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Protein

Fibrinogen-like protein 1

Gene

FGL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has hepatocyte mitogenic activity.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrinogen-like protein 1
Alternative name(s):
HP-041
Hepassocin
Hepatocyte-derived fibrinogen-related protein 1
Short name:
HFREP-1
Liver fibrinogen-related protein 1
Short name:
LFIRE-1
Gene namesi
Name:FGL1
Synonyms:HFREP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:3695. FGL1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • fibrinogen complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28133.

Polymorphism and mutation databases

BioMutaiFGL1.
DMDMi147744562.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Add
BLAST
Chaini23 – 312290Fibrinogen-like protein 1PRO_0000009105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 – 26InterchainPROSITE-ProRule annotation
Disulfide bondi83 ↔ 112PROSITE-ProRule annotation
Disulfide bondi248 ↔ 261PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ08830.
PaxDbiQ08830.
PeptideAtlasiQ08830.
PRIDEiQ08830.

PTM databases

iPTMnetiQ08830.
PhosphoSiteiQ08830.

Expressioni

Tissue specificityi

Liver specific.

Gene expression databases

BgeeiQ08830.
CleanExiHS_FGL1.
GenevisibleiQ08830. HS.

Organism-specific databases

HPAiHPA049320.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

BioGridi108558. 69 interactions.
IntActiQ08830. 2 interactions.
STRINGi9606.ENSP00000221204.

Structurei

3D structure databases

ProteinModelPortaliQ08830.
SMRiQ08830. Positions 42-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 306233Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili23 – 6139Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037127.
HOVERGENiHBG001644.
InParanoidiQ08830.
OMAiTTQEDYT.
OrthoDBiEOG7X9G60.
PhylomeDBiQ08830.
TreeFamiTF336658.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK
60 70 80 90 100
IKQLLQENEV QFLDKGDENT VIDLGSKRQY ADCSEIFNDG YKLSGFYKIK
110 120 130 140 150
PLQSPAEFSV YCDMSDGGGW TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK
160 170 180 190 200
HGEYWLGNKN LHFLTTQEDY TLKIDLADFE KNSRYAQYKN FKVGDEKNFY
210 220 230 240 250
ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD HDNYEGNCAE
260 270 280 290 300
EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
310
KIRPNDFIPN VI
Length:312
Mass (Da):36,379
Last modified:May 15, 2007 - v3
Checksum:i9297153AEA746C31
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691N → D in BAA03336 (PubMed:8390249).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151T → I.5 Publications
Corresponds to variant rs484373 [ dbSNP | Ensembl ].
VAR_024002
Natural varianti72 – 721I → V.4 Publications
Corresponds to variant rs3739406 [ dbSNP | Ensembl ].
VAR_024003
Natural varianti105 – 1051P → L.2 Publications
Corresponds to variant rs2653406 [ dbSNP | Ensembl ].
VAR_024004
Natural varianti111 – 1111Y → H.1 Publication
Corresponds to variant rs34019703 [ dbSNP | Ensembl ].
VAR_024005
Natural varianti114 – 1141M → V.
Corresponds to variant rs35311020 [ dbSNP | Ensembl ].
VAR_049067
Natural varianti121 – 1211T → S.1 Publication
Corresponds to variant rs34239530 [ dbSNP | Ensembl ].
VAR_024006
Natural varianti140 – 1401Y → F.1 Publication
Corresponds to variant rs35431851 [ dbSNP | Ensembl ].
VAR_024007
Natural varianti256 – 2561W → L.
Corresponds to variant rs2653414 [ dbSNP | Ensembl ].
VAR_049068

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14446 mRNA. Translation: BAA03336.1.
D87342 mRNA. Translation: BAB70690.1.
AF168954 mRNA. Translation: AAM88911.1.
BT006635 mRNA. Translation: AAP35281.1.
DQ086826 Genomic DNA. Translation: AAY68216.1.
AK289448 mRNA. Translation: BAF82137.1.
AC087273 Genomic DNA. No translation available.
BC007047 mRNA. Translation: AAH07047.1.
CCDSiCCDS6004.1.
PIRiJN0596.
RefSeqiNP_004458.3. NM_004467.3.
NP_671736.2. NM_147203.2.
NP_963846.1. NM_201552.1.
NP_963847.1. NM_201553.1.
UniGeneiHs.491143.

