Q08727 (HXA2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A2

Gene names

Name:	HOXA2
Synonyms:	HOXA-2

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Proboscipedia subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	Homeobox protein Hox-A2		PRO_0000200039
Regions
	DNA binding	140 – 199	60	Homeobox
	Motif	94 – 99	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	Q08727 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: C7C4CA10455C3B11	FASTA	375	40,998
	10 20 30 40 50 60 MNFEFEREIG FINSQPSLAE CLTSFPPVGD TFQSSSIKNS TLSHSTLIPP PFEQTIPSLN 70 80 90 100 110 120 PGGHPRHSGG GRPKASPRAR SGSPGPAGAP PPPEYPWMKE KKASKRSSLP PASASASAAG 130 140 150 160 170 180 PACLSHKDPL EIPDSGSGGS RRLRTAYTNT QLLELEKEFH FNKYLCRPRR VEIAALLDLT 190 200 210 220 230 240 ERQVKVWFQN RRMKHKRQTQ CKENQNGEGK FKGSEDPEKA AEDDEEEKAL FEQALGTVSG 250 260 270 280 290 300 ALLEREGYAF QQNALSQQQA QNAHNGESQS FPVSPLTSNE KNLKHFQHQS PTVQNCLSTM 310 320 330 340 350 360 AQNCAAGLNN DSPEALEVPS LQDFNVFSTD SCLQLSDAVS PSLPGSLDSP VDISADSFDF 370 FTDTLTTIDL QHLNY

References

[1]	"Hoxa-2 expression in normal and transposed rhombomeres: independent regulation in the neural tube and neural crest." Prince V.E., Lumsden A. Development 120:911-923(1994) [PubMed: 7600967] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X74323 mRNA. Translation: CAA52370.1.
IPI	IPI00584066.
PIR	I50589. S35941.
RefSeq	NP_990481.1. NM_205150.1.
UniGene	Gga.621.
3D structure databases
ProteinModelPortal	Q08727.
SMR	Q08727. Positions 140-198.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	396055.
KEGG	gga:396055.
Organism-specific databases
CTD	3199.
Phylogenomic databases
HOVERGEN	HBG006088.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KO	K09302.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA2_CHICK

Accession

Primary (citable) accession number: Q08727

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	December 14, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program