Q08828 (ADCY1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate cyclase type 1
EC=4.6.1.1

Alternative name(s):
ATP pyrophosphate-lyase 1
Adenylate cyclase type I
Adenylyl cyclase 1
Ca(2+)/calmodulin-activated adenylyl cyclase

Gene names

Name:

ADCY1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1119 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning.
Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Enzyme regulation	Activated by calcium/calmodulin. Inhibited by the G protein beta and gamma subunit complex.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Brain, retina and adrenal medulla.
Sequence similarities	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Calmodulin-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of phospholipase C activity Traceable author statement. Source: Reactome activation of protein kinase A activity Traceable author statement. Source: Reactome adenylate cyclase-activating G-protein coupled receptor signaling pathway Traceable author statement. Source: Reactome adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Traceable author statement. Source: Reactome axonogenesis Inferred from electronic annotation. Source: Compara cellular response to glucagon stimulus Traceable author statement. Source: Reactome circadian rhythm Inferred from electronic annotation. Source: Compara energy reserve metabolic process Traceable author statement. Source: Reactome epidermal growth factor receptor signaling pathway Traceable author statement. Source: Reactome fibroblast growth factor receptor signaling pathway Traceable author statement. Source: Reactome intracellular signal transduction Inferred from electronic annotation. Source: InterPro long-term memory Inferred from electronic annotation. Source: Compara nerve growth factor receptor signaling pathway Traceable author statement. Source: Reactome response to drug Inferred from electronic annotation. Source: Compara response to lithium ion Inferred from electronic annotation. Source: Compara synaptic transmission Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome water transport Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB nucleus Inferred from electronic annotation. Source: Compara plasma membrane Inferred from direct assay PubMed 11549699. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium- and calmodulin-responsive adenylate cyclase activity Non-traceable author statement Ref.3. Source: UniProtKB calmodulin binding Non-traceable author statement. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1119	1119	Adenylate cyclase type 1		PRO_0000195682
Regions
	Topological domain	1 – 63	63	Cytoplasmic Potential
	Transmembrane	64 – 84	21	Helical; Potential
	Transmembrane	88 – 108	21	Helical; Potential
	Transmembrane	125 – 145	21	Helical; Potential
	Transmembrane	158 – 178	21	Helical; Potential
	Transmembrane	183 – 203	21	Helical; Potential
	Transmembrane	214 – 234	21	Helical; Potential
	Topological domain	235 – 610	376	Cytoplasmic Potential
	Transmembrane	611 – 631	21	Helical; Potential
	Transmembrane	635 – 655	21	Helical; Potential
	Transmembrane	674 – 694	21	Helical; Potential
	Transmembrane	725 – 745	21	Helical; Potential
	Transmembrane	753 – 773	21	Helical; Potential
	Transmembrane	775 – 794	20	Helical; Potential
	Topological domain	795 – 1119	325	Cytoplasmic Potential
	Region	493 – 520	28	Interaction with calmodulin By similarity
	Region	1024 – 1047	24	Interaction with calmodulin By similarity
Sites
	Metal binding	308	1	Magnesium 1 By similarity
	Metal binding	308	1	Magnesium 2 By similarity
	Metal binding	309	1	Magnesium 2; via carbonyl oxygen By similarity
	Metal binding	352	1	Magnesium 1 By similarity
	Metal binding	352	1	Magnesium 2 By similarity
Amino acid modifications
	Glycosylation	704	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	456	1	P → L. Corresponds to variant rs12721473 [ dbSNP | Ensembl ].		VAR_029186
	Natural variant	940	1	A → T. Corresponds to variant rs45444695 [ dbSNP | Ensembl ].		VAR_029187
	Natural variant	984	1	V → M. Corresponds to variant rs2293106 [ dbSNP | Ensembl ].		VAR_048246

