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Q08775

- RUNX2_MOUSE

UniProt

Q08775 - RUNX2_MOUSE

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Protein
Runt-related transcription factor 2
Gene
Runx2, Aml3, Cbfa1, Osf2, Pebp2a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation By similarity. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).2 Publications

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. DNA binding Source: MGI
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  5. bHLH transcription factor binding Source: MGI
  6. chromatin binding Source: MGI
  7. protein binding Source: IntAct
  8. protein domain specific binding Source: MGI
  9. repressing transcription factor binding Source: MGI
  10. sequence-specific DNA binding transcription factor activity Source: MGI
  11. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. BMP signaling pathway Source: BHF-UCL
  2. T cell differentiation Source: MGI
  3. cell maturation Source: MGI
  4. cellular response to BMP stimulus Source: BHF-UCL
  5. chondrocyte development Source: MGI
  6. chondrocyte differentiation Source: MGI
  7. embryonic cranial skeleton morphogenesis Source: MGI
  8. embryonic forelimb morphogenesis Source: MGI
  9. endochondral ossification Source: MGI
  10. negative regulation of smoothened signaling pathway Source: MGI
  11. negative regulation of transcription, DNA-templated Source: UniProtKB
  12. odontogenesis of dentin-containing tooth Source: MGI
  13. osteoblast development Source: MGI
  14. osteoblast differentiation Source: MGI
  15. osteoblast fate commitment Source: MGI
  16. positive regulation of cell proliferation Source: MGI
  17. positive regulation of chondrocyte differentiation Source: MGI
  18. positive regulation of osteoblast differentiation Source: MGI
  19. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  20. positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: BHF-UCL
  21. positive regulation of transcription, DNA-templated Source: MGI
  22. regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  23. regulation of odontogenesis of dentin-containing tooth Source: MGI
  24. regulation of ossification Source: MGI
  25. regulation of osteoblast differentiation Source: MGI
  26. skeletal system development Source: MGI
  27. skeletal system morphogenesis Source: MGI
  28. stem cell differentiation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Runt-related transcription factor 2
Alternative name(s):
Acute myeloid leukemia 3 protein
Core-binding factor subunit alpha-1
Short name:
CBF-alpha-1
Oncogene AML-3
Osteoblast-specific transcription factor 2
Short name:
OSF-2
Polyomavirus enhancer-binding protein 2 alpha A subunit
Short name:
PEA2-alpha A
Short name:
PEBP2-alpha A
SL3-3 enhancer factor 1 alpha A subunit
SL3/AKV core-binding factor alpha A subunit
Gene namesi
Name:Runx2
Synonyms:Aml3, Cbfa1, Osf2, Pebp2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:99829. Runx2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nuclear chromatin Source: BHF-UCL
  3. nucleoplasm Source: Reactome
  4. nucleus Source: MGI
  5. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 607607Runt-related transcription factor 2
PRO_0000174660Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei537 – 5371Phosphoserine; by CDK1 By similarity

Post-translational modificationi

Phosphorylated; probably by MAP kinases (MAPK). Phosphorylation by HIPK3 is required for the SPEN/MINT and FGF2 transactivation during osteoblastic differentiation. Phosphorylation at Ser-537 by CDK1 promotes endothelial cell proliferation required for tumor angiogenesis probably by facilitating cell cycle progression By similarity.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ08775.
PRIDEiQ08775.

PTM databases

PhosphoSiteiQ08775.

Expressioni

Tissue specificityi

Found in thymus and testis, T-cell lines but not in B-cell lines. Isoform 2 is exclusively found in bone, particularly in osteoblasts; isoforms 3 and 4 are expressed in T-cell lines; isoforms 5, 6, 7, 8 and 9 can be found in osteoblasts and osteosarcoma cell lines.

Developmental stagei

Expression occurs early during skeletal development and is restricted to cells of the mesenchymal condensations and of the osteoblast lineage. Expression of isoform 2 in the embryo reaches a peak at 12.5 dpc.

