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Q08761

- PROS_MOUSE

UniProt

Q08761 - PROS_MOUSE

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Protein

Vitamin K-dependent protein S

Gene

Pros1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. blood coagulation Source: UniProtKB-KW
  2. fibrinolysis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Fibrinolysis, Hemostasis

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_225233. Cell surface interactions at the vascular wall.
REACT_245393. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
REACT_254191. Gamma-carboxylation of protein precursors.
REACT_255710. Removal of aminoterminal propeptides from gamma-carboxylated proteins.
REACT_259461. Common Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin K-dependent protein S
Gene namesi
Name:Pros1
Synonyms:Pros
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1095733. Pros1.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Propeptidei25 – 4117By similarityPRO_0000022123Add
BLAST
Chaini42 – 675634Vitamin K-dependent protein SPRO_0000022124Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei47 – 4714-carboxyglutamatePROSITE-ProRule annotation
Modified residuei48 – 4814-carboxyglutamatePROSITE-ProRule annotation
Modified residuei55 – 5514-carboxyglutamatePROSITE-ProRule annotation
Modified residuei57 – 5714-carboxyglutamatePROSITE-ProRule annotation
Disulfide bondi58 ↔ 63By similarity
Modified residuei60 – 6014-carboxyglutamatePROSITE-ProRule annotation
Modified residuei61 – 6114-carboxyglutamatePROSITE-ProRule annotation
Modified residuei66 – 6614-carboxyglutamatePROSITE-ProRule annotation
Modified residuei67 – 6714-carboxyglutamatePROSITE-ProRule annotation
Modified residuei70 – 7014-carboxyglutamatePROSITE-ProRule annotation
Modified residuei73 – 7314-carboxyglutamatePROSITE-ProRule annotation
Modified residuei77 – 7714-carboxyglutamatePROSITE-ProRule annotation
Disulfide bondi121 ↔ 134By similarity
Disulfide bondi126 ↔ 143By similarity
Modified residuei136 – 1361(3R)-3-hydroxyaspartateBy similarity
Disulfide bondi145 ↔ 154By similarity
Disulfide bondi161 ↔ 175By similarity
Disulfide bondi171 ↔ 184By similarity
Disulfide bondi186 ↔ 199By similarity
Disulfide bondi205 ↔ 217By similarity
Disulfide bondi212 ↔ 226By similarity
Disulfide bondi228 ↔ 241By similarity
Disulfide bondi247 ↔ 256By similarity
Disulfide bondi252 ↔ 265By similarity
Disulfide bondi267 ↔ 282By similarity
Disulfide bondi449 ↔ 475By similarity
Glycosylationi499 – 4991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi509 – 5091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi638 ↔ 665By similarity

Post-translational modificationi

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Hydroxylation, Zymogen

Proteomic databases

MaxQBiQ08761.
PaxDbiQ08761.
PRIDEiQ08761.

PTM databases

PhosphoSiteiQ08761.

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiQ08761.
CleanExiMM_PROS1.
ExpressionAtlasiQ08761. baseline and differential.
GenevestigatoriQ08761.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023629.

Structurei

3D structure databases

ProteinModelPortaliQ08761.
SMRiQ08761. Positions 46-86, 108-668.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 8746GlaPROSITE-ProRule annotationAdd
BLAST
Domaini117 – 15539EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini157 – 20044EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini201 – 24242EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini243 – 28341EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini299 – 475177Laminin G-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini484 – 665182Laminin G-like 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni88 – 11629Thrombin-sensitiveAdd
BLAST

Sequence similaritiesi

Contains 4 EGF-like domains.PROSITE-ProRule annotation
Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation
Contains 2 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG124763.
HOGENOMiHOG000065758.
HOVERGENiHBG051702.
InParanoidiQ08761.
KOiK03908.
OMAiWNMVSVE.
OrthoDBiEOG7R2BJ0.
PhylomeDBiQ08761.
TreeFamiTF352157.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
4.10.740.10. 1 hit.
InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000294. GLA_domain.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF07645. EGF_CA. 2 hits.
PF00594. Gla. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00001. GLABLOOD.
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 3 hits.
SM00069. GLA. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 1 hit.
SSF57630. SSF57630. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08761-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVLSARFRV LLACLALVIP VSETNFLSKE RASQVLVRKR RANTLFEETM
60 70 80 90 100
KGNLERECIE ELCNKEEARE VFENNPETDY FYPKYLGCLG AFRVGSFHAA
110 120 130 140 150
RQSANAYPDL RSCVKAISDQ CDPIPCNEDG YLACQDGQAA FTCFCKPGWQ
160 170 180 190 200
GDRCQYDVNE CKDPSNVNGG CSQICDNTPG SYHCSCKRGF AMLPNKKDCK
210 220 230 240 250
DLDECALKPS VCGTAVCKNI PGDFECECPD GYRYDPSSKS CKDVDECSEN
260 270 280 290 300
MCAQLCVNFP GGYSCYCDGK KGFKLAQDQK SCEGIPVCLS LDLDKNYELL
310 320 330 340 350
YLAEQFAGVV LYLKFRLPDI TRFSAEFDFR TYDSEGIILY AESLDHSNWL
360 370 380 390 400
LIALRDGKIE VQFKNEFSTQ ITTGGNVINN GIWNMVSVEE LDDSVSIKIA
410 420 430 440 450
KEAVMNINKL GSLFKPTDGF LDTKIYFAGL PRKVESALIK PINPRLDGCI
460 470 480 490 500
RGWNLMKQGA LGAKEIIEGK QNKHCFLNVE KGSYYPGSGI AQFSIDYNNV
510 520 530 540 550
TNAEGWQMNV TLNIRPSTGT GVMLALVSGG TVPFALSLVD SRSGTSQDIV
560 570 580 590 600
VFVENSVVAR LEAVSLCSDQ QSQLKCNVNR NGLELWTPLR KDVIYSKDLQ
610 620 630 640 650
RQLAVLDKAM KRTVATYLGG IPDISFSATP VNAFYSGCME VNINGVQLDL
660 670
DEAISKHKDI RAHSCPSVRK IQKNF
Length:675
Mass (Da):74,934
Last modified:November 1, 1995 - v1
Checksum:i79D51203E85AF31F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti493 – 4931F → L in AAA40006. (PubMed:8029814)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25469 mRNA. Translation: CAA80961.1.
L27439 mRNA. Translation: AAA40006.1.
CCDSiCCDS28263.1.
PIRiS43504. KXMSS.
RefSeqiNP_035303.1. NM_011173.2.
UniGeneiMm.127156.

Genome annotation databases

EnsembliENSMUST00000023629; ENSMUSP00000023629; ENSMUSG00000022912.
GeneIDi19128.
KEGGimmu:19128.
UCSCiuc007zpx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25469 mRNA. Translation: CAA80961.1 .
L27439 mRNA. Translation: AAA40006.1 .
CCDSi CCDS28263.1.
PIRi S43504. KXMSS.
RefSeqi NP_035303.1. NM_011173.2.
UniGenei Mm.127156.

3D structure databases

ProteinModelPortali Q08761.
SMRi Q08761. Positions 46-86, 108-668.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000023629.

PTM databases

PhosphoSitei Q08761.

Proteomic databases

MaxQBi Q08761.
PaxDbi Q08761.
PRIDEi Q08761.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023629 ; ENSMUSP00000023629 ; ENSMUSG00000022912 .
GeneIDi 19128.
KEGGi mmu:19128.
UCSCi uc007zpx.1. mouse.

Organism-specific databases

CTDi 5627.
MGIi MGI:1095733. Pros1.

Phylogenomic databases

eggNOGi NOG124763.
HOGENOMi HOG000065758.
HOVERGENi HBG051702.
InParanoidi Q08761.
KOi K03908.
OMAi WNMVSVE.
OrthoDBi EOG7R2BJ0.
PhylomeDBi Q08761.
TreeFami TF352157.

Enzyme and pathway databases

Reactomei REACT_225233. Cell surface interactions at the vascular wall.
REACT_245393. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
REACT_254191. Gamma-carboxylation of protein precursors.
REACT_255710. Removal of aminoterminal propeptides from gamma-carboxylated proteins.
REACT_259461. Common Pathway.

Miscellaneous databases

ChiTaRSi Pros1. mouse.
NextBioi 295742.
PROi Q08761.
SOURCEi Search...

Gene expression databases

Bgeei Q08761.
CleanExi MM_PROS1.
ExpressionAtlasi Q08761. baseline and differential.
Genevestigatori Q08761.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
4.10.740.10. 1 hit.
InterProi IPR017857. Coagulation_fac_subgr_Gla_dom.
IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000294. GLA_domain.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF07645. EGF_CA. 2 hits.
PF00594. Gla. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view ]
PRINTSi PR00001. GLABLOOD.
SMARTi SM00181. EGF. 1 hit.
SM00179. EGF_CA. 3 hits.
SM00069. GLA. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 1 hit.
SSF57630. SSF57630. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of a cDNA encoding the murine vitamin K-dependent protein S."
    Chu M.D., Sun J., Bird P.I.
    Biochim. Biophys. Acta 1217:325-328(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure of mouse protein S as determined by PCR amplification and DNA sequencing of cDNA."
    Lu D., Schmidel D.K., Long G.L.
    Thromb. Res. Suppl. 74:135-142(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-675.

Entry informationi

Entry nameiPROS_MOUSE
AccessioniPrimary (citable) accession number: Q08761
Secondary accession number(s): P43483
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3