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Q08761

- PROS_MOUSE

UniProt

Q08761 - PROS_MOUSE

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Protein
Vitamin K-dependent protein S
Gene
Pros1, Pros
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. blood coagulation Source: UniProtKB-KW
  2. fibrinolysis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Fibrinolysis, Hemostasis

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_225233. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin K-dependent protein S
Gene namesi
Name:Pros1
Synonyms:Pros
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1095733. Pros1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 By similarity
Add
BLAST
Propeptidei25 – 4117 By similarity
PRO_0000022123Add
BLAST
Chaini42 – 675634Vitamin K-dependent protein S
PRO_0000022124Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei47 – 4714-carboxyglutamate By similarity
Modified residuei48 – 4814-carboxyglutamate By similarity
Modified residuei55 – 5514-carboxyglutamate By similarity
Modified residuei57 – 5714-carboxyglutamate By similarity
Disulfide bondi58 ↔ 63 By similarity
Modified residuei60 – 6014-carboxyglutamate By similarity
Modified residuei61 – 6114-carboxyglutamate By similarity
Modified residuei66 – 6614-carboxyglutamate By similarity
Modified residuei67 – 6714-carboxyglutamate By similarity
Modified residuei70 – 7014-carboxyglutamate By similarity
Modified residuei73 – 7314-carboxyglutamate By similarity
Modified residuei77 – 7714-carboxyglutamate By similarity
Disulfide bondi121 ↔ 134 By similarity
Disulfide bondi126 ↔ 143 By similarity
Modified residuei136 – 1361(3R)-3-hydroxyaspartate By similarity
Disulfide bondi145 ↔ 154 By similarity
Disulfide bondi161 ↔ 175 By similarity
Disulfide bondi171 ↔ 184 By similarity
Disulfide bondi186 ↔ 199 By similarity
Disulfide bondi205 ↔ 217 By similarity
Disulfide bondi212 ↔ 226 By similarity
Disulfide bondi228 ↔ 241 By similarity
Disulfide bondi247 ↔ 256 By similarity
Disulfide bondi252 ↔ 265 By similarity
Disulfide bondi267 ↔ 282 By similarity
Disulfide bondi449 ↔ 475 By similarity
Glycosylationi499 – 4991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi509 – 5091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi638 ↔ 665 By similarity

Post-translational modificationi

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Hydroxylation, Zymogen

Proteomic databases

MaxQBiQ08761.
PaxDbiQ08761.
PRIDEiQ08761.

PTM databases

PhosphoSiteiQ08761.

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

ArrayExpressiQ08761.
BgeeiQ08761.
CleanExiMM_PROS1.
GenevestigatoriQ08761.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023629.

Structurei

3D structure databases

ProteinModelPortaliQ08761.
SMRiQ08761. Positions 46-86, 108-668.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 8746Gla
Add
BLAST
Domaini117 – 15539EGF-like 1
Add
BLAST
Domaini157 – 20044EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST
Domaini201 – 24242EGF-like 3; calcium-binding Reviewed prediction
Add
BLAST
Domaini243 – 28341EGF-like 4; calcium-binding Reviewed prediction
Add
BLAST
Domaini299 – 475177Laminin G-like 1
Add
BLAST
Domaini484 – 665182Laminin G-like 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni88 – 11629Thrombin-sensitive
Add
BLAST

Sequence similaritiesi

Contains 4 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG124763.
HOGENOMiHOG000065758.
HOVERGENiHBG051702.
InParanoidiQ08761.
KOiK03908.
OMAiWNMVSVE.
OrthoDBiEOG7R2BJ0.
PhylomeDBiQ08761.
TreeFamiTF352157.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
4.10.740.10. 1 hit.
InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000294. GLA_domain.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF07645. EGF_CA. 2 hits.
PF00594. Gla. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00001. GLABLOOD.
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 3 hits.
SM00069. GLA. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 1 hit.
SSF57630. SSF57630. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08761-1 [UniParc]FASTAAdd to Basket