Genome annotation databases

EnsembliENST00000381840; ENSP00000371262; ENSG00000104760.
ENST00000381841; ENSP00000371263; ENSG00000104760.
ENST00000398054; ENSP00000381131; ENSG00000104760.
ENST00000398056; ENSP00000381133; ENSG00000104760.
ENST00000427924; ENSP00000401952; ENSG00000104760.
ENST00000518650; ENSP00000428430; ENSG00000104760.
ENST00000522444; ENSP00000429757; ENSG00000104760.
GeneIDi2267.
KEGGihsa:2267.
UCSCiuc003wxx.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14446 mRNA. Translation: BAA03336.1.
D87342 mRNA. Translation: BAB70690.1.
AF168954 mRNA. Translation: AAM88911.1.
BT006635 mRNA. Translation: AAP35281.1.
DQ086826 Genomic DNA. Translation: AAY68216.1.
AK289448 mRNA. Translation: BAF82137.1.
AC087273 Genomic DNA. No translation available.
BC007047 mRNA. Translation: AAH07047.1.
CCDSiCCDS6004.1.
PIRiJN0596.
RefSeqiNP_004458.3. NM_004467.3.
NP_671736.2. NM_147203.2.
NP_963846.1. NM_201552.1.
NP_963847.1. NM_201553.1.
UniGeneiHs.491143.

3D structure databases

ProteinModelPortaliQ08830.
SMRiQ08830. Positions 42-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108558. 69 interactions.
IntActiQ08830. 2 interactions.
STRINGi9606.ENSP00000221204.

PTM databases

iPTMnetiQ08830.
PhosphoSiteiQ08830.

Polymorphism and mutation databases

BioMutaiFGL1.
DMDMi147744562.

Proteomic databases

MaxQBiQ08830.
PaxDbiQ08830.
PeptideAtlasiQ08830.
PRIDEiQ08830.

Protocols and materials databases

DNASUi2267.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381840; ENSP00000371262; ENSG00000104760.
ENST00000381841; ENSP00000371263; ENSG00000104760.
ENST00000398054; ENSP00000381131; ENSG00000104760.
ENST00000398056; ENSP00000381133; ENSG00000104760.
ENST00000427924; ENSP00000401952; ENSG00000104760.
ENST00000518650; ENSP00000428430; ENSG00000104760.
ENST00000522444; ENSP00000429757; ENSG00000104760.
GeneIDi2267.
KEGGihsa:2267.
UCSCiuc003wxx.4. human.

Organism-specific databases

CTDi2267.
GeneCardsiFGL1.
HGNCiHGNC:3695. FGL1.
HPAiHPA049320.
MIMi605776. gene.
neXtProtiNX_Q08830.
PharmGKBiPA28133.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037127.
HOVERGENiHBG001644.
InParanoidiQ08830.
OMAiTTQEDYT.
OrthoDBiEOG7X9G60.
PhylomeDBiQ08830.
TreeFamiTF336658.

Miscellaneous databases

ChiTaRSiFGL1. human.
GeneWikiiFGL1.
GenomeRNAii2267.
PROiQ08830.
SOURCEiSearch...

Gene expression databases

BgeeiQ08830.
CleanExiHS_FGL1.
GenevisibleiQ08830. HS.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1."
    Yamamoto T., Gotoh M., Sasaki H., Terada M., Kitajima M., Hirohashi S.
    Biochem. Biophys. Res. Commun. 193:681-687(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ILE-15 AND VAL-72.
    Tissue: Liver.
  2. "Molecular cloning and functional expression analysis of a cDNA for human hepassocin, a liver-specific protein with hepatocyte mitogenic activity."
    Hara H., Yoshimura H., Uchida S., Toyoda Y., Aoki M., Sakai Y., Morimoto S., Shiokawa K.
    Biochim. Biophys. Acta 1520:45-53(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANTS ILE-15 AND LEU-105.
    Tissue: Liver.
  3. "LFIRE-1, a liver-specific expressing gene on human chromosome 8p22, is frequently dowm-regulated and functions as tumor suppressor in human hepatocellular carcinoma."
    Yan J., Yu Y., Wang N., Xu Y.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ILE-15 AND VAL-72.
    Tissue: Liver.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-15 AND VAL-72.
    Tissue: Urinary bladder.
  6. SeattleSNPs variation discovery resource
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-15; VAL-72; LEU-105; HIS-111; SER-121 AND PHE-140.
  7. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiFGL1_HUMAN
AccessioniPrimary (citable) accession number: Q08830
Secondary accession number(s): A6NKU4
, Q4PJH9, Q53YF1, Q8NG32, Q96KW6, Q96QM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 15, 2007
Last modified: July 6, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.