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Q08653 (TRPE_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Anthranilate synthase component 1

EC=4.1.3.27
Alternative name(s):
Anthranilate synthase component I
Gene names
Name:trpE
Ordered Locus Names:TM_0142
OrganismThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [Reference proteome] [HAMAP]
Taxonomic identifier243274 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Subunit structure

Tetramer of two components I and two components II By similarity.

Miscellaneous

Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.

Sequence similarities

Belongs to the anthranilate synthase component I family.

Sequence caution

The sequence CAA52202.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionanthranilate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 461461Anthranilate synthase component 1
PRO_0000154116

Experimental info

Sequence conflict1041A → R in CAA52202. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q08653 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: DEA00256445C568C

FASTA46152,240
        10         20         30         40         50         60 
MGDSMHVLKL VSDLETPVST FMKVSRGEEF AFLLESVELG SAFGRHSFIG IGKKDVLVFE 

        70         80         90        100        110        120 
KGILRTSNQQ LDYTSSPLKA IKDWLEVYRY SVKHDELPSF RGGAVGFVSY DYISYIEKVK 

       130        140        150        160        170        180 
VKASVFPTFY FVVPEHLIIF DHLKNNVFII SDSPEELTSK VLSPFEEKPE KNVFVTEPES 

       190        200        210        220        230        240 
NFEREQFYKV VEKAKKYIVE GDIFQVVLSQ AFTFKTTLDP FYIYRALRMI NPSPYMFYLK 

       250        260        270        280        290        300 
FGDTVVLGSS PETMAKVEGD KATVKPIAGT RPRGRTVEED LKLERELLND EKEIAEHVML 

       310        320        330        340        350        360 
VDLGRNDLGR VCKEGTVRVE KKMVIERYSH VMHIVSQVSG ELKDDKDAVD VFEATFPAGT 

       370        380        390        400        410        420 
VSGAPKVRAM EIIEELEPTP RGPYAGAVGY FSFPDDKGRM NMDSAITIRS FFFKGKQGWL 

       430        440        450        460 
QAGAGIVYDS VPEREYQETL NKLRALFRSL EVAQKIQGGL F 

« Hide

References

« Hide 'large scale' references
[1]"Studies of the hyperthermophile Thermotoga maritima by random sequencing of cDNA and genomic libraries. Identification and sequencing of the trpEG (D) operon."
Kim C.W., Markiewicz P.G., Lee J.J., Schierle C.F., Miller J.H.
J. Mol. Biol. 231:960-981(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima."
Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. expand/collapse author list , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M.
Nature 399:323-329(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X74075 Genomic DNA. Translation: CAA52202.1. Different initiation.
AE000512 Genomic DNA. Translation: AAD35235.1.
PIRD72414.
RefSeqNP_227957.1. NC_000853.1.

3D structure databases

ProteinModelPortalQ08653.
ModBaseSearch...

Protein-protein interaction databases

STRING243274.TM0142.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD35235; AAD35235; TM_0142.
GeneID896972.
KEGGtma:TM0142.
PATRIC23935126. VBITheMar51294_0141.

Phylogenomic databases

eggNOGCOG0147.
KOK01657.
OMAIERYEHV.
ProtClustDBCLSK794948.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-281.
UniPathwayUPA00035; UER00040.

Family and domain databases

Gene3D3.60.120.10. 1 hit.
InterProIPR005801. ADC_synthase.
IPR019999. Anth_synth_I.
IPR006805. Anth_synth_I_N.
IPR015890. Chorismate-bd_C.
[Graphical view]
PfamPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view]
PRINTSPR00095. ANTSNTHASEI.
SUPFAMSSF56322. TRPE_1_chor_bd. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRPE_THEMA
AccessionPrimary (citable) accession number: Q08653
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: May 30, 2000
Last modified: May 1, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families