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Protein

Transcription factor Dp-1

Gene

Tfdp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi113 – 195Sequence analysisAdd BLAST83

GO - Molecular functioni

GO - Biological processi

  • anoikis Source: MGI
  • cell cycle Source: UniProtKB-KW
  • epidermis development Source: MGI
  • negative regulation of fat cell proliferation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of DNA biosynthetic process Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • transcription by RNA polymerase II Source: GOC

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-1538133 G0 and Early G1
R-MMU-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-MMU-69231 Cyclin D associated events in G1
R-MMU-8953750 Transcriptional Regulation by E2F6

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Dp-1
Alternative name(s):
DRTF1-polypeptide 1
E2F dimerization partner 1
Gene namesi
Name:Tfdp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:101934 Tfdp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194761 – 410Transcription factor Dp-1Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3N6-acetyllysineBy similarity1
Modified residuei23PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated by the BCR(KBTBD5) complex, leading to its subsequent degradation.1 Publication
Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ08639
PaxDbiQ08639
PeptideAtlasiQ08639
PRIDEiQ08639

PTM databases

iPTMnetiQ08639
PhosphoSitePlusiQ08639

Expressioni

Developmental stagei

In the intestinal epithelium, first expressed in undifferentiated and mesenchymal tissues, levels increasing by 12.5 dpc in the epithelial compartment. With epithelial differentiation at 15.5 dpc, Its expression increases substantially in the intervillus epithelium with lower levels in the mesenchyme. At later stages, expression continues in the intervillus epithelium. Also found at lower levels in the developing villi. In the developing brain, highest levels found between 11.5 and 13.5 dpc in the ventricular region. In the developing retina, it is expressed both in retinoblast and ganglion cell layers from 14.5 dpc to 6 days after birth. In other developing tissues, its expression is highest in the thymus. Also present in kidney, lung, liver, heart and chondrocytes. Weakly expressed in skeletal muscle and absent from choroid plexus.2 Publications

Gene expression databases

BgeeiENSMUSG00000038482
CleanExiMM_TFDP1
ExpressionAtlasiQ08639 baseline and differential
GenevisibleiQ08639 MM

Interactioni

Subunit structurei

Component of the E2F:DP transcription factor complex. Forms heterodimers with E2F family members. The complex can interact with hypophosphorylated retinoblastoma protein RB1 and related proteins (RBL1 and RBL2) that inhibit the E2F transactivation domain. This repression involves recruitment of histone deacetylase (HDAC). During the cell cycle, from mid-to-late G1 phase, RB family members become phosphorylated, detach from the DRTF1/E2F complex to render E2F transcriptionally active. Part of the E2F6.com-1 complex in G0 phase is composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 YAF2. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. The complex TFDP1:E2F1 interacts with CEBPA; the interaction prevents CEBPA binding to target gene promoters and represses its transcriptional activity (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Dvl1P511413EBI-1216575,EBI-1538407

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204138, 7 interactors
CORUMiQ08639
DIPiDIP-724N
IntActiQ08639, 8 interactors
MINTiQ08639
STRINGi10090.ENSMUSP00000127952

Structurei

3D structure databases

ProteinModelPortaliQ08639
SMRiQ08639
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni105 – 127Interaction with CEBPABy similarityAdd BLAST23
Regioni204 – 277DimerizationSequence analysisAdd BLAST74
Regioni211 – 327Enhances binding of RB protein to E2FBy similarityAdd BLAST117
Regioni214 – 246DCB1Add BLAST33
Regioni259 – 315DCB2Add BLAST57

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi161 – 195DEF boxAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi250 – 253Poly-Pro4
Compositional biasi395 – 410Asp/Glu-rich (acidic; NCB domain)Add BLAST16

Sequence similaritiesi

Belongs to the E2F/DP family.Curated

Phylogenomic databases

eggNOGiKOG2829 Eukaryota
ENOG410Y9QP LUCA
GeneTreeiENSGT00390000018222
HOGENOMiHOG000030696
HOVERGENiHBG009894
InParanoidiQ08639
KOiK04683
OMAiHPSTVNT
OrthoDBiEOG091G0AVY
PhylomeDBiQ08639
TreeFamiTF314396

Family and domain databases

CDDicd14458 DP_DD, 1 hit
Gene3Di1.10.10.10, 1 hit
1.20.140.80, 1 hit
InterProiView protein in InterPro
IPR028313 DP-1
IPR037241 E2F-DP_heterodim
IPR003316 E2F_WHTH_DNA-bd_dom
IPR038168 TF_DP_C_sf
IPR014889 Transc_factor_DP_C
IPR015648 Transcrpt_fac_DP
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12548 PTHR12548, 1 hit
PTHR12548:SF4 PTHR12548:SF4, 1 hit
PfamiView protein in Pfam
PF08781 DP, 1 hit
PF02319 E2F_TDP, 1 hit
PIRSFiPIRSF009404 Transcription_factor_DP, 1 hit
SMARTiView protein in SMART
SM01138 DP, 1 hit
SM01372 E2F_TDP, 1 hit
SUPFAMiSSF144074 SSF144074, 1 hit
SSF46785 SSF46785, 1 hit

Sequencei

Sequence statusi: Complete.

Q08639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDASLIEA NGELKVFIDQ NLSPGKGVVS LVAVHPSTVN TLGKQLLPKT
60 70 80 90 100
FGQSNVNITQ QVVIGTPQRP AASNTIVVGS PHTPNTHFVS QNQTSDSSPW
110 120 130 140 150
SAGKRNRKGE KNGKGLRHFS MKVCEKVQRK GTTSYNEVAD ELVAEFSAAD
160 170 180 190 200
NHILPNESAY DQKNIRRRVY DALNVLMAMN IISKEKKEIK WIGLPTNSAQ
210 220 230 240 250
ECQNLEVERQ RRLERIKQKQ SQLQELILQQ IAFKNLVQRN RQAEQQARRP
260 270 280 290 300
PPPNSVIHLP FIIVNTSRKT VIDCSISNDK FEYLFNFDNT FEIHDDIEVL
310 320 330 340 350
KRMGMACGLE SGNCSAEDLK VARSLVPKAL EPYVTEMAQG SIGGVFVTTT
360 370 380 390 400
GSTSNGTRLS ASDLSNGADG MLATSSNGSQ YSGSRVETPV SYVGEDDDDD
410
DDFNENDEED
Length:410
Mass (Da):45,231
Last modified:November 1, 1996 - v1
Checksum:iFEEA090C781071B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72310 mRNA Translation: CAA51056.1
CCDSiCCDS22110.1
PIRiB48585
RefSeqiNP_001278694.1, NM_001291765.1
NP_033387.1, NM_009361.3
XP_006508814.1, XM_006508751.3
UniGeneiMm.925

Genome annotation databases

EnsembliENSMUST00000170909; ENSMUSP00000127952; ENSMUSG00000038482
ENSMUST00000209885; ENSMUSP00000147881; ENSMUSG00000038482
GeneIDi21781
KEGGimmu:21781
UCSCiuc009kxp.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTFDP1_MOUSE
AccessioniPrimary (citable) accession number: Q08639
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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