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Q08652

- RET2_MOUSE

UniProt

Q08652 - RET2_MOUSE

Protein

Retinol-binding protein 2

Gene

Rbp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Intracellular transport of retinol.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei41 – 411Retinoic acidBy similarity
    Binding sitei109 – 1091Retinoic acidBy similarity

    GO - Molecular functioni

    1. retinal binding Source: UniProtKB-KW
    2. retinoid binding Source: MGI
    3. retinol binding Source: UniProtKB-KW
    4. transporter activity Source: InterPro

    GO - Biological processi

    1. retinoid metabolic process Source: MGI

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Retinol-binding, Vitamin A

    Enzyme and pathway databases

    ReactomeiREACT_198569. Retinoid metabolism and transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinol-binding protein 2
    Alternative name(s):
    Cellular retinol-binding protein II
    Short name:
    CRBP-II
    Gene namesi
    Name:Rbp2
    Synonyms:Crbpii
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:97877. Rbp2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. Golgi apparatus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 134133Retinol-binding protein 2PRO_0000067396Add
    BLAST

    Proteomic databases

    MaxQBiQ08652.
    PRIDEiQ08652.

    PTM databases

    PhosphoSiteiQ08652.

    Expressioni

    Tissue specificityi

    Expressed in prenatal liver, intestine and lung, and in adult intestine.

    Gene expression databases

    ArrayExpressiQ08652.
    BgeeiQ08652.
    CleanExiMM_RBP2.
    GenevestigatoriQ08652.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08652.
    SMRiQ08652. Positions 1-134.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG284832.
    GeneTreeiENSGT00750000117564.
    HOGENOMiHOG000004831.
    HOVERGENiHBG005633.
    InParanoidiQ08652.
    KOiK14622.
    OMAiQTKIIDQ.
    OrthoDBiEOG7NW6BZ.
    PhylomeDBiQ08652.
    TreeFamiTF316894.

    Family and domain databases

    Gene3Di2.40.128.20. 1 hit.
    InterProiIPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000463. Fatty_acid-bd.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view]
    PfamiPF00061. Lipocalin. 1 hit.
    [Graphical view]
    PRINTSiPR00178. FATTYACIDBP.
    SUPFAMiSSF50814. SSF50814. 1 hit.
    PROSITEiPS00214. FABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q08652-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKDQNGTWE MESNENFEGY MKALDIDFAT RKIAVRLTQT KIITQDGDNF    50
    KTKTNSTFRN YDLDFTVGVE FDEHTKGLDG RHVKTLVTWE GNTLVCVQKG 100
    EKENRGWKQW VEGDKLYLEL TCGDQVCRQV FKKK 134
    Length:134
    Mass (Da):15,610
    Last modified:January 23, 2007 - v2
    Checksum:i6B29171BA6A7AB63
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti98 – 981Q → H in BAB22708. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74154 mRNA. Translation: CAA52268.1.
    AK003312 mRNA. Translation: BAB22708.1.
    CCDSiCCDS23425.1.
    PIRiI48311. S34717.
    RefSeqiNP_033060.3. NM_009034.4.
    UniGeneiMm.12825.

    Genome annotation databases

    EnsembliENSMUST00000035029; ENSMUSP00000035029; ENSMUSG00000032454.
    GeneIDi19660.
    KEGGimmu:19660.
    UCSCiuc009rdk.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74154 mRNA. Translation: CAA52268.1 .
    AK003312 mRNA. Translation: BAB22708.1 .
    CCDSi CCDS23425.1.
    PIRi I48311. S34717.
    RefSeqi NP_033060.3. NM_009034.4.
    UniGenei Mm.12825.

    3D structure databases

    ProteinModelPortali Q08652.
    SMRi Q08652. Positions 1-134.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q08652.

    Proteomic databases

    MaxQBi Q08652.
    PRIDEi Q08652.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035029 ; ENSMUSP00000035029 ; ENSMUSG00000032454 .
    GeneIDi 19660.
    KEGGi mmu:19660.
    UCSCi uc009rdk.2. mouse.

    Organism-specific databases

    CTDi 5948.
    MGIi MGI:97877. Rbp2.

    Phylogenomic databases

    eggNOGi NOG284832.
    GeneTreei ENSGT00750000117564.
    HOGENOMi HOG000004831.
    HOVERGENi HBG005633.
    InParanoidi Q08652.
    KOi K14622.
    OMAi QTKIIDQ.
    OrthoDBi EOG7NW6BZ.
    PhylomeDBi Q08652.
    TreeFami TF316894.

    Enzyme and pathway databases

    Reactomei REACT_198569. Retinoid metabolism and transport.

    Miscellaneous databases

    NextBioi 296946.
    PROi Q08652.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q08652.
    Bgeei Q08652.
    CleanExi MM_RBP2.
    Genevestigatori Q08652.

    Family and domain databases

    Gene3Di 2.40.128.20. 1 hit.
    InterProi IPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000463. Fatty_acid-bd.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view ]
    Pfami PF00061. Lipocalin. 1 hit.
    [Graphical view ]
    PRINTSi PR00178. FATTYACIDBP.
    SUPFAMi SSF50814. SSF50814. 1 hit.
    PROSITEi PS00214. FABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The directly repeated RG(G/T)TCA motifs of the rat and mouse cellular retinol-binding protein II genes are promiscuous binding sites for RAR, RXR, HNF-4, and ARP-1 homo- and heterodimers."
      Nakshatri H., Chambon P.
      J. Biol. Chem. 269:890-902(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Intestine.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.

    Entry informationi

    Entry nameiRET2_MOUSE
    AccessioniPrimary (citable) accession number: Q08652
    Secondary accession number(s): Q9D1N1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3