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Protein

Syntaxin-3

Gene

Stx3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones.

GO - Molecular functioni

  1. arachidonic acid binding Source: HGNC
  2. SNAP receptor activity Source: FlyBase
  3. SNARE binding Source: GO_Central

GO - Biological processi

  1. intracellular protein transport Source: GO_Central
  2. intracellular transport Source: RGD
  3. long-term synaptic potentiation Source: Ensembl
  4. membrane fusion Source: RGD
  5. neuron projection development Source: HGNC
  6. synaptic vesicle docking involved in exocytosis Source: RGD
  7. synaptic vesicle fusion to presynaptic membrane Source: GO_Central
  8. vesicle docking Source: GO_Central
  9. vesicle-mediated transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-3
Gene namesi
Name:Stx3
Synonyms:Stx3a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi621005. Stx3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 263263CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei264 – 28421Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST
Topological domaini285 – 2895ExtracellularSequence Analysis

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. azurophil granule Source: Ensembl
  3. cell-cell junction Source: Ensembl
  4. dendrite Source: Ensembl
  5. endomembrane system Source: GO_Central
  6. extracellular vesicular exosome Source: Ensembl
  7. growth cone Source: HGNC
  8. integral component of membrane Source: GO_Central
  9. neuron projection Source: HGNC
  10. plasma membrane Source: BHF-UCL
  11. SNARE complex Source: HGNC
  12. specific granule Source: Ensembl
  13. synaptic vesicle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Syntaxin-3PRO_0000210201Add
BLAST

Proteomic databases

PaxDbiQ08849.
PRIDEiQ08849.

Expressioni

Tissue specificityi

Heart, spleen, lung and kidney.

Gene expression databases

ExpressionAtlasiQ08849. baseline.
GenevestigatoriQ08849.

Interactioni

Protein-protein interaction databases

BioGridi249660. 3 interactions.
IntActiQ08849. 2 interactions.
MINTiMINT-1509039.

Structurei

3D structure databases

ProteinModelPortaliQ08849.
SMRiQ08849. Positions 31-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 25363t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili32 – 11180Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5074.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiQ08849.
KOiK08486.
OMAiNMERHIE.
OrthoDBiEOG7X9G7R.
PhylomeDBiQ08849.
TreeFamiTF313763.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08849-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDRLEQLKA KQLTQDDDTD EVEIAIDNTA FMDEFFSEIE ETRLNIDKIS
60 70 80 90 100
EHVEEAKKLY SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK
110 120 130 140 150
HIEEDEVRSS ADLRIRKSQH SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ
160 170 180 190 200
RQLEITGKKT TDEELEEMLE SGNPAIFTSG IIDSQISKQA LSEIEGRHKD
210 220 230 240 250
IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV DHVEKARDET
260 270 280
KRAMKYQGQA RKKLIIIIVI VVVLLGILAL IIGLSVGLK
Length:289
Mass (Da):33,257
Last modified:November 1, 1996 - v1
Checksum:i4A8EAFD4684EEE6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20820 mRNA. Translation: AAA03045.1.
PIRiD48213.
RefSeqiNP_112386.1. NM_031124.1.
UniGeneiRn.10951.

Genome annotation databases

EnsembliENSRNOT00000028535; ENSRNOP00000028535; ENSRNOG00000021013.
GeneIDi81802.
KEGGirno:81802.
UCSCiRGD:621005. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20820 mRNA. Translation: AAA03045.1.
PIRiD48213.
RefSeqiNP_112386.1. NM_031124.1.
UniGeneiRn.10951.

3D structure databases

ProteinModelPortaliQ08849.
SMRiQ08849. Positions 31-246.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249660. 3 interactions.
IntActiQ08849. 2 interactions.
MINTiMINT-1509039.

Proteomic databases

PaxDbiQ08849.
PRIDEiQ08849.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028535; ENSRNOP00000028535; ENSRNOG00000021013.
GeneIDi81802.
KEGGirno:81802.
UCSCiRGD:621005. rat.

Organism-specific databases

CTDi6809.
RGDi621005. Stx3.

Phylogenomic databases

eggNOGiCOG5074.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiQ08849.
KOiK08486.
OMAiNMERHIE.
OrthoDBiEOG7X9G7R.
PhylomeDBiQ08849.
TreeFamiTF313763.

Miscellaneous databases

NextBioi615655.
PROiQ08849.

Gene expression databases

ExpressionAtlasiQ08849. baseline.
GenevestigatoriQ08849.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSTX3_RAT
AccessioniPrimary (citable) accession number: Q08849
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 4, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.