C-sea protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the ‘Function’ section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the ‘Names and taxonomy’ section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB-KW
• transmembrane receptor protein tyrosine kinase activity Source: InterPro

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componentⁱ

• integral component of membrane Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the ‘Sequence’ section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MGPRCLVCLL LLLAPSLLQA GAWQCRRIPF SSTRNFSVPY TLPSLDAGSP 
        60         70         80         90        100
VQNIAVFPDP PTVFVAVRNR ILVVDPELRL RSVLVTGPTG SAPCEICRLC 
       110        120        130        140        150
PAAVDAPGPE DVDNVLLLLD PVEPWLYSCG TARRGLCYLH QLDVRGSEVT 
       160        170        180        190        200
IASTRCLYSA AANSPVNCPD CVASPLGSTA TVVADRYTAS FYLGSTVNSS 
       210        220        230        240        250
VAARYSPRSV SVRRLKGTRD GFADPFHSLT VLPHYQDVYP IHYVHSFTDG 
       260        270        280        290        300
DHVYLVTVQP EFPGSSTFHT RLVRLSAHEP ELRRYREIVL DCRYESKRRR 
       310        320        330        340        350
RRRGAEEETE RDVAYNVLQA AHAARPGARL ARDLGIDGTE TVLFGAFAES 
       360        370        380        390        400
HPESRAPQHN SAVCAFPLRL LNQAIREGMD KCCGTGTQTL KRGLAFFQPQ 
       410        420        430        440        450
QYCPHSVNLS APVTNTSCWD QPTLVPAASH KVDLFNGRLS GTLLTSIFVT 
       460        470        480        490        500
VLQNVTVAHL GTAQGRVLQM VLQRSSSYVV ALTNFSLGEP GLVQHATGLQ 
       510        520        530        540        550
GHSLLFAAGT KVWRVNVTGP GCRHFSTCDR CLRAERFMGC GWCGNGCTRH 
       560        570        580        590        600
HECAGPWVQD SCPPVLTDFH PRSAPLRGQT RVTLCGMTFH SPPDPTAHHS 
       610        620        630        640        650
LPGPYRVAVG GRSCTVLLDE SESYRPLPTF RRKDFVDVLV CVLEPGEPAV 
       660        670        680        690        700
AAGPADVVLN VTESAGTSRF RVQGSSTLSG FVFVEPHIST LHPSFGPQGG 
       710        720        730        740        750
GTLMSLYGTH LSAGSSWRVT INGSECLLDG QPSEGDGEIR CTAPAATSLG 
       760        770        780        790        800
AAPVALWIDG EEFLAPLPFE YRPDPSVLTV VPNCSYGGST LTLIGTHLDS 
       810        820        830        840        850
VYRAKIQFQG GGGGKTEATE CEGPQSPNWL LCRSPAFPIE IKPVPGNLSV 
       860        870        880        890        900
LLDGAADRWL FRLRYFPQPQ MFSFGQQGER YQLKPGDNEI KVNQLGLDSV 
       910        920        930        940        950
AGCMNITMTV GGRDCHPNVL KNEVTCRVPR DVDLTPAGAP VQICVNGDCQ 
       960        970        980        990       1000
ALGLVLPASS LDMAASLALG TGVTFLVCCV LAAVLLRWRW RKRRGLENLE 
      1010       1020       1030       1040       1050
LLVHPPRIEH PITIQRPNVD YREVQVLPVA DSPGLARPHA HFASAGADAA 
      1060       1070       1080       1090       1100
GGGSPVPLLR TTSCCLEDLR PELLEEVKDI LIPEERLITH RSRVIGRGHF 
      1110       1120       1130       1140       1150
GSVYHGTYMD PLLGNLHCAV KSLHRITDLE EVEEFLREGI LMKSFHHPQV 
      1160       1170       1180       1190       1200
LSLLGVCLPR HGLPLVVLPY MRHGDLRHFI RAQERSPTVK ELIGFGLQVA 
      1210       1220       1230       1240       1250
LGMEYLAQKK FVHRDLAARN CMLDETLTVK VADFGLARDV FGKEYYSIRQ 
      1260       1270       1280       1290       1300
HRHAKLPVKW MALESLQTQK FTTKSDVWSF GVLMWELLTR GASPYPEVDP 
      1310       1320       1330       1340       1350
YDMARYLLRG RRLPQPQPCP DTLYGVMLSC WAPTPEERPS FSGLVCELER 
      1360       1370       1380       1390       1400
VLASLEGERY VNLAVTYVNL ESGPPFPPAP RGQLPDSEDE EDEEDEEDED 

AAVR                                             

Sequence databases

Genome annotation databases

<p>This section provides links to the UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>). UniRef consists of clusters for UniProtKB sequences (including isoforms) and selected UniParc sequences, in order to obtain complete coverage of the sequence space at resolutions of 100%, 90% and 50% identity.<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Caution