Q08722 (CD47_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leukocyte surface antigen CD47

Alternative name(s):
Antigenic surface determinant protein OA3
Integrin-associated protein
Short name=IAP
Protein MER6
CD_antigen=CD47

Gene names

Name:	CD47
Synonyms:	MER6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus By similarity. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. Ref.2 Ref.10 Ref.12
Subunit structure	Interacts with THBS1 and fibrinogen By similarity. Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2. Ref.8 Ref.10 Ref.12
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.2.
Tissue specificity	Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.
Sequence similarities	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Pyrrolidone carboxylic acid
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Traceable author statement. Source: Reactome cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW integrin-mediated signaling pathway Traceable author statement PubMed 8294396. Source: ProtInc leukocyte migration Traceable author statement. Source: Reactome opsonization Inferred from electronic annotation. Source: Compara positive regulation of T cell activation Inferred from direct assay Ref.12. Source: UniProtKB positive regulation of cell proliferation Inferred from direct assay Ref.12. Source: UniProtKB positive regulation of cell-cell adhesion Inferred from direct assay Ref.12. Source: UniProtKB positive regulation of inflammatory response Inferred from electronic annotation. Source: Compara positive regulation of phagocytosis Inferred from electronic annotation. Source: Compara response to bacterium Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular vesicular exosome Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.7. Source: ProtInc
Molecular_function	thrombospondin receptor activity Inferred from physical interaction PubMed 15700281. Source: BHF-UCL
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SIRPG	Q9P1W8	2	EBI-1268321,EBI-1268284

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform OA3-323 (identifier: Q08722-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform OA3-293 (identifier: Q08722-2)

The sequence of this isoform differs from the canonical sequence as follows:
     293-323: Missing.

Isoform OA3-305 (identifier: Q08722-3)

The sequence of this isoform differs from the canonical sequence as follows:
     304-305: KA → NN
     306-323: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform OA3-312 (identifier: Q08722-4)

The sequence of this isoform differs from the canonical sequence as follows:
     312-323: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 18

18

Potential

Chain

19 – 323

305

Leukocyte surface antigen CD47

PRO_0000014880

Regions

Topological domain

19 – 141

123

Extracellular Potential

Transmembrane

142 – 162

21

Helical; Potential

Topological domain

163 – 176

14

Cytoplasmic Potential

Transmembrane

177 – 197

21

Helical; Potential

Topological domain

198 – 207

10

Extracellular Potential

Transmembrane

208 – 228

21

Helical; Potential

Topological domain

229 – 235

7

Cytoplasmic Potential

Transmembrane

236 – 256

21

Helical; Potential

Topological domain

257 – 268

12

Extracellular Potential

Transmembrane

269 – 289

21

Helical; Potential

Topological domain

290 – 323

34

Cytoplasmic Potential

Domain

19 – 127

109

Ig-like V-type

Amino acid modifications

Modified residue

19

1

Pyrrolidone carboxylic acid

Glycosylation

23

1

N-linked (GlcNAc...) Ref.15

Glycosylation

34

1

N-linked (GlcNAc...)

Glycosylation

50

1

N-linked (GlcNAc...) Ref.14 Ref.15

Glycosylation

73

1

N-linked (GlcNAc...) Ref.13 Ref.14 Ref.15

Glycosylation

111

1

N-linked (GlcNAc...) Ref.13 Ref.15

Glycosylation

206

1

N-linked (GlcNAc...) Potential

Disulfide bond

33 ↔ 263

Ref.9 Ref.15

Disulfide bond

41 ↔ 114

Ref.9 Ref.15

Natural variations

Alternative sequence

293 – 323

31

Missing in isoform OA3-293.

VSP_002535

Alternative sequence

304 – 305

2

KA → NN in isoform OA3-305.

VSP_002536

Alternative sequence

306 – 323

18

Missing in isoform OA3-305.

VSP_002537

Alternative sequence

312 – 323

12

Missing in isoform OA3-312.

VSP_002538

Secondary structure

1

.

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323

Helix Strand Turn

Details...

Beta strand

26 – 30

5

Beta strand

35 – 39

5

Beta strand

42 – 45

4

Helix

51 – 53

3

Beta strand

54 – 60

7

Beta strand

63 – 69

7

Helix

70 – 72

3

Beta strand

74 – 76

3

Helix

79 – 81

3

Helix

88 – 93

6

Beta strand

98 – 101

4

Helix

102 – 106

5

Beta strand

110 – 118

9

Beta strand

121 – 131

11

Sequences

	Sequence		Length	Mass (Da)
	Isoform OA3-323 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 5D20730A2632D550	FASTA	323	35,214
	10 20 30 40 50 60 MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN TTEVYVKWKF 70 80 90 100 110 120 KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM DKSDAVSHTG NYTCEVTELT 130 140 150 160 170 180 REGETIIELK YRVVSWFSPN ENILIVIFPI FAILLFWGQF GIKTLKYRSG GMDEKTIALL 190 200 210 220 230 240 VAGLVITVIV IVGAILFVPG EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA 250 260 270 280 290 300 ILVIQVIAYI LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVASNQKTIQ 310 320 PPRKAVEEPL NAFKESKGMM NDE
	Isoform OA3-293 [UniParc]. Checksum: 81A2F6696D11F4E1	FASTA	292	31,743
	10 20 30 40 50 60 MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN TTEVYVKWKF 70 80 90 100 110 120 KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM DKSDAVSHTG NYTCEVTELT 130 140 150 160 170 180 REGETIIELK YRVVSWFSPN ENILIVIFPI FAILLFWGQF GIKTLKYRSG GMDEKTIALL 190 200 210 220 230 240 VAGLVITVIV IVGAILFVPG EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA 250 260 270 280 290 ILVIQVIAYI LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FV
	Isoform OA3-305 [UniParc]. Checksum: 145DD178068F8DBD	FASTA	305	33,192
	10 20 30 40 50 60 MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN TTEVYVKWKF 70 80 90 100 110 120 KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM DKSDAVSHTG NYTCEVTELT 130 140 150 160 170 180 REGETIIELK YRVVSWFSPN ENILIVIFPI FAILLFWGQF GIKTLKYRSG GMDEKTIALL 190 200 210 220 230 240 VAGLVITVIV IVGAILFVPG EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA 250 260 270 280 290 300 ILVIQVIAYI LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVASNQKTIQ PPRNN
	Isoform OA3-312 [UniParc]. Checksum: 8BBBB21A590D4DCA	FASTA	311	33,845
	10 20 30 40 50 60 MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN TTEVYVKWKF 70 80 90 100 110 120 KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM DKSDAVSHTG NYTCEVTELT 130 140 150 160 170 180 REGETIIELK YRVVSWFSPN ENILIVIFPI FAILLFWGQF GIKTLKYRSG GMDEKTIALL 190 200 210 220 230 240 VAGLVITVIV IVGAILFVPG EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA 250 260 270 280 290 300 ILVIQVIAYI LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVASNQKTIQ 310 PPRKAVEEPL N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains." Campbell I.G., Freemont P.S., Foulkes W., Trowsdale J. Cancer Res. 52:5416-5420(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM OA3-323). Tissue: Ovary.
[2]	"Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane spanning domains implicated in alpha-v beta-3-dependent ligand binding." Lindberg F.P., Gresham H.D., Schwarz E., Brown E.J. J. Cell Biol. 123:485-496(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM OA3-305), FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY. Tissue: Myelomonocyte.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM OA3-305).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM OA3-323). Tissue: Brain.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM OA3-305). Tissue: Hippocampus, Leiomyosarcoma and Ovarian adenocarcinoma.
[7]	"Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3." Mawby W.J., Holmes C.H., Anstee D.J., Spring F.A., Tanner M.J.A. Biochem. J. 304:525-530(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE, IDENTIFICATION AS CD47. Tissue: Erythrocyte.
[8]	"Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane." Wu A.-L., Wang J., Zheleznyak A., Brown E.J. Mol. Cell 4:619-625(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH UBQLN1 AND UBQLN2.
[9]	"Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains." Rebres R.A., Vaz L.E., Green J.M., Brown E.J. J. Biol. Chem. 276:34607-34616(2001) [PubMed] [Europe PMC] [Abstract] Cited for: DISULFIDE BOND.
[10]	"Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation." Latour S., Tanaka H., Demeure C., Mateo V., Rubio M., Brown E.J., Maliszewski C., Lindberg F.P., Oldenborg A., Ullrich A., Delespesse G., Sarfati M. J. Immunol. 167:2547-2554(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH SIRPA.
[11]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[12]	"Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation." Piccio L., Vermi W., Boles K.S., Fuchs A., Strader C.A., Facchetti F., Cella M., Colonna M. Blood 105:2421-2427(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH SIRPG. Tissue: T-cell.
[13]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-73 AND ASN-111, MASS SPECTROMETRY. Tissue: Liver.
[14]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-50 AND ASN-73, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[15]	"Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47." Hatherley D., Graham S.C., Turner J., Harlos K., Stuart D.I., Barclay A.N. Mol. Cell 31:266-277(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 19-136 IN COMPLEX WITH SIRPA, DISULFIDE BOND, GLYCOSYLATION AT ASN-23; ASN-50; ASN-73 AND ASN-111, PYROGLUTAMATE FORMATION AT GLN-19.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X69398 mRNA. Translation: CAA49196.1.
Z25521 mRNA. Translation: CAA80977.1.
BT006907 mRNA. Translation: AAP35553.1.
AK289813 mRNA. Translation: BAF82502.1.
CH471052 Genomic DNA. Translation: EAW79733.1.
CH471052 Genomic DNA. Translation: EAW79734.1.
BC010016 mRNA. Translation: AAH10016.1.
BC012884 mRNA. Translation: AAH12884.1.
BC037306 mRNA. Translation: AAH37306.1.

