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Protein

40S ribosomal protein S10-A

Gene

RPS10A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role as a positive regulator of the GCN2 kinase activity by stimulating GCN1-mediated GCN2 activation (PubMed:25437641).1 Publication

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cellular response to amino acid starvation Source: UniProtKB
  • cytoplasmic translation Source: SGD
  • positive regulation of protein kinase activity Source: UniProtKB
  • ribosomal small subunit assembly Source: GO_Central
  • rRNA export from nucleus Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-33778-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-SCE-72702. Ribosomal scanning and start codon recognition.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S10-A
Gene namesi
Name:RPS10A
Ordered Locus Names:YOR293W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR293W.
SGDiS000005819. RPS10A.

Subcellular locationi

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001163761 – 10540S ribosomal protein S10-AAdd BLAST105

Post-translational modificationi

The N-terminus is not modified.

Proteomic databases

MaxQBiQ08745.
PRIDEiQ08745.
TopDownProteomicsiQ08745.

PTM databases

iPTMnetiQ08745.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:9559554). The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S) (PubMed:9559554). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:9559554). Interacts with GCN1 (via middle region); this interaction is direct and promotes GCN2 kinase activity (PubMed:25437641).2 Publications

Protein-protein interaction databases

BioGridi34681. 80 interactors.
IntActiQ08745. 10 interactors.
MINTiMINT-2786873.

Structurei

Secondary structure

1105
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 18Combined sources14
Beta strandi19 – 25Combined sources7
Beta strandi33 – 37Combined sources5
Helixi39 – 51Combined sources13
Beta strandi53 – 56Combined sources4
Turni60 – 62Combined sources3
Beta strandi63 – 68Combined sources6
Helixi70 – 79Combined sources10
Helixi88 – 90Combined sources3
Turni93 – 95Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10101-105[»]
3J6Yelectron microscopy6.10101-105[»]
3J77electron microscopy6.20101-105[»]
3J78electron microscopy6.30101-105[»]
3V88X-ray3.00K1-105[»]
4U3NX-ray3.20C0/c01-105[»]
4U3UX-ray2.90C0/c01-105[»]
4U4NX-ray3.10C0/c01-105[»]
4U4OX-ray3.60C0/c01-105[»]
4U4QX-ray3.00C0/c01-105[»]
4U4RX-ray2.80C0/c01-105[»]
4U4UX-ray3.00C0/c01-105[»]
4U4YX-ray3.20C0/c01-105[»]
4U4ZX-ray3.10C0/c01-105[»]
4U50X-ray3.20C0/c01-105[»]
4U51X-ray3.20C0/c01-105[»]
4U52X-ray3.00C0/c01-105[»]
4U53X-ray3.30C0/c01-105[»]
4U55X-ray3.20C0/c01-105[»]
4U56X-ray3.45C0/c01-105[»]
4U6FX-ray3.10C0/c01-105[»]
4V88X-ray3.00AK/CK1-105[»]
4V8Yelectron microscopy4.30AK1-105[»]
4V8Zelectron microscopy6.60AK1-105[»]
4V92electron microscopy3.70K1-93[»]
5DATX-ray3.15C0/c01-105[»]
5DC3X-ray3.25C01-105[»]
c01-103[»]
5FCIX-ray3.40C01-105[»]
c01-84[»]
5FCJX-ray3.10C0/c01-84[»]
5I4LX-ray3.10C0/c01-98[»]
5JUOelectron microscopy4.00HB1-105[»]
5JUPelectron microscopy3.50HB1-105[»]
5JUSelectron microscopy4.20HB1-105[»]
5JUTelectron microscopy4.00HB1-105[»]
5JUUelectron microscopy4.00HB1-105[»]
ProteinModelPortaliQ08745.
SMRiQ08745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S10e family.Curated

