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Reviewed, UniProtKB/Swiss-Prot Q08761 (PROS_MOUSE)

Last modified June 16, 2009. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Vitamin K-dependent protein S
Gene names
Name: Pros1
Synonyms: Pros
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length675 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.

Subcellular location

Secreted.

Tissue specificity

Plasma.

Post-translational modification

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains By similarity.

Sequence similarities

Contains 4 EGF-like domains.

Contains 1 Gla (gamma-carboxy-glutamate) domain.

Contains 2 laminin G-like domains.

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Ontologies

Keywords
   Biological processBlood coagulation
   Cellular componentSecreted
   DomainEGF-like domain
Repeat
Signal
   LigandCalcium
   PTMCleavage on pair of basic residues
Disulfide bond
Gamma-carboxyglutamic acid
Glycoprotein
Hydroxylation
Zymogen
Gene Ontology (GO)
   Biological processblood coagulation

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncalcium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 By similarity
Propeptide25 – 4117 By similarity
PRO_0000022123
Chain42 – 675634Vitamin K-dependent protein S
PRO_0000022124

Regions

Domain42 – 8746Gla
Domain117 – 15539EGF-like 1
Domain157 – 20044EGF-like 2; calcium-binding Potential
Domain201 – 24242EGF-like 3; calcium-binding Potential
Domain243 – 28341EGF-like 4; calcium-binding Potential
Domain299 – 475177Laminin G-like 1
Domain484 – 665182Laminin G-like 2
Region88 – 11629Thrombin-sensitive

Amino acid modifications

Modified residue4714-carboxyglutamate By similarity
Modified residue4814-carboxyglutamate By similarity
Modified residue5514-carboxyglutamate By similarity
Modified residue5714-carboxyglutamate By similarity
Modified residue6014-carboxyglutamate By similarity
Modified residue6114-carboxyglutamate By similarity
Modified residue6614-carboxyglutamate By similarity
Modified residue6714-carboxyglutamate By similarity
Modified residue7014-carboxyglutamate By similarity
Modified residue7314-carboxyglutamate By similarity
Modified residue7714-carboxyglutamate By similarity
Modified residue1361(3R)-3-hydroxyaspartate By similarity
Glycosylation4991N-linked (GlcNAc...) Potential
Glycosylation5091N-linked (GlcNAc...) Potential
Disulfide bond58 ↔ 63 By similarity
Disulfide bond121 ↔ 134 By similarity
Disulfide bond126 ↔ 143 By similarity
Disulfide bond145 ↔ 154 By similarity
Disulfide bond161 ↔ 175 By similarity
Disulfide bond171 ↔ 184 By similarity
Disulfide bond186 ↔ 199 By similarity
Disulfide bond205 ↔ 217 By similarity
Disulfide bond212 ↔ 226 By similarity
Disulfide bond228 ↔ 241 By similarity
Disulfide bond247 ↔ 256 By similarity
Disulfide bond252 ↔ 265 By similarity
Disulfide bond267 ↔ 282 By similarity
Disulfide bond449 ↔ 475 By similarity
Disulfide bond638 ↔ 665 By similarity

Experimental info

Sequence conflict4931F → L in AAA40006. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Q08761-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 79D51203E85AF31F

FASTA67574,934
        10         20         30         40         50         60 
MRVLSARFRV LLACLALVIP VSETNFLSKE RASQVLVRKR RANTLFEETM KGNLERECIE 

        70         80         90        100        110        120 
ELCNKEEARE VFENNPETDY FYPKYLGCLG AFRVGSFHAA RQSANAYPDL RSCVKAISDQ 

       130        140        150        160        170        180 
CDPIPCNEDG YLACQDGQAA FTCFCKPGWQ GDRCQYDVNE CKDPSNVNGG CSQICDNTPG 

       190        200        210        220        230        240 
SYHCSCKRGF AMLPNKKDCK DLDECALKPS VCGTAVCKNI PGDFECECPD GYRYDPSSKS 

       250        260        270        280        290        300 
CKDVDECSEN MCAQLCVNFP GGYSCYCDGK KGFKLAQDQK SCEGIPVCLS LDLDKNYELL 

       310        320        330        340        350        360 
YLAEQFAGVV LYLKFRLPDI TRFSAEFDFR TYDSEGIILY AESLDHSNWL LIALRDGKIE 

       370        380        390        400        410        420 
VQFKNEFSTQ ITTGGNVINN GIWNMVSVEE LDDSVSIKIA KEAVMNINKL GSLFKPTDGF 

       430        440        450        460        470        480 
LDTKIYFAGL PRKVESALIK PINPRLDGCI RGWNLMKQGA LGAKEIIEGK QNKHCFLNVE 

       490        500        510        520        530        540 
KGSYYPGSGI AQFSIDYNNV TNAEGWQMNV TLNIRPSTGT GVMLALVSGG TVPFALSLVD 

       550        560        570        580        590        600 
SRSGTSQDIV VFVENSVVAR LEAVSLCSDQ QSQLKCNVNR NGLELWTPLR KDVIYSKDLQ 

       610        620        630        640        650        660 
RQLAVLDKAM KRTVATYLGG IPDISFSATP VNAFYSGCME VNINGVQLDL DEAISKHKDI 

       670 
RAHSCPSVRK IQKNF

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References

[1]"Cloning and sequencing of a cDNA encoding the murine vitamin K-dependent protein S."
Chu M.D., Sun J., Bird P.I.
Biochim. Biophys. Acta 1217:325-328(1994) [PubMed: 8148380] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure of mouse protein S as determined by PCR amplification and DNA sequencing of cDNA."
Lu D., Schmidel D.K., Long G.L.
Thromb. Res. Suppl. 74:135-142(1994) [PubMed: 8029814] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-675.
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z25469 mRNA. Translation: CAA80961.1.
L27439 mRNA. Translation: AAA40006.1.
IPIIPI00124374.
PIRKXMSS. S43504.
RefSeqNP_035303.1.
UniGeneMm.127156

3D structure databases

HSSPHSSP built from PDB template 1CFH based on UniProtKB P00740.
SMRQ08761. Positions 200-283.
ModBaseSearch...

Genome annotation databases

EnsemblENSMUSG00000022912. Mus musculus. [Contig view]
GeneID19128.
KEGGmmu:19128.

Organism-specific databases

MGIMGI:1095733. Pros1.

Phylogenomic databases

HOGENOMQ08761.
HOVERGENQ08761.
OMAQ08761. NMVSVEE.

Gene expression databases

ArrayExpressQ08761.
BgeeQ08761.
CleanExMM_PROS1.
GermOnlineENSMUSG00000022912. Mus musculus.

Family and domain databases

InterProIPR017857. Coagulation_fac_subset_Gla.
IPR002383. Coagulation_factor_Gla.
IPR013320. ConA-like_subgrp.
IPR006210. EGF-like.
IPR013032. EGF-like_reg_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_CS.
IPR000742. EGF_3.
IPR001881. EGF_Ca_bd.
IPR013091. EGF_Ca_bd_2.
IPR018097. EGF_Ca_bd_CS.
IPR000294. GLA_domain.
IPR001791. Laminin_G.
IPR012679. Laminin_G_1.
IPR012680. Laminin_G_2.
[Graphical view]
Gene3DG3DSA:4.10.740.10. Coagulation_factor_Gla. 1 hit.
G3DSA:2.60.120.200. ConA_like_subgrp. 1 hit.
PfamPF07645. EGF_CA. 3 hits.
PF00594. Gla. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSPR00001. GLABLOOD.
SMARTSM00181. EGF. 1 hit.
SM00179. EGF_CA. 3 hits.
SM00069. GLA. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
PROSITEPS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio295742.
SOURCESearch...

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Entry information

Entry namePROS_MOUSE
AccessionPrimary (citable) accession number: Q08761
Secondary accession number(s): P43483
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 16, 2009
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents