Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Syntaxin-5

Gene

Stx5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates endoplasmic reticulum to Golgi transport (PubMed:10930451, PubMed:14742712, PubMed:9506515). Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus (PubMed:18167358).4 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-RNO-5694530. Cargo concentration in the ER.
R-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-5
Gene namesi
Name:Stx5
Synonyms:Stx5a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi68426. Stx5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 333CytoplasmicSequence analysisAdd BLAST333
Transmembranei334 – 354Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini355VesicularSequence analysis1

GO - Cellular componenti

  • cell-cell adherens junction Source: Ensembl
  • cytosol Source: GOC
  • endoplasmic reticulum Source: RGD
  • endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
  • Golgi membrane Source: RGD
  • integral component of membrane Source: GO_Central
  • nucleoplasm Source: Ensembl
  • SNARE complex Source: RGD
  • vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102071 – 355Syntaxin-5Add BLAST355

Proteomic databases

PaxDbiQ08851.
PRIDEiQ08851.

PTM databases

PhosphoSitePlusiQ08851.

Miscellaneous databases

PMAP-CutDBQ08851.

Expressioni

Tissue specificityi

Expressed in the brain, heart, spleen, lung, liver, kidney and testis.1 Publication

Gene expression databases

BgeeiENSRNOG00000018847.
GenevisibleiQ08851. RN.

Interactioni

Subunit structurei

Part of a ternary complex containing STX5A, NSFL1C and VCP (PubMed:9506515). Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, GOSR2 and YKT6. This complex also includes VTI1A (By similarity). Interacts with COG4 (By similarity). Interacts with GM130/GOLGA2 (PubMed:18167358).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Gosr1Q6293115EBI-2028244,EBI-7837133
Uso1P415428EBI-2028244,EBI-4423297

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249255. 2 interactors.
IntActiQ08851. 11 interactors.
MINTiMINT-4565555.
STRINGi10116.ENSRNOP00000025664.

Structurei

3D structure databases

ProteinModelPortaliQ08851.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini263 – 325t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili287 – 318Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0812. Eukaryota.
ENOG410Y2MB. LUCA.
GeneTreeiENSGT00390000000652.
HOGENOMiHOG000194860.
HOVERGENiHBG001973.
InParanoidiQ08851.
KOiK08490.
OMAiNQPGINN.
OrthoDBiEOG091G0HR8.
PhylomeDBiQ08851.
TreeFamiTF315068.

Family and domain databases

InterProiIPR021538. Syntaxin-5_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF11416. Syntaxin-5_N. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: Q08851-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIPRKRYGSK NTDQGVYLGL SKTQVLSPAT AINSSSDIAP LPTPVALVPS
60 70 80 90 100
PPDTMSCRDR TQEFLSACKS LQSRQNGIQT NKPALHATRQ CSEFTLMARR
110 120 130 140 150
IGKDLSNTFA KLEKLTILAK RKSLFDDKAV EIEELTYIIK QDINSLNKQI
160 170 180 190 200
AQLQDFVRAK GSQSGRHLQT HSNTIVVSLQ SKLASMSNDF KSVLEVRTEN
210 220 230 240 250
LKQQRNRREQ FSRAPVSALP LAPNNLGGGP IVLGGESRAS RDVAIDMMDP
260 270 280 290 300
RTSQQLQLID EQDSYIQSRA DTMQNIESTI VELGSIFQQL AHMVKEQEET
310 320 330 340 350
IQRIDENVLG AQLDVEAAHS EILKYFQSVT SNRWLMVKIF LILIVFFIIF

VVFLA
Length:355
Mass (Da):39,751
Last modified:September 5, 2006 - v2
Checksum:i0B0D0B2C261A39B4
GO
Isoform 2 (identifier: Q08851-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Note: Produced by alternative initiation at Met-55 of isoform 1.
Show »
Length:301
Mass (Da):34,117
Checksum:iF560A1A079C8A9F7
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0201171 – 54Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20822 mRNA. Translation: AAA03047.1.
BC127489 mRNA. Translation: AAI27490.1.
U87971 mRNA. Translation: AAB93844.1.
PIRiF48213.
RefSeqiNP_113892.2. NM_031704.2. [Q08851-1]
XP_006231059.1. XM_006230997.2. [Q08851-1]
UniGeneiRn.5782.

Genome annotation databases

EnsembliENSRNOT00000025664; ENSRNOP00000025664; ENSRNOG00000018847. [Q08851-1]
GeneIDi65134.
KEGGirno:65134.
UCSCiRGD:68426. rat. [Q08851-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20822 mRNA. Translation: AAA03047.1.
BC127489 mRNA. Translation: AAI27490.1.
U87971 mRNA. Translation: AAB93844.1.
PIRiF48213.
RefSeqiNP_113892.2. NM_031704.2. [Q08851-1]
XP_006231059.1. XM_006230997.2. [Q08851-1]
UniGeneiRn.5782.

3D structure databases

ProteinModelPortaliQ08851.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249255. 2 interactors.
IntActiQ08851. 11 interactors.
MINTiMINT-4565555.
STRINGi10116.ENSRNOP00000025664.

PTM databases

PhosphoSitePlusiQ08851.

Proteomic databases

PaxDbiQ08851.
PRIDEiQ08851.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025664; ENSRNOP00000025664; ENSRNOG00000018847. [Q08851-1]
GeneIDi65134.
KEGGirno:65134.
UCSCiRGD:68426. rat. [Q08851-1]

Organism-specific databases

CTDi6811.
RGDi68426. Stx5.

Phylogenomic databases

eggNOGiKOG0812. Eukaryota.
ENOG410Y2MB. LUCA.
GeneTreeiENSGT00390000000652.
HOGENOMiHOG000194860.
HOVERGENiHBG001973.
InParanoidiQ08851.
KOiK08490.
OMAiNQPGINN.
OrthoDBiEOG091G0HR8.
PhylomeDBiQ08851.
TreeFamiTF315068.

Enzyme and pathway databases

ReactomeiR-RNO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-RNO-5694530. Cargo concentration in the ER.
R-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811438. Intra-Golgi traffic.

Miscellaneous databases

PMAP-CutDBQ08851.
PROiQ08851.

Gene expression databases

BgeeiENSRNOG00000018847.
GenevisibleiQ08851. RN.

Family and domain databases

InterProiIPR021538. Syntaxin-5_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF11416. Syntaxin-5_N. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTX5_RAT
AccessioniPrimary (citable) accession number: Q08851
Secondary accession number(s): A0JPL4, O55200
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 5, 2006
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.