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Q08705 (CTCF_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional repressor CTCF
Alternative name(s):
11-zinc finger protein
CCCTC-binding factor
CTCFL paralog
Gene names
Name:CTCF
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length728 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as both a transcriptional activator and repressor of the MYC gene. Ref.1

Subcellular location

Nucleus Ref.1.

Sequence similarities

Belongs to the CTCF zinc-finger protein family.

Contains 11 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
Repressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

YBX1P678092EBI-932806,EBI-354065From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 728728Transcriptional repressor CTCF
PRO_0000047227

Regions

Zinc finger266 – 28823C2H2-type 1
Zinc finger294 – 31623C2H2-type 2
Zinc finger322 – 34524C2H2-type 3
Zinc finger351 – 37323C2H2-type 4
Zinc finger379 – 40123C2H2-type 5
Zinc finger407 – 43024C2H2-type 6
Zinc finger437 – 46024C2H2-type 7
Zinc finger467 – 48923C2H2-type 8
Zinc finger495 – 51723C2H2-type 9
Zinc finger523 – 54624C2H2-type 10
Zinc finger555 – 57723C2H2-type 11; atypical

Sequences

Sequence LengthMass (Da)Tools
Q08705 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 6F58E25CFDAE17C8

FASTA72882,828
        10         20         30         40         50         60 
MEGEAVEAIV EESETFIKGK ERKTYQRRRE GGQEDEACHI APNQADGGEV VQDVNSGVQM 

        70         80         90        100        110        120 
VMMEHLDPTL LQMKTEVMEG AVPQETEATV DDTQIITLQV VNMEEQPINL GELQLVQVPV 

       130        140        150        160        170        180 
PVTVPVATTS VEELQGAYEN EVSKGGLQEG EPMICHTLPL PEGFQVVKVG ANGEVETLEQ 

       190        200        210        220        230        240 
GELQPQEDPN WQKDPDYQPP AKKTKKNKKS KLRYTEEGKD VDVSVYDFEE EQQEGLLSEV 

       250        260        270        280        290        300 
NAEKVVGNMK PPKPTKIKKK GVKKTFQCEL CSYTCPRRSN LDRHMKSHTD ERPHKCHLCG 

       310        320        330        340        350        360 
RAFRTVTLLR NHLNTHTGTR PHKCPDCDMA FVTSGELVRH RRYKHTHEKP FKCSMCDYAS 

       370        380        390        400        410        420 
VEVSKLKRHI RSHTGERPFQ CSLCSYASRD TYKLKRHMRT HSGEKPYECY ICHARFTQSG 

       430        440        450        460        470        480 
TMKMHILQKH TENVAKFHCP HCDTVIARKS DLGVHLRKQH SYIEQGKKCR YCDAVFHERY 

       490        500        510        520        530        540 
ALIQHQKSHK NEKRFKCDQC DYACRQERHM VMHKRTHTGE KPYACSHCDK TFRQKQLLDM 

       550        560        570        580        590        600 
HFKRYHDPNF VPAAFVCSKC GKTFTRRNTM ARHADNCSGL DGGEGENGGE TKKGKRGRKR 

       610        620        630        640        650        660 
KMRSKKEDSS DSEENAEPDL DDNEDEEETA VEIEAEPEVS AEAPAPPPSK KRRGRPPGKA 

       670        680        690        700        710        720 
ATQTKQSQPA AIIQVEDQNT GEIENIIVEV KKEPDAETVE EEEEAQPAVV EAPNGDLTPE 


MILSMMDR 

« Hide

References

[1]"CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms."
Klenova E.M., Nicolas R.H., Paterson H.F., Carne A.F., Heath C.M., Goodwin G.H., Neiman P.E., Lobanenkov V.V.
Mol. Cell. Biol. 13:7612-7624(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z22605 mRNA. Translation: CAA80319.1.
PIRA54603.
RefSeqNP_990663.1. NM_205332.4.
UniGeneGga.3278.

3D structure databases

ProteinModelPortalQ08705.
SMRQ08705. Positions 399-462, 515-591.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ08705. 3 interactions.
STRING9031.ENSGALP00000033975.

Proteomic databases

PaxDbQ08705.
PRIDEQ08705.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396274.
KEGGgga:396274.

Organism-specific databases

CTD10664.

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000276534.
HOVERGENHBG000350.
PhylomeDBQ08705.

Family and domain databases

Gene3D3.30.160.60. 9 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816325.
PROQ08705.

Entry information

Entry nameCTCF_CHICK
AccessionPrimary (citable) accession number: Q08705
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families