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Q08782

- CCL2_CAVPO

UniProt

Q08782 - CCL2_CAVPO

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Protein

C-C motif chemokine 2

Gene

CCL2

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Chemotactic factor that attracts monocytes, but not neutrophils.

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 2
Alternative name(s):
Monocyte chemoattractant protein 1
Monocyte chemotactic protein 1
Short name:
MCP-1
Small-inducible cytokine A2
Gene namesi
Name:CCL2
Synonyms:MCP1, SCYA2
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 12097C-C motif chemokine 2PRO_0000005144Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium.By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000012126.

Structurei

3D structure databases

ProteinModelPortaliQ08782.
SMRiQ08782. Positions 24-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46819.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ08782.
OMAiNKEICAD.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08782-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQRSSVLLCL LVIEATFCSL LMAQPDGVNT PTCCYTFNKQ IPLKRVKGYE
60 70 80 90 100
RITSSRCPQE AVIFRTLKNK EVCADPTQKW VQDYIAKLDQ RTQQKQNSTA
110 120
PQTSKPLNIR FTTQDPKNRS
Length:120
Mass (Da):13,741
Last modified:November 1, 1995 - v1
Checksum:i5905596851CF1C54
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04985 mRNA. Translation: AAA37047.1.
PIRiI48147.
RefSeqiNP_001166397.1. NM_001172926.1.

Genome annotation databases

EnsembliENSCPOT00000013601; ENSCPOP00000012126; ENSCPOG00000013468.
GeneIDi100135494.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04985 mRNA. Translation: AAA37047.1 .
PIRi I48147.
RefSeqi NP_001166397.1. NM_001172926.1.

3D structure databases

ProteinModelPortali Q08782.
SMRi Q08782. Positions 24-93.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000012126.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCPOT00000013601 ; ENSCPOP00000012126 ; ENSCPOG00000013468 .
GeneIDi 100135494.

Organism-specific databases

CTDi 6347.

Phylogenomic databases

eggNOGi NOG46819.
GeneTreei ENSGT00730000110714.
HOGENOMi HOG000036686.
HOVERGENi HBG017871.
InParanoidi Q08782.
OMAi NKEICAD.
OrthoDBi EOG7C5MC2.
TreeFami TF334888.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning of guinea pig monocyte chemoattractant protein-1 and expression of the recombinant protein."
    Yoshimura T.
    J. Immunol. 150:5025-5032(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Z.
    Tissue: Spleen.

Entry informationi

Entry nameiCCL2_CAVPO
AccessioniPrimary (citable) accession number: Q08782
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3