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Reviewed, UniProtKB/Swiss-Prot Q08727 (HXA2_CHICK)

Last modified November 24, 2009. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Homeobox protein Hox-A2
Gene names
Name: HOXA2
Synonyms: HOXA-2
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

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Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family. Proboscipedia subfamily.

Contains 1 homeobox DNA-binding domain.

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Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
Gene Ontology (GO)
   Biological processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: InterPro

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Homeobox protein Hox-A2
PRO_0000200039

Regions

DNA binding140 – 19960Homeobox
Motif94 – 996Antp-type hexapeptide

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Sequences

Sequence LengthMass (Da)Tools
Q08727-1 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: C7C4CA10455C3B11

FASTA37540,998
        10         20         30         40         50         60 
MNFEFEREIG FINSQPSLAE CLTSFPPVGD TFQSSSIKNS TLSHSTLIPP PFEQTIPSLN 

        70         80         90        100        110        120 
PGGHPRHSGG GRPKASPRAR SGSPGPAGAP PPPEYPWMKE KKASKRSSLP PASASASAAG 

       130        140        150        160        170        180 
PACLSHKDPL EIPDSGSGGS RRLRTAYTNT QLLELEKEFH FNKYLCRPRR VEIAALLDLT 

       190        200        210        220        230        240 
ERQVKVWFQN RRMKHKRQTQ CKENQNGEGK FKGSEDPEKA AEDDEEEKAL FEQALGTVSG 

       250        260        270        280        290        300 
ALLEREGYAF QQNALSQQQA QNAHNGESQS FPVSPLTSNE KNLKHFQHQS PTVQNCLSTM 

       310        320        330        340        350        360 
AQNCAAGLNN DSPEALEVPS LQDFNVFSTD SCLQLSDAVS PSLPGSLDSP VDISADSFDF 

       370 
FTDTLTTIDL QHLNY

« Hide

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References

[1]"Hoxa-2 expression in normal and transposed rhombomeres: independent regulation in the neural tube and neural crest."
Prince V.E., Lumsden A.
Development 120:911-923(1994) [PubMed: 7600967] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

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Cross-references

Sequence databases

X74323 mRNA. Translation: CAA52370.1.
IPIIPI00584066.
PIRI50589.
S35941.
RefSeqNP_990481.1.
UniGeneGga.621

3D structure databases

SMRQ08727. Positions 142-198.
ModBaseSearch...

Genome annotation databases

GeneID396055.
KEGGgga:396055.

Organism-specific databases

CTD396055.

Phylogenomic databases

HOVERGENQ08727.

Family and domain databases

InterProIPR001356. Homeobox.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR020479. Homeobox_region.
IPR009057. Homeodomain-like.
IPR012287. Homeodomain-rel.
[Graphical view]
Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameHXA2_CHICK
AccessionPrimary (citable) accession number: Q08727
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 24, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents