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Q08727

- HXA2_CHICK

UniProt

Q08727 - HXA2_CHICK

Protein

Homeobox protein Hox-A2

Gene

HOXA2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi140 – 19960HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: Ensembl
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. brain segmentation Source: Ensembl
    3. cell fate determination Source: Ensembl
    4. dorsal/ventral pattern formation Source: Ensembl
    5. embryonic viscerocranium morphogenesis Source: Ensembl
    6. middle ear morphogenesis Source: Ensembl
    7. motor neuron axon guidance Source: Ensembl
    8. negative regulation of neuron differentiation Source: Ensembl
    9. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    10. osteoblast development Source: Ensembl
    11. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    12. rhombomere 2 development Source: Ensembl
    13. rhombomere 3 morphogenesis Source: Ensembl
    14. segment specification Source: Ensembl
    15. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A2
    Gene namesi
    Name:HOXA2
    Synonyms:HOXA-2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 2

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Homeobox protein Hox-A2PRO_0000200039Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ08727.
    SMRiQ08727. Positions 140-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi94 – 996Antp-type hexapeptide

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    GeneTreeiENSGT00750000117389.
    HOVERGENiHBG006088.
    KOiK09302.
    PhylomeDBiQ08727.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q08727-1 [UniParc]FASTAAdd to Basket

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    MNFEFEREIG FINSQPSLAE CLTSFPPVGD TFQSSSIKNS TLSHSTLIPP    50
    PFEQTIPSLN PGGHPRHSGG GRPKASPRAR SGSPGPAGAP PPPEYPWMKE 100
    KKASKRSSLP PASASASAAG PACLSHKDPL EIPDSGSGGS RRLRTAYTNT 150
    QLLELEKEFH FNKYLCRPRR VEIAALLDLT ERQVKVWFQN RRMKHKRQTQ 200
    CKENQNGEGK FKGSEDPEKA AEDDEEEKAL FEQALGTVSG ALLEREGYAF 250
    QQNALSQQQA QNAHNGESQS FPVSPLTSNE KNLKHFQHQS PTVQNCLSTM 300
    AQNCAAGLNN DSPEALEVPS LQDFNVFSTD SCLQLSDAVS PSLPGSLDSP 350
    VDISADSFDF FTDTLTTIDL QHLNY 375
    Length:375
    Mass (Da):40,998
    Last modified:October 1, 1994 - v1
    Checksum:iC7C4CA10455C3B11
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74323 mRNA. Translation: CAA52370.1.
    PIRiI50589.
    S35941.
    RefSeqiNP_990481.1. NM_205150.2.
    UniGeneiGga.524.

    Genome annotation databases

    EnsembliENSGALT00000018004; ENSGALP00000017982; ENSGALG00000011053.
    ENSGALT00000043590; ENSGALP00000043247; ENSGALG00000011053.
    GeneIDi396055.
    KEGGigga:396055.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74323 mRNA. Translation: CAA52370.1 .
    PIRi I50589.
    S35941.
    RefSeqi NP_990481.1. NM_205150.2.
    UniGenei Gga.524.

    3D structure databases

    ProteinModelPortali Q08727.
    SMRi Q08727. Positions 140-198.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000018004 ; ENSGALP00000017982 ; ENSGALG00000011053 .
    ENSGALT00000043590 ; ENSGALP00000043247 ; ENSGALG00000011053 .
    GeneIDi 396055.
    KEGGi gga:396055.

    Organism-specific databases

    CTDi 3199.

    Phylogenomic databases

    GeneTreei ENSGT00750000117389.
    HOVERGENi HBG006088.
    KOi K09302.
    PhylomeDBi Q08727.

    Miscellaneous databases

    NextBioi 20816115.
    PROi Q08727.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hoxa-2 expression in normal and transposed rhombomeres: independent regulation in the neural tube and neural crest."
      Prince V.E., Lumsden A.
      Development 120:911-923(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiHXA2_CHICK
    AccessioniPrimary (citable) accession number: Q08727
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3