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Protein

Lysozyme B

Gene

LysB

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei50PROSITE-ProRule annotation1
Active sitei68PROSITE-ProRule annotation1

GO - Molecular functioni

  • lysozyme activity Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-DME-6798695 Neutrophil degranulation
R-DME-6803157 Antimicrobial peptides

Protein family/group databases

CAZyiGH22 Glycoside Hydrolase Family 22

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme B (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase B
Gene namesi
Name:LysB
ORF Names:CG1179
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0004425 LysB

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000001851019 – 140Lysozyme BAdd BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 139PROSITE-ProRule annotation
Disulfide bondi45 ↔ 129PROSITE-ProRule annotation
Disulfide bondi80 ↔ 96PROSITE-ProRule annotation
Disulfide bondi92 ↔ 110PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ08694
PRIDEiQ08694

Expressioni

Tissue specificityi

Found in the midgut.

Developmental stagei

Maximal expression is found during the third larval instar, it drops to become undetectable in the late pupal stage. The expression in adults is similar to that of first and second larval instars.

Gene expression databases

BgeeiFBgn0004425
ExpressionAtlasiQ08694 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi63671, 2 interactors
DIPiDIP-20169N
STRINGi7227.FBpp0072524

Structurei

3D structure databases

ProteinModelPortaliQ08694
SMRiQ08694
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXGD Eukaryota
ENOG4111QHM LUCA
GeneTreeiENSGT00550000074398
HOGENOMiHOG000263866
InParanoidiQ08694
KOiK01185
OMAiPHATNGC
OrthoDBiEOG091G0R9V
PhylomeDBiQ08694

Family and domain databases

CDDicd00119 LYZ1, 1 hit
InterProiView protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000974 Glyco_hydro_22_lys
IPR023346 Lysozyme-like_dom_sf
PfamiView protein in Pfam
PF00062 Lys, 1 hit
PRINTSiPR00137 LYSOZYME
PR00135 LYZLACT
SMARTiView protein in SMART
SM00263 LYZ1, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08694-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAFIVLVAL ALAAPALGRT MDRCSLAREM SNLGVPRDQL ARWACIAEHE
60 70 80 90 100
SSYRTGVVGP ENYNGSNDYG IFQINDYYWC APPSGRFSYN ECGLSCNALL
110 120 130 140
TDDITHSVRC AQKVLSQQGW SAWSTWHYCS GWLPSIDDCF
Length:140
Mass (Da):15,612
Last modified:February 21, 2001 - v2
Checksum:i70AFA5321857F093
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12 – 13LA → SG in CAA80227 (PubMed:8159165).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22225 Genomic DNA Translation: CAA80227.1
AE014296 Genomic DNA Translation: AAF47448.1
PIRiS41574
RefSeqiNP_001261245.1, NM_001274316.1
NP_523882.1, NM_079158.3
UniGeneiDm.23958

Genome annotation databases

EnsemblMetazoaiFBtr0072628; FBpp0072524; FBgn0004425
FBtr0336738; FBpp0307718; FBgn0004425
GeneIDi38125
KEGGidme:Dmel_CG1179

Similar proteinsi

Entry informationi

Entry nameiLYSB_DROME
AccessioniPrimary (citable) accession number: Q08694
Secondary accession number(s): P37158, Q9W0J8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: February 21, 2001
Last modified: May 23, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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