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Q08722

- CD47_HUMAN

UniProt

Q08722 - CD47_HUMAN

Protein

Leukocyte surface antigen CD47

Gene

CD47

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus By similarity. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.By similarity3 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. thrombospondin receptor activity Source: BHF-UCL

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. cell adhesion Source: UniProtKB-KW
    3. extracellular matrix organization Source: Reactome
    4. integrin-mediated signaling pathway Source: ProtInc
    5. leukocyte migration Source: Reactome
    6. opsonization Source: Ensembl
    7. positive regulation of cell-cell adhesion Source: UniProtKB
    8. positive regulation of cell proliferation Source: UniProtKB
    9. positive regulation of inflammatory response Source: Ensembl
    10. positive regulation of phagocytosis Source: Ensembl
    11. positive regulation of T cell activation Source: UniProtKB
    12. response to bacterium Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_12051. Cell surface interactions at the vascular wall.
    REACT_13552. Integrin cell surface interactions.
    REACT_23916. Signal regulatory protein (SIRP) family interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leukocyte surface antigen CD47
    Alternative name(s):
    Antigenic surface determinant protein OA3
    Integrin-associated protein
    Short name:
    IAP
    Protein MER6
    CD_antigen: CD47
    Gene namesi
    Name:CD47
    Synonyms:MER6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:1682. CD47.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26222.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 323305Leukocyte surface antigen CD47PRO_0000014880Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei19 – 191Pyrrolidone carboxylic acid1 Publication
    Glycosylationi23 – 231N-linked (GlcNAc...)1 Publication
    Disulfide bondi33 ↔ 263
    Glycosylationi34 – 341N-linked (GlcNAc...)
    Disulfide bondi41 ↔ 114
    Glycosylationi50 – 501N-linked (GlcNAc...)2 Publications
    Glycosylationi73 – 731N-linked (GlcNAc...)3 Publications
    Glycosylationi111 – 1111N-linked (GlcNAc...)2 Publications
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    MaxQBiQ08722.
    PaxDbiQ08722.
    PRIDEiQ08722.

    PTM databases

    PhosphoSiteiQ08722.

    Expressioni

    Tissue specificityi

    Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.

    Gene expression databases

    BgeeiQ08722.
    CleanExiHS_CD47.
    GenevestigatoriQ08722.

    Organism-specific databases

    HPAiCAB016055.
    HPA044659.

    Interactioni

    Subunit structurei

    Interacts with THBS1 and fibrinogen By similarity. Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SIRPGQ9P1W82EBI-1268321,EBI-1268284

    Protein-protein interaction databases

    BioGridi107399. 5 interactions.
    IntActiQ08722. 2 interactions.
    STRINGi9606.ENSP00000355361.

    Structurei

    Secondary structure

    1
    323
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi26 – 305
    Beta strandi35 – 395
    Beta strandi42 – 454
    Helixi51 – 533
    Beta strandi54 – 607
    Beta strandi63 – 697
    Helixi70 – 723
    Beta strandi74 – 763
    Helixi79 – 813
    Helixi88 – 936
    Beta strandi98 – 1014
    Helixi102 – 1065
    Beta strandi110 – 1189
    Beta strandi121 – 13111

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2JJSX-ray1.85C/D20-136[»]
    2JJTX-ray2.30C/D20-136[»]
    2VSCX-ray1.90A/B/C/D20-136[»]
    4CMMX-ray1.92B20-136[»]
    4KJYX-ray1.93A/C19-135[»]
    ProteinModelPortaliQ08722.
    SMRiQ08722. Positions 19-134.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ08722.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 141123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini163 – 17614CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini198 – 20710ExtracellularSequence Analysis
    Topological domaini229 – 2357CytoplasmicSequence Analysis
    Topological domaini257 – 26812ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini290 – 32334CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei177 – 19721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei208 – 22821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei269 – 28921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 127109Ig-like V-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42016.
    HOGENOMiHOG000013020.
    HOVERGENiHBG003808.
    KOiK06266.
    OMAiVYMKFVA.
    OrthoDBiEOG79GT78.
    PhylomeDBiQ08722.
    TreeFamiTF336026.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR006704. CD47.
    IPR013147. CD47_TM.
    IPR013270. CD47_Vset.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PANTHERiPTHR10613. PTHR10613. 1 hit.
    PfamiPF04549. CD47. 1 hit.
    PF08204. V-set_CD47. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform OA3-323 (identifier: Q08722-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN    50
    TTEVYVKWKF KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM 100
    DKSDAVSHTG NYTCEVTELT REGETIIELK YRVVSWFSPN ENILIVIFPI 150
    FAILLFWGQF GIKTLKYRSG GMDEKTIALL VAGLVITVIV IVGAILFVPG 200
    EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA ILVIQVIAYI 250
    LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVASNQKTIQ 300
    PPRKAVEEPL NAFKESKGMM NDE 323
    Length:323
    Mass (Da):35,214
    Last modified:November 1, 1995 - v1
    Checksum:i5D20730A2632D550
    GO
    Isoform OA3-293 (identifier: Q08722-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         293-323: Missing.

    Show »
    Length:292
    Mass (Da):31,743
    Checksum:i81A2F6696D11F4E1
    GO
    Isoform OA3-305 (identifier: Q08722-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         304-305: KA → NN
         306-323: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:305
    Mass (Da):33,192
    Checksum:i145DD178068F8DBD
    GO
    Isoform OA3-312 (identifier: Q08722-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         312-323: Missing.

    Show »
    Length:311
    Mass (Da):33,845
    Checksum:i8BBBB21A590D4DCA
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei293 – 32331Missing in isoform OA3-293. CuratedVSP_002535Add
    BLAST
    Alternative sequencei304 – 3052KA → NN in isoform OA3-305. 3 PublicationsVSP_002536
    Alternative sequencei306 – 32318Missing in isoform OA3-305. 3 PublicationsVSP_002537Add
    BLAST
    Alternative sequencei312 – 32312Missing in isoform OA3-312. CuratedVSP_002538Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69398 mRNA. Translation: CAA49196.1.
    Z25521 mRNA. Translation: CAA80977.1.
    BT006907 mRNA. Translation: AAP35553.1.
    AK289813 mRNA. Translation: BAF82502.1.
    CH471052 Genomic DNA. Translation: EAW79733.1.
    CH471052 Genomic DNA. Translation: EAW79734.1.
    BC010016 mRNA. Translation: AAH10016.1.
    BC012884 mRNA. Translation: AAH12884.1.
    BC037306 mRNA. Translation: AAH37306.1.
    CCDSiCCDS43125.1. [Q08722-3]
    CCDS43126.1. [Q08722-1]
    PIRiA48997.
    RefSeqiNP_001768.1. NM_001777.3. [Q08722-1]
    NP_942088.1. NM_198793.2. [Q08722-3]
    UniGeneiHs.446414.

    Genome annotation databases

    EnsembliENST00000355354; ENSP00000347512; ENSG00000196776. [Q08722-3]
    ENST00000361309; ENSP00000355361; ENSG00000196776. [Q08722-1]
    GeneIDi961.
    KEGGihsa:961.
    UCSCiuc003dwt.1. human. [Q08722-1]
    uc003dwv.1. human. [Q08722-3]

    Polymorphism databases

    DMDMi1171879.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69398 mRNA. Translation: CAA49196.1 .
    Z25521 mRNA. Translation: CAA80977.1 .
    BT006907 mRNA. Translation: AAP35553.1 .
    AK289813 mRNA. Translation: BAF82502.1 .
    CH471052 Genomic DNA. Translation: EAW79733.1 .
    CH471052 Genomic DNA. Translation: EAW79734.1 .
    BC010016 mRNA. Translation: AAH10016.1 .
    BC012884 mRNA. Translation: AAH12884.1 .
    BC037306 mRNA. Translation: AAH37306.1 .
    CCDSi CCDS43125.1. [Q08722-3 ]
    CCDS43126.1. [Q08722-1 ]
    PIRi A48997.
    RefSeqi NP_001768.1. NM_001777.3. [Q08722-1 ]
    NP_942088.1. NM_198793.2. [Q08722-3 ]
    UniGenei Hs.446414.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2JJS X-ray 1.85 C/D 20-136 [» ]
    2JJT X-ray 2.30 C/D 20-136 [» ]
    2VSC X-ray 1.90 A/B/C/D 20-136 [» ]
    4CMM X-ray 1.92 B 20-136 [» ]
    4KJY X-ray 1.93 A/C 19-135 [» ]
    ProteinModelPortali Q08722.
    SMRi Q08722. Positions 19-134.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107399. 5 interactions.
    IntActi Q08722. 2 interactions.
    STRINGi 9606.ENSP00000355361.

    PTM databases

    PhosphoSitei Q08722.

    Polymorphism databases

    DMDMi 1171879.

    Proteomic databases

    MaxQBi Q08722.
    PaxDbi Q08722.
    PRIDEi Q08722.

    Protocols and materials databases

    DNASUi 961.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355354 ; ENSP00000347512 ; ENSG00000196776 . [Q08722-3 ]
    ENST00000361309 ; ENSP00000355361 ; ENSG00000196776 . [Q08722-1 ]
    GeneIDi 961.
    KEGGi hsa:961.
    UCSCi uc003dwt.1. human. [Q08722-1 ]
    uc003dwv.1. human. [Q08722-3 ]

    Organism-specific databases

    CTDi 961.
    GeneCardsi GC03M107761.
    HGNCi HGNC:1682. CD47.
    HPAi CAB016055.
    HPA044659.
    MIMi 601028. gene.
    neXtProti NX_Q08722.
    PharmGKBi PA26222.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42016.
    HOGENOMi HOG000013020.
    HOVERGENi HBG003808.
    KOi K06266.
    OMAi VYMKFVA.
    OrthoDBi EOG79GT78.
    PhylomeDBi Q08722.
    TreeFami TF336026.

    Enzyme and pathway databases

    Reactomei REACT_12051. Cell surface interactions at the vascular wall.
    REACT_13552. Integrin cell surface interactions.
    REACT_23916. Signal regulatory protein (SIRP) family interactions.

    Miscellaneous databases

    ChiTaRSi CD47. human.
    EvolutionaryTracei Q08722.
    GeneWikii CD47.
    GenomeRNAii 961.
    NextBioi 4012.
    PROi Q08722.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q08722.
    CleanExi HS_CD47.
    Genevestigatori Q08722.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR006704. CD47.
    IPR013147. CD47_TM.
    IPR013270. CD47_Vset.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    PANTHERi PTHR10613. PTHR10613. 1 hit.
    Pfami PF04549. CD47. 1 hit.
    PF08204. V-set_CD47. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains."
      Campbell I.G., Freemont P.S., Foulkes W., Trowsdale J.
      Cancer Res. 52:5416-5420(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM OA3-323).
      Tissue: Ovary.
    2. "Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane spanning domains implicated in alpha-v beta-3-dependent ligand binding."
      Lindberg F.P., Gresham H.D., Schwarz E., Brown E.J.
      J. Cell Biol. 123:485-496(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM OA3-305), FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.
      Tissue: Myelomonocyte.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM OA3-305).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM OA3-323).
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM OA3-305).
      Tissue: Hippocampus, Leiomyosarcoma and Ovarian adenocarcinoma.
    7. "Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3."
      Mawby W.J., Holmes C.H., Anstee D.J., Spring F.A., Tanner M.J.A.
      Biochem. J. 304:525-530(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, IDENTIFICATION AS CD47.
      Tissue: Erythrocyte.
    8. "Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane."
      Wu A.-L., Wang J., Zheleznyak A., Brown E.J.
      Mol. Cell 4:619-625(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UBQLN1 AND UBQLN2.
    9. "Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains."
      Rebres R.A., Vaz L.E., Green J.M., Brown E.J.
      J. Biol. Chem. 276:34607-34616(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BOND.
    10. "Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation."
      Latour S., Tanaka H., Demeure C., Mateo V., Rubio M., Brown E.J., Maliszewski C., Lindberg F.P., Oldenborg A., Ullrich A., Delespesse G., Sarfati M.
      J. Immunol. 167:2547-2554(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SIRPA.
    11. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
    12. "Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation."
      Piccio L., Vermi W., Boles K.S., Fuchs A., Strader C.A., Facchetti F., Cella M., Colonna M.
      Blood 105:2421-2427(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SIRPG.
      Tissue: T-cell.
    13. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-73 AND ASN-111.
      Tissue: Liver.
    14. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-50 AND ASN-73.
      Tissue: Leukemic T-cell.
    15. "Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47."
      Hatherley D., Graham S.C., Turner J., Harlos K., Stuart D.I., Barclay A.N.
      Mol. Cell 31:266-277(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 19-136 IN COMPLEX WITH SIRPA, DISULFIDE BOND, GLYCOSYLATION AT ASN-23; ASN-50; ASN-73 AND ASN-111, PYROGLUTAMATE FORMATION AT GLN-19.

    Entry informationi

    Entry nameiCD47_HUMAN
    AccessioniPrimary (citable) accession number: Q08722
    Secondary accession number(s): A8K198
    , D3DN59, Q53Y71, Q96A60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 139 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3