Reviewed,
UniProtKB/Swiss-Prot Q08653 (TRPE_THEMA)
Last modified
June 16, 2009.
Version 75.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Anthranilate synthase component 1 EC=4.1.3.27 Alternative name(s): Anthranilate synthase component I | ||||
| Gene names |
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| Organism | Thermotoga maritima [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 2336 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga |
Protein attributes
| Sequence length | 461 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. |
| Pathway | Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5. |
| Subunit structure | Tetramer of two components I and two components II By similarity. |
| Miscellaneous | Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity. |
| Sequence similarities | Belongs to the anthranilate synthase component I family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis |
| Molecular function | Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | anthranilate synthase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Studies of the hyperthermophile Thermotoga maritima by random sequencing of cDNA and genomic libraries. Identification and sequencing of the trpEG (D) operon." Kim C.W., Markiewicz P.G., Lee J.J., Schierle C.F., Miller J.H. J. Mol. Biol. 231:960-981(1993) [PubMed: 7685830] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. Fraser C.M.Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099. |
Cross-references
Sequence databases | |
|---|---|
| X74075 Genomic DNA. Translation: CAA52202.1. Different initiation. AE000512 Genomic DNA. Translation: AAD35235.1. | |
| PIR | D72414. |
| RefSeq | NP_227957.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1K0G based on UniProtKB P05041. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 896972. |
| GenomeReviews | Gene locus TM_0142 in contig AE000512_GR. |
| KEGG | tma:TM0142. |
| NMPDR | fig|243274.1.peg.141. |
| TIGR | TM_0142. |
Phylogenomic databases | |
| HOGENOM | Q08653. |
| OMA | Q08653. VEFARNG. |
Enzyme and pathway databases | |
| BioCyc | MetaCyc:MON-281. TMAR243274:TM_0142-MON. |
| BRENDA | 4.1.3.27. 16699. |
Family and domain databases | |
| InterPro | IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR005256. Anth_synthI. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. [Graphical view] |
| Gene3D | G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit. |
| PANTHER | PTHR11236. TRPE_1_chor_bd. 1 hit. |
| Pfam | PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view] |
| PRINTS | PR00095. ANTSNTHASEI. |
| ProDom | PD000779. Anth_synth_chor. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00564. trpE_most. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | TRPE_THEMA | ||||||||
| Accession | Primary (citable) accession number: Q08653 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