Gene expression databases

ArrayExpressiQ08775.
BgeeiQ08775.
CleanExiMM_RUNX2.
GenevestigatoriQ08775.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80). Interacts with CCNB1, KAT6A and KAT6B By similarity. Interacts with HIVEP3. Interacts with IFI204. Interaction with SATB2; the interaction results in enhanced DNA binding and transactivation by these transcription factors. Binds to HIPK3. Interacts (isoform 3) with DDX5. Interacts with FOXO1 (via a C-terminal region); the interaction inhibits RUNX2 transcriptional activity towards BGLAP.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DDX5P178442EBI-6119991,EBI-351962From a different organism.
Ddx5Q6AYI12EBI-903354,EBI-931635From a different organism.
Hdac4Q6NZM93EBI-903354,EBI-646397
Twist2Q9D0302EBI-903354,EBI-2903190

Protein-protein interaction databases

BioGridi198518. 21 interactions.
DIPiDIP-36316N.
IntActiQ08775. 11 interactions.
MINTiMINT-4133380.

Structurei

3D structure databases

ProteinModelPortaliQ08775.
SMRiQ08775. Positions 189-338.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini187 – 315129Runt
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 8888Interaction with IFI204
Add
BLAST
Regioni242 – 25817Required for interaction with FOXO1
Add
BLAST
Regioni422 – 525104Interaction with KAT6A By similarity
Add
BLAST
Regioni460 – 55495Interaction with KAT6B By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi128 – 15629Poly-Gln
Add
BLAST
Compositional biasi158 – 17518Poly-Ala
Add
BLAST
Compositional biasi323 – 607285Pro/Ser/Thr-rich
Add
BLAST

Domaini

A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes and contains the phosphorylation sites.

Sequence similaritiesi

Contains 1 Runt domain.

Phylogenomic databases

eggNOGiNOG123889.
GeneTreeiENSGT00390000016964.
HOVERGENiHBG060268.
InParanoidiQ08775.
KOiK09278.
OMAiXVVALGE.
OrthoDBiEOG7WQ7TV.
PhylomeDBiQ08775.

Family and domain databases

Gene3Di2.60.40.720. 1 hit.
4.10.770.10. 1 hit.
InterProiIPR000040. AML1_Runt.
IPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR013524. Runt_dom.
IPR027384. Runx_central_dom.
IPR013711. RunxI_C_dom.
[Graphical view]
PANTHERiPTHR11950. PTHR11950. 1 hit.
PfamiPF00853. Runt. 1 hit.
PF08504. RunxI. 1 hit.
[Graphical view]
PRINTSiPR00967. ONCOGENEAML1.
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS51062. RUNT. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q08775-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLHSPHKQPQ NHKCGANFLQ EDCKKALAFK WLISAGHYQP PRPTESVSAL    50
TTVHAGIFKA ASSIYNRGHK FYLEKKGGTM ASNSLFSAVT PCQQSFFWDP 100
STSRRFSPPS SSLQPGKMSD VSPVVAAQQQ QQQQQQQQQQ QQQQQQQQQQ 150
QQQQQQEAAA AAAAAAAAAA AAAAAVPRLR PPHDNRTMVE IIADHPAELV 200
RTDSPNFLCS VLPSHWRCNK TLPVAFKVVA LGEVPDGTVV TVMAGNDENY 250
SAELRNASAV MKNQVARFND LRFVGRSGRG KSFTLTITVF TNPPQVATYH 300
RAIKVTVDGP REPRRHRQKL DDSKPSLFSD RLSDLGRIPH PSMRVGVPPQ 350
NPRPSLNSAP SPFNPQGQSQ ITDPRQAQSS PPWSYDQSYP SYLSQMTSPS 400
IHSTTPLSST RGTGLPAITD VPRRISDDDT ATSDFCLWPS SLSKKSQAGA 450
SELGPFSDPR QFPSISSLTE SRFSNPRMHY PATFTYTPPV TSGMSLGMSA 500
TTHYHTYLPP PYPGSSQSQS GPFQTSSTPY LYYGTSSASY QFPMVPGGDR 550
SPSRMVPPCT TTSNGSTLLN PNLPNQNDGV DADGSHSSSP TVLNSSGRMD 600
ESVWRPY 607
Length:607
Mass (Da):66,205
Last modified:November 2, 2001 - v2
Checksum:iE87A4497ED19EE0E
GO
Isoform 2 (identifier: Q08775-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-57: Missing.

Show »
Length:596
Mass (Da):65,154
Checksum:i3365DB4F7F199BA0
GO
Isoform 3 (identifier: Q08775-3) [UniParc]FASTAAdd to Basket

Also known as: PEBP2-alpha A1

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: MLHSPHKQPQ...VTPCQQSFFW → MRIPV
     156-156: Missing.

