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Protein

Regulator of ribosome biosynthesis

Gene

RRS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for ribosome biogenesis.1 Publication

GO - Biological processi

  • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • ribosomal large subunit biogenesis Source: SGD
  • ribosomal large subunit export from nucleus Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-33779-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of ribosome biosynthesis
Gene namesi
Name:RRS1
Ordered Locus Names:YOR294W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR294W.
SGDiS000005820. RRS1.

Subcellular locationi

GO - Cellular componenti

  • nuclear periphery Source: SGD
  • nucleolus Source: SGD
  • nucleoplasm Source: SGD
  • preribosome, large subunit precursor Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Depletion causes defects in processing of pre- rRNA and assembly of ribosomal subunits.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Regulator of ribosome biosynthesisPRO_0000185379Add
BLAST

Proteomic databases

MaxQBiQ08746.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MPS3P470694EBI-16026,EBI-25811
RPF2P361605EBI-16026,EBI-15881

Protein-protein interaction databases

BioGridi34682. 89 interactions.
DIPiDIP-4081N.
IntActiQ08746. 44 interactions.
MINTiMINT-484080.

Structurei

Secondary structure

1
203
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi20 – 223Combined sources
Helixi23 – 253Combined sources
Beta strandi27 – 304Combined sources
Helixi36 – 394Combined sources
Helixi46 – 6520Combined sources
Beta strandi68 – 725Combined sources
Beta strandi88 – 914Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5A53X-ray2.40A9-73[»]
B85-106[»]
ProteinModelPortaliQ08746.
SMRiQ08746. Positions 9-106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RRS1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000005213.
HOGENOMiHOG000180297.
InParanoidiQ08746.
KOiK14852.
OMAiWLVEVDD.
OrthoDBiEOG7673NV.

Family and domain databases

InterProiIPR007023. Ribosom_reg.
[Graphical view]
PANTHERiPTHR17602. PTHR17602. 1 hit.
PfamiPF04939. RRS1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEDYKNLP VTVEKPIPVV YDLGNLAAFD SNVLDKNDLD SSNARREEKI
60 70 80 90 100
KSLTRDNVQL LINQLLSLPM KTTTESVGGT GGQSSVMTLL QLPDPTTDLP
110 120 130 140 150
REKPLPKAKA MTKWEKFAAK KGIKPKERAG KMIYDEASGE WVPKWGYKGA
160 170 180 190 200
NKKLDDQWLV EVDDKVKGTD NELIDPRTLN RAERKRLVKK NEKQQRRNMK

NAL
Length:203
Mass (Da):22,963
Last modified:November 1, 1996 - v1
Checksum:i7DFF6C51DDD2ADD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75202 Genomic DNA. Translation: CAA99522.1.
BK006948 Genomic DNA. Translation: DAA11059.1.
PIRiS67198.
RefSeqiNP_014937.1. NM_001183713.1.

Genome annotation databases

EnsemblFungiiYOR294W; YOR294W; YOR294W.
GeneIDi854469.
KEGGisce:YOR294W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75202 Genomic DNA. Translation: CAA99522.1.
BK006948 Genomic DNA. Translation: DAA11059.1.
PIRiS67198.
RefSeqiNP_014937.1. NM_001183713.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5A53X-ray2.40A9-73[»]
B85-106[»]
ProteinModelPortaliQ08746.
SMRiQ08746. Positions 9-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34682. 89 interactions.
DIPiDIP-4081N.
IntActiQ08746. 44 interactions.
MINTiMINT-484080.

Proteomic databases

MaxQBiQ08746.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR294W; YOR294W; YOR294W.
GeneIDi854469.
KEGGisce:YOR294W.

Organism-specific databases

EuPathDBiFungiDB:YOR294W.
SGDiS000005820. RRS1.

Phylogenomic databases

GeneTreeiENSGT00390000005213.
HOGENOMiHOG000180297.
InParanoidiQ08746.
KOiK14852.
OMAiWLVEVDD.
OrthoDBiEOG7673NV.

Enzyme and pathway databases

BioCyciYEAST:G3O-33779-MONOMER.

Miscellaneous databases

PROiQ08746.

Family and domain databases

InterProiIPR007023. Ribosom_reg.
[Graphical view]
PANTHERiPTHR17602. PTHR17602. 1 hit.
PfamiPF04939. RRS1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of a 36.2 kb fragment from the right arm of yeast chromosome XV reveals 19 open reading frames including SNF2 (5' end), CPA1, SLY41, a putative transport ATPase, a putative ribosomal protein and an SNF2 homologue."
    Poirey R., Cziepluch C., Tobiasch E., Pujol A., Kordes E., Jauniaux J.-C.
    Yeast 13:479-482(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "RRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae."
    Tsuno A., Miyoshi K., Tsujii R., Miyakawa T., Mizuta K.
    Mol. Cell. Biol. 20:2066-2074(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiRRS1_YEAST
AccessioniPrimary (citable) accession number: Q08746
Secondary accession number(s): D6W2Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.