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Q087K2

- SYL_SHEFN

UniProt

Q087K2 - SYL_SHEFN

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Shewanella frigidimarina (strain NCIMB 400)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei625 – 6251ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSFRI318167:GIXS-738-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Sfri_0705
OrganismiShewanella frigidimarina (strain NCIMB 400)
Taxonomic identifieri318167 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000684: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 863863Leucine--tRNA ligasePRO_0000334817Add
BLAST

Proteomic databases

PRIDEiQ087K2.

Interactioni

Protein-protein interaction databases

STRINGi318167.Sfri_0705.

Structurei

3D structure databases

ProteinModelPortaliQ087K2.
SMRiQ087K2. Positions 228-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi622 – 6265"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q087K2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQELYNPSEI EALVQKHWHE HKTFEVTEDE SKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VVARYQRLQG KNVLQPIGWD SFGLPAENAA INNKASPAPW
110 120 130 140 150
TYENIDYMKN QLKLLGFGYD WSREIATCTP EYYRWEQWFF TQLYAKGLVY
160 170 180 190 200
KKTSSVNWCP NDETVLANEQ VQDGCCWRCD TEVIQKEIPQ WFIKITDYAE
210 220 230 240 250
ELLNDIDTLD GWPEQVKAMQ RNWIGRSEGI EMTFAVADSD ASFDIYTTRP
260 270 280 290 300
DTLMGVTYVA IAAGHPLAEQ SAQNNPELAA FLEECKNADT TEAAMASMEK
310 320 330 340 350
KGVATGLQAI HPISGKLVPI WVANFVLMNY GTGAVMSVPA HDQRDYEFAT
360 370 380 390 400
KYQLAIEAVI KPVDGEVDVS KEAYTEKGVV FNSGDAFPEL DGLDFQAAFE
410 420 430 440 450
AIDARLTAEG KGKRQVNYRL RDWGVSRQRY WGAPIPMVTL ADGTVVPTPE
460 470 480 490 500
DQLPVILPED VVMDGIQSPI KADKAWAETT VNGQPATRET DTFDTFMESS
510 520 530 540 550
WYYARYCSPH ADEMLDPAKA NYWLPVDQYI GGIEHACMHL LYFRFFHKLL
560 570 580 590 600
RDAGLVNSDE PAKQLLTQGM VLADAYYYTN EKGARVWVSP LEVTVVEKDD
610 620 630 640 650
KGRIIKAIDN QGHELVYTGM SKMSKSKNNG IDPQVMVEKY GADTVRLFMM
660 670 680 690 700
FASPPELTLE WQESGVEGAH RFIKRFWKLA SDHVAAGKTE ALDTSKLNAD
710 720 730 740 750
QKALRRELHK TIAKVSDDIA RRQMFNTAVA SVMELMNHLL KASQETAQDR
760 770 780 790 800
ALLAEALSAV TRLLYPIVPH MTFTLWNELG NEGDIEDSRW PEVDESALVE
810 820 830 840 850
DSKLIVVQVN GKVRAKITVA ADASKEDVEA LGMSDEHVQK HTEGLTVRKV
860
IYVPGKLLSI VAN
Length:863
Mass (Da):97,261
Last modified:May 20, 2008 - v2
Checksum:i1675C3830AD8D792
GO

Sequence cautioni

The sequence ABI70563.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000447 Genomic DNA. Translation: ABI70563.1. Different initiation.
RefSeqiYP_749401.1. NC_008345.1.

Genome annotation databases

EnsemblBacteriaiABI70563; ABI70563; Sfri_0705.
GeneIDi4278748.
KEGGisfr:Sfri_0705.
PATRICi23495227. VBISheFri14343_0729.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000447 Genomic DNA. Translation: ABI70563.1 . Different initiation.
RefSeqi YP_749401.1. NC_008345.1.

3D structure databases

ProteinModelPortali Q087K2.
SMRi Q087K2. Positions 228-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 318167.Sfri_0705.

Proteomic databases

PRIDEi Q087K2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI70563 ; ABI70563 ; Sfri_0705 .
GeneIDi 4278748.
KEGGi sfr:Sfri_0705.
PATRICi 23495227. VBISheFri14343_0729.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SFRI318167:GIXS-738-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCIMB 400.

Entry informationi

Entry nameiSYL_SHEFN
AccessioniPrimary (citable) accession number: Q087K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3