Show »
Length:513
Mass (Da):55,752
Checksum:iEAF92506819B2D28
GO
Isoform 4 (identifier: Q08775-4) [UniParc]FASTAAdd to Basket

Also known as: PEBP2-alpha A2

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: MLHSPHKQPQ...VTPCQQSFFW → MRIPV
     156-156: Missing.
     399-400: PS → LS
     401-607: Missing.

Show »
Length:306
Mass (Da):33,599
Checksum:i0CF6BFF4B8CD4DBB
GO
Isoform 5 (identifier: Q08775-5) [UniParc]FASTAAdd to Basket

Also known as: G1

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Show »
Length:528
Mass (Da):57,417
Checksum:i1675D3EA1CB5D4EE
GO
Isoform 6 (identifier: Q08775-6) [UniParc]FASTAAdd to Basket

Also known as: G2

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
     316-373: Missing.

Show »
Length:470
Mass (Da):51,032
Checksum:iE77D395B48886713
GO
Isoform 7 (identifier: Q08775-7) [UniParc]FASTAAdd to Basket

Also known as: U1

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
     427-439: DDDTATSDFCLWP → GFCGTTTTTTTKL
     440-607: Missing.

Show »
Length:360
Mass (Da):39,277
Checksum:i38F2DE7E6AC8747C
GO
Isoform 8 (identifier: Q08775-8) [UniParc]FASTAAdd to Basket

Also known as: Y1

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
     428-607: DDTATSDFCL...RMDESVWRPY → SEPSTLDSQS...QPVPEAPDAN

Show »
Length:548
Mass (Da):58,669
Checksum:iC05C800013B5A912
GO
Isoform 9 (identifier: Q08775-9) [UniParc]FASTAAdd to Basket

Also known as: Y2

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
     316-373: Missing.
     428-607: DDTATSDFCL...RMDESVWRPY → SEPSTLDSQS...QPVPEAPDAN

Show »
Length:490
Mass (Da):52,285
Checksum:i86043D899DFA524F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9898MLHSP…QSFFW → MRIPV in isoform 3 and isoform 4.
VSP_005940Add
BLAST
Alternative sequencei1 – 7979Missing in isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9.
VSP_005939Add
BLAST
Alternative sequencei47 – 5711Missing in isoform 2.
VSP_005941Add
BLAST
Alternative sequencei156 – 1561Missing in isoform 3 and isoform 4.
VSP_005942
Alternative sequencei316 – 37358Missing in isoform 6 and isoform 9.
VSP_005943Add
BLAST
Alternative sequencei399 – 4002PS → LS in isoform 4.
VSP_005944
Alternative sequencei401 – 607207Missing in isoform 4.
VSP_005945Add
BLAST
Alternative sequencei427 – 43913DDDTA…FCLWP → GFCGTTTTTTTKL in isoform 7.
VSP_005946Add
BLAST
Alternative sequencei428 – 607180DDTAT…VWRPY → SEPSTLDSQSSTTLFLSSEE PGPSTAALPSPSSSCEPQPF SPSPMLPPLLQPLSTASTVP APCVPRRTGLYTIVTSSPEA APHLVDWMPSCPTATSPGVR GKDHERPQTMMAPAPALASE RGHSQHAGPARDDHAEHPGT SPKPCAPPAAAATLEASVGD ILVELRTMNGHLDIIAKALT KLASSLVPQSQPVPEAPDAN in isoform 8 and isoform 9.
VSP_005947Add
BLAST
Alternative sequencei440 – 607168Missing in isoform 7.
VSP_005948Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti266 – 2661A → S in AAC78626. 1 Publication
Sequence conflicti280 – 2801G → S in AAC78626. 1 Publication
Sequence conflicti373 – 3731D → N in AAC78626. 1 Publication
Sequence conflicti375 – 3751R → T in AAC78626. 1 Publication
Sequence conflicti396 – 3961M → L in AAC78626. 1 Publication
Sequence conflicti459 – 4591P → L in AAC78626. 1 Publication
Sequence conflicti472 – 4721R → P in AAC78626. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14636 mRNA. Translation: BAA03485.1.
D14637 mRNA. Translation: BAA03486.1.
AF010284 mRNA. Translation: AAB65409.1.
AF005936 mRNA. Translation: AAB82419.1.
AF053948 Genomic DNA. Translation: AAC77440.1.
AF053951 mRNA. Translation: AAC78623.1.
AF053956 mRNA. Translation: AAC78626.1.
AF134836 Genomic DNA. Translation: AAF22568.1.
AF134836 Genomic DNA. Translation: AAF22569.1.
AB013129 Genomic DNA. Translation: BAA85345.1.
AB013129 Genomic DNA. Translation: BAA85346.1.
AH009404 Genomic DNA. Translation: AAF73290.1.
CCDSiCCDS37624.2. [Q08775-5]
PIRiA48233.
RefSeqiNP_001139510.1. NM_001146038.2. [Q08775-5]
NP_001258556.1. NM_001271627.1. [Q08775-5]
NP_033950.2. NM_009820.5. [Q08775-5]
XP_006523607.1. XM_006523544.1. [Q08775-1]
XP_006523608.1. XM_006523545.1. [Q08775-2]
UniGeneiMm.391013.
Mm.391017.
Mm.491666.

