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Q08727 (HXA2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-A2
Gene names
Name:HOXA2
Synonyms:HOXA-2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family. Proboscipedia subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanterior/posterior pattern specification

Inferred from electronic annotation. Source: Ensembl

brain segmentation

Inferred from electronic annotation. Source: Ensembl

cell fate determination

Inferred from electronic annotation. Source: Ensembl

dorsal/ventral pattern formation

Inferred from electronic annotation. Source: Ensembl

embryonic viscerocranium morphogenesis

Inferred from electronic annotation. Source: Ensembl

middle ear morphogenesis

Inferred from electronic annotation. Source: Ensembl

motor neuron axon guidance

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

osteoblast development

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

rhombomere 2 development

Inferred from electronic annotation. Source: Ensembl

rhombomere 3 morphogenesis

Inferred from electronic annotation. Source: Ensembl

segment specification

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Homeobox protein Hox-A2
PRO_0000200039

Regions

DNA binding140 – 19960Homeobox
Motif94 – 996Antp-type hexapeptide

Sequences

Sequence LengthMass (Da)Tools
Q08727 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: C7C4CA10455C3B11

FASTA37540,998
        10         20         30         40         50         60 
MNFEFEREIG FINSQPSLAE CLTSFPPVGD TFQSSSIKNS TLSHSTLIPP PFEQTIPSLN 

        70         80         90        100        110        120 
PGGHPRHSGG GRPKASPRAR SGSPGPAGAP PPPEYPWMKE KKASKRSSLP PASASASAAG 

       130        140        150        160        170        180 
PACLSHKDPL EIPDSGSGGS RRLRTAYTNT QLLELEKEFH FNKYLCRPRR VEIAALLDLT 

       190        200        210        220        230        240 
ERQVKVWFQN RRMKHKRQTQ CKENQNGEGK FKGSEDPEKA AEDDEEEKAL FEQALGTVSG 

       250        260        270        280        290        300 
ALLEREGYAF QQNALSQQQA QNAHNGESQS FPVSPLTSNE KNLKHFQHQS PTVQNCLSTM 

       310        320        330        340        350        360 
AQNCAAGLNN DSPEALEVPS LQDFNVFSTD SCLQLSDAVS PSLPGSLDSP VDISADSFDF 

       370 
FTDTLTTIDL QHLNY 

« Hide

References

[1]"Hoxa-2 expression in normal and transposed rhombomeres: independent regulation in the neural tube and neural crest."
Prince V.E., Lumsden A.
Development 120:911-923(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X74323 mRNA. Translation: CAA52370.1.
PIRI50589.
S35941.
RefSeqNP_990481.1. NM_205150.2.
UniGeneGga.524.

3D structure databases

ProteinModelPortalQ08727.
SMRQ08727. Positions 140-198.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000018004; ENSGALP00000017982; ENSGALG00000011053.
ENSGALT00000043590; ENSGALP00000043247; ENSGALG00000011053.
GeneID396055.
KEGGgga:396055.

Organism-specific databases

CTD3199.

Phylogenomic databases

GeneTreeENSGT00750000117389.
HOVERGENHBG006088.
KOK09302.
PhylomeDBQ08727.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816115.
PROQ08727.

Entry information

Entry nameHXA2_CHICK
AccessionPrimary (citable) accession number: Q08727
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries