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Protein

Syntaxin-3

Gene

Stx3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones.

GO - Molecular functioni

  • arachidonic acid binding Source: HGNC
  • SNAP receptor activity Source: FlyBase
  • SNARE binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processNeurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-449836. Other interleukin signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-3
Gene namesi
Name:Stx3
Synonyms:Stx3a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621005. Stx3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 263CytoplasmicSequence analysisAdd BLAST263
Transmembranei264 – 284Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini285 – 289ExtracellularSequence analysis5

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • azurophil granule Source: Ensembl
  • cell-cell junction Source: Ensembl
  • dendrite Source: Ensembl
  • extracellular exosome Source: Ensembl
  • growth cone Source: HGNC
  • integral component of membrane Source: GO_Central
  • lamellipodium Source: Ensembl
  • melanosome Source: Ensembl
  • neuron projection Source: HGNC
  • photoreceptor cell terminal bouton Source: Ensembl
  • plasma membrane Source: BHF-UCL
  • postsynapse Source: Ensembl
  • presynaptic membrane Source: Ensembl
  • ribbon synapse Source: Ensembl
  • SNARE complex Source: HGNC
  • specific granule Source: Ensembl
  • synaptic vesicle Source: GO_Central
  • zymogen granule membrane Source: Ensembl

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102011 – 289Syntaxin-3Add BLAST289

Proteomic databases

PaxDbiQ08849.
PRIDEiQ08849.

PTM databases

iPTMnetiQ08849.
PhosphoSitePlusiQ08849.

Expressioni

Tissue specificityi

Heart, spleen, lung and kidney.

Gene expression databases

BgeeiENSRNOG00000021013.
ExpressionAtlasiQ08849. baseline and differential.
GenevisibleiQ08849. RN.

Interactioni

GO - Molecular functioni

  • SNAP receptor activity Source: FlyBase
  • SNARE binding Source: GO_Central

Protein-protein interaction databases

BioGridi249660. 3 interactors.
IntActiQ08849. 2 interactors.
MINTiMINT-1509039.
STRINGi10116.ENSRNOP00000028535.

Structurei

3D structure databases

ProteinModelPortaliQ08849.
SMRiQ08849.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 253t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 111Sequence analysisAdd BLAST80

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiQ08849.
KOiK08486.
OMAiKRAVKYQ.
OrthoDBiEOG091G0EUK.
PhylomeDBiQ08849.
TreeFamiTF313763.

Family and domain databases

InterProiView protein in InterPro
IPR010989. SNARE.
IPR031186. Stx3.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR000727. T_SNARE_dom.
PANTHERiPTHR19957:SF192. PTHR19957:SF192. 1 hit.
PfamiView protein in Pfam
PF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
SMARTiView protein in SMART
SM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiView protein in PROSITE
PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDRLEQLKA KQLTQDDDTD EVEIAIDNTA FMDEFFSEIE ETRLNIDKIS
60 70 80 90 100
EHVEEAKKLY SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK
110 120 130 140 150
HIEEDEVRSS ADLRIRKSQH SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ
160 170 180 190 200
RQLEITGKKT TDEELEEMLE SGNPAIFTSG IIDSQISKQA LSEIEGRHKD
210 220 230 240 250
IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV DHVEKARDET
260 270 280
KRAMKYQGQA RKKLIIIIVI VVVLLGILAL IIGLSVGLK
Length:289
Mass (Da):33,257
Last modified:November 1, 1996 - v1
Checksum:i4A8EAFD4684EEE6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20820 mRNA. Translation: AAA03045.1.
PIRiD48213.
RefSeqiNP_112386.1. NM_031124.1.
XP_017445263.1. XM_017589774.1.
UniGeneiRn.10951.

Genome annotation databases

EnsembliENSRNOT00000028535; ENSRNOP00000028535; ENSRNOG00000021013.
GeneIDi81802.
KEGGirno:81802.
UCSCiRGD:621005. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20820 mRNA. Translation: AAA03045.1.
PIRiD48213.
RefSeqiNP_112386.1. NM_031124.1.
XP_017445263.1. XM_017589774.1.
UniGeneiRn.10951.

3D structure databases

ProteinModelPortaliQ08849.
SMRiQ08849.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249660. 3 interactors.
IntActiQ08849. 2 interactors.
MINTiMINT-1509039.
STRINGi10116.ENSRNOP00000028535.

PTM databases

iPTMnetiQ08849.
PhosphoSitePlusiQ08849.

Proteomic databases

PaxDbiQ08849.
PRIDEiQ08849.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028535; ENSRNOP00000028535; ENSRNOG00000021013.
GeneIDi81802.
KEGGirno:81802.
UCSCiRGD:621005. rat.

Organism-specific databases

CTDi6809.
RGDi621005. Stx3.

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiQ08849.
KOiK08486.
OMAiKRAVKYQ.
OrthoDBiEOG091G0EUK.
PhylomeDBiQ08849.
TreeFamiTF313763.

Enzyme and pathway databases

ReactomeiR-RNO-449836. Other interleukin signaling.

Miscellaneous databases

PROiPR:Q08849.

Gene expression databases

BgeeiENSRNOG00000021013.
ExpressionAtlasiQ08849. baseline and differential.
GenevisibleiQ08849. RN.

Family and domain databases

InterProiView protein in InterPro
IPR010989. SNARE.
IPR031186. Stx3.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR000727. T_SNARE_dom.
PANTHERiPTHR19957:SF192. PTHR19957:SF192. 1 hit.
PfamiView protein in Pfam
PF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
SMARTiView protein in SMART
SM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiView protein in PROSITE
PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSTX3_RAT
AccessioniPrimary (citable) accession number: Q08849
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.