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Q08826

- SNX3_YEAST

UniProt

Q08826 - SNX3_YEAST

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Protein

Sorting nexin-3

Gene

SNX3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei81 – 811Phosphatidylinositol 3-phosphate1 Publication
Binding sitei83 – 831Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen1 Publication
Binding sitei112 – 1121Phosphatidylinositol 3-phosphate1 Publication
Binding sitei127 – 1271Phosphatidylinositol 3-phosphate1 Publication

GO - Molecular functioni

  1. phosphatidylinositol-3-phosphate binding Source: SGD

GO - Biological processi

  1. late endosome to Golgi transport Source: SGD
  2. protein localization Source: SGD
  3. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33828-MONOMER.
ReactomeiREACT_188772. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-3
Alternative name(s):
Golgi retention deficient protein 19
Gene namesi
Name:SNX3
Synonyms:GRD19
Ordered Locus Names:YOR357C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR357c.
SGDiS000005884. SNX3.

Subcellular locationi

Cytoplasm 1 Publication. Golgi apparatus membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated. Prevacuolar compartment membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated
Note: Mainly cytoplasmic. A minor amount associates with membranes.

GO - Cellular componenti

  1. cytosol Source: SGD
  2. endosome Source: SGD
  3. Golgi apparatus Source: UniProtKB-KW
  4. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162Sorting nexin-3PRO_0000213805Add
BLAST

Proteomic databases

MaxQBiQ08826.
PaxDbiQ08826.
PeptideAtlasiQ08826.

Expressioni

Gene expression databases

GenevestigatoriQ08826.

Interactioni

Subunit structurei

Monomer. Interacts with RBD2, YIF1, YIP1 and YIP5.2 Publications

Protein-protein interaction databases

BioGridi34742. 37 interactions.
IntActiQ08826. 15 interactions.
MINTiMINT-3976730.
STRINGi4932.YOR357C.

Structurei

Secondary structure

1
162
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi36 – 4611Combined sources
Beta strandi50 – 534Combined sources
Beta strandi57 – 6610Combined sources
Beta strandi74 – 818Combined sources
Helixi82 – 9817Combined sources
Helixi117 – 1193Combined sources
Helixi121 – 13919Combined sources
Helixi142 – 1476Combined sources
Helixi149 – 1568Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCSX-ray2.03A1-162[»]
1OCUX-ray2.30A/B1-162[»]
DisProtiDP00482.
ProteinModelPortaliQ08826.
SMRiQ08826. Positions 28-161.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08826.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 161124PXPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5391.
GeneTreeiENSGT00650000093174.
HOGENOMiHOG000234882.
InParanoidiQ08826.
KOiK17918.
OMAiNPITHGV.
OrthoDBiEOG7B320H.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08826-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPREFKSFGS TEKSLLSKGH GEPSYSEIYA EPENFLEIEV HNPKTHIPNG
60 70 80 90 100
MDSKGMFTDY EIICRTNLPS FHKRVSKVRR RYSDFEFFRK CLIKEISMLN
110 120 130 140 150
HPKVMVPHLP GKILLSNRFS NEVIEERRQG LNTWMQSVAG HPLLQSGSKV
160
LVRFIEAEKF VG
Length:162
Mass (Da):18,770
Last modified:November 1, 1996 - v1
Checksum:i0633831F6CF165FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016101 Genomic DNA. Translation: AAC15913.1.
Z75265 Genomic DNA. Translation: CAA99686.1.
BK006948 Genomic DNA. Translation: DAA11118.1.
PIRiS67269.
RefSeqiNP_015002.3. NM_001183777.3.

Genome annotation databases

EnsemblFungiiYOR357C; YOR357C; YOR357C.
GeneIDi854539.
KEGGisce:YOR357C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016101 Genomic DNA. Translation: AAC15913.1 .
Z75265 Genomic DNA. Translation: CAA99686.1 .
BK006948 Genomic DNA. Translation: DAA11118.1 .
PIRi S67269.
RefSeqi NP_015002.3. NM_001183777.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OCS X-ray 2.03 A 1-162 [» ]
1OCU X-ray 2.30 A/B 1-162 [» ]
DisProti DP00482.
ProteinModelPortali Q08826.
SMRi Q08826. Positions 28-161.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34742. 37 interactions.
IntActi Q08826. 15 interactions.
MINTi MINT-3976730.
STRINGi 4932.YOR357C.

Proteomic databases

MaxQBi Q08826.
PaxDbi Q08826.
PeptideAtlasi Q08826.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOR357C ; YOR357C ; YOR357C .
GeneIDi 854539.
KEGGi sce:YOR357C.

Organism-specific databases

CYGDi YOR357c.
SGDi S000005884. SNX3.

Phylogenomic databases

eggNOGi COG5391.
GeneTreei ENSGT00650000093174.
HOGENOMi HOG000234882.
InParanoidi Q08826.
KOi K17918.
OMAi NPITHGV.
OrthoDBi EOG7B320H.

Enzyme and pathway databases

BioCyci YEAST:G3O-33828-MONOMER.
Reactomei REACT_188772. WNT ligand biogenesis and trafficking.

Miscellaneous databases

EvolutionaryTracei Q08826.
NextBioi 976940.
PROi Q08826.

Gene expression databases

Genevestigatori Q08826.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR001683. Phox.
[Graphical view ]
Pfami PF00787. PX. 1 hit.
[Graphical view ]
SMARTi SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Retrieval of resident late-Golgi membrane proteins from the prevacuolar compartment of Saccharomyces cerevisiae is dependent on the function of Grd19p."
    Voos W., Stevens T.H.
    J. Cell Biol. 140:577-590(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The phox homology (PX) domain protein interaction network in yeast."
    Vollert C.S., Uetz P.
    Mol. Cell. Proteomics 3:1053-1064(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RBD2; YIF1; YIP1 AND YIP5.
  5. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: X-RAY CRYSTALLOGRAPHY (2.03 ANGSTROMS) IN COMPLEX WITH PHOSPHATIDYLINOSITOL 3-PHOSPHATE, SUBUNIT.

Entry informationi

Entry nameiSNX3_YEAST
AccessioniPrimary (citable) accession number: Q08826
Secondary accession number(s): D6W352
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3