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Protein

N-terminal acetyltransferase A complex subunit NAT5

Gene

NAT5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Non-essential component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover.

GO - Molecular functioni

  • peptide alpha-N-acetyltransferase activity Source: SGD

GO - Biological processi

  • N-terminal protein amino acid acetylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-33744-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
N-terminal acetyltransferase A complex subunit NAT5 (EC:2.3.1.-)
Short name:
NatA complex subunit NAT5
Gene namesi
Name:NAT5
Ordered Locus Names:YOR253W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR253W.
SGDiS000005779. NAT5.

Subcellular locationi

GO - Cellular componenti

  • NatA complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002406421 – 176N-terminal acetyltransferase A complex subunit NAT5Add BLAST176

Proteomic databases

MaxQBiQ08689.
PRIDEiQ08689.

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase A (NatA) complex, which is composed of ARD1, NAT1 and NAT5.1 Publication

Protein-protein interaction databases

BioGridi34643. 24 interactors.
IntActiQ08689. 4 interactors.
MINTiMINT-2782295.

Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 9Combined sources5
Helixi13 – 15Combined sources3
Helixi16 – 26Combined sources11
Helixi33 – 39Combined sources7
Beta strandi59 – 66Combined sources8
Beta strandi69 – 79Combined sources11
Beta strandi90 – 98Combined sources9
Helixi100 – 102Combined sources3
Beta strandi104 – 106Combined sources3
Helixi107 – 121Combined sources15
Beta strandi126 – 132Combined sources7
Helixi136 – 144Combined sources9
Beta strandi148 – 159Combined sources12
Beta strandi165 – 174Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XNHX-ray2.10C1-176[»]
4XPDX-ray2.81C1-176[»]
4Y49X-ray3.95C/I/O1-176[»]
ProteinModelPortaliQ08689.
SMRiQ08689.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 176N-acetyltransferasePROSITE-ProRule annotationAdd BLAST163

Sequence similaritiesi

Belongs to the acetyltransferase family.Curated
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000238056.
InParanoidiQ08689.
KOiK20793.
OMAiIAYYSEI.
OrthoDBiEOG092C55DH.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08689-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRDICTLDN VYANNLGMLT KLAHVTVPNL YQDAFFSALF AEDSLVAKNK
60 70 80 90 100
KPSSKKDVHF TQMAYYSEIP VGGLVAKLVP KKQNELSLKG IQIEFLGVLP
110 120 130 140 150
NYRHKSIGSK LLKFAEDKCS ECHQHNVFVY LPAVDDLTKQ WFIAHGFEQV
160 170
GETVNNFIKG VNGDEQDAIL LKKHIS
Length:176
Mass (Da):19,727
Last modified:November 1, 1996 - v1
Checksum:i4F09DC597A690BA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75161 Genomic DNA. Translation: CAA99475.1.
AY557750 Genomic DNA. Translation: AAS56076.1.
BK006948 Genomic DNA. Translation: DAA11020.1.
PIRiS67150.
RefSeqiNP_014896.3. NM_001183672.3.

Genome annotation databases

EnsemblFungiiYOR253W; YOR253W; YOR253W.
GeneIDi854427.
KEGGisce:YOR253W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75161 Genomic DNA. Translation: CAA99475.1.
AY557750 Genomic DNA. Translation: AAS56076.1.
BK006948 Genomic DNA. Translation: DAA11020.1.
PIRiS67150.
RefSeqiNP_014896.3. NM_001183672.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XNHX-ray2.10C1-176[»]
4XPDX-ray2.81C1-176[»]
4Y49X-ray3.95C/I/O1-176[»]
ProteinModelPortaliQ08689.
SMRiQ08689.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34643. 24 interactors.
IntActiQ08689. 4 interactors.
MINTiMINT-2782295.

Proteomic databases

MaxQBiQ08689.
PRIDEiQ08689.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR253W; YOR253W; YOR253W.
GeneIDi854427.
KEGGisce:YOR253W.

Organism-specific databases

EuPathDBiFungiDB:YOR253W.
SGDiS000005779. NAT5.

Phylogenomic databases

HOGENOMiHOG000238056.
InParanoidiQ08689.
KOiK20793.
OMAiIAYYSEI.
OrthoDBiEOG092C55DH.

Enzyme and pathway databases

BioCyciYEAST:G3O-33744-MONOMER.

Miscellaneous databases

PROiQ08689.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAT5_YEAST
AccessioniPrimary (citable) accession number: Q08689
Secondary accession number(s): D6W2V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2370 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.