGLPATALG 

      1030       1040       1050       1060       1070       1080 
FNPPEHDVMK CKPRHKNDNL INGLTLLRYI IIGTYVGIAT VSIFVYWFLF YPDSDMHTLI 

      1090       1100       1110       1120       1130       1140 
NFYQLSHYNQ CKAWNNFRVN KVYDMSEDHC SYFSAGKIKA STLSLSVLVL IEMFNALNAL 

      1150       1160       1170       1180       1190       1200 
SEYNSLFEIP PWRNMYLVLA TIGSLLLHVL ILYIPPLARI FGVVPLSAYD WFLVFLWSFP 

      1210       1220 
VIILDEIIKF YAKRKLKEEQ RTKKIKID

« Hide

References

[1]"Cloning of a Ca(2+)-ATPase gene of Plasmodium falciparum and comparison with vertebrate Ca(2+)-ATPases."
Kimura M., Yamaguchi Y., Takada S., Tanabe K.
J. Cell Sci. 104:1129-1136(1993) [PubMed: 8314897] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X71765 Genomic DNA. Translation: CAA50664.1.
PIRS37621.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1U5Nmodel-A1-1228[»]
ProteinModelPortalQ08853.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR005834. Dehalogen-like_hydro.
IPR023214. HAD-like_dom.
[Graphical view]
Gene3DG3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 3 hits.
G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 3 hits.
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01494. ATPase_P-type. 3 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATC_PLAFK
AccessionPrimary (citable) accession number: Q08853
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents