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Q08761

- PROS_MOUSE

UniProt

Q08761 - PROS_MOUSE

Protein

Vitamin K-dependent protein S

Gene

Pros1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. blood coagulation Source: UniProtKB-KW
    2. fibrinolysis Source: UniProtKB-KW

    Keywords - Biological processi

    Blood coagulation, Fibrinolysis, Hemostasis

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_225233. Cell surface interactions at the vascular wall.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vitamin K-dependent protein S
    Gene namesi
    Name:Pros1
    Synonyms:Pros
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1095733. Pros1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Propeptidei25 – 4117By similarityPRO_0000022123Add
    BLAST
    Chaini42 – 675634Vitamin K-dependent protein SPRO_0000022124Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei47 – 4714-carboxyglutamatePROSITE-ProRule annotation
    Modified residuei48 – 4814-carboxyglutamatePROSITE-ProRule annotation
    Modified residuei55 – 5514-carboxyglutamatePROSITE-ProRule annotation
    Modified residuei57 – 5714-carboxyglutamatePROSITE-ProRule annotation
    Disulfide bondi58 ↔ 63By similarity
    Modified residuei60 – 6014-carboxyglutamatePROSITE-ProRule annotation
    Modified residuei61 – 6114-carboxyglutamatePROSITE-ProRule annotation
    Modified residuei66 – 6614-carboxyglutamatePROSITE-ProRule annotation
    Modified residuei67 – 6714-carboxyglutamatePROSITE-ProRule annotation
    Modified residuei70 – 7014-carboxyglutamatePROSITE-ProRule annotation
    Modified residuei73 – 7314-carboxyglutamatePROSITE-ProRule annotation
    Modified residuei77 – 7714-carboxyglutamatePROSITE-ProRule annotation
    Disulfide bondi121 ↔ 134By similarity
    Disulfide bondi126 ↔ 143By similarity
    Modified residuei136 – 1361(3R)-3-hydroxyaspartateBy similarity
    Disulfide bondi145 ↔ 154By similarity
    Disulfide bondi161 ↔ 175By similarity
    Disulfide bondi171 ↔ 184By similarity
    Disulfide bondi186 ↔ 199By similarity
    Disulfide bondi205 ↔ 217By similarity
    Disulfide bondi212 ↔ 226By similarity
    Disulfide bondi228 ↔ 241By similarity
    Disulfide bondi247 ↔ 256By similarity
    Disulfide bondi252 ↔ 265By similarity
    Disulfide bondi267 ↔ 282By similarity
    Disulfide bondi449 ↔ 475By similarity
    Glycosylationi499 – 4991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi509 – 5091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi638 ↔ 665By similarity

    Post-translational modificationi

    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Hydroxylation, Zymogen

    Proteomic databases

    MaxQBiQ08761.
    PaxDbiQ08761.
    PRIDEiQ08761.

    PTM databases

    PhosphoSiteiQ08761.

    Expressioni

    Tissue specificityi

    Plasma.

    Gene expression databases

    ArrayExpressiQ08761.
    BgeeiQ08761.
    CleanExiMM_PROS1.
    GenevestigatoriQ08761.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000023629.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08761.
    SMRiQ08761. Positions 46-86, 108-668.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 8746GlaPROSITE-ProRule annotationAdd
    BLAST
    Domaini117 – 15539EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini157 – 20044EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini201 – 24242EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini243 – 28341EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini299 – 475177Laminin G-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini484 – 665182Laminin G-like 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni88 – 11629Thrombin-sensitiveAdd
    BLAST

    Sequence similaritiesi

    Contains 4 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation
    Contains 2 laminin G-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG124763.
    HOGENOMiHOG000065758.
    HOVERGENiHBG051702.
    InParanoidiQ08761.
    KOiK03908.
    OMAiWNMVSVE.
    OrthoDBiEOG7R2BJ0.
    PhylomeDBiQ08761.
    TreeFamiTF352157.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    4.10.740.10. 1 hit.
    InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR000294. GLA_domain.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    [Graphical view]
    PfamiPF07645. EGF_CA. 2 hits.
    PF00594. Gla. 1 hit.
    PF00054. Laminin_G_1. 1 hit.
    PF02210. Laminin_G_2. 1 hit.
    [Graphical view]
    PRINTSiPR00001. GLABLOOD.
    SMARTiSM00181. EGF. 1 hit.
    SM00179. EGF_CA. 3 hits.
    SM00069. GLA. 1 hit.
    SM00282. LamG. 2 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.
    SSF57184. SSF57184. 1 hit.
    SSF57630. SSF57630. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 4 hits.
    PS01187. EGF_CA. 3 hits.
    PS00011. GLA_1. 1 hit.
    PS50998. GLA_2. 1 hit.
    PS50025. LAM_G_DOMAIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q08761-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVLSARFRV LLACLALVIP VSETNFLSKE RASQVLVRKR RANTLFEETM    50
    KGNLERECIE ELCNKEEARE VFENNPETDY FYPKYLGCLG AFRVGSFHAA 100
    RQSANAYPDL RSCVKAISDQ CDPIPCNEDG YLACQDGQAA FTCFCKPGWQ 150
    GDRCQYDVNE CKDPSNVNGG CSQICDNTPG SYHCSCKRGF AMLPNKKDCK 200
    DLDECALKPS VCGTAVCKNI PGDFECECPD GYRYDPSSKS CKDVDECSEN 250
    MCAQLCVNFP GGYSCYCDGK KGFKLAQDQK SCEGIPVCLS LDLDKNYELL 300
    YLAEQFAGVV LYLKFRLPDI TRFSAEFDFR TYDSEGIILY AESLDHSNWL 350
    LIALRDGKIE VQFKNEFSTQ ITTGGNVINN GIWNMVSVEE LDDSVSIKIA 400
    KEAVMNINKL GSLFKPTDGF LDTKIYFAGL PRKVESALIK PINPRLDGCI 450
    RGWNLMKQGA LGAKEIIEGK QNKHCFLNVE KGSYYPGSGI AQFSIDYNNV 500
    TNAEGWQMNV TLNIRPSTGT GVMLALVSGG TVPFALSLVD SRSGTSQDIV 550
    VFVENSVVAR LEAVSLCSDQ QSQLKCNVNR NGLELWTPLR KDVIYSKDLQ 600
    RQLAVLDKAM KRTVATYLGG IPDISFSATP VNAFYSGCME VNINGVQLDL 650
    DEAISKHKDI RAHSCPSVRK IQKNF 675
    Length:675
    Mass (Da):74,934
    Last modified:November 1, 1995 - v1
    Checksum:i79D51203E85AF31F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti493 – 4931F → L in AAA40006. (PubMed:8029814)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z25469 mRNA. Translation: CAA80961.1.
    L27439 mRNA. Translation: AAA40006.1.
    CCDSiCCDS28263.1.
    PIRiS43504. KXMSS.
    RefSeqiNP_035303.1. NM_011173.2.
    UniGeneiMm.127156.

    Genome annotation databases

    EnsembliENSMUST00000023629; ENSMUSP00000023629; ENSMUSG00000022912.
    GeneIDi19128.
    KEGGimmu:19128.
    UCSCiuc007zpx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z25469 mRNA. Translation: CAA80961.1 .
    L27439 mRNA. Translation: AAA40006.1 .
    CCDSi CCDS28263.1.
    PIRi S43504. KXMSS.
    RefSeqi NP_035303.1. NM_011173.2.
    UniGenei Mm.127156.

    3D structure databases

    ProteinModelPortali Q08761.
    SMRi Q08761. Positions 46-86, 108-668.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000023629.

    PTM databases

    PhosphoSitei Q08761.

    Proteomic databases

    MaxQBi Q08761.
    PaxDbi Q08761.
    PRIDEi Q08761.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023629 ; ENSMUSP00000023629 ; ENSMUSG00000022912 .
    GeneIDi 19128.
    KEGGi mmu:19128.
    UCSCi uc007zpx.1. mouse.

    Organism-specific databases

    CTDi 5627.
    MGIi MGI:1095733. Pros1.

    Phylogenomic databases

    eggNOGi NOG124763.
    HOGENOMi HOG000065758.
    HOVERGENi HBG051702.
    InParanoidi Q08761.
    KOi K03908.
    OMAi WNMVSVE.
    OrthoDBi EOG7R2BJ0.
    PhylomeDBi Q08761.
    TreeFami TF352157.

    Enzyme and pathway databases

    Reactomei REACT_225233. Cell surface interactions at the vascular wall.

    Miscellaneous databases

    NextBioi 295742.
    PROi Q08761.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q08761.
    Bgeei Q08761.
    CleanExi MM_PROS1.
    Genevestigatori Q08761.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    4.10.740.10. 1 hit.
    InterProi IPR017857. Coagulation_fac_subgr_Gla_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR000294. GLA_domain.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    [Graphical view ]
    Pfami PF07645. EGF_CA. 2 hits.
    PF00594. Gla. 1 hit.
    PF00054. Laminin_G_1. 1 hit.
    PF02210. Laminin_G_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00001. GLABLOOD.
    SMARTi SM00181. EGF. 1 hit.
    SM00179. EGF_CA. 3 hits.
    SM00069. GLA. 1 hit.
    SM00282. LamG. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    SSF57184. SSF57184. 1 hit.
    SSF57630. SSF57630. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 4 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 4 hits.
    PS01187. EGF_CA. 3 hits.
    PS00011. GLA_1. 1 hit.
    PS50998. GLA_2. 1 hit.
    PS50025. LAM_G_DOMAIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of a cDNA encoding the murine vitamin K-dependent protein S."
      Chu M.D., Sun J., Bird P.I.
      Biochim. Biophys. Acta 1217:325-328(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure of mouse protein S as determined by PCR amplification and DNA sequencing of cDNA."
      Lu D., Schmidel D.K., Long G.L.
      Thromb. Res. Suppl. 74:135-142(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-675.

    Entry informationi

    Entry nameiPROS_MOUSE
    AccessioniPrimary (citable) accession number: Q08761
    Secondary accession number(s): P43483
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3