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Q08782

- CCL2_CAVPO

UniProt

Q08782 - CCL2_CAVPO

Protein

C-C motif chemokine 2

Gene

CCL2

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Chemotactic factor that attracts monocytes, but not neutrophils.

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 2
    Alternative name(s):
    Monocyte chemoattractant protein 1
    Monocyte chemotactic protein 1
    Short name:
    MCP-1
    Small-inducible cytokine A2
    Gene namesi
    Name:CCL2
    Synonyms:MCP1, SCYA2
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 12097C-C motif chemokine 2PRO_0000005144Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi33 ↔ 57By similarity
    Disulfide bondi34 ↔ 73By similarity
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

    Interactioni

    Subunit structurei

    Monomer or homodimer; in equilibrium.By similarity

    Protein-protein interaction databases

    STRINGi10141.ENSCPOP00000012126.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08782.
    SMRiQ08782. Positions 24-93.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46819.
    GeneTreeiENSGT00730000110714.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiQ08782.
    OMAiNKEICAD.
    OrthoDBiEOG7C5MC2.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q08782-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRSSVLLCL LVIEATFCSL LMAQPDGVNT PTCCYTFNKQ IPLKRVKGYE    50
    RITSSRCPQE AVIFRTLKNK EVCADPTQKW VQDYIAKLDQ RTQQKQNSTA 100
    PQTSKPLNIR FTTQDPKNRS 120
    Length:120
    Mass (Da):13,741
    Last modified:November 1, 1995 - v1
    Checksum:i5905596851CF1C54
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04985 mRNA. Translation: AAA37047.1.
    PIRiI48147.
    RefSeqiNP_001166397.1. NM_001172926.1.

    Genome annotation databases

    EnsembliENSCPOT00000013601; ENSCPOP00000012126; ENSCPOG00000013468.
    GeneIDi100135494.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04985 mRNA. Translation: AAA37047.1 .
    PIRi I48147.
    RefSeqi NP_001166397.1. NM_001172926.1.

    3D structure databases

    ProteinModelPortali Q08782.
    SMRi Q08782. Positions 24-93.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10141.ENSCPOP00000012126.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCPOT00000013601 ; ENSCPOP00000012126 ; ENSCPOG00000013468 .
    GeneIDi 100135494.

    Organism-specific databases

    CTDi 6347.

    Phylogenomic databases

    eggNOGi NOG46819.
    GeneTreei ENSGT00730000110714.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi Q08782.
    OMAi NKEICAD.
    OrthoDBi EOG7C5MC2.
    TreeFami TF334888.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of guinea pig monocyte chemoattractant protein-1 and expression of the recombinant protein."
      Yoshimura T.
      J. Immunol. 150:5025-5032(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Z.
      Tissue: Spleen.

    Entry informationi

    Entry nameiCCL2_CAVPO
    AccessioniPrimary (citable) accession number: Q08782
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3