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Q08727

- HXA2_CHICK

UniProt

Q08727 - HXA2_CHICK

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Protein

Homeobox protein Hox-A2

Gene

HOXA2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi140 – 19960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: Ensembl
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. brain segmentation Source: Ensembl
  3. cell fate determination Source: Ensembl
  4. dorsal/ventral pattern formation Source: Ensembl
  5. embryonic viscerocranium morphogenesis Source: Ensembl
  6. middle ear morphogenesis Source: Ensembl
  7. motor neuron axon guidance Source: Ensembl
  8. negative regulation of neuron differentiation Source: Ensembl
  9. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  10. osteoblast development Source: Ensembl
  11. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  12. rhombomere 2 development Source: Ensembl
  13. rhombomere 3 morphogenesis Source: Ensembl
  14. segment specification Source: Ensembl
  15. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A2
Gene namesi
Name:HOXA2
Synonyms:HOXA-2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Homeobox protein Hox-A2PRO_0000200039Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ08727.
SMRiQ08727. Positions 140-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi94 – 996Antp-type hexapeptide

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00760000118940.
HOVERGENiHBG006088.
InParanoidiQ08727.
KOiK09302.
PhylomeDBiQ08727.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08727-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFEFEREIG FINSQPSLAE CLTSFPPVGD TFQSSSIKNS TLSHSTLIPP
60 70 80 90 100
PFEQTIPSLN PGGHPRHSGG GRPKASPRAR SGSPGPAGAP PPPEYPWMKE
110 120 130 140 150
KKASKRSSLP PASASASAAG PACLSHKDPL EIPDSGSGGS RRLRTAYTNT
160 170 180 190 200
QLLELEKEFH FNKYLCRPRR VEIAALLDLT ERQVKVWFQN RRMKHKRQTQ
210 220 230 240 250
CKENQNGEGK FKGSEDPEKA AEDDEEEKAL FEQALGTVSG ALLEREGYAF
260 270 280 290 300
QQNALSQQQA QNAHNGESQS FPVSPLTSNE KNLKHFQHQS PTVQNCLSTM
310 320 330 340 350
AQNCAAGLNN DSPEALEVPS LQDFNVFSTD SCLQLSDAVS PSLPGSLDSP
360 370
VDISADSFDF FTDTLTTIDL QHLNY
Length:375
Mass (Da):40,998
Last modified:October 1, 1994 - v1
Checksum:iC7C4CA10455C3B11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74323 mRNA. Translation: CAA52370.1.
PIRiI50589.
S35941.
RefSeqiNP_990481.1. NM_205150.2.
UniGeneiGga.524.

Genome annotation databases

EnsembliENSGALT00000018004; ENSGALP00000017982; ENSGALG00000011053.
ENSGALT00000043590; ENSGALP00000043247; ENSGALG00000011053.
GeneIDi396055.
KEGGigga:396055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74323 mRNA. Translation: CAA52370.1 .
PIRi I50589.
S35941.
RefSeqi NP_990481.1. NM_205150.2.
UniGenei Gga.524.

3D structure databases

ProteinModelPortali Q08727.
SMRi Q08727. Positions 140-198.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000018004 ; ENSGALP00000017982 ; ENSGALG00000011053 .
ENSGALT00000043590 ; ENSGALP00000043247 ; ENSGALG00000011053 .
GeneIDi 396055.
KEGGi gga:396055.

Organism-specific databases

CTDi 3199.

Phylogenomic databases

GeneTreei ENSGT00760000118940.
HOVERGENi HBG006088.
InParanoidi Q08727.
KOi K09302.
PhylomeDBi Q08727.

Miscellaneous databases

NextBioi 20816115.
PROi Q08727.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Hoxa-2 expression in normal and transposed rhombomeres: independent regulation in the neural tube and neural crest."
    Prince V.E., Lumsden A.
    Development 120:911-923(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHXA2_CHICK
AccessioniPrimary (citable) accession number: Q08727
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 26, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3