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Protein

CMRF35-like molecule 6

Gene

CD300C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • cellular defense response Source: ProtInc
  • immune system process Source: UniProtKB-KW
  • regulation of immune response Source: Reactome

Keywordsi

Molecular functionReceptor
Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
CMRF35-like molecule 6
Short name:
CLM-6
Alternative name(s):
CD300 antigen-like family member C
CMRF35-A1
Short name:
CMRF-35
Immunoglobulin superfamily member 16
Short name:
IgSF16
CD_antigen: CD300c
Gene namesi
Name:CD300C
Synonyms:CMRF35, CMRF35A, CMRF35A1, IGSF16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000167850.3.
HGNCiHGNC:19320. CD300C.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 183ExtracellularSequence analysisAdd BLAST163
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 224CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167850.
PharmGKBiPA142672150.

Polymorphism and mutation databases

DMDMi1705938.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001468121 – 224CMRF35-like molecule 6Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 110PROSITE-ProRule annotation
Disulfide bondi57 ↔ 65PROSITE-ProRule annotation
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ08708.
PeptideAtlasiQ08708.
PRIDEiQ08708.

PTM databases

iPTMnetiQ08708.
PhosphoSitePlusiQ08708.

Expressioni

Tissue specificityi

Present on the surface of monocytes, neutrophils, a proportion of peripheral blood T- and B-lymphocytes and lymphocytic cell lines.

Gene expression databases

BgeeiENSG00000167850.
CleanExiHS_CD300C.
GenevisibleiQ08708. HS.

Organism-specific databases

HPAiHPA014523.

Interactioni

Protein-protein interaction databases

BioGridi116080. 5 interactors.
IntActiQ08708. 3 interactors.
STRINGi9606.ENSP00000329507.

Structurei

3D structure databases

ProteinModelPortaliQ08708.
SMRiQ08708.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 130Ig-like V-typeAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi123 – 175Pro-richAdd BLAST53

Sequence similaritiesi

Belongs to the CD300 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J32Z. Eukaryota.
ENOG410ZH9V. LUCA.
GeneTreeiENSGT00470000042273.
HOGENOMiHOG000231065.
HOVERGENiHBG063279.
InParanoidiQ08708.
KOiK06719.
OMAiMTARAWA.
OrthoDBiEOG091G0RAD.
PhylomeDBiQ08708.
TreeFamiTF334441.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTARAWASWR SSALLLLLVP GYFPLSHPMT VAGPVGGSLS VQCRYEKEHR
60 70 80 90 100
TLNKFWCRPP QILRCDKIVE TKGSAGKRNG RVSIRDSPAN LSFTVTLENL
110 120 130 140 150
TEEDAGTYWC GVDTPWLRDF HDPIVEVEVS VFPAGTTTAS SPQSSMGTSG
160 170 180 190 200
PPTKLPVHTW PSVTRKDSPE PSPHPGSLFS NVRFLLLVLL ELPLLLSMLG
210 220
AVLWVNRPQR SSRSRQNWPK GENQ
Length:224
Mass (Da):24,830
Last modified:October 1, 1996 - v1
Checksum:i60C88716D84600D2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03913371T → I. Corresponds to variant dbSNP:rs11870245Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66171 mRNA. Translation: CAA46948.1.
AF373866
, AF373863, AF373864, AF373865 Genomic DNA. Translation: AAK64272.1.
BC022279 mRNA. Translation: AAH22279.1.
CCDSiCCDS11701.1.
PIRiI37243.
RefSeqiNP_006669.1. NM_006678.4.
UniGeneiHs.2605.

Genome annotation databases

EnsembliENST00000330793; ENSP00000329507; ENSG00000167850.
GeneIDi10871.
KEGGihsa:10871.
UCSCiuc002jky.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCLM6_HUMAN
AccessioniPrimary (citable) accession number: Q08708
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 27, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families