Phylogenomic databases

GeneTreeiENSGT00440000034918.
HOGENOMiHOG000216624.
InParanoidiQ08745.
KOiK02947.
OMAiHIFPATY.
OrthoDBiEOG092C5V0H.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005326. S10_plectin_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03501. S10_plectin. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMPKEDRNK IHQYLFQEGV VVAKKDFNQA KHEEIDTKNL YVIKALQSLT
60 70 80 90 100
SKGYVKTQFS WQYYYYTLTE EGVEYLREYL NLPEHIVPGT YIQERNPTQR

PQRRY
Length:105
Mass (Da):12,739
Last modified:November 1, 1996 - v1
Checksum:iE104B39336EE64BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75201 Genomic DNA. Translation: CAA99521.1.
BK006948 Genomic DNA. Translation: DAA11057.1.
PIRiS67197.
RefSeqiNP_014936.1. NM_001183712.1.

Genome annotation databases

EnsemblFungiiYOR293W; YOR293W; YOR293W.
GeneIDi854468.
KEGGisce:YOR293W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75201 Genomic DNA. Translation: CAA99521.1.
BK006948 Genomic DNA. Translation: DAA11057.1.
PIRiS67197.
RefSeqiNP_014936.1. NM_001183712.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10101-105[»]
3J6Yelectron microscopy6.10101-105[»]
3J77electron microscopy6.20101-105[»]
3J78electron microscopy6.30101-105[»]
3V88X-ray3.00K1-105[»]
4U3NX-ray3.20C0/c01-105[»]
4U3UX-ray2.90C0/c01-105[»]
4U4NX-ray3.10C0/c01-105[»]
4U4OX-ray3.60C0/c01-105[»]
4U4QX-ray3.00C0/c01-105[»]
4U4RX-ray2.80C0/c01-105[»]
4U4UX-ray3.00C0/c01-105[»]
4U4YX-ray3.20C0/c01-105[»]
4U4ZX-ray3.10C0/c01-105[»]
4U50X-ray3.20C0/c01-105[»]
4U51X-ray3.20C0/c01-105[»]
4U52X-ray3.00C0/c01-105[»]
4U53X-ray3.30C0/c01-105[»]
4U55X-ray3.20C0/c01-105[»]
4U56X-ray3.45C0/c01-105[»]
4U6FX-ray3.10C0/c01-105[»]
4V88X-ray3.00AK/CK1-105[»]
4V8Yelectron microscopy4.30AK1-105[»]
4V8Zelectron microscopy6.60AK1-105[»]
4V92electron microscopy3.70K1-93[»]
5DATX-ray3.15C0/c01-105[»]
5DC3X-ray3.25C01-105[»]
c01-103[»]
5FCIX-ray3.40C01-105[»]
c01-84[»]
5FCJX-ray3.10C0/c01-84[»]
5I4LX-ray3.10C0/c01-98[»]
5JUOelectron microscopy4.00HB1-105[»]
5JUPelectron microscopy3.50HB1-105[»]
5JUSelectron microscopy4.20HB1-105[»]
5JUTelectron microscopy4.00HB1-105[»]
5JUUelectron microscopy4.00HB1-105[»]
ProteinModelPortaliQ08745.
SMRiQ08745.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34681. 80 interactors.
IntActiQ08745. 10 interactors.
MINTiMINT-2786873.

PTM databases

iPTMnetiQ08745.

Proteomic databases

MaxQBiQ08745.
PRIDEiQ08745.
TopDownProteomicsiQ08745.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR293W; YOR293W; YOR293W.
GeneIDi854468.
KEGGisce:YOR293W.

Organism-specific databases

EuPathDBiFungiDB:YOR293W.
SGDiS000005819. RPS10A.

Phylogenomic databases

GeneTreeiENSGT00440000034918.
HOGENOMiHOG000216624.
InParanoidiQ08745.
KOiK02947.
OMAiHIFPATY.
OrthoDBiEOG092C5V0H.

Enzyme and pathway databases

BioCyciYEAST:G3O-33778-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-SCE-72702. Ribosomal scanning and start codon recognition.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiQ08745.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005326. S10_plectin_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03501. S10_plectin. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRS10A_YEAST
AccessioniPrimary (citable) accession number: Q08745
Secondary accession number(s): D6W2Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 54100 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for S10 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.