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UniProtKB - Q08757 (Q08757_CHICK)

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Protein
Submitted name:

C-sea protein

Gene

c-sea

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1121ATPUniRule annotation1
Active sitei1215Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1095 – 1103ATPUniRule annotation9

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionKinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
C-sea proteinImported
Gene namesi
Name:c-seaImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei963 – 986HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500416642521 – 1404Sequence analysisAdd BLAST1384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1245Phosphotyrosine; by autocatalysisUniRule annotation1
Modified residuei1246Phosphotyrosine; by autocatalysisUniRule annotation1
Modified residuei1360Phosphotyrosine; by autocatalysisUniRule annotation1
Modified residuei1367Phosphotyrosine; by autocatalysisUniRule annotation1

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ08757.
PRIDEiQ08757.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004891.

Structurei

3D structure databases

ProteinModelPortaliQ08757.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 517SemaInterPro annotationAdd BLAST491
Domaini1089 – 1352Protein kinaseInterPro annotationAdd BLAST264

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1095. Eukaryota.
KOG3610. Eukaryota.
ENOG410XPVX. LUCA.
HOVERGENiHBG006348.
KOiK05100.
PhylomeDBiQ08757.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016201. PSI.
IPR001627. Semap_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016244. Tyr_kinase_HGF/MSP_rcpt.
IPR015943. WD40/YVTN_repeat-like_dom.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 1 hit.
PIRSFiPIRSF000617. TyrPK_HGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00429. IPT. 3 hits.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF81296. SSF81296. 3 hits.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS51004. SEMA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPRCLVCLL LLLAPSLLQA GAWQCRRIPF SSTRNFSVPY TLPSLDAGSP 
        60         70         80         90        100
VQNIAVFPDP PTVFVAVRNR ILVVDPELRL RSVLVTGPTG SAPCEICRLC 
       110        120        130        140        150
PAAVDAPGPE DVDNVLLLLD PVEPWLYSCG TARRGLCYLH QLDVRGSEVT 
       160        170        180        190        200
IASTRCLYSA AANSPVNCPD CVASPLGSTA TVVADRYTAS FYLGSTVNSS 
       210        220        230        240        250
VAARYSPRSV SVRRLKGTRD GFADPFHSLT VLPHYQDVYP IHYVHSFTDG 
       260        270        280        290        300
DHVYLVTVQP EFPGSSTFHT RLVRLSAHEP ELRRYREIVL DCRYESKRRR 
       310        320        330        340        350
RRRGAEEETE RDVAYNVLQA AHAARPGARL ARDLGIDGTE TVLFGAFAES 
       360        370        380        390        400
HPESRAPQHN SAVCAFPLRL LNQAIREGMD KCCGTGTQTL KRGLAFFQPQ 
       410        420        430        440        450
QYCPHSVNLS APVTNTSCWD QPTLVPAASH KVDLFNGRLS GTLLTSIFVT 
       460        470        480        490        500
VLQNVTVAHL GTAQGRVLQM VLQRSSSYVV ALTNFSLGEP GLVQHATGLQ 
       510        520        530        540        550
GHSLLFAAGT KVWRVNVTGP GCRHFSTCDR CLRAERFMGC GWCGNGCTRH 
       560        570        580        590        600
HECAGPWVQD SCPPVLTDFH PRSAPLRGQT RVTLCGMTFH SPPDPTAHHS 
       610        620        630        640        650
LPGPYRVAVG GRSCTVLLDE SESYRPLPTF RRKDFVDVLV CVLEPGEPAV 
       660        670        680        690        700
AAGPADVVLN VTESAGTSRF RVQGSSTLSG FVFVEPHIST LHPSFGPQGG 
       710        720        730        740        750
GTLMSLYGTH LSAGSSWRVT INGSECLLDG QPSEGDGEIR CTAPAATSLG 
       760        770        780        790        800
AAPVALWIDG EEFLAPLPFE YRPDPSVLTV VPNCSYGGST LTLIGTHLDS 
       810        820        830        840        850
VYRAKIQFQG GGGGKTEATE CEGPQSPNWL LCRSPAFPIE IKPVPGNLSV 
       860        870        880        890        900
LLDGAADRWL FRLRYFPQPQ MFSFGQQGER YQLKPGDNEI KVNQLGLDSV 
       910        920        930        940        950
AGCMNITMTV GGRDCHPNVL KNEVTCRVPR DVDLTPAGAP VQICVNGDCQ 
       960        970        980        990       1000
ALGLVLPASS LDMAASLALG TGVTFLVCCV LAAVLLRWRW RKRRGLENLE 
      1010       1020       1030       1040       1050
LLVHPPRIEH PITIQRPNVD YREVQVLPVA DSPGLARPHA HFASAGADAA 
      1060       1070       1080       1090       1100
GGGSPVPLLR TTSCCLEDLR PELLEEVKDI LIPEERLITH RSRVIGRGHF 
      1110       1120       1130       1140       1150
GSVYHGTYMD PLLGNLHCAV KSLHRITDLE EVEEFLREGI LMKSFHHPQV 
      1160       1170       1180       1190       1200
LSLLGVCLPR HGLPLVVLPY MRHGDLRHFI RAQERSPTVK ELIGFGLQVA 
      1210       1220       1230       1240       1250
LGMEYLAQKK FVHRDLAARN CMLDETLTVK VADFGLARDV FGKEYYSIRQ 
      1260       1270       1280       1290       1300
HRHAKLPVKW MALESLQTQK FTTKSDVWSF GVLMWELLTR GASPYPEVDP 
      1310       1320       1330       1340       1350
YDMARYLLRG RRLPQPQPCP DTLYGVMLSC WAPTPEERPS FSGLVCELER 
      1360       1370       1380       1390       1400
VLASLEGERY VNLAVTYVNL ESGPPFPPAP RGQLPDSEDE EDEEDEEDED 

AAVR
Length:1,404
Mass (Da):153,851
Last modified:November 1, 1996 - v1
Checksum:iD0BC9EC193E27848
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12024 Genomic DNA. Translation: AAA48729.1.
PIRiA48196.
RefSeqiNP_001026634.1. NM_001031463.1.
UniGeneiGga.29675.

Genome annotation databases

GeneIDi427573.
KEGGigga:427573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12024 Genomic DNA. Translation: AAA48729.1.
PIRiA48196.
RefSeqiNP_001026634.1. NM_001031463.1.
UniGeneiGga.29675.

3D structure databases

ProteinModelPortaliQ08757.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004891.

Proteomic databases

PaxDbiQ08757.
PRIDEiQ08757.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi427573.
KEGGigga:427573.

Organism-specific databases

CTDi4486.

Phylogenomic databases

eggNOGiKOG1095. Eukaryota.
KOG3610. Eukaryota.
ENOG410XPVX. LUCA.
HOVERGENiHBG006348.
KOiK05100.
PhylomeDBiQ08757.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016201. PSI.
IPR001627. Semap_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016244. Tyr_kinase_HGF/MSP_rcpt.
IPR015943. WD40/YVTN_repeat-like_dom.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 1 hit.
PIRSFiPIRSF000617. TyrPK_HGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00429. IPT. 3 hits.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF81296. SSF81296. 3 hits.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS51004. SEMA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ08757_CHICK
AccessioniPrimary (citable) accession number: Q08757
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.