Q08743 (YO292_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vacuolar membrane protein YOR292C

Gene names

Ordered Locus Names:

YOR292C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Vacuole membrane; Multi-pass membrane protein Ref.4.
Post-translational modification	N-glycosylated.
Sequence similarities	Belongs to the peroxisomal membrane protein PXMP2/4 family.

Ontologies

Keywords
Cellular component	Membrane Vacuole
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	fungal-type vacuole Inferred from direct assay Ref.4. Source: SGD integral to membrane Inferred from sequence model PubMed 12192589. Source: SGD vacuolar membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Vacuolar membrane protein YOR292C		PRO_0000245252
Regions
	Topological domain	1 – 52	52	Vacuolar Potential
	Transmembrane	53 – 73	21	Helical; Potential
	Topological domain	74 – 81	8	Cytoplasmic Potential
	Transmembrane	82 – 102	21	Helical; Potential
	Topological domain	103 – 183	81	Vacuolar Potential
	Transmembrane	184 – 204	21	Helical; Potential
	Topological domain	205 – 225	21	Cytoplasmic Potential
	Transmembrane	226 – 246	21	Helical; Potential
	Topological domain	247 – 260	14	Vacuolar Potential
	Transmembrane	261 – 281	21	Helical; Potential
	Topological domain	282 – 309	28	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	19	1	N-linked (GlcNAc...) Potential
	Glycosylation	121	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q08743 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: A3BD32893F595536	FASTA	309	36,195
	10 20 30 40 50 60 MPLQLFGRDQ IVVHYDNGNM SNDDQNHQSV LGSWTRRAAA ALRTLMNKRI QRITLTHWLL 70 80 90 100 110 120 LVIWVTSLWK FTSHYRQLYA NSAVFATLCT NILLFGISDI LAQSIACFYS YHVDPIPQIL 130 140 150 160 170 180 NDTFHHVQNN RDVENGGGYE SDELSIFNDF TSEHSSYTDN DDYPELDRPL ATFKTDTFDF 190 200 210 220 230 240 FRWGCFMFWG FFISFFQAPW YKFLNFFYTE DPTVVQVFER VLSDQLLYSP ISLYCFFMFS 250 260 270 280 290 300 NYVMEGGDKD TLGKKIQRLY ISTLGCNYLV WPMVQFINFL IMPRDFQAPF SSSVGVVWNC FLSMRNASK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of a 36.2 kb fragment from the right arm of yeast chromosome XV reveals 19 open reading frames including SNF2 (5' end), CPA1, SLY41, a putative transport ATPase, a putative ribosomal protein and an SNF2 homologue." Poirey R., Cziepluch C., Tobiasch E., Pujol A., Kordes E., Jauniaux J.-C. Yeast 13:479-482(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K. Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A.
[6]	"Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes." Kung L.A., Tao S.-C., Qian J., Smith M.G., Snyder M., Zhu H. Mol. Syst. Biol. 5:308-308(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z75200 Genomic DNA. Translation: CAA99520.1. BK006948 Genomic DNA. Translation: DAA11056.1.
PIR	S67196.
RefSeq	NP_014935.3. NM_001183711.3.
3D structure databases
ProteinModelPortal	Q08743.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1733N.
IntAct	Q08743. 2 interactions.
MINT	MINT-385832.
STRING	4932.YOR292C.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YOR292C; YOR292C; YOR292C.
GeneID	854467.
KEGG	sce:YOR292C.
Organism-specific databases
CYGD	YOR292c.
SGD	S000005818. YOR292C.
Phylogenomic databases
eggNOG	NOG260124.
HOGENOM	HOG000246702.
OMA	NCFLSMR.
OrthoDB	EOG43247D.
Enzyme and pathway databases
BioCyc	YEAST:G3O-33777-MONOMER.
Gene expression databases
Genevestigator	Q08743.
GermOnline	YOR292C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR007248. Mpv17_PMP22. [Graphical view]
PANTHER	PTHR11266. PTHR11266. 1 hit.
Pfam	PF04117. Mpv17_PMP22. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	976756.

Entry information

Entry name

YO292_YEAST

Accession

Primary (citable) accession number: Q08743
Secondary accession number(s): D6W2Z0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	November 1, 1996
Last modified:	May 29, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program