Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q086F9 (TYPH_SHEFN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
Ordered Locus Names:Sfri_1003
OrganismShewanella frigidimarina (strain NCIMB 400) [Complete proteome] [HAMAP]
Taxonomic identifier318167 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis By similarity. HAMAP-Rule MF_01628

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01628

Pathway

Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. HAMAP-Rule MF_01628

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01628

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Thymidine phosphorylase HAMAP-Rule MF_01628
PRO_1000069669

Sequences

Sequence LengthMass (Da)Tools
Q086F9 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: 5108CD1FF1389C97

FASTA44346,947
        10         20         30         40         50         60 
MFLAQEIIRK KRNGDVLSTA EIQFFVDGIT HNTVSEGQIA AFGMAVYFKD MNMDERIALT 

        70         80         90        100        110        120 
IAMRDSGTVL NWDSLGLNGP IIDKHSTGGV GDVISLMLGP MAAACGGYVP MISGRGLGHT 

       130        140        150        160        170        180 
GGTLDKFDAI PGYQTEPSSE LFRKVVKDAG VAIIGQTGDL VPADKRFYSI RDNTATVESI 

       190        200        210        220        230        240 
SLITASILSK KLAAGLDALA MDVKVGSGAF MPTYEASEEL ARSITAVANG AGTKTTALLT 

       250        260        270        280        290        300 
DMNQVLASCA GNAVEVREAI NFLTGQYRNP RLYAVTMGLC AEMLILGGIA QNEAEARHKL 

       310        320        330        340        350        360 
NTVLDNGKAA EAFAKMVSGL GGPTDFVEAY DKYLPHAKIV RPVYANTSGF AYKMDTRELG 

       370        380        390        400        410        420 
LAVVTLGGGR RKPGDALDYS VGLTQVCALG QEVNKDVPLA MIHAQSEDAF AEAAAAIQQA 

       430        440 
IIIGDSAPEK TPEIYRYIRA SDL 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000447 Genomic DNA. Translation: ABI70856.1.
RefSeqYP_749694.1. NC_008345.1.

3D structure databases

ProteinModelPortalQ086F9.
SMRQ086F9. Positions 1-438.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING318167.Sfri_1003.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI70856; ABI70856; Sfri_1003.
GeneID4278377.
KEGGsfr:Sfri_1003.
PATRIC23495861. VBISheFri14343_1037.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0213.
HOGENOMHOG000047313.
KOK00758.
OMADVWRRMI.
OrthoDBEOG61ZTGG.
ProtClustDBPRK05820.

Enzyme and pathway databases

BioCycSFRI318167:GIXS-1046-MONOMER.
UniPathwayUPA00578; UER00638.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_01628. Thymid_phosp.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_SHEFN
AccessionPrimary (citable) accession number: Q086F9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 31, 2006
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways