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Protein

Superoxide dismutase [Fe]

Gene

sod

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Fe cationNote: Binds 1 Fe cation per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi34 – 341Iron
Metal bindingi85 – 851Iron
Metal bindingi171 – 1711Iron
Metal bindingi175 – 1751Iron

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciSACI330779:GH9J-194-MONOMER.
BRENDAi1.15.1.1. 6160.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Fe] (EC:1.15.1.1)
Gene namesi
Name:sod
Synonyms:sodF
Ordered Locus Names:Saci_0195
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 211210Superoxide dismutase [Fe]PRO_0000160009Add
BLAST

Interactioni

Subunit structurei

Homotetramer at high temperature; homodimer at room temperature.

Protein-protein interaction databases

STRINGi330779.Saci_0195.

Structurei

Secondary structure

1
211
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni19 – 257Combined sources
Helixi28 – 369Combined sources
Helixi38 – 5821Combined sources
Helixi68 – 9023Combined sources
Turni95 – 973Combined sources
Helixi104 – 11411Combined sources
Helixi117 – 13014Combined sources
Beta strandi133 – 1419Combined sources
Turni143 – 1453Combined sources
Beta strandi148 – 1547Combined sources
Turni155 – 1573Combined sources
Beta strandi166 – 1716Combined sources
Helixi174 – 1763Combined sources
Helixi178 – 1814Combined sources
Helixi185 – 1928Combined sources
Helixi193 – 1953Combined sources
Helixi198 – 2069Combined sources
Turni207 – 2104Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B06X-ray2.20A/B/C/D/E/F2-211[»]
ProteinModelPortaliQ08713.
SMRiQ08713. Positions 4-211.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08713.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG04147. Archaea.
COG0605. LUCA.
HOGENOMiHOG000013583.
KOiK04564.
OMAiEQVYDHQ.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08713-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQVIQLKRY EFPQLPYKVD ALEPYISKDI IDVHYNGHHK GYVNGANSLL
60 70 80 90 100
DRLEKLIKGD LPQGQYDLQG ILRGLTFNIN GHKLHAIYWN NMAPAGKGGG
110 120 130 140 150
KPGGALADLI NKQYGSFDRF KQVFSESANS LPGSGWTVLY YDNESGNLQI
160 170 180 190 200
MTVENHFMNH IAELPVILIV DEFEHAYYLQ YKNKRGDYLN AWWNVVNWDD
210
AEKRLQKYLN K
Length:211
Mass (Da):24,266
Last modified:January 23, 2007 - v3
Checksum:i184829345CC5D13D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63386 Genomic DNA. Translation: CAA44993.1.
CP000077 Genomic DNA. Translation: AAY79614.1.
PIRiS34616.
RefSeqiWP_011277115.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY79614; AAY79614; Saci_0195.
GeneIDi3474008.
KEGGisai:Saci_0195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63386 Genomic DNA. Translation: CAA44993.1.
CP000077 Genomic DNA. Translation: AAY79614.1.
PIRiS34616.
RefSeqiWP_011277115.1. NC_007181.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B06X-ray2.20A/B/C/D/E/F2-211[»]
ProteinModelPortaliQ08713.
SMRiQ08713. Positions 4-211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi330779.Saci_0195.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY79614; AAY79614; Saci_0195.
GeneIDi3474008.
KEGGisai:Saci_0195.

Phylogenomic databases

eggNOGiarCOG04147. Archaea.
COG0605. LUCA.
HOGENOMiHOG000013583.
KOiK04564.
OMAiEQVYDHQ.

Enzyme and pathway databases

BioCyciSACI330779:GH9J-194-MONOMER.
BRENDAi1.15.1.1. 6160.

Miscellaneous databases

EvolutionaryTraceiQ08713.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence, transcription and phylogeny of the gene encoding the superoxide dismutase of Sulfolobus acidocaldarius."
    Klenk H.-P., Schleper C., Schwass V., Brudler R.
    Biochim. Biophys. Acta 1174:95-98(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.
  3. "Refined crystal structure of a superoxide dismutase from the hyperthermophilic archaeon Sulfolobus acidocaldarius at 2.2-A resolution."
    Knapp S., Kardinahl S., Hellgren N., Tibbelin G., Schaefer G., Ladenstein R.
    J. Mol. Biol. 285:689-702(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Entry informationi

Entry nameiSODF_SULAC
AccessioniPrimary (citable) accession number: Q08713
Secondary accession number(s): Q4JC65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: November 11, 2015
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.