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UniProtKB - Q08757 (Q08757_CHICK)

UniProt

Q08757 - Q08757_CHICK

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Protein
Submitted name:

C-sea protein

Gene

c-sea

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1121 – 11211ATPUniRule annotation
Active sitei1215 – 12151Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1095 – 11039ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
C-sea proteinImported
Gene namesi
Name:c-seaImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei963 – 98624HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 14041384Sequence analysisPRO_5004166425Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1245 – 12451Phosphotyrosine; by autocatalysisUniRule annotation
Modified residuei1246 – 12461Phosphotyrosine; by autocatalysisUniRule annotation
Modified residuei1360 – 13601Phosphotyrosine; by autocatalysisUniRule annotation
Modified residuei1367 – 13671Phosphotyrosine; by autocatalysisUniRule annotation

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ08757.
PRIDEiQ08757.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004891.

Structurei

3D structure databases

ProteinModelPortaliQ08757.
SMRiQ08757. Positions 1058-1357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 517491SemaInterPro annotationAdd
BLAST
Domaini1089 – 1352264Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation
Contains Sema domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1095. Eukaryota.
KOG3610. Eukaryota.
ENOG410XPVX. LUCA.
HOVERGENiHBG006348.
KOiK05100.
PhylomeDBiQ08757.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR011009. Kinase-like_dom.
IPR016201. Plexin-like_fold.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001627. Semap_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016244. Tyr_kinase_HGF/MSP_rcpt.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
PIRSFiPIRSF000617. TyrPK_HGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00429. IPT. 3 hits.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF81296. SSF81296. 3 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPRCLVCLL LLLAPSLLQA GAWQCRRIPF SSTRNFSVPY TLPSLDAGSP 
        60         70         80         90        100
VQNIAVFPDP PTVFVAVRNR ILVVDPELRL RSVLVTGPTG SAPCEICRLC 
       110        120        130        140        150
PAAVDAPGPE DVDNVLLLLD PVEPWLYSCG TARRGLCYLH QLDVRGSEVT 
       160        170        180        190        200
IASTRCLYSA AANSPVNCPD CVASPLGSTA TVVADRYTAS FYLGSTVNSS 
       210        220        230        240        250
VAARYSPRSV SVRRLKGTRD GFADPFHSLT VLPHYQDVYP IHYVHSFTDG 
       260        270        280        290        300
DHVYLVTVQP EFPGSSTFHT RLVRLSAHEP ELRRYREIVL DCRYESKRRR 
       310        320        330        340        350
RRRGAEEETE RDVAYNVLQA AHAARPGARL ARDLGIDGTE TVLFGAFAES 
       360        370        380        390        400
HPESRAPQHN SAVCAFPLRL LNQAIREGMD KCCGTGTQTL KRGLAFFQPQ 
       410        420        430        440        450
QYCPHSVNLS APVTNTSCWD QPTLVPAASH KVDLFNGRLS GTLLTSIFVT 
       460        470        480        490        500
VLQNVTVAHL GTAQGRVLQM VLQRSSSYVV ALTNFSLGEP GLVQHATGLQ 
       510        520        530        540        550
GHSLLFAAGT KVWRVNVTGP GCRHFSTCDR CLRAERFMGC GWCGNGCTRH 
       560        570        580        590        600
HECAGPWVQD SCPPVLTDFH PRSAPLRGQT RVTLCGMTFH SPPDPTAHHS 
       610        620        630        640        650
LPGPYRVAVG GRSCTVLLDE SESYRPLPTF RRKDFVDVLV CVLEPGEPAV 
       660        670        680        690        700
AAGPADVVLN VTESAGTSRF RVQGSSTLSG FVFVEPHIST LHPSFGPQGG 
       710        720        730        740        750
GTLMSLYGTH LSAGSSWRVT INGSECLLDG QPSEGDGEIR CTAPAATSLG 
       760        770        780        790        800
AAPVALWIDG EEFLAPLPFE YRPDPSVLTV VPNCSYGGST LTLIGTHLDS 
       810        820        830        840        850
VYRAKIQFQG GGGGKTEATE CEGPQSPNWL LCRSPAFPIE IKPVPGNLSV 
       860        870        880        890        900
LLDGAADRWL FRLRYFPQPQ MFSFGQQGER YQLKPGDNEI KVNQLGLDSV 
       910        920        930        940        950
AGCMNITMTV GGRDCHPNVL KNEVTCRVPR DVDLTPAGAP VQICVNGDCQ 
       960        970        980        990       1000
ALGLVLPASS LDMAASLALG TGVTFLVCCV LAAVLLRWRW RKRRGLENLE 
      1010       1020       1030       1040       1050
LLVHPPRIEH PITIQRPNVD YREVQVLPVA DSPGLARPHA HFASAGADAA 
      1060       1070       1080       1090       1100
GGGSPVPLLR TTSCCLEDLR PELLEEVKDI LIPEERLITH RSRVIGRGHF 
      1110       1120       1130       1140       1150
GSVYHGTYMD PLLGNLHCAV KSLHRITDLE EVEEFLREGI LMKSFHHPQV 
      1160       1170       1180       1190       1200
LSLLGVCLPR HGLPLVVLPY MRHGDLRHFI RAQERSPTVK ELIGFGLQVA 
      1210       1220       1230       1240       1250
LGMEYLAQKK FVHRDLAARN CMLDETLTVK VADFGLARDV FGKEYYSIRQ 
      1260       1270       1280       1290       1300
HRHAKLPVKW MALESLQTQK FTTKSDVWSF GVLMWELLTR GASPYPEVDP 
      1310       1320       1330       1340       1350
YDMARYLLRG RRLPQPQPCP DTLYGVMLSC WAPTPEERPS FSGLVCELER 
      1360       1370       1380       1390       1400
VLASLEGERY VNLAVTYVNL ESGPPFPPAP RGQLPDSEDE EDEEDEEDED 

AAVR
Length:1,404
Mass (Da):153,851
Last modified:November 1, 1996 - v1
Checksum:iD0BC9EC193E27848
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12024 Genomic DNA. Translation: AAA48729.1.
PIRiA48196.
RefSeqiNP_001026634.1. NM_001031463.1.
UniGeneiGga.29675.

Genome annotation databases

GeneIDi427573.
KEGGigga:427573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12024 Genomic DNA. Translation: AAA48729.1.
PIRiA48196.
RefSeqiNP_001026634.1. NM_001031463.1.
UniGeneiGga.29675.

3D structure databases

ProteinModelPortaliQ08757.
SMRiQ08757. Positions 1058-1357.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004891.

Proteomic databases

PaxDbiQ08757.
PRIDEiQ08757.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi427573.
KEGGigga:427573.

Organism-specific databases

CTDi4486.

Phylogenomic databases

eggNOGiKOG1095. Eukaryota.
KOG3610. Eukaryota.
ENOG410XPVX. LUCA.
HOVERGENiHBG006348.
KOiK05100.
PhylomeDBiQ08757.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR011009. Kinase-like_dom.
IPR016201. Plexin-like_fold.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001627. Semap_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016244. Tyr_kinase_HGF/MSP_rcpt.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
PIRSFiPIRSF000617. TyrPK_HGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00429. IPT. 3 hits.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF81296. SSF81296. 3 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ08757_CHICK
AccessioniPrimary (citable) accession number: Q08757
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.