ID   HXA2_CHICK              Reviewed;         375 AA.
AC   Q08727;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   24-JAN-2024, entry version 143.
DE   RecName: Full=Homeobox protein Hox-A2;
GN   Name=HOXA2; Synonyms=HOXA-2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7600967; DOI=10.1242/dev.120.4.911;
RA   Prince V.E., Lumsden A.;
RT   "Hoxa-2 expression in normal and transposed rhombomeres: independent
RT   regulation in the neural tube and neural crest.";
RL   Development 120:911-923(1994).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Proboscipedia
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X74323; CAA52370.1; -; mRNA.
DR   PIR; I50589; I50589.
DR   PIR; S35941; S35941.
DR   RefSeq; NP_990481.1; NM_205150.2.
DR   AlphaFoldDB; Q08727; -.
DR   SMR; Q08727; -.
DR   BioGRID; 676323; 1.
DR   STRING; 9031.ENSGALP00000044883; -.
DR   PaxDb; 9031-ENSGALP00000017982; -.
DR   Ensembl; ENSGALT00000052233; ENSGALP00000044883; ENSGALG00000040521.
DR   Ensembl; ENSGALT00010004079.1; ENSGALP00010002376.1; ENSGALG00010001790.1.
DR   Ensembl; ENSGALT00015002157; ENSGALP00015001346; ENSGALG00015001035.
DR   GeneID; 396055; -.
DR   KEGG; gga:396055; -.
DR   CTD; 3199; -.
DR   VEuPathDB; HostDB:geneid_396055; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000155029; -.
DR   HOGENOM; CLU_048378_0_0_1; -.
DR   InParanoid; Q08727; -.
DR   OMA; VHNGESQ; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; Q08727; -.
DR   PRO; PR:Q08727; -.
DR   Proteomes; UP000000539; Chromosome 2.
DR   Bgee; ENSGALG00000040521; Expressed in ovary and 7 other cell types or tissues.
DR   ExpressionAtlas; Q08727; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45664:SF3; HOMEOBOX PROTEIN HOX-A2; 1.
DR   PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..375
FT                   /note="Homeobox protein Hox-A2"
FT                   /id="PRO_0000200039"
FT   DNA_BIND        140..199
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          29..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          193..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          255..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           94..99
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        29..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        199..218
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   375 AA;  40998 MW;  C7C4CA10455C3B11 CRC64;
     MNFEFEREIG FINSQPSLAE CLTSFPPVGD TFQSSSIKNS TLSHSTLIPP PFEQTIPSLN
     PGGHPRHSGG GRPKASPRAR SGSPGPAGAP PPPEYPWMKE KKASKRSSLP PASASASAAG
     PACLSHKDPL EIPDSGSGGS RRLRTAYTNT QLLELEKEFH FNKYLCRPRR VEIAALLDLT
     ERQVKVWFQN RRMKHKRQTQ CKENQNGEGK FKGSEDPEKA AEDDEEEKAL FEQALGTVSG
     ALLEREGYAF QQNALSQQQA QNAHNGESQS FPVSPLTSNE KNLKHFQHQS PTVQNCLSTM
     AQNCAAGLNN DSPEALEVPS LQDFNVFSTD SCLQLSDAVS PSLPGSLDSP VDISADSFDF
     FTDTLTTIDL QHLNY
//