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Protein

Retinol-binding protein 2

Gene

Rbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Intracellular transport of retinol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411Retinoic acidBy similarity
Binding sitei109 – 1091Retinoic acidBy similarity

GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinoid binding Source: MGI
  • retinol binding Source: UniProtKB-KW
  • transporter activity Source: InterPro

GO - Biological processi

  • retinoid metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Retinol-binding, Vitamin A

Enzyme and pathway databases

ReactomeiREACT_295031. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 2
Alternative name(s):
Cellular retinol-binding protein II
Short name:
CRBP-II
Gene namesi
Name:Rbp2
Synonyms:Crbpii
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97877. Rbp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 134133Retinol-binding protein 2PRO_0000067396Add
BLAST

Proteomic databases

MaxQBiQ08652.
PRIDEiQ08652.

PTM databases

PhosphoSiteiQ08652.

Expressioni

Tissue specificityi

Expressed in prenatal liver, intestine and lung, and in adult intestine.

Gene expression databases

BgeeiQ08652.
CleanExiMM_RBP2.
ExpressionAtlasiQ08652. baseline and differential.
GenevisibleiQ08652. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035029.

Structurei

3D structure databases

ProteinModelPortaliQ08652.
SMRiQ08652. Positions 1-134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG284832.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004831.
HOVERGENiHBG005633.
InParanoidiQ08652.
KOiK14622.
OMAiQNGTWEM.
OrthoDBiEOG7NW6BZ.
PhylomeDBiQ08652.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08652-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKDQNGTWE MESNENFEGY MKALDIDFAT RKIAVRLTQT KIITQDGDNF
60 70 80 90 100
KTKTNSTFRN YDLDFTVGVE FDEHTKGLDG RHVKTLVTWE GNTLVCVQKG
110 120 130
EKENRGWKQW VEGDKLYLEL TCGDQVCRQV FKKK
Length:134
Mass (Da):15,610
Last modified:January 23, 2007 - v2
Checksum:i6B29171BA6A7AB63
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti98 – 981Q → H in BAB22708 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74154 mRNA. Translation: CAA52268.1.
AK003312 mRNA. Translation: BAB22708.1.
CCDSiCCDS23425.1.
PIRiI48311. S34717.
RefSeqiNP_033060.3. NM_009034.4.
UniGeneiMm.12825.

Genome annotation databases

EnsembliENSMUST00000035029; ENSMUSP00000035029; ENSMUSG00000032454.
ENSMUST00000187905; ENSMUSP00000140630; ENSMUSG00000032454.
ENSMUST00000189446; ENSMUSP00000140676; ENSMUSG00000032454.
GeneIDi19660.
KEGGimmu:19660.
UCSCiuc009rdk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74154 mRNA. Translation: CAA52268.1.
AK003312 mRNA. Translation: BAB22708.1.
CCDSiCCDS23425.1.
PIRiI48311. S34717.
RefSeqiNP_033060.3. NM_009034.4.
UniGeneiMm.12825.

3D structure databases

ProteinModelPortaliQ08652.
SMRiQ08652. Positions 1-134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035029.

PTM databases

PhosphoSiteiQ08652.

Proteomic databases

MaxQBiQ08652.
PRIDEiQ08652.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035029; ENSMUSP00000035029; ENSMUSG00000032454.
ENSMUST00000187905; ENSMUSP00000140630; ENSMUSG00000032454.
ENSMUST00000189446; ENSMUSP00000140676; ENSMUSG00000032454.
GeneIDi19660.
KEGGimmu:19660.
UCSCiuc009rdk.2. mouse.

Organism-specific databases

CTDi5948.
MGIiMGI:97877. Rbp2.

Phylogenomic databases

eggNOGiNOG284832.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004831.
HOVERGENiHBG005633.
InParanoidiQ08652.
KOiK14622.
OMAiQNGTWEM.
OrthoDBiEOG7NW6BZ.
PhylomeDBiQ08652.
TreeFamiTF316894.

Enzyme and pathway databases

ReactomeiREACT_295031. Retinoid metabolism and transport.

Miscellaneous databases

NextBioi296946.
PROiQ08652.
SOURCEiSearch...

Gene expression databases

BgeeiQ08652.
CleanExiMM_RBP2.
ExpressionAtlasiQ08652. baseline and differential.
GenevisibleiQ08652. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The directly repeated RG(G/T)TCA motifs of the rat and mouse cellular retinol-binding protein II genes are promiscuous binding sites for RAR, RXR, HNF-4, and ARP-1 homo- and heterodimers."
    Nakshatri H., Chambon P.
    J. Biol. Chem. 269:890-902(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.

Entry informationi

Entry nameiRET2_MOUSE
AccessioniPrimary (citable) accession number: Q08652
Secondary accession number(s): Q9D1N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.