Vitamin K-dependent protein S precursor - Mus musculus (Mouse)

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Q08761 (PROS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 123. History...

Clusters with 100%, 90%, 50% identity |

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Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Vitamin K-dependent protein S

Gene names

Name:	Pros1
Synonyms:	Pros

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	675 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
Subcellular location	Secreted.
Tissue specificity	Plasma.
Post-translational modification	The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains By similarity.
Sequence similarities	Contains 4 EGF-like domains. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 2 laminin G-like domains.

Ontologies

Keywords
Biological process	Blood coagulation Fibrinolysis Hemostasis
Cellular component	Secreted
Domain	EGF-like domain Repeat Signal
Ligand	Calcium
PTM	Cleavage on pair of basic residues Disulfide bond Gamma-carboxyglutamic acid Glycoprotein Hydroxylation Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Inferred from electronic annotation. Source: UniProtKB-KW fibrinolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

24

By similarity

Propeptide

17

By similarity

PRO_0000022123

Chain

634

Vitamin K-dependent protein S

PRO_0000022124

Regions

Domain

46

Gla

Domain

39

EGF-like 1

Domain

44

EGF-like 2; calcium-binding Potential

Domain

42

EGF-like 3; calcium-binding Potential

Domain

41

EGF-like 4; calcium-binding Potential

Domain

177

Laminin G-like 1

Domain

182

Laminin G-like 2

Region

29

Thrombin-sensitive

Amino acid modifications

Modified residue

1

4-carboxyglutamate By similarity

Modified residue

1

4-carboxyglutamate By similarity

Modified residue

1

4-carboxyglutamate By similarity

Modified residue

1

4-carboxyglutamate By similarity

Modified residue

1

4-carboxyglutamate By similarity

Modified residue

1

4-carboxyglutamate By similarity

Modified residue

1

4-carboxyglutamate By similarity

Modified residue

1

4-carboxyglutamate By similarity

Modified residue

1

4-carboxyglutamate By similarity

Modified residue

1

4-carboxyglutamate By similarity

Modified residue

1

4-carboxyglutamate By similarity

Modified residue

1

(3R)-3-hydroxyaspartate By similarity

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Experimental info

Sequence conflict

1

F → L in AAA40006. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q08761 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 79D51203E85AF31F
Show »

675

74,934

        10         20         30         40         50         60 
MRVLSARFRV LLACLALVIP VSETNFLSKE RASQVLVRKR RANTLFEETM KGNLERECIE 

        70         80         90        100        110        120 
ELCNKEEARE VFENNPETDY FYPKYLGCLG AFRVGSFHAA RQSANAYPDL RSCVKAISDQ 

       130        140        150        160        170        180 
CDPIPCNEDG YLACQDGQAA FTCFCKPGWQ GDRCQYDVNE CKDPSNVNGG CSQICDNTPG 

       190        200        210        220        230        240 
SYHCSCKRGF AMLPNKKDCK DLDECALKPS VCGTAVCKNI PGDFECECPD GYRYDPSSKS 

       250        260        270        280        290        300 
CKDVDECSEN MCAQLCVNFP GGYSCYCDGK KGFKLAQDQK SCEGIPVCLS LDLDKNYELL 

       310        320        330        340        350        360 
YLAEQFAGVV LYLKFRLPDI TRFSAEFDFR TYDSEGIILY AESLDHSNWL LIALRDGKIE 

       370        380        390        400        410        420 
VQFKNEFSTQ ITTGGNVINN GIWNMVSVEE LDDSVSIKIA KEAVMNINKL GSLFKPTDGF 

       430        440        450        460        470        480 
LDTKIYFAGL PRKVESALIK PINPRLDGCI RGWNLMKQGA LGAKEIIEGK QNKHCFLNVE 

       490        500        510        520        530        540 
KGSYYPGSGI AQFSIDYNNV TNAEGWQMNV TLNIRPSTGT GVMLALVSGG TVPFALSLVD 

       550        560        570        580        590        600 
SRSGTSQDIV VFVENSVVAR LEAVSLCSDQ QSQLKCNVNR NGLELWTPLR KDVIYSKDLQ 

       610        620        630        640        650        660 
RQLAVLDKAM KRTVATYLGG IPDISFSATP VNAFYSGCME VNINGVQLDL DEAISKHKDI 

       670 
RAHSCPSVRK IQKNF

References

[1]	"Cloning and sequencing of a cDNA encoding the murine vitamin K-dependent protein S." Chu M.D., Sun J., Bird P.I. Biochim. Biophys. Acta 1217:325-328(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structure of mouse protein S as determined by PCR amplification and DNA sequencing of cDNA." Lu D., Schmidel D.K., Long G.L. Thromb. Res. Suppl. 74:135-142(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-675.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z25469 mRNA. Translation: CAA80961.1. L27439 mRNA. Translation: AAA40006.1.
IPI	IPI00124374.
PIR	KXMSS. S43504.
RefSeq	NP_035303.1. NM_011173.2.
UniGene	Mm.127156.
3D structure databases
ProteinModelPortal	Q08761.
SMR	Q08761. Positions 46-86, 108-668.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000023629.
PTM databases
PhosphoSite	Q08761.
Proteomic databases
PaxDb	Q08761.
PRIDE	Q08761.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000023629; ENSMUSP00000023629; ENSMUSG00000022912.
GeneID	19128.
KEGG	mmu:19128.
Organism-specific databases
CTD	5627.
MGI	MGI:1095733. Pros1.
Phylogenomic databases
eggNOG	NOG124763.
HOGENOM	HOG000065758.
HOVERGEN	HBG051702.
InParanoid	Q08761.
KO	K03908.
OMA	WNMVSVE.
OrthoDB	EOG4PRSQB.
Gene expression databases
ArrayExpress	Q08761.
Bgee	Q08761.
CleanEx	MM_PROS1.
Genevestigator	Q08761.
GermOnline	ENSMUSG00000022912. Mus musculus.
Family and domain databases
Gene3D	2.60.120.200. 2 hits. 4.10.740.10. 1 hit.
InterPro	IPR017857. Coagulation_fac_subgr_Gla_dom. IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR000294. GLA_domain. IPR001791. Laminin_G. [Graphical view]
Pfam	PF07645. EGF_CA. 3 hits. PF00594. Gla. 1 hit. PF00054. Laminin_G_1. 1 hit. PF02210. Laminin_G_2. 1 hit. [Graphical view]
PRINTS	PR00001. GLABLOOD.
SMART	SM00181. EGF. 1 hit. SM00179. EGF_CA. 3 hits. SM00069. GLA. 1 hit. SM00282. LamG. 2 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 2 hits. SSF57630. VitK_dep_GLA. 1 hit.
PROSITE	PS00010. ASX_HYDROXYL. 4 hits. PS00022. EGF_1. 1 hit. PS01186. EGF_2. 3 hits. PS50026. EGF_3. 4 hits. PS01187. EGF_CA. 3 hits. PS00011. GLA_1. 1 hit. PS50998. GLA_2. 1 hit. PS50025. LAM_G_DOMAIN. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	295742.
SOURCE	Search...

Entry information

Entry name

PROS_MOUSE

Accession

Primary (citable) accession number: Q08761
Secondary accession number(s): P43483

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 123 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents