Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q08722

- CD47_HUMAN

UniProt

Q08722 - CD47_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leukocyte surface antigen CD47

Gene

CD47

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.By similarity3 Publications

GO - Molecular functioni

  1. thrombospondin receptor activity Source: BHF-UCL

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. cell adhesion Source: UniProtKB-KW
  3. extracellular matrix organization Source: Reactome
  4. integrin-mediated signaling pathway Source: ProtInc
  5. leukocyte migration Source: Reactome
  6. opsonization Source: Ensembl
  7. positive regulation of cell-cell adhesion Source: UniProtKB
  8. positive regulation of cell proliferation Source: UniProtKB
  9. positive regulation of inflammatory response Source: Ensembl
  10. positive regulation of phagocytosis Source: Ensembl
  11. positive regulation of T cell activation Source: UniProtKB
  12. response to bacterium Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_12051. Cell surface interactions at the vascular wall.
REACT_13552. Integrin cell surface interactions.
REACT_23916. Signal regulatory protein (SIRP) family interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte surface antigen CD47
Alternative name(s):
Antigenic surface determinant protein OA3
Integrin-associated protein
Short name:
IAP
Protein MER6
CD_antigen: CD47
Gene namesi
Name:CD47
Synonyms:MER6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:1682. CD47.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26222.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 323305Leukocyte surface antigen CD47PRO_0000014880Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Pyrrolidone carboxylic acid1 Publication
Glycosylationi23 – 231N-linked (GlcNAc...)1 Publication
Disulfide bondi33 ↔ 263
Glycosylationi34 – 341N-linked (GlcNAc...)
Disulfide bondi41 ↔ 114
Glycosylationi50 – 501N-linked (GlcNAc...)2 Publications
Glycosylationi73 – 731N-linked (GlcNAc...)3 Publications
Glycosylationi111 – 1111N-linked (GlcNAc...)2 Publications
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiQ08722.
PaxDbiQ08722.
PRIDEiQ08722.

PTM databases

PhosphoSiteiQ08722.

Expressioni

Tissue specificityi

Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.

Gene expression databases

BgeeiQ08722.
CleanExiHS_CD47.
GenevestigatoriQ08722.

Organism-specific databases

HPAiCAB016055.
HPA044659.

Interactioni

Subunit structurei

Interacts with THBS1 and fibrinogen (By similarity). Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SIRPGQ9P1W82EBI-1268321,EBI-1268284

Protein-protein interaction databases

BioGridi107399. 12 interactions.
IntActiQ08722. 2 interactions.
STRINGi9606.ENSP00000355361.

Structurei

Secondary structure

1
323
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 305
Beta strandi35 – 395
Beta strandi42 – 454
Helixi51 – 533
Beta strandi54 – 607
Beta strandi63 – 697
Helixi70 – 723
Beta strandi74 – 763
Helixi79 – 813
Helixi88 – 936
Beta strandi98 – 1014
Helixi102 – 1065
Beta strandi110 – 1189
Beta strandi121 – 13111

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JJSX-ray1.85C/D20-136[»]
2JJTX-ray2.30C/D20-136[»]
2VSCX-ray1.90A/B/C/D20-136[»]
4CMMX-ray1.92B20-136[»]
4KJYX-ray1.93A/C19-135[»]
ProteinModelPortaliQ08722.
SMRiQ08722. Positions 19-134.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08722.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 141123ExtracellularSequence AnalysisAdd
BLAST
Topological domaini163 – 17614CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini198 – 20710ExtracellularSequence Analysis
Topological domaini229 – 2357CytoplasmicSequence Analysis
Topological domaini257 – 26812ExtracellularSequence AnalysisAdd
BLAST
Topological domaini290 – 32334CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST
Transmembranei177 – 19721HelicalSequence AnalysisAdd
BLAST
Transmembranei208 – 22821HelicalSequence AnalysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence AnalysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 127109Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42016.
GeneTreeiENSGT00390000007697.
HOGENOMiHOG000013020.
HOVERGENiHBG003808.
InParanoidiQ08722.
KOiK06266.
OMAiVYMKFVA.
OrthoDBiEOG79GT78.
PhylomeDBiQ08722.
TreeFamiTF336026.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR006704. CD47.
IPR013147. CD47_TM.
IPR013270. CD47_Vset.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PANTHERiPTHR10613. PTHR10613. 1 hit.
PfamiPF04549. CD47. 1 hit.
PF08204. V-set_CD47. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform OA3-323 (identifier: Q08722-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN
60 70 80 90 100
TTEVYVKWKF KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM
110 120 130 140 150
DKSDAVSHTG NYTCEVTELT REGETIIELK YRVVSWFSPN ENILIVIFPI
160 170 180 190 200
FAILLFWGQF GIKTLKYRSG GMDEKTIALL VAGLVITVIV IVGAILFVPG
210 220 230 240 250
EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA ILVIQVIAYI
260 270 280 290 300
LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVASNQKTIQ
310 320
PPRKAVEEPL NAFKESKGMM NDE
Length:323
Mass (Da):35,214
Last modified:November 1, 1995 - v1
Checksum:i5D20730A2632D550
GO
Isoform OA3-293 (identifier: Q08722-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     293-323: Missing.

Show »
Length:292
Mass (Da):31,743
Checksum:i81A2F6696D11F4E1
GO
Isoform OA3-305 (identifier: Q08722-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-305: KA → NN
     306-323: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:305
Mass (Da):33,192
Checksum:i145DD178068F8DBD
GO
Isoform OA3-312 (identifier: Q08722-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-323: Missing.

Show »
Length:311
Mass (Da):33,845
Checksum:i8BBBB21A590D4DCA
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei293 – 32331Missing in isoform OA3-293. CuratedVSP_002535Add
BLAST
Alternative sequencei304 – 3052KA → NN in isoform OA3-305. 3 PublicationsVSP_002536
Alternative sequencei306 – 32318Missing in isoform OA3-305. 3 PublicationsVSP_002537Add
BLAST
Alternative sequencei312 – 32312Missing in isoform OA3-312. CuratedVSP_002538Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69398 mRNA. Translation: CAA49196.1.
Z25521 mRNA. Translation: CAA80977.1.
BT006907 mRNA. Translation: AAP35553.1.
AK289813 mRNA. Translation: BAF82502.1.
CH471052 Genomic DNA. Translation: EAW79733.1.
CH471052 Genomic DNA. Translation: EAW79734.1.
BC010016 mRNA. Translation: AAH10016.1.
BC012884 mRNA. Translation: AAH12884.1.
BC037306 mRNA. Translation: AAH37306.1.
CCDSiCCDS43125.1. [Q08722-3]
CCDS43126.1. [Q08722-1]
PIRiA48997.
RefSeqiNP_001768.1. NM_001777.3. [Q08722-1]
NP_942088.1. NM_198793.2. [Q08722-3]
UniGeneiHs.446414.

Genome annotation databases

EnsembliENST00000355354; ENSP00000347512; ENSG00000196776. [Q08722-3]
ENST00000361309; ENSP00000355361; ENSG00000196776. [Q08722-1]
GeneIDi961.
KEGGihsa:961.
UCSCiuc003dwt.1. human. [Q08722-1]
uc003dwv.1. human. [Q08722-3]

Polymorphism databases

DMDMi1171879.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69398 mRNA. Translation: CAA49196.1 .
Z25521 mRNA. Translation: CAA80977.1 .
BT006907 mRNA. Translation: AAP35553.1 .
AK289813 mRNA. Translation: BAF82502.1 .
CH471052 Genomic DNA. Translation: EAW79733.1 .
CH471052 Genomic DNA. Translation: EAW79734.1 .
BC010016 mRNA. Translation: AAH10016.1 .
BC012884 mRNA. Translation: AAH12884.1 .
BC037306 mRNA. Translation: AAH37306.1 .
CCDSi CCDS43125.1. [Q08722-3 ]
CCDS43126.1. [Q08722-1 ]
PIRi A48997.
RefSeqi NP_001768.1. NM_001777.3. [Q08722-1 ]
NP_942088.1. NM_198793.2. [Q08722-3 ]
UniGenei Hs.446414.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2JJS X-ray 1.85 C/D 20-136 [» ]
2JJT X-ray 2.30 C/D 20-136 [» ]
2VSC X-ray 1.90 A/B/C/D 20-136 [» ]
4CMM X-ray 1.92 B 20-136 [» ]
4KJY X-ray 1.93 A/C 19-135 [» ]
ProteinModelPortali Q08722.
SMRi Q08722. Positions 19-134.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107399. 12 interactions.
IntActi Q08722. 2 interactions.
STRINGi 9606.ENSP00000355361.

PTM databases

PhosphoSitei Q08722.

Polymorphism databases

DMDMi 1171879.

Proteomic databases

MaxQBi Q08722.
PaxDbi Q08722.
PRIDEi Q08722.

Protocols and materials databases

DNASUi 961.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355354 ; ENSP00000347512 ; ENSG00000196776 . [Q08722-3 ]
ENST00000361309 ; ENSP00000355361 ; ENSG00000196776 . [Q08722-1 ]
GeneIDi 961.
KEGGi hsa:961.
UCSCi uc003dwt.1. human. [Q08722-1 ]
uc003dwv.1. human. [Q08722-3 ]

Organism-specific databases

CTDi 961.
GeneCardsi GC03M107761.
HGNCi HGNC:1682. CD47.
HPAi CAB016055.
HPA044659.
MIMi 601028. gene.
neXtProti NX_Q08722.
PharmGKBi PA26222.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42016.
GeneTreei ENSGT00390000007697.
HOGENOMi HOG000013020.
HOVERGENi HBG003808.
InParanoidi Q08722.
KOi K06266.
OMAi VYMKFVA.
OrthoDBi EOG79GT78.
PhylomeDBi Q08722.
TreeFami TF336026.

Enzyme and pathway databases

Reactomei REACT_12051. Cell surface interactions at the vascular wall.
REACT_13552. Integrin cell surface interactions.
REACT_23916. Signal regulatory protein (SIRP) family interactions.

Miscellaneous databases

ChiTaRSi CD47. human.
EvolutionaryTracei Q08722.
GeneWikii CD47.
GenomeRNAii 961.
NextBioi 4012.
PROi Q08722.
SOURCEi Search...

Gene expression databases

Bgeei Q08722.
CleanExi HS_CD47.
Genevestigatori Q08722.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR006704. CD47.
IPR013147. CD47_TM.
IPR013270. CD47_Vset.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view ]
PANTHERi PTHR10613. PTHR10613. 1 hit.
Pfami PF04549. CD47. 1 hit.
PF08204. V-set_CD47. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains."
    Campbell I.G., Freemont P.S., Foulkes W., Trowsdale J.
    Cancer Res. 52:5416-5420(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM OA3-323).
    Tissue: Ovary.
  2. "Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane spanning domains implicated in alpha-v beta-3-dependent ligand binding."
    Lindberg F.P., Gresham H.D., Schwarz E., Brown E.J.
    J. Cell Biol. 123:485-496(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM OA3-305), FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.
    Tissue: Myelomonocyte.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM OA3-305).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM OA3-323).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM OA3-305).
    Tissue: Hippocampus, Leiomyosarcoma and Ovarian adenocarcinoma.
  7. "Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3."
    Mawby W.J., Holmes C.H., Anstee D.J., Spring F.A., Tanner M.J.A.
    Biochem. J. 304:525-530(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, IDENTIFICATION AS CD47.
    Tissue: Erythrocyte.
  8. "Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane."
    Wu A.-L., Wang J., Zheleznyak A., Brown E.J.
    Mol. Cell 4:619-625(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UBQLN1 AND UBQLN2.
  9. "Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains."
    Rebres R.A., Vaz L.E., Green J.M., Brown E.J.
    J. Biol. Chem. 276:34607-34616(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BOND.
  10. "Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation."
    Latour S., Tanaka H., Demeure C., Mateo V., Rubio M., Brown E.J., Maliszewski C., Lindberg F.P., Oldenborg A., Ullrich A., Delespesse G., Sarfati M.
    J. Immunol. 167:2547-2554(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SIRPA.
  11. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
  12. "Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation."
    Piccio L., Vermi W., Boles K.S., Fuchs A., Strader C.A., Facchetti F., Cella M., Colonna M.
    Blood 105:2421-2427(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SIRPG.
    Tissue: T-cell.
  13. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-73 AND ASN-111.
    Tissue: Liver.
  14. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-50 AND ASN-73.
    Tissue: Leukemic T-cell.
  15. "Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47."
    Hatherley D., Graham S.C., Turner J., Harlos K., Stuart D.I., Barclay A.N.
    Mol. Cell 31:266-277(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 19-136 IN COMPLEX WITH SIRPA, DISULFIDE BOND, GLYCOSYLATION AT ASN-23; ASN-50; ASN-73 AND ASN-111, PYROGLUTAMATE FORMATION AT GLN-19.

Entry informationi

Entry nameiCD47_HUMAN
AccessioniPrimary (citable) accession number: Q08722
Secondary accession number(s): A8K198
, D3DN59, Q53Y71, Q96A60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3