« Hide

MRVLSARFRV LLACLALVIP VSETNFLSKE RASQVLVRKR RANTLFEETM    50
KGNLERECIE ELCNKEEARE VFENNPETDY FYPKYLGCLG AFRVGSFHAA 100
RQSANAYPDL RSCVKAISDQ CDPIPCNEDG YLACQDGQAA FTCFCKPGWQ 150
GDRCQYDVNE CKDPSNVNGG CSQICDNTPG SYHCSCKRGF AMLPNKKDCK 200
DLDECALKPS VCGTAVCKNI PGDFECECPD GYRYDPSSKS CKDVDECSEN 250
MCAQLCVNFP GGYSCYCDGK KGFKLAQDQK SCEGIPVCLS LDLDKNYELL 300
YLAEQFAGVV LYLKFRLPDI TRFSAEFDFR TYDSEGIILY AESLDHSNWL 350
LIALRDGKIE VQFKNEFSTQ ITTGGNVINN GIWNMVSVEE LDDSVSIKIA 400
KEAVMNINKL GSLFKPTDGF LDTKIYFAGL PRKVESALIK PINPRLDGCI 450
RGWNLMKQGA LGAKEIIEGK QNKHCFLNVE KGSYYPGSGI AQFSIDYNNV 500
TNAEGWQMNV TLNIRPSTGT GVMLALVSGG TVPFALSLVD SRSGTSQDIV 550
VFVENSVVAR LEAVSLCSDQ QSQLKCNVNR NGLELWTPLR KDVIYSKDLQ 600
RQLAVLDKAM KRTVATYLGG IPDISFSATP VNAFYSGCME VNINGVQLDL 650
DEAISKHKDI RAHSCPSVRK IQKNF 675
Length:675
Mass (Da):74,934
Last modified:November 1, 1995 - v1
Checksum:i79D51203E85AF31F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti493 – 4931F → L in AAA40006. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z25469 mRNA. Translation: CAA80961.1.
L27439 mRNA. Translation: AAA40006.1.
CCDSiCCDS28263.1.
PIRiS43504. KXMSS.
RefSeqiNP_035303.1. NM_011173.2.
UniGeneiMm.127156.

Genome annotation databases

EnsembliENSMUST00000023629; ENSMUSP00000023629; ENSMUSG00000022912.
GeneIDi19128.
KEGGimmu:19128.
UCSCiuc007zpx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z25469 mRNA. Translation: CAA80961.1 .
L27439 mRNA. Translation: AAA40006.1 .
CCDSi CCDS28263.1.
PIRi S43504. KXMSS.
RefSeqi NP_035303.1. NM_011173.2.
UniGenei Mm.127156.

3D structure databases

ProteinModelPortali Q08761.
SMRi Q08761. Positions 46-86, 108-668.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000023629.

PTM databases

PhosphoSitei Q08761.

Proteomic databases

MaxQBi Q08761.
PaxDbi Q08761.
PRIDEi Q08761.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023629 ; ENSMUSP00000023629 ; ENSMUSG00000022912 .
GeneIDi 19128.
KEGGi mmu:19128.
UCSCi uc007zpx.1. mouse.

Organism-specific databases

CTDi 5627.
MGIi MGI:1095733. Pros1.

Phylogenomic databases

eggNOGi NOG124763.
HOGENOMi HOG000065758.
HOVERGENi HBG051702.
InParanoidi Q08761.
KOi K03908.
OMAi WNMVSVE.
OrthoDBi EOG7R2BJ0.
PhylomeDBi Q08761.
TreeFami TF352157.

Enzyme and pathway databases

Reactomei REACT_225233. Cell surface interactions at the vascular wall.

Miscellaneous databases

NextBioi 295742.
PROi Q08761.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q08761.
Bgeei Q08761.
CleanExi MM_PROS1.
Genevestigatori Q08761.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
4.10.740.10. 1 hit.
InterProi IPR017857. Coagulation_fac_subgr_Gla_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000294. GLA_domain.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF07645. EGF_CA. 2 hits.
PF00594. Gla. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view ]
PRINTSi PR00001. GLABLOOD.
SMARTi SM00181. EGF. 1 hit.
SM00179. EGF_CA. 3 hits.
SM00069. GLA. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 1 hit.
SSF57630. SSF57630. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of a cDNA encoding the murine vitamin K-dependent protein S."
    Chu M.D., Sun J., Bird P.I.
    Biochim. Biophys. Acta 1217:325-328(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure of mouse protein S as determined by PCR amplification and DNA sequencing of cDNA."
    Lu D., Schmidel D.K., Long G.L.
    Thromb. Res. Suppl. 74:135-142(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-675.

Entry informationi

Entry nameiPROS_MOUSE
AccessioniPrimary (citable) accession number: Q08761
Secondary accession number(s): P43483
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi