Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q08705

- CTCF_CHICK

UniProt

Q08705 - CTCF_CHICK

Protein

Transcriptional repressor CTCF

Gene

CTCF

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Acts as both a transcriptional activator and repressor of the MYC gene.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri266 – 28823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri294 – 31623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri322 – 34524C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri351 – 37323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri379 – 40123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri407 – 43024C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri437 – 46024C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri467 – 48923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri495 – 51723C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri523 – 54624C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri555 – 57723C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional repressor CTCF
    Alternative name(s):
    11-zinc finger protein
    CCCTC-binding factor
    CTCFL paralog
    Gene namesi
    Name:CTCF
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 728728Transcriptional repressor CTCFPRO_0000047227Add
    BLAST

    Proteomic databases

    PaxDbiQ08705.
    PRIDEiQ08705.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    YBX1P678092EBI-932806,EBI-354065From a different organism.

    Protein-protein interaction databases

    IntActiQ08705. 3 interactions.
    STRINGi9031.ENSGALP00000033975.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08705.
    SMRiQ08705. Positions 399-462, 515-591.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CTCF zinc-finger protein family.Curated
    Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri266 – 28823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri294 – 31623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri322 – 34524C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri351 – 37323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri379 – 40123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri407 – 43024C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri437 – 46024C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri467 – 48923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri495 – 51723C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri523 – 54624C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri555 – 57723C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000276534.
    HOVERGENiHBG000350.
    PhylomeDBiQ08705.

    Family and domain databases

    Gene3Di3.30.160.60. 9 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 11 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q08705-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGEAVEAIV EESETFIKGK ERKTYQRRRE GGQEDEACHI APNQADGGEV    50
    VQDVNSGVQM VMMEHLDPTL LQMKTEVMEG AVPQETEATV DDTQIITLQV 100
    VNMEEQPINL GELQLVQVPV PVTVPVATTS VEELQGAYEN EVSKGGLQEG 150
    EPMICHTLPL PEGFQVVKVG ANGEVETLEQ GELQPQEDPN WQKDPDYQPP 200
    AKKTKKNKKS KLRYTEEGKD VDVSVYDFEE EQQEGLLSEV NAEKVVGNMK 250
    PPKPTKIKKK GVKKTFQCEL CSYTCPRRSN LDRHMKSHTD ERPHKCHLCG 300
    RAFRTVTLLR NHLNTHTGTR PHKCPDCDMA FVTSGELVRH RRYKHTHEKP 350
    FKCSMCDYAS VEVSKLKRHI RSHTGERPFQ CSLCSYASRD TYKLKRHMRT 400
    HSGEKPYECY ICHARFTQSG TMKMHILQKH TENVAKFHCP HCDTVIARKS 450
    DLGVHLRKQH SYIEQGKKCR YCDAVFHERY ALIQHQKSHK NEKRFKCDQC 500
    DYACRQERHM VMHKRTHTGE KPYACSHCDK TFRQKQLLDM HFKRYHDPNF 550
    VPAAFVCSKC GKTFTRRNTM ARHADNCSGL DGGEGENGGE TKKGKRGRKR 600
    KMRSKKEDSS DSEENAEPDL DDNEDEEETA VEIEAEPEVS AEAPAPPPSK 650
    KRRGRPPGKA ATQTKQSQPA AIIQVEDQNT GEIENIIVEV KKEPDAETVE 700
    EEEEAQPAVV EAPNGDLTPE MILSMMDR 728
    Length:728
    Mass (Da):82,828
    Last modified:October 1, 1996 - v1
    Checksum:i6F58E25CFDAE17C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22605 mRNA. Translation: CAA80319.1.
    PIRiA54603.
    RefSeqiNP_990663.1. NM_205332.4.
    UniGeneiGga.3278.

    Genome annotation databases

    GeneIDi396274.
    KEGGigga:396274.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22605 mRNA. Translation: CAA80319.1 .
    PIRi A54603.
    RefSeqi NP_990663.1. NM_205332.4.
    UniGenei Gga.3278.

    3D structure databases

    ProteinModelPortali Q08705.
    SMRi Q08705. Positions 399-462, 515-591.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q08705. 3 interactions.
    STRINGi 9031.ENSGALP00000033975.

    Proteomic databases

    PaxDbi Q08705.
    PRIDEi Q08705.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396274.
    KEGGi gga:396274.

    Organism-specific databases

    CTDi 10664.

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000276534.
    HOVERGENi HBG000350.
    PhylomeDBi Q08705.

    Miscellaneous databases

    NextBioi 20816325.
    PROi Q08705.

    Family and domain databases

    Gene3Di 3.30.160.60. 9 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 11 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms."
      Klenova E.M., Nicolas R.H., Paterson H.F., Carne A.F., Heath C.M., Goodwin G.H., Neiman P.E., Lobanenkov V.V.
      Mol. Cell. Biol. 13:7612-7624(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiCTCF_CHICK
    AccessioniPrimary (citable) accession number: Q08705
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3