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Protein

Superoxide dismutase [Fe]

Gene

sod

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Fe cationNote: Binds 1 Fe cation per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi34Iron1
Metal bindingi85Iron1
Metal bindingi171Iron1
Metal bindingi175Iron1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.15.1.1. 6160.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Fe] (EC:1.15.1.1)
Gene namesi
Name:sod
Synonyms:sodF
Ordered Locus Names:Saci_0195
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001600092 – 211Superoxide dismutase [Fe]Add BLAST210

Interactioni

Subunit structurei

Homotetramer at high temperature; homodimer at room temperature.

Protein-protein interaction databases

STRINGi330779.Saci_0195.

Structurei

Secondary structure

1211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni19 – 25Combined sources7
Helixi28 – 36Combined sources9
Helixi38 – 58Combined sources21
Helixi68 – 90Combined sources23
Turni95 – 97Combined sources3
Helixi104 – 114Combined sources11
Helixi117 – 130Combined sources14
Beta strandi133 – 141Combined sources9
Turni143 – 145Combined sources3
Beta strandi148 – 154Combined sources7
Turni155 – 157Combined sources3
Beta strandi166 – 171Combined sources6
Helixi174 – 176Combined sources3
Helixi178 – 181Combined sources4
Helixi185 – 192Combined sources8
Helixi193 – 195Combined sources3
Helixi198 – 206Combined sources9
Turni207 – 210Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B06X-ray2.20A/B/C/D/E/F2-211[»]
ProteinModelPortaliQ08713.
SMRiQ08713.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08713.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG04147. Archaea.
COG0605. LUCA.
HOGENOMiHOG000013583.
KOiK04564.
OMAiEQVYDHQ.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08713-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQVIQLKRY EFPQLPYKVD ALEPYISKDI IDVHYNGHHK GYVNGANSLL
60 70 80 90 100
DRLEKLIKGD LPQGQYDLQG ILRGLTFNIN GHKLHAIYWN NMAPAGKGGG
110 120 130 140 150
KPGGALADLI NKQYGSFDRF KQVFSESANS LPGSGWTVLY YDNESGNLQI
160 170 180 190 200
MTVENHFMNH IAELPVILIV DEFEHAYYLQ YKNKRGDYLN AWWNVVNWDD
210
AEKRLQKYLN K
Length:211
Mass (Da):24,266
Last modified:January 23, 2007 - v3
Checksum:i184829345CC5D13D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63386 Genomic DNA. Translation: CAA44993.1.
CP000077 Genomic DNA. Translation: AAY79614.1.
PIRiS34616.
RefSeqiWP_011277115.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY79614; AAY79614; Saci_0195.
GeneIDi3474008.
KEGGisai:Saci_0195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63386 Genomic DNA. Translation: CAA44993.1.
CP000077 Genomic DNA. Translation: AAY79614.1.
PIRiS34616.
RefSeqiWP_011277115.1. NC_007181.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B06X-ray2.20A/B/C/D/E/F2-211[»]
ProteinModelPortaliQ08713.
SMRiQ08713.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi330779.Saci_0195.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY79614; AAY79614; Saci_0195.
GeneIDi3474008.
KEGGisai:Saci_0195.

Phylogenomic databases

eggNOGiarCOG04147. Archaea.
COG0605. LUCA.
HOGENOMiHOG000013583.
KOiK04564.
OMAiEQVYDHQ.

Enzyme and pathway databases

BRENDAi1.15.1.1. 6160.

Miscellaneous databases

EvolutionaryTraceiQ08713.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSODF_SULAC
AccessioniPrimary (citable) accession number: Q08713
Secondary accession number(s): Q4JC65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.