Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q08849

- STX3_RAT

UniProt

Q08849 - STX3_RAT

Protein

Syntaxin-3

Gene

Stx3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Potentially involved in docking of synaptic vesicles at presynaptic active zones.

    GO - Molecular functioni

    1. arachidonic acid binding Source: HGNC
    2. protein binding Source: BHF-UCL
    3. SNAP receptor activity Source: FlyBase

    GO - Biological processi

    1. intracellular protein transport Source: InterPro
    2. intracellular transport Source: RGD
    3. membrane fusion Source: RGD
    4. neuron projection development Source: HGNC
    5. synaptic vesicle docking involved in exocytosis Source: RGD
    6. vesicle-mediated transport Source: RGD

    Keywords - Biological processi

    Neurotransmitter transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-3
    Gene namesi
    Name:Stx3
    Synonyms:Stx3a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi621005. Stx3.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. azurophil granule Source: Ensembl
    3. cell-cell junction Source: Ensembl
    4. growth cone Source: HGNC
    5. integral component of membrane Source: UniProtKB-KW
    6. neuron projection Source: HGNC
    7. plasma membrane Source: BHF-UCL
    8. SNARE complex Source: HGNC
    9. specific granule Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Syntaxin-3PRO_0000210201Add
    BLAST

    Proteomic databases

    PaxDbiQ08849.
    PRIDEiQ08849.

    Expressioni

    Tissue specificityi

    Heart, spleen, lung and kidney.

    Gene expression databases

    GenevestigatoriQ08849.

    Interactioni

    Protein-protein interaction databases

    BioGridi249660. 3 interactions.
    IntActiQ08849. 2 interactions.
    MINTiMINT-1509039.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08849.
    SMRiQ08849. Positions 31-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 263263CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini285 – 2895ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei264 – 28421Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini191 – 25363t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili32 – 11180Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the syntaxin family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5074.
    GeneTreeiENSGT00730000110552.
    HOGENOMiHOG000286023.
    HOVERGENiHBG000497.
    InParanoidiQ08849.
    KOiK08486.
    OMAiTSGIMDS.
    OrthoDBiEOG7X9G7R.
    PhylomeDBiQ08849.
    TreeFamiTF313763.

    Family and domain databases

    InterProiIPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PfamiPF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view]
    SMARTiSM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47661. SSF47661. 1 hit.
    PROSITEiPS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q08849-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDRLEQLKA KQLTQDDDTD EVEIAIDNTA FMDEFFSEIE ETRLNIDKIS    50
    EHVEEAKKLY SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK 100
    HIEEDEVRSS ADLRIRKSQH SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ 150
    RQLEITGKKT TDEELEEMLE SGNPAIFTSG IIDSQISKQA LSEIEGRHKD 200
    IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV DHVEKARDET 250
    KRAMKYQGQA RKKLIIIIVI VVVLLGILAL IIGLSVGLK 289
    Length:289
    Mass (Da):33,257
    Last modified:November 1, 1996 - v1
    Checksum:i4A8EAFD4684EEE6F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L20820 mRNA. Translation: AAA03045.1.
    PIRiD48213.
    RefSeqiNP_112386.1. NM_031124.1.
    XP_006231156.1. XM_006231094.1.
    UniGeneiRn.10951.

    Genome annotation databases

    EnsembliENSRNOT00000028535; ENSRNOP00000028535; ENSRNOG00000021013.
    GeneIDi81802.
    KEGGirno:81802.
    UCSCiRGD:621005. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L20820 mRNA. Translation: AAA03045.1 .
    PIRi D48213.
    RefSeqi NP_112386.1. NM_031124.1.
    XP_006231156.1. XM_006231094.1.
    UniGenei Rn.10951.

    3D structure databases

    ProteinModelPortali Q08849.
    SMRi Q08849. Positions 31-246.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249660. 3 interactions.
    IntActi Q08849. 2 interactions.
    MINTi MINT-1509039.

    Proteomic databases

    PaxDbi Q08849.
    PRIDEi Q08849.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028535 ; ENSRNOP00000028535 ; ENSRNOG00000021013 .
    GeneIDi 81802.
    KEGGi rno:81802.
    UCSCi RGD:621005. rat.

    Organism-specific databases

    CTDi 6809.
    RGDi 621005. Stx3.

    Phylogenomic databases

    eggNOGi COG5074.
    GeneTreei ENSGT00730000110552.
    HOGENOMi HOG000286023.
    HOVERGENi HBG000497.
    InParanoidi Q08849.
    KOi K08486.
    OMAi TSGIMDS.
    OrthoDBi EOG7X9G7R.
    PhylomeDBi Q08849.
    TreeFami TF313763.

    Miscellaneous databases

    NextBioi 615655.
    PROi Q08849.

    Gene expression databases

    Genevestigatori Q08849.

    Family and domain databases

    InterProi IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    Pfami PF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view ]
    SMARTi SM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47661. SSF47661. 1 hit.
    PROSITEi PS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiSTX3_RAT
    AccessioniPrimary (citable) accession number: Q08849
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3