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Protein

Vitamin K-dependent protein S

Gene

Pros1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processBlood coagulation, Fibrinolysis, Hemostasis
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-140875 Common Pathway of Fibrin Clot Formation
R-MMU-159740 Gamma-carboxylation of protein precursors
R-MMU-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-MMU-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-MMU-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin K-dependent protein S
Gene namesi
Name:Pros1
Synonyms:Pros
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1095733 Pros1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
PropeptideiPRO_000002212325 – 41By similarityAdd BLAST17
ChainiPRO_000002212442 – 675Vitamin K-dependent protein SAdd BLAST634

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei474-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei484-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei554-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei574-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Disulfide bondi58 ↔ 63By similarity
Modified residuei604-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei614-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei664-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei674-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei704-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei734-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei774-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Disulfide bondi121 ↔ 134By similarity
Disulfide bondi126 ↔ 143By similarity
Modified residuei136(3R)-3-hydroxyaspartateBy similarity1
Disulfide bondi145 ↔ 154By similarity
Disulfide bondi161 ↔ 175By similarity
Disulfide bondi171 ↔ 184By similarity
Disulfide bondi186 ↔ 199By similarity
Disulfide bondi205 ↔ 217By similarity
Disulfide bondi212 ↔ 226By similarity
Disulfide bondi228 ↔ 241By similarity
Disulfide bondi247 ↔ 256By similarity
Disulfide bondi252 ↔ 265By similarity
Disulfide bondi267 ↔ 282By similarity
Disulfide bondi449 ↔ 475By similarity
Glycosylationi499N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi509N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi638 ↔ 665By similarity

Post-translational modificationi

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Hydroxylation, Zymogen

Proteomic databases

PaxDbiQ08761
PeptideAtlasiQ08761
PRIDEiQ08761

PTM databases

iPTMnetiQ08761
PhosphoSitePlusiQ08761

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSMUSG00000022912
CleanExiMM_PROS1
ExpressionAtlasiQ08761 baseline and differential
GenevisibleiQ08761 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023629

Structurei

3D structure databases

ProteinModelPortaliQ08761
SMRiQ08761
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 87GlaPROSITE-ProRule annotationAdd BLAST46
Domaini117 – 155EGF-like 1PROSITE-ProRule annotationAdd BLAST39
Domaini157 – 200EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST44
Domaini201 – 242EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini243 – 283EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini299 – 475Laminin G-like 1PROSITE-ProRule annotationAdd BLAST177
Domaini484 – 665Laminin G-like 2PROSITE-ProRule annotationAdd BLAST182

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 116Thrombin-sensitiveAdd BLAST29

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IGF6 Eukaryota
ENOG410ZTGU LUCA
GeneTreeiENSGT00530000063339
HOGENOMiHOG000065758
HOVERGENiHBG051702
InParanoidiQ08761
KOiK03908
OMAiWNMVSVE
OrthoDBiEOG091G02L2
PhylomeDBiQ08761
TreeFamiTF352157

Family and domain databases

Gene3Di4.10.740.10, 1 hit
InterProiView protein in InterPro
IPR017857 Coagulation_fac-like_Gla_dom
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR035972 GLA-like_dom_SF
IPR000294 GLA_domain
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
IPR033189 PROS1
PANTHERiPTHR24040:SF0 PTHR24040:SF0, 1 hit
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF07645 EGF_CA, 2 hits
PF00594 Gla, 1 hit
PF00054 Laminin_G_1, 1 hit
PRINTSiPR00001 GLABLOOD
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 4 hits
SM00069 GLA, 1 hit
SM00282 LamG, 2 hits
SUPFAMiSSF49899 SSF49899, 2 hits
SSF57184 SSF57184, 1 hit
SSF57630 SSF57630, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 3 hits
PS00011 GLA_1, 1 hit
PS50998 GLA_2, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08761-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLSARFRV LLACLALVIP VSETNFLSKE RASQVLVRKR RANTLFEETM
60 70 80 90 100
KGNLERECIE ELCNKEEARE VFENNPETDY FYPKYLGCLG AFRVGSFHAA
110 120 130 140 150
RQSANAYPDL RSCVKAISDQ CDPIPCNEDG YLACQDGQAA FTCFCKPGWQ
160 170 180 190 200
GDRCQYDVNE CKDPSNVNGG CSQICDNTPG SYHCSCKRGF AMLPNKKDCK
210 220 230 240 250
DLDECALKPS VCGTAVCKNI PGDFECECPD GYRYDPSSKS CKDVDECSEN
260 270 280 290 300
MCAQLCVNFP GGYSCYCDGK KGFKLAQDQK SCEGIPVCLS LDLDKNYELL
310 320 330 340 350
YLAEQFAGVV LYLKFRLPDI TRFSAEFDFR TYDSEGIILY AESLDHSNWL
360 370 380 390 400
LIALRDGKIE VQFKNEFSTQ ITTGGNVINN GIWNMVSVEE LDDSVSIKIA
410 420 430 440 450
KEAVMNINKL GSLFKPTDGF LDTKIYFAGL PRKVESALIK PINPRLDGCI
460 470 480 490 500
RGWNLMKQGA LGAKEIIEGK QNKHCFLNVE KGSYYPGSGI AQFSIDYNNV
510 520 530 540 550
TNAEGWQMNV TLNIRPSTGT GVMLALVSGG TVPFALSLVD SRSGTSQDIV
560 570 580 590 600
VFVENSVVAR LEAVSLCSDQ QSQLKCNVNR NGLELWTPLR KDVIYSKDLQ
610 620 630 640 650
RQLAVLDKAM KRTVATYLGG IPDISFSATP VNAFYSGCME VNINGVQLDL
660 670
DEAISKHKDI RAHSCPSVRK IQKNF
Length:675
Mass (Da):74,934
Last modified:November 1, 1995 - v1
Checksum:i79D51203E85AF31F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti493F → L in AAA40006 (PubMed:8029814).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25469 mRNA Translation: CAA80961.1
L27439 mRNA Translation: AAA40006.1
CCDSiCCDS28263.1
PIRiS43504 KXMSS
RefSeqiNP_035303.1, NM_011173.3
UniGeneiMm.127156

Genome annotation databases

EnsembliENSMUST00000023629; ENSMUSP00000023629; ENSMUSG00000022912
GeneIDi19128
KEGGimmu:19128
UCSCiuc007zpx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPROS_MOUSE
AccessioniPrimary (citable) accession number: Q08761
Secondary accession number(s): P43483
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health