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Protein

CMRF35-like molecule 6

Gene

CD300C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • cellular defense response Source: ProtInc
  • immune system process Source: UniProtKB-KW
  • regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
CMRF35-like molecule 6
Short name:
CLM-6
Alternative name(s):
CD300 antigen-like family member C
CMRF35-A1
Short name:
CMRF-35
Immunoglobulin superfamily member 16
Short name:
IgSF16
CD_antigen: CD300c
Gene namesi
Name:CD300C
Synonyms:CMRF35, CMRF35A, CMRF35A1, IGSF16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:19320. CD300C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 183163ExtracellularSequence analysisAdd
BLAST
Transmembranei184 – 20421HelicalSequence analysisAdd
BLAST
Topological domaini205 – 22420CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672150.

Polymorphism and mutation databases

DMDMi1705938.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 224204CMRF35-like molecule 6PRO_0000014681Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 110PROSITE-ProRule annotation
Disulfide bondi57 ↔ 65PROSITE-ProRule annotation
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ08708.
PeptideAtlasiQ08708.
PRIDEiQ08708.

PTM databases

iPTMnetiQ08708.

Expressioni

Tissue specificityi

Present on the surface of monocytes, neutrophils, a proportion of peripheral blood T- and B-lymphocytes and lymphocytic cell lines.

Gene expression databases

BgeeiQ08708.
CleanExiHS_CD300C.
GenevisibleiQ08708. HS.

Organism-specific databases

HPAiHPA014523.

Interactioni

Protein-protein interaction databases

BioGridi116080. 5 interactions.
IntActiQ08708. 3 interactions.
STRINGi9606.ENSP00000329507.

Structurei

3D structure databases

ProteinModelPortaliQ08708.
SMRiQ08708. Positions 30-134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 130109Ig-like V-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi123 – 17553Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the CD300 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J32Z. Eukaryota.
ENOG410ZH9V. LUCA.
GeneTreeiENSGT00470000042273.
HOGENOMiHOG000231065.
HOVERGENiHBG063279.
InParanoidiQ08708.
KOiK06719.
OMAiMTARAWA.
OrthoDBiEOG7FFMST.
PhylomeDBiQ08708.
TreeFamiTF334441.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTARAWASWR SSALLLLLVP GYFPLSHPMT VAGPVGGSLS VQCRYEKEHR
60 70 80 90 100
TLNKFWCRPP QILRCDKIVE TKGSAGKRNG RVSIRDSPAN LSFTVTLENL
110 120 130 140 150
TEEDAGTYWC GVDTPWLRDF HDPIVEVEVS VFPAGTTTAS SPQSSMGTSG
160 170 180 190 200
PPTKLPVHTW PSVTRKDSPE PSPHPGSLFS NVRFLLLVLL ELPLLLSMLG
210 220
AVLWVNRPQR SSRSRQNWPK GENQ
Length:224
Mass (Da):24,830
Last modified:October 1, 1996 - v1
Checksum:i60C88716D84600D2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti71 – 711T → I.
Corresponds to variant rs11870245 [ dbSNP | Ensembl ].
VAR_039133

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66171 mRNA. Translation: CAA46948.1.
AF373866
, AF373863, AF373864, AF373865 Genomic DNA. Translation: AAK64272.1.
BC022279 mRNA. Translation: AAH22279.1.
CCDSiCCDS11701.1.
PIRiI37243.
RefSeqiNP_006669.1. NM_006678.4.
UniGeneiHs.2605.

Genome annotation databases

EnsembliENST00000330793; ENSP00000329507; ENSG00000167850.
GeneIDi10871.
KEGGihsa:10871.
UCSCiuc002jky.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66171 mRNA. Translation: CAA46948.1.
AF373866
, AF373863, AF373864, AF373865 Genomic DNA. Translation: AAK64272.1.
BC022279 mRNA. Translation: AAH22279.1.
CCDSiCCDS11701.1.
PIRiI37243.
RefSeqiNP_006669.1. NM_006678.4.
UniGeneiHs.2605.

3D structure databases

ProteinModelPortaliQ08708.
SMRiQ08708. Positions 30-134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116080. 5 interactions.
IntActiQ08708. 3 interactions.
STRINGi9606.ENSP00000329507.

PTM databases

iPTMnetiQ08708.

Polymorphism and mutation databases

DMDMi1705938.

Proteomic databases

PaxDbiQ08708.
PeptideAtlasiQ08708.
PRIDEiQ08708.

Protocols and materials databases

DNASUi10871.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330793; ENSP00000329507; ENSG00000167850.
GeneIDi10871.
KEGGihsa:10871.
UCSCiuc002jky.3. human.

Organism-specific databases

CTDi10871.
GeneCardsiCD300C.
HGNCiHGNC:19320. CD300C.
HPAiHPA014523.
MIMi606786. gene.
neXtProtiNX_Q08708.
PharmGKBiPA142672150.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J32Z. Eukaryota.
ENOG410ZH9V. LUCA.
GeneTreeiENSGT00470000042273.
HOGENOMiHOG000231065.
HOVERGENiHBG063279.
InParanoidiQ08708.
KOiK06719.
OMAiMTARAWA.
OrthoDBiEOG7FFMST.
PhylomeDBiQ08708.
TreeFamiTF334441.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GeneWikiiCD300C.
GenomeRNAii10871.
PROiQ08708.
SOURCEiSearch...

Gene expression databases

BgeeiQ08708.
CleanExiHS_CD300C.
GenevisibleiQ08708. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor."
    Jackson D.G., Hart D.N.J., Starling G., Bell J.I.
    Eur. J. Immunol. 22:1157-1163(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 family."
    Clark G.J., Cooper B., Fitzpatrick S., Green B.J., Hart D.N.
    Tissue Antigens 57:415-423(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  4. "Novel immunoglobulin superfamily gene cluster, mapping to a region of human chromosome 17q25, linked to psoriasis susceptibility."
    Speckman R.A., Wright Daw J.A., Helms C., Duan S., Cao L., Taillon-Miller P., Kwok P.Y., Menter A., Bowcock A.M.
    Hum. Genet. 112:34-41(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiCLM6_HUMAN
AccessioniPrimary (citable) accession number: Q08708
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 6, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.