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Protein

Sorting nexin-3

Gene

SNX3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81Phosphatidylinositol 3-phosphate1 Publication1
Binding sitei83Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen1 Publication1
Binding sitei112Phosphatidylinositol 3-phosphate1 Publication1
Binding sitei127Phosphatidylinositol 3-phosphate1 Publication1

GO - Molecular functioni

  • phosphatidylinositol-3-phosphate binding Source: SGD

GO - Biological processi

  • autophagy Source: GO_Central
  • CVT pathway Source: GO_Central
  • endocytosis Source: GO_Central
  • late endosome to Golgi transport Source: SGD
  • protein localization Source: SGD
  • vesicle organization Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33828-MONOMER.
ReactomeiR-SCE-3238698. WNT ligand biogenesis and trafficking.
R-SCE-5689880. Ub-specific processing proteases.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-3
Alternative name(s):
Golgi retention deficient protein 19
Gene namesi
Name:SNX3
Synonyms:GRD19
Ordered Locus Names:YOR357C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR357C.
SGDiS000005884. SNX3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • endosome Source: SGD
  • extrinsic component of membrane Source: GO_Central
  • Golgi membrane Source: UniProtKB-SubCell
  • late endosome membrane Source: UniProtKB-SubCell
  • pre-autophagosomal structure Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138051 – 162Sorting nexin-3Add BLAST162

Proteomic databases

MaxQBiQ08826.
PRIDEiQ08826.

PTM databases

iPTMnetiQ08826.

Interactioni

Subunit structurei

Monomer. Interacts with RBD2, YIF1, YIP1 and YIP5.2 Publications

Protein-protein interaction databases

BioGridi34742. 36 interactors.
IntActiQ08826. 15 interactors.
MINTiMINT-3976730.

Structurei

Secondary structure

1162
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi36 – 46Combined sources11
Beta strandi50 – 53Combined sources4
Beta strandi57 – 66Combined sources10
Beta strandi74 – 81Combined sources8
Helixi82 – 98Combined sources17
Helixi117 – 119Combined sources3
Helixi121 – 139Combined sources19
Helixi142 – 147Combined sources6
Helixi149 – 156Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCSX-ray2.03A1-162[»]
1OCUX-ray2.30A/B1-162[»]
DisProtiDP00482.
ProteinModelPortaliQ08826.
SMRiQ08826.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08826.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 161PXPROSITE-ProRule annotationAdd BLAST124

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00650000093174.
HOGENOMiHOG000234882.
InParanoidiQ08826.
KOiK17918.
OMAiILCRTNI.
OrthoDBiEOG092C4ZGK.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPREFKSFGS TEKSLLSKGH GEPSYSEIYA EPENFLEIEV HNPKTHIPNG
60 70 80 90 100
MDSKGMFTDY EIICRTNLPS FHKRVSKVRR RYSDFEFFRK CLIKEISMLN
110 120 130 140 150
HPKVMVPHLP GKILLSNRFS NEVIEERRQG LNTWMQSVAG HPLLQSGSKV
160
LVRFIEAEKF VG
Length:162
Mass (Da):18,770
Last modified:November 1, 1996 - v1
Checksum:i0633831F6CF165FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016101 Genomic DNA. Translation: AAC15913.1.
Z75265 Genomic DNA. Translation: CAA99686.1.
BK006948 Genomic DNA. Translation: DAA11118.1.
PIRiS67269.
RefSeqiNP_015002.3. NM_001183777.3.

Genome annotation databases

EnsemblFungiiYOR357C; YOR357C; YOR357C.
GeneIDi854539.
KEGGisce:YOR357C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016101 Genomic DNA. Translation: AAC15913.1.
Z75265 Genomic DNA. Translation: CAA99686.1.
BK006948 Genomic DNA. Translation: DAA11118.1.
PIRiS67269.
RefSeqiNP_015002.3. NM_001183777.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCSX-ray2.03A1-162[»]
1OCUX-ray2.30A/B1-162[»]
DisProtiDP00482.
ProteinModelPortaliQ08826.
SMRiQ08826.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34742. 36 interactors.
IntActiQ08826. 15 interactors.
MINTiMINT-3976730.

PTM databases

iPTMnetiQ08826.

Proteomic databases

MaxQBiQ08826.
PRIDEiQ08826.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR357C; YOR357C; YOR357C.
GeneIDi854539.
KEGGisce:YOR357C.

Organism-specific databases

EuPathDBiFungiDB:YOR357C.
SGDiS000005884. SNX3.

Phylogenomic databases

GeneTreeiENSGT00650000093174.
HOGENOMiHOG000234882.
InParanoidiQ08826.
KOiK17918.
OMAiILCRTNI.
OrthoDBiEOG092C4ZGK.

Enzyme and pathway databases

BioCyciYEAST:G3O-33828-MONOMER.
ReactomeiR-SCE-3238698. WNT ligand biogenesis and trafficking.
R-SCE-5689880. Ub-specific processing proteases.

Miscellaneous databases

EvolutionaryTraceiQ08826.
PROiQ08826.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX3_YEAST
AccessioniPrimary (citable) accession number: Q08826
Secondary accession number(s): D6W352
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.