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Q08642

- PADI2_MOUSE

UniProt

Q08642 - PADI2_MOUSE

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Protein

Protein-arginine deiminase type-2

Gene

Padi2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the deimination of arginine residues of proteins.

Catalytic activityi

Protein L-arginine + H2O = protein L-citrulline + NH3.

Cofactori

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein-arginine deiminase activity Source: UniProtKB-EC

GO - Biological processi

  1. chromatin-mediated maintenance of transcription Source: Ensembl
  2. histone H3-R26 citrullination Source: Ensembl
  3. intracellular estrogen receptor signaling pathway Source: Ensembl
  4. negative regulation of chemokine-mediated signaling pathway Source: Ensembl
  5. negative regulation of lymphocyte chemotaxis Source: Ensembl
  6. regulation of chromatin disassembly Source: Ensembl
  7. substantia nigra development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BRENDAi3.5.3.15. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine deiminase type-2 (EC:3.5.3.15)
Alternative name(s):
Peptidylarginine deiminase II
Protein-arginine deiminase type II
Gene namesi
Name:Padi2
Synonyms:Pdi, Pdi2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1338892. Padi2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
  3. transcriptionally active chromatin Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 673673Protein-arginine deiminase type-2PRO_0000220027Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei352 – 3521Citrulline1 Publication

Keywords - PTMi

Acetylation, Citrullination

Proteomic databases

MaxQBiQ08642.
PaxDbiQ08642.
PRIDEiQ08642.

PTM databases

PhosphoSiteiQ08642.

Expressioni

Tissue specificityi

Expressed in various tissues including muscle, uterus, spinal cord, salivary gland and pancreas.1 Publication

Developmental stagei

Expressed during the estrus cycle. Expressed during diestrus and proestrus with an eight fold decline when estrus cycle is reached.

Gene expression databases

BgeeiQ08642.
CleanExiMM_PADI2.
GenevestigatoriQ08642.

Interactioni

Protein-protein interaction databases

BioGridi202093. 1 interaction.
IntActiQ08642. 1 interaction.
MINTiMINT-4106481.

Structurei

3D structure databases

ProteinModelPortaliQ08642.
SMRiQ08642. Positions 15-673.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

eggNOGiNOG42085.
GeneTreeiENSGT00390000008680.
HOGENOMiHOG000220908.
HOVERGENiHBG053016.
InParanoidiQ08642.
KOiK01481.
OMAiCLETHVR.
OrthoDBiEOG7P5T09.
TreeFamiTF331952.

Family and domain databases

InterProiIPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
IPR016296. Protein-arginine_deiminase_sub.
[Graphical view]
PANTHERiPTHR10837. PTHR10837. 1 hit.
PfamiPF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMiSSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08642-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQPPIRENML RERTVRLQYG SRVEAVYVLG TQLWTDVYSA APAGAKTFSL
60 70 80 90 100
KHSEGVKVEV VRDGEAEEVV TNGKQRWALS PSSTLRLSMA QASTEASSDK
110 120 130 140 150
VTVNYYEEEG SAPIDQAGLF LTAIEISLDV DADRDGEVEK NNPKKASWTW
160 170 180 190 200
GPEGQGAILL VNCDRDTPWL PKEDCSDEKV YSKQDLQDMS QMILRTKGPD
210 220 230 240 250
RLPAGYEIVL YISMSDSDKV GVFYVENPFF GQRYIHILGR QKLYHVVKYT
260 270 280 290 300
GGSAELLFFV EGLCFPDESF SGLVSIHVSL LEYMAEGIPL TPIFTDTVMF
310 320 330 340 350
RIAPWIMTPN ILPPVSVFVC CMKDNYLFLK EVKNLVEKTN CELKVCFQYM
360 370 380 390 400
NRGDRWIQDE IEFGYIEAPH KGFPVVLDSP RDGNLKDFPI KQLLGPDFGY
410 420 430 440 450
VTREPLFETV TSLDSFGNLE VSPPVTVNGK EYPLGRILIG SSFPLSGGRR
460 470 480 490 500
MTKVVRDFLQ AQQVQAPVEL YSDWLTVGHV DEFMTFIPIP GKKEFRLLMA
510 520 530 540 550
STSACYQLFR EKQKAGHGEA VMFKGLGGMS SKRITINKIL SNESLTQENQ
560 570 580 590 600
YFQRCLDWNR DILKRELALT EKDIIDLPAL FKMDENHQAR AFFPNMVNMI
610 620 630 640 650
VLDKDLGIPK PFGPQVEEEC CLETHVRGLL EPLGLACTFI DDISAYHKFL
660 670
GEVHCGTNVR RKPFTFKWWH MVP
Length:673
Mass (Da):76,250
Last modified:July 27, 2011 - v2
Checksum:iF72A36079DA914E0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti665 – 6651T → A in BAA04012. (PubMed:8354274)Curated
Sequence conflicti665 – 6651T → A in AAH40350. (PubMed:15489334)Curated
Sequence conflicti665 – 6651T → A in AAH49947. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16580 mRNA. Translation: BAA04012.1.
AB121692 Genomic DNA. Translation: BAD16624.1.
AL645625, AL807805 Genomic DNA. Translation: CAM16760.1.
AL807805, AL645625 Genomic DNA. Translation: CAM25735.1.
BC040350 mRNA. Translation: AAH40350.1.
BC049947 mRNA. Translation: AAH49947.1.
CCDSiCCDS18857.1.
PIRiS35038. DIMSR1.
RefSeqiNP_032838.2. NM_008812.2.
UniGeneiMm.2296.

Genome annotation databases

EnsembliENSMUST00000030765; ENSMUSP00000030765; ENSMUSG00000028927.
GeneIDi18600.
KEGGimmu:18600.
UCSCiuc008vni.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16580 mRNA. Translation: BAA04012.1 .
AB121692 Genomic DNA. Translation: BAD16624.1 .
AL645625 , AL807805 Genomic DNA. Translation: CAM16760.1 .
AL807805 , AL645625 Genomic DNA. Translation: CAM25735.1 .
BC040350 mRNA. Translation: AAH40350.1 .
BC049947 mRNA. Translation: AAH49947.1 .
CCDSi CCDS18857.1.
PIRi S35038. DIMSR1.
RefSeqi NP_032838.2. NM_008812.2.
UniGenei Mm.2296.

3D structure databases

ProteinModelPortali Q08642.
SMRi Q08642. Positions 15-673.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202093. 1 interaction.
IntActi Q08642. 1 interaction.
MINTi MINT-4106481.

Chemistry

ChEMBLi CHEMBL2321611.

PTM databases

PhosphoSitei Q08642.

Proteomic databases

MaxQBi Q08642.
PaxDbi Q08642.
PRIDEi Q08642.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030765 ; ENSMUSP00000030765 ; ENSMUSG00000028927 .
GeneIDi 18600.
KEGGi mmu:18600.
UCSCi uc008vni.2. mouse.

Organism-specific databases

CTDi 11240.
MGIi MGI:1338892. Padi2.

Phylogenomic databases

eggNOGi NOG42085.
GeneTreei ENSGT00390000008680.
HOGENOMi HOG000220908.
HOVERGENi HBG053016.
InParanoidi Q08642.
KOi K01481.
OMAi CLETHVR.
OrthoDBi EOG7P5T09.
TreeFami TF331952.

Enzyme and pathway databases

BRENDAi 3.5.3.15. 3474.

Miscellaneous databases

NextBioi 294502.
PROi Q08642.
SOURCEi Search...

Gene expression databases

Bgeei Q08642.
CleanExi MM_PADI2.
Genevestigatori Q08642.

Family and domain databases

InterProi IPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
IPR016296. Protein-arginine_deiminase_sub.
[Graphical view ]
PANTHERi PTHR10837. PTHR10837. 1 hit.
Pfami PF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMi SSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA nucleotide sequence and primary structure of mouse uterine peptidylarginine deiminase. Detection of a 3'-untranslated nucleotide sequence common to the mRNA of transiently expressed genes and rapid turnover of this enzyme's mRNA in the estrous cycle."
    Tsuchida M., Takahara H., Minami N., Arai T., Kobayashi Y., Tsujimoto H., Fukazawa C., Sugawara K.
    Eur. J. Biochem. 215:677-685(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ACETYLATION AT MET-1, CITRULLINATION AT ARG-352, PARTIAL PROTEIN SEQUENCE.
  2. "Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6."
    Chavanas S., Mechin M.-C., Takahara H., Kawada A., Nachat R., Serre G., Simon M.
    Gene 330:19-27(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland and Salivary gland.
  5. "Three types of mouse peptidylarginine deiminase: characterization and tissue distribution."
    Terakawa H., Takahara H., Sugawara K.
    J. Biochem. 110:661-666(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiPADI2_MOUSE
AccessioniPrimary (citable) accession number: Q08642
Secondary accession number(s): Q75WD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3