Reviewed, UniProtKB/Swiss-Prot Q08830 (FGL1_HUMAN)

Names and origin

Protein names

Recommended name:
    Fibrinogen-like protein 1
Alternative name(s):
    Hepatocyte-derived fibrinogen-related protein 1
      Short name=HFREP-1
    Hepassocin
    Liver fibrinogen-related protein 1
      Short name=LFIRE-1
    HP-041

Gene names

Name:	FGL1
Synonyms:	HFREP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Has hepatocyte mitogenic activity.
Subunit structure	Homodimer Probable.
Subcellular location	Secreted.
Tissue specificity	Liver specific.
Sequence similarities	Contains 1 fibrinogen C-terminal domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Coiled coil Signal
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	fibrinogen complex Ref.1 Traceable author statement. Source: ProtInc
Molecular function	receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22
	Chain	23 – 312	290	Fibrinogen-like protein 1		PRO_0000009105
Regions
	Domain	74 – 306	233	Fibrinogen C-terminal
	Coiled coil	23 – 61	39	Potential
Amino acid modifications
	Disulfide bond	26		Interchain Potential
	Disulfide bond	83 ↔ 112		By similarity
	Disulfide bond	248 ↔ 261		By similarity
Natural variations
	Natural variant	15	1	T → I: dbSNP rs484373.		VAR_024002
	Natural variant	72	1	I → V: dbSNP rs3739406.		VAR_024003
	Natural variant	105	1	P → L: dbSNP rs2653406.		VAR_024004
	Natural variant	111	1	Y → H: dbSNP rs34019703.		VAR_024005
	Natural variant	121	1	T → S: dbSNP rs34239530.		VAR_024006
	Natural variant	140	1	Y → F: dbSNP rs35431851.		VAR_024007
Experimental info
	Sequence conflict	69	1	N → D in BAA03336. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q08830-1 [UniParc]. Last modified May 15, 2007. Version 3. Checksum: 9297153AEA746C31	FASTA	312	36,379
	10 20 30 40 50 60 MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV 70 80 90 100 110 120 QFLDKGDENT VIDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW 130 140 150 160 170 180 TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE 190 200 210 220 230 240 KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD 250 260 270 280 290 300 HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM 310 KIRPNDFIPN VI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1." Yamamoto T., Gotoh M., Sasaki H., Terada M., Kitajima M., Hirohashi S. Biochem. Biophys. Res. Commun. 193:681-687(1993) [PubMed: 8390249] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ILE-15 AND VAL-72. Tissue: Liver.
[2]	"Molecular cloning and functional expression analysis of a cDNA for human hepassocin, a liver-specific protein with hepatocyte mitogenic activity." Hara H., Yoshimura H., Uchida S., Toyoda Y., Aoki M., Sakai Y., Morimoto S., Shiokawa K. Biochim. Biophys. Acta 1520:45-53(2001) [PubMed: 11470158] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANTS ILE-15 AND LEU-105. Tissue: Liver.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	SeattleSNPs program for genomic applications Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-15; VAL-72; LEU-105; HIS-111; SER-121 AND PHE-140.
[5]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed: 16421571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Web resources

SeattleSNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	D14446 mRNA. Translation: BAA03336.1. D87342 mRNA. Translation: BAB70690.1. BT006635 mRNA. Translation: AAP35281.1. DQ086826 Genomic DNA. Translation: AAY68216.1. AC087273 Genomic DNA. No translation available. BC007047 mRNA. Translation: AAH07047.1.
PIR	JN0596.
RefSeq	NP_004458.3. NP_671736.2. NP_963846.1. NP_963847.1.
UniGene	Hs.491143
3D structure databases
HSSP	HSSP built from PDB template 1FZD based on UniProtKB P02671.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000104760. Homo sapiens. [Contig view]
GeneID	2267.
KEGG	hsa:2267.
Organism-specific databases
HGNC	HGNC:3695. FGL1.
MIM	605776. gene.
PharmGKB	PA28133.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q08830.
HOVERGEN	Q08830.
Gene expression databases
ArrayExpress	Q08830.
CleanEx	HS_FGL1.
GermOnline	ENSG00000104760. Homo sapiens.
Family and domain databases
InterPro	IPR002181. Fibrinogen_a/b/g_C. IPR014715. Fibrinogen_a/b/g_C_2. [Graphical view]
Gene3D	G3DSA:4.10.530.10. Fibrinogen_a/b/g_C_2. 1 hit.
Pfam	PF00147. Fibrinogen_C. 1 hit. [Graphical view]
SMART	SM00186. FBG. 1 hit. [Graphical view]
PROSITE	PS00514. FIBRINOGEN_C_1. 1 hit. PS51406. FIBRINOGEN_C_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	9211.
SOURCE	Search...

Entry information

Entry name

FGL1_HUMAN

Accession

Primary (citable) accession number: Q08830
Secondary accession number(s): A6NKU4 , Q4PJH9, Q53YF1, Q96KW6, Q96QM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	May 15, 2007
Last modified:	November 25, 2008
This is version 75 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)