ID   TRPE_THEMA              Reviewed;         461 AA.
AC   Q08653;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   16-JUN-2009, entry version 75.
DE   RecName: Full=Anthranilate synthase component 1;
DE            EC=4.1.3.27;
DE   AltName: Full=Anthranilate synthase component I;
GN   Name=trpE; OrderedLocusNames=TM_0142;
OS   Thermotoga maritima.
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=2336;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=93294870; PubMed=7685830; DOI=10.1006/jmbi.1993.1345;
RA   Kim C.W., Markiewicz P.G., Lee J.J., Schierle C.F., Miller J.H.;
RT   "Studies of the hyperthermophile Thermotoga maritima by random
RT   sequencing of cDNA and genomic libraries. Identification and
RT   sequencing of the trpEG (D) operon.";
RL   J. Mol. Biol. 231:960-981(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / MSB8 / DSM 3109 / JCM 10099;
RX   MEDLINE=99287316; PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J.,
RA   Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A.,
RA   McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M.,
RA   Stewart A.M., Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L.,
RA   Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O.,
RA   Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
CC   -!- CATALYTIC ACTIVITY: Chorismate + L-glutamine = anthranilate +
CC       pyruvate + L-glutamate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 1/5.
CC   -!- SUBUNIT: Tetramer of two components I and two components II (By
CC       similarity).
CC   -!- MISCELLANEOUS: Component I catalyzes the formation of anthranilate
CC       using ammonia rather than glutamine, whereas component II provides
CC       glutamine amidotransferase activity.
CC   -!- SIMILARITY: Belongs to the anthranilate synthase component I
CC       family.
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DR   EMBL; X74075; CAA52202.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE000512; AAD35235.1; -; Genomic_DNA.
DR   PIR; D72414; D72414.
DR   RefSeq; NP_227957.1; -.
DR   HSSP; P05041; 1K0G.
DR   GeneID; 896972; -.
DR   GenomeReviews; AE000512_GR; TM_0142.
DR   KEGG; tma:TM0142; -.
DR   NMPDR; fig|243274.1.peg.141; -.
DR   TIGR; TM_0142; -.
DR   HOGENOM; Q08653; -.
DR   OMA; Q08653; VEFARNG.
DR   BioCyc; MetaCyc:MON-281; -.
DR   BioCyc; TMAR243274:TM_0142-MON; -.
DR   BRENDA; 4.1.3.27; 16699.
DR   GO; GO:0004049; F:anthranilate synthase activity; IEA:EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR006805; Anth_synth_I_N.
DR   InterPro; IPR005256; Anth_synthI.
DR   InterPro; IPR019999; Anthranilate_synth_I_C.
DR   InterPro; IPR015890; Chorismate-bd_C.
DR   Gene3D; G3DSA:3.60.120.10; TRPE_1_chor_bd; 1.
DR   PANTHER; PTHR11236; TRPE_1_chor_bd; 1.
DR   Pfam; PF04715; Anth_synt_I_N; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   PRINTS; PR00095; ANTSNTHASEI.
DR   ProDom; PD000779; Anth_synth_chor; 1.
DR   TIGRFAMs; TIGR00564; trpE_most; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Tryptophan biosynthesis.
FT   CHAIN         1    461       Anthranilate synthase component 1.
FT                                /FTId=PRO_0000154116.
FT   CONFLICT    104    104       A -> R (in Ref. 1; CAA52202).
SQ   SEQUENCE   461 AA;  52240 MW;  DEA00256445C568C CRC64;
     MGDSMHVLKL VSDLETPVST FMKVSRGEEF AFLLESVELG SAFGRHSFIG IGKKDVLVFE
     KGILRTSNQQ LDYTSSPLKA IKDWLEVYRY SVKHDELPSF RGGAVGFVSY DYISYIEKVK
     VKASVFPTFY FVVPEHLIIF DHLKNNVFII SDSPEELTSK VLSPFEEKPE KNVFVTEPES
     NFEREQFYKV VEKAKKYIVE GDIFQVVLSQ AFTFKTTLDP FYIYRALRMI NPSPYMFYLK
     FGDTVVLGSS PETMAKVEGD KATVKPIAGT RPRGRTVEED LKLERELLND EKEIAEHVML
     VDLGRNDLGR VCKEGTVRVE KKMVIERYSH VMHIVSQVSG ELKDDKDAVD VFEATFPAGT
     VSGAPKVRAM EIIEELEPTP RGPYAGAVGY FSFPDDKGRM NMDSAITIRS FFFKGKQGWL
     QAGAGIVYDS VPEREYQETL NKLRALFRSL EVAQKIQGGL F
//