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Protein
Submitted name:

C-sea protein

Gene

c-sea

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1121 – 11211ATPUniRule annotation
Active sitei1215 – 12151Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1095 – 11039ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
C-sea proteinImported
Gene namesi
Name:c-seaImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei963 – 98624HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 14041384Sequence analysisPRO_5004166425Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1245 – 12451Phosphotyrosine; by autocatalysisUniRule annotation
Modified residuei1246 – 12461Phosphotyrosine; by autocatalysisUniRule annotation
Modified residuei1360 – 13601Phosphotyrosine; by autocatalysisUniRule annotation
Modified residuei1367 – 13671Phosphotyrosine; by autocatalysisUniRule annotation

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ08757.
PRIDEiQ08757.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004891.

Structurei

3D structure databases

ProteinModelPortaliQ08757.
SMRiQ08757. Positions 1058-1357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 517491SemaInterPro annotationAdd
BLAST
Domaini1089 – 1352264Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation
Contains Sema domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1095. Eukaryota.
KOG3610. Eukaryota.
ENOG410XPVX. LUCA.
HOVERGENiHBG006348.
KOiK05100.
PhylomeDBiQ08757.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR011009. Kinase-like_dom.
IPR016201. Plexin-like_fold.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001627. Semap_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016244. Tyr_kinase_HGF/MSP_rcpt.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
PIRSFiPIRSF000617. TyrPK_HGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00429. IPT. 3 hits.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF81296. SSF81296. 3 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPRCLVCLL LLLAPSLLQA GAWQCRRIPF SSTRNFSVPY TLPSLDAGSP
60 70 80 90 100
VQNIAVFPDP PTVFVAVRNR ILVVDPELRL RSVLVTGPTG SAPCEICRLC
110 120 130 140 150
PAAVDAPGPE DVDNVLLLLD PVEPWLYSCG TARRGLCYLH QLDVRGSEVT
160 170 180 190 200
IASTRCLYSA AANSPVNCPD CVASPLGSTA TVVADRYTAS FYLGSTVNSS
210 220 230 240 250
VAARYSPRSV SVRRLKGTRD GFADPFHSLT VLPHYQDVYP IHYVHSFTDG
260 270 280 290 300
DHVYLVTVQP EFPGSSTFHT RLVRLSAHEP ELRRYREIVL DCRYESKRRR
310 320 330 340 350
RRRGAEEETE RDVAYNVLQA AHAARPGARL ARDLGIDGTE TVLFGAFAES
360 370 380 390 400
HPESRAPQHN SAVCAFPLRL LNQAIREGMD KCCGTGTQTL KRGLAFFQPQ
410 420 430 440 450
QYCPHSVNLS APVTNTSCWD QPTLVPAASH KVDLFNGRLS GTLLTSIFVT
460 470 480 490 500
VLQNVTVAHL GTAQGRVLQM VLQRSSSYVV ALTNFSLGEP GLVQHATGLQ
510 520 530 540 550
GHSLLFAAGT KVWRVNVTGP GCRHFSTCDR CLRAERFMGC GWCGNGCTRH
560 570 580 590 600
HECAGPWVQD SCPPVLTDFH PRSAPLRGQT RVTLCGMTFH SPPDPTAHHS
610 620 630 640 650
LPGPYRVAVG GRSCTVLLDE SESYRPLPTF RRKDFVDVLV CVLEPGEPAV
660 670 680 690 700
AAGPADVVLN VTESAGTSRF RVQGSSTLSG FVFVEPHIST LHPSFGPQGG
710 720 730 740 750
GTLMSLYGTH LSAGSSWRVT INGSECLLDG QPSEGDGEIR CTAPAATSLG
760 770 780 790 800
AAPVALWIDG EEFLAPLPFE YRPDPSVLTV VPNCSYGGST LTLIGTHLDS
810 820 830 840 850
VYRAKIQFQG GGGGKTEATE CEGPQSPNWL LCRSPAFPIE IKPVPGNLSV
860 870 880 890 900
LLDGAADRWL FRLRYFPQPQ MFSFGQQGER YQLKPGDNEI KVNQLGLDSV
910 920 930 940 950
AGCMNITMTV GGRDCHPNVL KNEVTCRVPR DVDLTPAGAP VQICVNGDCQ
960 970 980 990 1000
ALGLVLPASS LDMAASLALG TGVTFLVCCV LAAVLLRWRW RKRRGLENLE
1010 1020 1030 1040 1050
LLVHPPRIEH PITIQRPNVD YREVQVLPVA DSPGLARPHA HFASAGADAA
1060 1070 1080 1090 1100
GGGSPVPLLR TTSCCLEDLR PELLEEVKDI LIPEERLITH RSRVIGRGHF
1110 1120 1130 1140 1150
GSVYHGTYMD PLLGNLHCAV KSLHRITDLE EVEEFLREGI LMKSFHHPQV
1160 1170 1180 1190 1200
LSLLGVCLPR HGLPLVVLPY MRHGDLRHFI RAQERSPTVK ELIGFGLQVA
1210 1220 1230 1240 1250
LGMEYLAQKK FVHRDLAARN CMLDETLTVK VADFGLARDV FGKEYYSIRQ
1260 1270 1280 1290 1300
HRHAKLPVKW MALESLQTQK FTTKSDVWSF GVLMWELLTR GASPYPEVDP
1310 1320 1330 1340 1350
YDMARYLLRG RRLPQPQPCP DTLYGVMLSC WAPTPEERPS FSGLVCELER
1360 1370 1380 1390 1400
VLASLEGERY VNLAVTYVNL ESGPPFPPAP RGQLPDSEDE EDEEDEEDED

AAVR
Length:1,404
Mass (Da):153,851
Last modified:November 1, 1996 - v1
Checksum:iD0BC9EC193E27848
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12024 Genomic DNA. Translation: AAA48729.1.
PIRiA48196.
RefSeqiNP_001026634.1. NM_001031463.1.
UniGeneiGga.29675.

Genome annotation databases

GeneIDi427573.
KEGGigga:427573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12024 Genomic DNA. Translation: AAA48729.1.
PIRiA48196.
RefSeqiNP_001026634.1. NM_001031463.1.
UniGeneiGga.29675.

3D structure databases

ProteinModelPortaliQ08757.
SMRiQ08757. Positions 1058-1357.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004891.

Proteomic databases

PaxDbiQ08757.
PRIDEiQ08757.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi427573.
KEGGigga:427573.

Organism-specific databases

CTDi4486.

Phylogenomic databases

eggNOGiKOG1095. Eukaryota.
KOG3610. Eukaryota.
ENOG410XPVX. LUCA.
HOVERGENiHBG006348.
KOiK05100.
PhylomeDBiQ08757.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR011009. Kinase-like_dom.
IPR016201. Plexin-like_fold.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001627. Semap_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016244. Tyr_kinase_HGF/MSP_rcpt.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
PIRSFiPIRSF000617. TyrPK_HGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00429. IPT. 3 hits.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF81296. SSF81296. 3 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The protooncogene c-sea encodes a transmembrane protein-tyrosine kinase related to the Met/hepatocyte growth factor/scatter factor receptor."
    Huff J.L., Jelinek M.A., Borgman C.A., Lansing T.J., Parsons J.T.
    Proc. Natl. Acad. Sci. U.S.A. 90:6140-6144(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ08757_CHICK
AccessioniPrimary (citable) accession number: Q08757
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.