Genome annotation databases

EnsembliENSMUST00000113571; ENSMUSP00000109201; ENSMUSG00000039153. [Q08775-5]
ENSMUST00000159943; ENSMUSP00000124918; ENSMUSG00000039153. [Q08775-5]
ENSMUST00000160673; ENSMUSP00000123743; ENSMUSG00000039153. [Q08775-2]
GeneIDi12393.
KEGGimmu:12393.
UCSCiuc008cqa.2. mouse. [Q08775-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14636 mRNA. Translation: BAA03485.1 .
D14637 mRNA. Translation: BAA03486.1 .
AF010284 mRNA. Translation: AAB65409.1 .
AF005936 mRNA. Translation: AAB82419.1 .
AF053948 Genomic DNA. Translation: AAC77440.1 .
AF053951 mRNA. Translation: AAC78623.1 .
AF053956 mRNA. Translation: AAC78626.1 .
AF134836 Genomic DNA. Translation: AAF22568.1 .
AF134836 Genomic DNA. Translation: AAF22569.1 .
AB013129 Genomic DNA. Translation: BAA85345.1 .
AB013129 Genomic DNA. Translation: BAA85346.1 .
AH009404 Genomic DNA. Translation: AAF73290.1 .
CCDSi CCDS37624.2. [Q08775-5 ]
PIRi A48233.
RefSeqi NP_001139510.1. NM_001146038.2. [Q08775-5 ]
NP_001258556.1. NM_001271627.1. [Q08775-5 ]
NP_033950.2. NM_009820.5. [Q08775-5 ]
XP_006523607.1. XM_006523544.1. [Q08775-1 ]
XP_006523608.1. XM_006523545.1. [Q08775-2 ]
UniGenei Mm.391013.
Mm.391017.
Mm.491666.

3D structure databases

ProteinModelPortali Q08775.
SMRi Q08775. Positions 189-338.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198518. 21 interactions.
DIPi DIP-36316N.
IntActi Q08775. 11 interactions.
MINTi MINT-4133380.

Chemistry

ChEMBLi CHEMBL1681609.

PTM databases

PhosphoSitei Q08775.

Proteomic databases

PaxDbi Q08775.
PRIDEi Q08775.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000113571 ; ENSMUSP00000109201 ; ENSMUSG00000039153 . [Q08775-5 ]
ENSMUST00000159943 ; ENSMUSP00000124918 ; ENSMUSG00000039153 . [Q08775-5 ]
ENSMUST00000160673 ; ENSMUSP00000123743 ; ENSMUSG00000039153 . [Q08775-2 ]
GeneIDi 12393.
KEGGi mmu:12393.
UCSCi uc008cqa.2. mouse. [Q08775-1 ]

Organism-specific databases

CTDi 860.
MGIi MGI:99829. Runx2.

Phylogenomic databases

eggNOGi NOG123889.
GeneTreei ENSGT00390000016964.
HOVERGENi HBG060268.
InParanoidi Q08775.
KOi K09278.
OMAi XVVALGE.
OrthoDBi EOG7WQ7TV.
PhylomeDBi Q08775.

Enzyme and pathway databases

Reactomei REACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

Miscellaneous databases

ChiTaRSi RUNX2. mouse.
NextBioi 281136.
PROi Q08775.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q08775.
Bgeei Q08775.
CleanExi MM_RUNX2.
Genevestigatori Q08775.

Family and domain databases

Gene3Di 2.60.40.720. 1 hit.
4.10.770.10. 1 hit.
InterProi IPR000040. AML1_Runt.
IPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR013524. Runt_dom.
IPR027384. Runx_central_dom.
IPR013711. RunxI_C_dom.
[Graphical view ]
PANTHERi PTHR11950. PTHR11950. 1 hit.
Pfami PF00853. Runt. 1 hit.
PF08504. RunxI. 1 hit.
[Graphical view ]
PRINTSi PR00967. ONCOGENEAML1.
SUPFAMi SSF49417. SSF49417. 1 hit.
PROSITEi PS51062. RUNT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene."
    Ogawa E., Maruyama M., Kagoshima H., Inuzuka M., Lu J., Satake M., Shigesada K., Ito Y.
    Proc. Natl. Acad. Sci. U.S.A. 90:6859-6863(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
  2. "Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation."
    Ducy P., Zhang R., Geoffroy V., Ridall A.L., Karsenty G.
    Cell 89:747-754(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Osteoblast.
  3. "Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene."
    Stewart M., Terry A., Hu M., O'Hara M., Blyth K., Baxter E., Cameron E., Onions D.E., Neil J.C.
    Proc. Natl. Acad. Sci. U.S.A. 94:8646-8651(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5; 6; 7; 8 AND 9).
    Strain: CD2-MYC.
  4. "Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor."
    Xiao Z.S., Thomas R., Hinson T.K., Quarles L.D.
    Gene 214:187-197(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 2 AND 6), ALTERNATIVE SPLICING.
  5. "Isolation and characterization of the distal promoter region of mouse Cbfa1."
    Fujiwara M., Tagashira S., Harada H., Ogawa S., Katsumata T., Nakatsuka M., Komori T., Takada H.
    Biochim. Biophys. Acta 1446:265-272(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98 (ISOFORMS 1 AND 2).
  6. "Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha."
    Ogawa E., Inuzuka M., Maruyama M., Satake M., Naito-Fujimoto M., Ito Y., Shigesada K.
    Virology 194:314-331(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 263-277 AND 305-319.
  7. "Analysis of the two PEBP2aA/cbfa1 promoter regions."
    Chi X.-Z., Bae S.-C.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35.
    Strain: 129.
  8. "Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts."
    Komori T., Yagi H., Nomura S., Yamaguchi A., Sasaki K., Deguchi K., Shimizu Y., Bronson R.T., Gao Y.-H., Inada M., Sato M., Okamoto R., Kitamura Y., Yoshiki S., Kishimoto T.
    Cell 89:755-764(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1."
    Xiao G., Jiang D., Thomas P., Benson M.D., Guan K., Karsenty G., Franceschi R.T.
    J. Biol. Chem. 275:4453-4459(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
  10. "The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation."
    Liu C.-J., Chang E., Yu J., Carlson C.S., Prazak L., Yu X.-P., Ding B., Lengyel P., Di Cesare P.E.
    J. Biol. Chem. 280:2788-2796(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IFI204.
  11. "SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation."
    Dobreva G., Chahrour M., Dautzenberg M., Chirivella L., Kanzler B., Farinas I., Karsenty G., Grosschedl R.
    Cell 125:971-986(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SATB2.
  12. "Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3."
    Jones D.C., Wein M.N., Oukka M., Hofstaetter J.G., Glimcher M.J., Glimcher L.H.
    Science 312:1223-1227(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HIVEP3.
  13. Cited for: INTERACTION WITH DDX5.
  14. "Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3."
    Sierra O.L., Towler D.A.
    Mol. Endocrinol. 24:1478-1497(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION BY HIPK3, INTERACTION WITH HIPK3.
  15. "Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts."
    Yang S., Xu H., Yu S., Cao H., Fan J., Ge C., Fransceschi R.T., Dong H.H., Xiao G.
    J. Biol. Chem. 286:19149-19158(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FOXO1.

Entry informationi

Entry nameiRUNX2_MOUSE
AccessioniPrimary (citable) accession number: Q08775
Secondary accession number(s): O35183
, Q08776, Q9JLN0, Q9QUQ6, Q9QY29, Q9R0U4, Q9Z2J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 2, 2001
Last modified: September 3, 2014
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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