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Protein

Regulator of ribosome biosynthesis

Gene

RRS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for ribosome biogenesis.1 Publication

GO - Biological processi

  • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • ribosomal large subunit biogenesis Source: SGD
  • ribosomal large subunit export from nucleus Source: SGD

Keywordsi

Biological processRibosome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-33779-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of ribosome biosynthesis
Gene namesi
Name:RRS1
Ordered Locus Names:YOR294W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR294W
SGDiS000005820 RRS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Depletion causes defects in processing of pre- rRNA and assembly of ribosomal subunits.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001853791 – 203Regulator of ribosome biosynthesisAdd BLAST203

Proteomic databases

MaxQBiQ08746
PaxDbiQ08746
PRIDEiQ08746

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi34682, 203 interactors
DIPiDIP-4081N
IntActiQ08746, 46 interactors
MINTiQ08746
STRINGi4932.YOR294W

Structurei

Secondary structure

1203
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi20 – 22Combined sources3
Helixi23 – 25Combined sources3
Beta strandi27 – 30Combined sources4
Helixi36 – 39Combined sources4
Helixi46 – 65Combined sources20
Beta strandi70 – 72Combined sources3
Beta strandi88 – 91Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JCTelectron microscopy3.08w1-203[»]
5A53X-ray2.40A9-73[»]
B85-106[»]
5WXLX-ray1.90B/D20-121[»]
6FT6electron microscopy3.90w1-203[»]
ProteinModelPortaliQ08746
SMRiQ08746
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RRS1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000005213
HOGENOMiHOG000180297
InParanoidiQ08746
KOiK14852
OMAiNELQHKR
OrthoDBiEOG092C5GIA

Family and domain databases

InterProiView protein in InterPro
IPR007023 Ribosom_reg
PANTHERiPTHR17602 PTHR17602, 1 hit
PfamiView protein in Pfam
PF04939 RRS1, 1 hit

Sequencei

Sequence statusi: Complete.

Q08746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEDYKNLP VTVEKPIPVV YDLGNLAAFD SNVLDKNDLD SSNARREEKI
60 70 80 90 100
KSLTRDNVQL LINQLLSLPM KTTTESVGGT GGQSSVMTLL QLPDPTTDLP
110 120 130 140 150
REKPLPKAKA MTKWEKFAAK KGIKPKERAG KMIYDEASGE WVPKWGYKGA
160 170 180 190 200
NKKLDDQWLV EVDDKVKGTD NELIDPRTLN RAERKRLVKK NEKQQRRNMK

NAL
Length:203
Mass (Da):22,963
Last modified:November 1, 1996 - v1
Checksum:i7DFF6C51DDD2ADD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75202 Genomic DNA Translation: CAA99522.1
BK006948 Genomic DNA Translation: DAA11059.1
PIRiS67198
RefSeqiNP_014937.1, NM_001183713.1

Genome annotation databases

EnsemblFungiiYOR294W; YOR294W; YOR294W
GeneIDi854469
KEGGisce:YOR294W

Similar proteinsi

Entry informationi

Entry nameiRRS1_YEAST
AccessioniPrimary (citable) accession number: Q08746
Secondary accession number(s): D6W2Z3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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