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Q08849 (STX3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syntaxin-3
Gene names
Name:Stx3
Synonyms:Stx3a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potentially involved in docking of synaptic vesicles at presynaptic active zones.

Subcellular location

Membrane; Single-pass type IV membrane protein Potential.

Tissue specificity

Heart, spleen, lung and kidney.

Sequence similarities

Belongs to the syntaxin family.

Contains 1 t-SNARE coiled-coil homology domain.

Ontologies

Keywords
   Biological processNeurotransmitter transport
Transport
   Cellular componentMembrane
   DomainCoiled coil
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processintracellular protein transport

Inferred from electronic annotation. Source: InterPro

intracellular transport

Traceable author statement Ref.1. Source: RGD

membrane fusion

Inferred from direct assay PubMed 19109692. Source: RGD

neuron projection development

Inferred from direct assay PubMed 16598260. Source: HGNC

synaptic vesicle docking involved in exocytosis

Traceable author statement Ref.1. Source: RGD

vesicle-mediated transport

Traceable author statement Ref.1. Source: RGD

   Cellular_componentSNARE complex

Inferred from direct assay PubMed 16598260. Source: HGNC

apical plasma membrane

Inferred from electronic annotation. Source: Ensembl

azurophil granule

Inferred from electronic annotation. Source: Ensembl

cell-cell junction

Inferred from electronic annotation. Source: Ensembl

growth cone

Inferred from direct assay PubMed 16598260. Source: HGNC

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

neuron projection

Inferred from direct assay PubMed 16598260. Source: HGNC

plasma membrane

Inferred from direct assay PubMed 17442889. Source: BHF-UCL

specific granule

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionSNAP receptor activity

Inferred from direct assay PubMed 19109692. Source: FlyBase

arachidonic acid binding

Inferred from direct assay PubMed 16598260. Source: HGNC

protein binding

Inferred from physical interaction PubMed 17442889. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Syntaxin-3
PRO_0000210201

Regions

Topological domain1 – 263263Cytoplasmic Potential
Transmembrane264 – 28421Helical; Anchor for type IV membrane protein; Potential
Topological domain285 – 2895Extracellular Potential
Domain191 – 25363t-SNARE coiled-coil homology
Coiled coil32 – 11180 Potential

Sequences

Sequence LengthMass (Da)Tools
Q08849 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 4A8EAFD4684EEE6F

FASTA28933,257
        10         20         30         40         50         60 
MKDRLEQLKA KQLTQDDDTD EVEIAIDNTA FMDEFFSEIE ETRLNIDKIS EHVEEAKKLY 

        70         80         90        100        110        120 
SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK HIEEDEVRSS ADLRIRKSQH 

       130        140        150        160        170        180 
SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ RQLEITGKKT TDEELEEMLE SGNPAIFTSG 

       190        200        210        220        230        240 
IIDSQISKQA LSEIEGRHKD IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV 

       250        260        270        280 
DHVEKARDET KRAMKYQGQA RKKLIIIIVI VVVLLGILAL IIGLSVGLK 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L20820 mRNA. Translation: AAA03045.1.
PIRD48213.
RefSeqNP_112386.1. NM_031124.1.
XP_006231156.1. XM_006231094.1.
UniGeneRn.10951.

3D structure databases

ProteinModelPortalQ08849.
SMRQ08849. Positions 31-246.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid249660. 3 interactions.
IntActQ08849. 2 interactions.
MINTMINT-1509039.

Proteomic databases

PaxDbQ08849.
PRIDEQ08849.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000028535; ENSRNOP00000028535; ENSRNOG00000021013.
GeneID81802.
KEGGrno:81802.
UCSCRGD:621005. rat.

Organism-specific databases

CTD6809.
RGD621005. Stx3.

Phylogenomic databases

eggNOGCOG5074.
GeneTreeENSGT00730000110552.
HOGENOMHOG000286023.
HOVERGENHBG000497.
InParanoidQ08849.
KOK08486.
OMATSGIMDS.
OrthoDBEOG7X9G7R.
PhylomeDBQ08849.
TreeFamTF313763.

Gene expression databases

GenevestigatorQ08849.

Family and domain databases

InterProIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMSSF47661. SSF47661. 1 hit.
PROSITEPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio615655.
PROQ08849.

Entry information

Entry nameSTX3_RAT
AccessionPrimary (citable) accession number: Q08849
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families