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Protein

Probable oxidoreductase ENV9

Gene

ENV9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable dehydrogenase required for replication of Brome mosaic virus. Involved in vacuolar processing and morphology.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei173SubstrateBy similarity1
Active sitei202Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi47 – 53NAD or NADPBy similarity7

GO - Molecular functioni

  • oxidoreductase activity Source: SGD

GO - Biological processi

  • vacuolar protein processing Source: SGD
  • vacuole organization Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciYEAST:G3O-33739-MONOMER.
ReactomeiR-SCE-2453902. The canonical retinoid cycle in rods (twilight vision).
R-SCE-5365859. RA biosynthesis pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable oxidoreductase ENV9 (EC:1.1.1.-)
Alternative name(s):
Late endosome and vacuole interface protein 9
Gene namesi
Name:ENV9
Ordered Locus Names:YOR246C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR246C.
SGDiS000005772. ENV9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • lipid particle Source: UniProtKB-SubCell
  • mitochondrion Source: SGD
  • vacuole Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Lipid droplet, Membrane

Pathology & Biotechi

Disruption phenotypei

Exhibits lumenal vesicles within vacuoles suggestive of vacuole fusion/fission defects. Leads to internal accumulation of precursor CPY.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002452561 – 330Probable oxidoreductase ENV9Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi282N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ08651.
PRIDEiQ08651.

Interactioni

Protein-protein interaction databases

BioGridi34637. 83 interactors.
DIPiDIP-5387N.
MINTiMINT-506778.

Structurei

3D structure databases

ProteinModelPortaliQ08651.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119068.
InParanoidiQ08651.
OrthoDBiEOG092C4YUU.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 2 hits.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDPRILPYY DPAVERKIAV VTGGNTGIGW YTVLHLYLHG FVVYICGRNS
60 70 80 90 100
HKISKAIQEI LAEAKKRCHE DDDGSSPGAG PGPSIQRLGS LHYIHLDLTD
110 120 130 140 150
LKCVERAALK ILKLEDHIDV LVNNAGIMAV PLEMTKDGFE VQLQTNYISH
160 170 180 190 200
FIFTMRLLPL LRHCRGRIIS LSSIGHHLEF MYWKLSKTWD YKPNMLFTWF
210 220 230 240 250
RYAMSKTALI QCTKMLAIKY PDVLCLSVHP GLVMNTNLFS YWTRLPIVGI
260 270 280 290 300
FFWLLFQVVG FFFGVSNEQG SLASLKCALD PNLSVEKDNG KYFTTGGKES
310 320 330
KSSYVSNNVD EAASTWIWTV HQLRDRGFDI
Length:330
Mass (Da):37,485
Last modified:November 1, 1996 - v1
Checksum:i7556FC07BB4F6F0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75154 Genomic DNA. Translation: CAA99467.1.
BK006948 Genomic DNA. Translation: DAA11014.1.
PIRiS67139.
RefSeqiNP_014889.3. NM_001183665.3.

Genome annotation databases

EnsemblFungiiYOR246C; YOR246C; YOR246C.
GeneIDi854420.
KEGGisce:YOR246C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75154 Genomic DNA. Translation: CAA99467.1.
BK006948 Genomic DNA. Translation: DAA11014.1.
PIRiS67139.
RefSeqiNP_014889.3. NM_001183665.3.

3D structure databases

ProteinModelPortaliQ08651.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34637. 83 interactors.
DIPiDIP-5387N.
MINTiMINT-506778.

Proteomic databases

MaxQBiQ08651.
PRIDEiQ08651.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR246C; YOR246C; YOR246C.
GeneIDi854420.
KEGGisce:YOR246C.

Organism-specific databases

EuPathDBiFungiDB:YOR246C.
SGDiS000005772. ENV9.

Phylogenomic databases

GeneTreeiENSGT00760000119068.
InParanoidiQ08651.
OrthoDBiEOG092C4YUU.

Enzyme and pathway databases

BioCyciYEAST:G3O-33739-MONOMER.
ReactomeiR-SCE-2453902. The canonical retinoid cycle in rods (twilight vision).
R-SCE-5365859. RA biosynthesis pathway.

Miscellaneous databases

PROiQ08651.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 2 hits.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiENV9_YEAST
AccessioniPrimary (citable) accession number: Q08651
Secondary accession number(s): D6W2U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 892 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.