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Protein

Transcriptional repressor CTCF

Gene

CTCF

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as both a transcriptional activator and repressor of the MYC gene.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri266 – 28823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri294 – 31623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri322 – 34524C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri379 – 40123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 43024C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 46024C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri523 – 54624C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri555 – 57723C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor CTCF
Alternative name(s):
11-zinc finger protein
CCCTC-binding factor
CTCFL paralog
Gene namesi
Name:CTCF
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 728728Transcriptional repressor CTCFPRO_0000047227Add
BLAST

Proteomic databases

PaxDbiQ08705.
PRIDEiQ08705.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
YBX1P678092EBI-932806,EBI-354065From a different organism.

Protein-protein interaction databases

IntActiQ08705. 3 interactions.
STRINGi9031.ENSGALP00000033975.

Structurei

3D structure databases

ProteinModelPortaliQ08705.
SMRiQ08705. Positions 399-462, 515-591.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CTCF zinc-finger protein family.Curated
Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri266 – 28823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri294 – 31623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri322 – 34524C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri379 – 40123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 43024C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 46024C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri523 – 54624C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri555 – 57723C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000276534.
HOVERGENiHBG000350.
InParanoidiQ08705.
PhylomeDBiQ08705.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08705-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGEAVEAIV EESETFIKGK ERKTYQRRRE GGQEDEACHI APNQADGGEV
60 70 80 90 100
VQDVNSGVQM VMMEHLDPTL LQMKTEVMEG AVPQETEATV DDTQIITLQV
110 120 130 140 150
VNMEEQPINL GELQLVQVPV PVTVPVATTS VEELQGAYEN EVSKGGLQEG
160 170 180 190 200
EPMICHTLPL PEGFQVVKVG ANGEVETLEQ GELQPQEDPN WQKDPDYQPP
210 220 230 240 250
AKKTKKNKKS KLRYTEEGKD VDVSVYDFEE EQQEGLLSEV NAEKVVGNMK
260 270 280 290 300
PPKPTKIKKK GVKKTFQCEL CSYTCPRRSN LDRHMKSHTD ERPHKCHLCG
310 320 330 340 350
RAFRTVTLLR NHLNTHTGTR PHKCPDCDMA FVTSGELVRH RRYKHTHEKP
360 370 380 390 400
FKCSMCDYAS VEVSKLKRHI RSHTGERPFQ CSLCSYASRD TYKLKRHMRT
410 420 430 440 450
HSGEKPYECY ICHARFTQSG TMKMHILQKH TENVAKFHCP HCDTVIARKS
460 470 480 490 500
DLGVHLRKQH SYIEQGKKCR YCDAVFHERY ALIQHQKSHK NEKRFKCDQC
510 520 530 540 550
DYACRQERHM VMHKRTHTGE KPYACSHCDK TFRQKQLLDM HFKRYHDPNF
560 570 580 590 600
VPAAFVCSKC GKTFTRRNTM ARHADNCSGL DGGEGENGGE TKKGKRGRKR
610 620 630 640 650
KMRSKKEDSS DSEENAEPDL DDNEDEEETA VEIEAEPEVS AEAPAPPPSK
660 670 680 690 700
KRRGRPPGKA ATQTKQSQPA AIIQVEDQNT GEIENIIVEV KKEPDAETVE
710 720
EEEEAQPAVV EAPNGDLTPE MILSMMDR
Length:728
Mass (Da):82,828
Last modified:October 1, 1996 - v1
Checksum:i6F58E25CFDAE17C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22605 mRNA. Translation: CAA80319.1.
PIRiA54603.
RefSeqiNP_990663.2. NM_205332.5.
UniGeneiGga.3278.

Genome annotation databases

GeneIDi396274.
KEGGigga:396274.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22605 mRNA. Translation: CAA80319.1.
PIRiA54603.
RefSeqiNP_990663.2. NM_205332.5.
UniGeneiGga.3278.

3D structure databases

ProteinModelPortaliQ08705.
SMRiQ08705. Positions 399-462, 515-591.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ08705. 3 interactions.
STRINGi9031.ENSGALP00000033975.

Proteomic databases

PaxDbiQ08705.
PRIDEiQ08705.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396274.
KEGGigga:396274.

Organism-specific databases

CTDi10664.

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000276534.
HOVERGENiHBG000350.
InParanoidiQ08705.
PhylomeDBiQ08705.

Miscellaneous databases

NextBioi20816325.
PROiQ08705.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms."
    Klenova E.M., Nicolas R.H., Paterson H.F., Carne A.F., Heath C.M., Goodwin G.H., Neiman P.E., Lobanenkov V.V.
    Mol. Cell. Biol. 13:7612-7624(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCTCF_CHICK
AccessioniPrimary (citable) accession number: Q08705
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 29, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.