Sequences

	Sequence		Length	Mass (Da)
	Q08828 [UniParc]. Last modified April 12, 2005. Version 2. Checksum: E8DDC8FCB58743D7	FASTA	1,119	123,440
	10 20 30 40 50 60 MAGAPRGGGG GGGGAGEPGG AERAAGTSRR RGLRACDEEF ACPELEALFR GYTLRLEQAA 70 80 90 100 110 120 TLKALAVLSL LAGALALAEL LGAPGPAPGL AKGSHPVHCV LFLALLVVTN VRSLQVPQLQ 130 140 150 160 170 180 QVGQLALLFS LTFALLCCPF ALGGPARGSA GAAGGPATAE QGVWQLLLVT FVSYALLPVR 190 200 210 220 230 240 SLLAIGFGLV VAASHLLVTA TLVPAKRPRL WRTLGANALL FVGVNMYGVF VRILTERSQR 250 260 270 280 290 300 KAFLQARSCI EDRLRLEDEN EKQERLLMSL LPRNVAMEMK EDFLKPPERI FHKIYIQRHD 310 320 330 340 350 360 NVSILFADIV GFTGLASQCT AQELVKLLNE LFGKFDELAT ENHCRRIKIL GDCYYCVSGL 370 380 390 400 410 420 TQPKTDHAHC CVEMGLDMID TITSVAEATE VDLNMRVGLH TGRVLCGVLG LRKWQYDVWS 430 440 450 460 470 480 NDVTLANVME AAGLPGKVHI TKTTLACLNG DYEVEPGYGH ERNSFLKTHN IETFFIVPSH 490 500 510 520 530 540 RRKIFPGLIL SDIKPAKRMK FKTVCYLLVQ LMHCRKMFKA EIPFSNVMTC EDDDKRRALR 550 560 570 580 590 600 TASEKLRNRS SFSTNVVYTT PGTRVNRYIS RLLEARQTEL EMADLNFFTL KYKHVEREQK 610 620 630 640 650 660 YHQLQDEYFT SAVVLTLILA ALFGLVYLLI FPQSVVVLLL LVFCICFLVA CVLYLHITRV 670 680 690 700 710 720 QCFPGCLTIQ IRTVLCIFIV VLIYSVAQGC VVGCLPWAWS SKPNSSLVVL SSGGQRTALP 730 740 750 760 770 780 TLPCESTHHA LLCCLVGTLP LAIFFRVSSL PKMILLSGLT TSYILVLELS GYTRTGGGAV 790 800 810 820 830 840 SGRSYEPIVA ILLFSCALAL HARQVDIRLR LDYLWAAQAE EEREDMEKVK LDNRRILFNL 850 860 870 880 890 900 LPAHVAQHFL MSNPRNMDLY YQSYSQVGVM FASIPNFNDF YIELDGNNMG VECLRLLNEI 910 920 930 940 950 960 IADFDELMEK DFYKDIEKIK TIGSTYMAAV GLAPTSGTKA KKSISSHLST LADFAIEMFD 970 980 990 1000 1010 1020 VLDEINYQSY NDFVLRVGIN VGPVVAGVIG ARRPQYDIWG NTVNVASRMD STGVQGRIQV 1030 1040 1050 1060 1070 1080 TEEVHRLLRR CPYHFVCRGK VSVKGKGEML TYFLEGRTDG NGSQIRSLGL DRKMCPFGRA 1090 1100 1110 GLQGRRPPVC PMPGVSVRAG LPPHSPGQYL PSAAAGKEA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase." Villacres E.C., Xia Z., Bookbinder L.H., Edelhoff S., Disteche C.M., Storm D.R. Genomics 16:473-478(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 281-1119. Tissue: Fetal brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC069008 Genomic DNA. Translation: AAS07467.1. AC091439 Genomic DNA. No translation available. CH236960 Genomic DNA. Translation: EAL23741.1. L05500 mRNA. Translation: AAA02907.1.
IPI	IPI00784385.
PIR	A47007.
RefSeq	NP_066939.1. NM_021116.2.
UniGene	Hs.192215.
3D structure databases
ProteinModelPortal	Q08828.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000297323.
PTM databases
PhosphoSite	Q08828.
Polymorphism databases
DMDM	62512172.
Proteomic databases
PaxDb	Q08828.
PRIDE	Q08828.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000297323; ENSP00000297323; ENSG00000164742.
GeneID	107.
KEGG	hsa:107.
UCSC	uc003tne.4. human.
Organism-specific databases
CTD	107.
GeneCards	GC07P045580.
H-InvDB	HIX0033533.
HGNC	HGNC:232. ADCY1.
HPA	CAB018364.
MIM	103072. gene.
neXtProt	NX_Q08828.
PharmGKB	PA24560.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2114.
HOGENOM	HOG000006941.
HOVERGEN	HBG050458.
InParanoid	Q08828.
KO	K08041.
OMA	CLPWAWS.
OrthoDB	EOG4TQM8C.
Enzyme and pathway databases
BRENDA	4.6.1.1. 2681.
Pathway_Interaction_DB	endothelinpathway. Endothelins. lysophospholipid_pathway. LPA receptor mediated events. lpa4_pathway. LPA4-mediated signaling events.
Reactome	REACT_111102. Signal Transduction. REACT_111217. Metabolism. REACT_116125. Disease. REACT_13685. Neuronal System. REACT_15518. Transmembrane transport of small molecules. REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q08828.
Bgee	Q08828.
CleanEx	HS_ADCY1.
Genevestigator	Q08828.
GermOnline	ENSG00000164742. Homo sapiens.
Family and domain databases
Gene3D	3.30.70.1230. 2 hits.
InterPro	IPR001054. A/G_cyclase. IPR018297. A/G_cyclase_CS. [Graphical view]
Pfam	PF00211. Guanylate_cyc. 2 hits. [Graphical view]
SMART	SM00044. CYCc. 2 hits. [Graphical view]
SUPFAM	SSF55073. A/G_cyclase. 2 hits.
PROSITE	PS00452. GUANYLATE_CYCLASE_1. 2 hits. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q08828.
ChEMBL	CHEMBL2899.
ChiTaRS	ADCY1. human.
DrugBank	DB00640. Adenosine. DB00131. Adenosine monophosphate. DB00171. Adenosine triphosphate.
GenomeRNAi	107.
NextBio	415.
SOURCE	Search...

Entry information

Entry name

ADCY1_HUMAN

Accession

Primary (citable) accession number: Q08828
Secondary accession number(s): A4D2L8, Q75MI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	April 12, 2005
Last modified:	May 1, 2013
This is version 121 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.