Q08830 (FGL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibrinogen-like protein 1

Alternative name(s):
HP-041
Hepassocin
Hepatocyte-derived fibrinogen-related protein 1
Short name=HFREP-1
Liver fibrinogen-related protein 1
Short name=LFIRE-1

Gene names

Name:	FGL1
Synonyms:	HFREP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has hepatocyte mitogenic activity.
Subunit structure	Homodimer Probable.
Subcellular location	Secreted.
Tissue specificity	Liver specific.
Sequence similarities	Contains 1 fibrinogen C-terminal domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Coiled coil Signal
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	fibrinogen complex Traceable author statement. Source: ProtInc
Molecular function	receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22
	Chain	23 – 312	290	Fibrinogen-like protein 1		PRO_0000009105
Regions
	Domain	74 – 306	233	Fibrinogen C-terminal
	Coiled coil	23 – 61	39	Potential
Amino acid modifications
	Disulfide bond	26		Interchain Potential
	Disulfide bond	83 ↔ 112		By similarity
	Disulfide bond	248 ↔ 261		By similarity
Natural variations
	Natural variant	15	1	T → I. Ref.1 Ref.2 Ref.4 Corresponds to variant rs484373 [ dbSNP | Ensembl ].		VAR_024002
	Natural variant	72	1	I → V. Ref.1 Ref.4 Corresponds to variant rs3739406 [ dbSNP | Ensembl ].		VAR_024003
	Natural variant	105	1	P → L. Ref.2 Ref.4 Corresponds to variant rs2653406 [ dbSNP | Ensembl ].		VAR_024004
	Natural variant	111	1	Y → H. Ref.4 Corresponds to variant rs34019703 [ dbSNP | Ensembl ].		VAR_024005
	Natural variant	114	1	M → V. Corresponds to variant rs35311020 [ dbSNP | Ensembl ].		VAR_049067
	Natural variant	121	1	T → S. Ref.4 Corresponds to variant rs34239530 [ dbSNP | Ensembl ].		VAR_024006
	Natural variant	140	1	Y → F. Ref.4 Corresponds to variant rs35431851 [ dbSNP | Ensembl ].		VAR_024007
	Natural variant	256	1	W → L. Corresponds to variant rs2653414 [ dbSNP | Ensembl ].		VAR_049068
Experimental info
	Sequence conflict	69	1	N → D in BAA03336. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q08830 [UniParc]. Last modified May 15, 2007. Version 3. Checksum: 9297153AEA746C31	FASTA	312	36,379
	10 20 30 40 50 60 MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV 70 80 90 100 110 120 QFLDKGDENT VIDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW 130 140 150 160 170 180 TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE 190 200 210 220 230 240 KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD 250 260 270 280 290 300 HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM 310 KIRPNDFIPN VI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1." Yamamoto T., Gotoh M., Sasaki H., Terada M., Kitajima M., Hirohashi S. Biochem. Biophys. Res. Commun. 193:681-687(1993) [PubMed: 8390249] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ILE-15 AND VAL-72. Tissue: Liver.
[2]	"Molecular cloning and functional expression analysis of a cDNA for human hepassocin, a liver-specific protein with hepatocyte mitogenic activity." Hara H., Yoshimura H., Uchida S., Toyoda Y., Aoki M., Sakai Y., Morimoto S., Shiokawa K. Biochim. Biophys. Acta 1520:45-53(2001) [PubMed: 11470158] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANTS ILE-15 AND LEU-105. Tissue: Liver.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	SeattleSNPs variation discovery resource Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-15; VAL-72; LEU-105; HIS-111; SER-121 AND PHE-140.
[5]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed: 16421571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Web resources

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	D14446 mRNA. Translation: BAA03336.1. D87342 mRNA. Translation: BAB70690.1. BT006635 mRNA. Translation: AAP35281.1. DQ086826 Genomic DNA. Translation: AAY68216.1. AC087273 Genomic DNA. No translation available. BC007047 mRNA. Translation: AAH07047.1.
IPI	IPI00303482.
PIR	JN0596.
RefSeq	NP_004458.3. NM_004467.3. NP_671736.2. NM_147203.2. NP_963846.1. NM_201552.1. NP_963847.1. NM_201553.1.
UniGene	Hs.491143.
3D structure databases
ProteinModelPortal	Q08830.
SMR	Q08830. Positions 24-311.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q08830. 1 interaction.
STRING	Q08830.
Polymorphism databases
DMDM	147744562.
Proteomic databases
PRIDE	Q08830.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000221204; ENSP00000221204; ENSG00000104760. ENST00000381840; ENSP00000371262; ENSG00000104760. ENST00000381841; ENSP00000371263; ENSG00000104760. ENST00000398054; ENSP00000381131; ENSG00000104760. ENST00000398056; ENSP00000381133; ENSG00000104760. ENST00000427924; ENSP00000401952; ENSG00000104760.
GeneID	2267.
KEGG	hsa:2267.
UCSC	uc003wxx.1. human.
Organism-specific databases
CTD	2267.
GeneCards	GC08M017766.
H-InvDB	HIX0019031.
HGNC	HGNC:3695. FGL1.
MIM	605776. gene.
neXtProt	NX_Q08830.
PharmGKB	PA28133.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14215.
HOGENOM	HBG715866.
HOVERGEN	HBG001644.
InParanoid	Q08830.
OMA	HEKEVQF.
OrthoDB	EOG4M0F2C.
PhylomeDB	Q08830.
Gene expression databases
ArrayExpress	Q08830.
Bgee	Q08830.
CleanEx	HS_FGL1.
Genevestigator	Q08830.
GermOnline	ENSG00000104760. Homo sapiens.
Family and domain databases
InterPro	IPR002181. Fibrinogen_a/b/g_C. IPR014716. Fibrinogen_a/b/g_C_1. IPR014715. Fibrinogen_a/b/g_C_2. IPR020837. Fibrinogen_CS. [Graphical view]
Gene3D	G3DSA:3.90.215.10. Fibrinogen_a/b/g_C_1. 1 hit. G3DSA:4.10.530.10. Fibrinogen_a/b/g_C_2. 1 hit.
Pfam	PF00147. Fibrinogen_C. 1 hit. [Graphical view]
SMART	SM00186. FBG. 1 hit. [Graphical view]
SUPFAM	SSF56496. Fibrinogen_a/b/g_C. 1 hit.
PROSITE	PS00514. FIBRINOGEN_C_1. 1 hit. PS51406. FIBRINOGEN_C_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	9211.
SOURCE	Search...

Entry information

Entry name

FGL1_HUMAN

Accession

Primary (citable) accession number: Q08830
Secondary accession number(s): A6NKU4 , Q4PJH9, Q53YF1, Q96KW6, Q96QM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	May 15, 2007
Last modified:	January 25, 2012
This is version 99 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.