ID   CFI_MAIZE               Reviewed;         231 AA.
AC   Q08704;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   16-JUN-2009, entry version 42.
DE   RecName: Full=Chalcone--flavonone isomerase;
DE            Short=Chalcone isomerase;
DE            EC=5.5.1.6;
GN   Name=CHI; Synonyms=CHI1;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae;
OC   PACCAD clade; Panicoideae; Andropogoneae; Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   MEDLINE=94104592; PubMed=8277939;
RA   Grotewold E., Peterson T.;
RT   "Isolation and characterization of a maize gene encoding chalcone
RT   flavonone isomerase.";
RL   Mol. Gen. Genet. 242:1-8(1994).
CC   -!- FUNCTION: Catalyzes the intramolecular cyclization of bicyclic
CC       chalcones into tricyclic (S)-flavanones. Responsible for the
CC       isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed
CC       chalcone) into naringenin (By similarity).
CC   -!- CATALYTIC ACTIVITY: A chalcone = a flavanone.
CC   -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid
CC       biosynthesis.
CC   -!- TISSUE SPECIFICITY: Pericarp.
CC   -!- MISCELLANEOUS: Part of the biosynthetic pathway for all classes of
CC       flavonoids, a large class of secondary plant metabolites, many of
CC       which are brightly colored.
CC   -!- SIMILARITY: Belongs to the chalcone isomerase family.
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DR   EMBL; Z22760; CAA80441.1; -; Genomic_DNA.
DR   PIR; S41570; S41570.
DR   HSSP; P28012; 1EYQ.
DR   Gramene; Q08704; -.
DR   MaizeGDB; 56296; -.
DR   BRENDA; 5.5.1.6; 289.
DR   GO; GO:0045430; F:chalcone isomerase activity; IEA:EC.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR016088; Chalcone_isomerase_3-sand.
DR   InterPro; IPR003466; Chalcone_isomerase_subgr.
DR   Gene3D; G3DSA:3.50.70.10; Chalcone; 1.
DR   Pfam; PF02431; Chalcone; 1.
PE   2: Evidence at transcript level;
KW   Flavonoid biosynthesis; Isomerase.
FT   CHAIN         1    231       Chalcone--flavonone isomerase.
FT                                /FTId=PRO_0000166433.
FT   BINDING      46     46       Substrate (By similarity).
FT   BINDING     111    111       Substrate (By similarity).
FT   BINDING     188    188       Substrate (By similarity).
FT   SITE        104    104       Important for catalytic activity (By
FT                                similarity).
SQ   SEQUENCE   231 AA;  24250 MW;  AD64A8B04213F9F5 CRC64;
     MACRRWWSTA VVFPPVARPP GSAGSHFLGG AGVRGVEIGG NFIKFTAIGV YLEDAAVPAL
     AKKWGGKTAD ELASDAAFFR DVVTGDFEKF TRVTMILPLT GEQYAEKVTE NCVAFWKAAG
     LYTDAEGVAV EKFREVFKPE TFAPGRSILF THSPAGVLTV AFSKDSSVPA AGGVAIENKR
     LCEAVLESII GERGVSPAAK LSLAARVSEL LAKETAAAAD APQAEPVSIT A
//