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Q087K2

- SYL_SHEFN

UniProt

Q087K2 - SYL_SHEFN

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Shewanella frigidimarina (strain NCIMB 400)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei625 – 6251ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSFRI318167:GIXS-738-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Sfri_0705
    OrganismiShewanella frigidimarina (strain NCIMB 400)
    Taxonomic identifieri318167 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000000684: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 863863Leucine--tRNA ligasePRO_0000334817Add
    BLAST

    Proteomic databases

    PRIDEiQ087K2.

    Interactioni

    Protein-protein interaction databases

    STRINGi318167.Sfri_0705.

    Structurei

    3D structure databases

    ProteinModelPortaliQ087K2.
    SMRiQ087K2. Positions 228-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi622 – 6265"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q087K2-1 [UniParc]FASTAAdd to Basket

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    MQELYNPSEI EALVQKHWHE HKTFEVTEDE SKEKFYCLSM FPYPSGRLHM    50
    GHVRNYTIGD VVARYQRLQG KNVLQPIGWD SFGLPAENAA INNKASPAPW 100
    TYENIDYMKN QLKLLGFGYD WSREIATCTP EYYRWEQWFF TQLYAKGLVY 150
    KKTSSVNWCP NDETVLANEQ VQDGCCWRCD TEVIQKEIPQ WFIKITDYAE 200
    ELLNDIDTLD GWPEQVKAMQ RNWIGRSEGI EMTFAVADSD ASFDIYTTRP 250
    DTLMGVTYVA IAAGHPLAEQ SAQNNPELAA FLEECKNADT TEAAMASMEK 300
    KGVATGLQAI HPISGKLVPI WVANFVLMNY GTGAVMSVPA HDQRDYEFAT 350
    KYQLAIEAVI KPVDGEVDVS KEAYTEKGVV FNSGDAFPEL DGLDFQAAFE 400
    AIDARLTAEG KGKRQVNYRL RDWGVSRQRY WGAPIPMVTL ADGTVVPTPE 450
    DQLPVILPED VVMDGIQSPI KADKAWAETT VNGQPATRET DTFDTFMESS 500
    WYYARYCSPH ADEMLDPAKA NYWLPVDQYI GGIEHACMHL LYFRFFHKLL 550
    RDAGLVNSDE PAKQLLTQGM VLADAYYYTN EKGARVWVSP LEVTVVEKDD 600
    KGRIIKAIDN QGHELVYTGM SKMSKSKNNG IDPQVMVEKY GADTVRLFMM 650
    FASPPELTLE WQESGVEGAH RFIKRFWKLA SDHVAAGKTE ALDTSKLNAD 700
    QKALRRELHK TIAKVSDDIA RRQMFNTAVA SVMELMNHLL KASQETAQDR 750
    ALLAEALSAV TRLLYPIVPH MTFTLWNELG NEGDIEDSRW PEVDESALVE 800
    DSKLIVVQVN GKVRAKITVA ADASKEDVEA LGMSDEHVQK HTEGLTVRKV 850
    IYVPGKLLSI VAN 863
    Length:863
    Mass (Da):97,261
    Last modified:May 20, 2008 - v2
    Checksum:i1675C3830AD8D792
    GO

    Sequence cautioni

    The sequence ABI70563.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000447 Genomic DNA. Translation: ABI70563.1. Different initiation.
    RefSeqiYP_749401.1. NC_008345.1.

    Genome annotation databases

    EnsemblBacteriaiABI70563; ABI70563; Sfri_0705.
    GeneIDi4278748.
    KEGGisfr:Sfri_0705.
    PATRICi23495227. VBISheFri14343_0729.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000447 Genomic DNA. Translation: ABI70563.1 . Different initiation.
    RefSeqi YP_749401.1. NC_008345.1.

    3D structure databases

    ProteinModelPortali Q087K2.
    SMRi Q087K2. Positions 228-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 318167.Sfri_0705.

    Proteomic databases

    PRIDEi Q087K2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI70563 ; ABI70563 ; Sfri_0705 .
    GeneIDi 4278748.
    KEGGi sfr:Sfri_0705.
    PATRICi 23495227. VBISheFri14343_0729.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SFRI318167:GIXS-738-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCIMB 400.

    Entry informationi

    Entry nameiSYL_SHEFN
    AccessioniPrimary (citable) accession number: Q087K2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3