Q08821 (HXA1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A1

Alternative name(s):
Hox.lab2

Gene names

Name:

hoxa1

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	240 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Labial subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 240	›240	Homeobox protein Hox-A1		PRO_0000200035
Regions
	DNA binding	134 – 193	60	Homeobox
	Motif	109 – 114	6	Antp-type hexapeptide
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q08821 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 1CE50299E305D2FE	FASTA	240	26,585
	10 20 30 40 50 60 AYAHSSCGSN YGMQNFSPGY SHFPIHQETE VSSGFPQSVY SGNIASSVVQ HQQHQSYIEG 70 80 90 100 110 120 SAHYIHHSYG PEQNLSVANY NNNVASLHIS QREVCHSPSS ETSPGPTQTF DWMKVKRNPP 130 140 150 160 170 180 KTGKAGEYGY AGQPNTARTN FTTKQLTELE KEFHFNKYLT RARRVEIAAA LQLNETQVKI 190 200 210 220 230 240 WFQNRRMKQK KREKEGLLPI SPSTSTGSDE KSEELSEKSN SSPCAPSPAS STSDHLSASG

References

[1]	"Retinoic acid perturbs the expression of Xhox.lab genes and alters mesodermal determination in Xenopus laevis." Sive H.L., Cheng P.F. Genes Dev. 5:1321-1332(1991) [PubMed: 1678362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X62053 mRNA. Translation: CAA43981.1. L25856 mRNA. Translation: AAA03479.1.
PIR	B40357.
UniGene	Xl.283.
3D structure databases
ProteinModelPortal	Q08821.
SMR	Q08821. Positions 108-195.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Xenbase	XB-GENE-6252179. hoxa1.
Phylogenomic databases
HOVERGEN	HBG006089.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA1_XENLA

Accession

Primary (citable) accession number: Q08821

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program