IPI

IPI00216514.
IPI00216516.
IPI00374740.
IPI00872082.

PIR

A48997.

RefSeq

NP_001768.1. NM_001777.3.
NP_942088.1. NM_198793.2.

UniGene

Hs.446414.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2JJS	X-ray	1.85	C/D	20-136	[»]
2JJT	X-ray	2.30	C/D	20-136	[»]
2VSC	X-ray	1.90	A/B/C/D	20-136	[»]

ProteinModelPortal

Q08722.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q08722. 2 interactions.

STRING

9606.ENSP00000355361.

PTM databases

PhosphoSite

Q08722.

Polymorphism databases

DMDM

1171879.

Proteomic databases

PaxDb

Q08722.

PRIDE

Q08722.

Protocols and materials databases

DNASU

961.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000355354; ENSP00000347512; ENSG00000196776.
ENST00000361309; ENSP00000355361; ENSG00000196776.

GeneID

961.

KEGG

hsa:961.

UCSC

uc003dwt.1. human.
uc003dwv.1. human.

Organism-specific databases

CTD

961.

GeneCards

GC03M107761.

HGNC

HGNC:1682. CD47.

HPA

CAB016055.

MIM

601028. gene.

neXtProt

NX_Q08722.

PharmGKB

PA26222.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG42016.

HOGENOM

HOG000013020.

HOVERGEN

HBG003808.

KO

K06266.

OMA

VYMKFVA.

PhylomeDB

Q08722.

Enzyme and pathway databases

Pathway_Interaction_DB

avb3_integrin_pathway. Integrins in angiogenesis.

Reactome

REACT_111155. Cell-Cell communication.
REACT_604. Hemostasis.

Gene expression databases

Bgee

Q08722.

CleanEx

HS_CD47.

Genevestigator

Q08722.

GermOnline

ENSG00000196776. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.

InterPro

IPR006704. CD47.
IPR013147. CD47_TM.
IPR013270. CD47_Vset.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]

PANTHER

PTHR10613. PTHR10613. 1 hit.

Pfam

PF04549. CD47. 1 hit.
PF08204. V-set_CD47. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

CD47. human.

EvolutionaryTrace

Q08722.

GenomeRNAi

961.

NextBio

4012.

SOURCE

Search...

Entry information

Entry name

CD47_HUMAN

Accession

Primary (citable) accession number: Q08722
Secondary accession number(s): A8K198 , D3DN59, Q53Y71, Q96A60

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 126 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.