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Q08638

- BGLA_THEMA

UniProt

Q08638 - BGLA_THEMA

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Protein

Beta-glucosidase A

Gene

bglA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei166 – 1661Proton donorSequence Analysis
Active sitei351 – 3511NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-glucosidase A (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase
Cellobiase
Gentiobiase
Gene namesi
Name:bglA
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Beta-glucosidase APRO_0000063879Add
BLAST

Structurei

Secondary structure

1
446
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi11 – 155Combined sources
Helixi18 – 214Combined sources
Helixi27 – 293Combined sources
Helixi34 – 396Combined sources
Helixi46 – 483Combined sources
Beta strandi51 – 533Combined sources
Helixi57 – 7014Combined sources
Beta strandi75 – 795Combined sources
Helixi82 – 854Combined sources
Beta strandi89 – 913Combined sources
Helixi95 – 11016Combined sources
Beta strandi114 – 1229Combined sources
Helixi126 – 1294Combined sources
Turni130 – 1323Combined sources
Helixi133 – 1353Combined sources
Helixi139 – 15416Combined sources
Turni155 – 1573Combined sources
Beta strandi160 – 1656Combined sources
Helixi167 – 1759Combined sources
Helixi187 – 21125Combined sources
Beta strandi216 – 23116Combined sources
Helixi233 – 24614Combined sources
Helixi249 – 2579Combined sources
Helixi262 – 2687Combined sources
Helixi269 – 2713Combined sources
Helixi276 – 2794Combined sources
Helixi280 – 2834Combined sources
Beta strandi288 – 30215Combined sources
Helixi307 – 3093Combined sources
Beta strandi310 – 3134Combined sources
Helixi329 – 34214Combined sources
Beta strandi347 – 3526Combined sources
Helixi369 – 38719Combined sources
Beta strandi392 – 3987Combined sources
Helixi406 – 4116Combined sources
Beta strandi416 – 4194Combined sources
Turni421 – 4233Combined sources
Beta strandi426 – 4283Combined sources
Helixi430 – 44112Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OD0X-ray2.11A/B2-446[»]
1OIFX-ray2.12A/B2-446[»]
1OIMX-ray2.15A/B2-446[»]
1OINX-ray2.15A/B2-446[»]
1UZ1X-ray2.00A/B2-446[»]
1W3JX-ray2.00A/B2-446[»]
2CBUX-ray1.85A/B2-446[»]
2CBVX-ray1.95A/B2-446[»]
2CESX-ray2.15A/B2-446[»]
2CETX-ray1.97A/B2-446[»]
2J75X-ray1.85A/B2-446[»]
2J77X-ray2.10A/B2-446[»]
2J78X-ray1.65A/B2-446[»]
2J79X-ray1.94A/B2-446[»]
2J7BX-ray1.87A/B2-446[»]
2J7CX-ray2.09A/B2-446[»]
2J7DX-ray2.24A/B2-446[»]
2J7EX-ray2.19A/B2-446[»]
2J7FX-ray2.28A/B2-446[»]
2J7GX-ray1.91A/B2-446[»]
2J7HX-ray1.95A/B2-446[»]
2JALX-ray1.90A/B2-446[»]
2VRJX-ray1.90A/B2-446[»]
2WBGX-ray1.85A/B/C/D2-446[»]
2WC3X-ray2.00A/B/C/D2-446[»]
2WC4X-ray1.70A/B/C/D2-446[»]
4GXPX-ray3.00A/B/C1-446[»]
ProteinModelPortaliQ08638.
SMRiQ08638. Positions 2-445.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08638.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.Curated

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR017736. Glyco_hydro_1_beta-glucosidase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR03356. BGL. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08638-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNVKKFPEGF LWGVATASYQ IEGSPLADGA GMSIWHTFSH TPGNVKNGDT
60 70 80 90 100
GDVACDHYNR WKEDIEIIEK LGVKAYRFSI SWPRILPEGT GRVNQKGLDF
110 120 130 140 150
YNRIIDTLLE KGITPFVTIY HWDLPFALQL KGGWANREIA DWFAEYSRVL
160 170 180 190 200
FENFGDRVKN WITLNEPWVV AIVGHLYGVH APGMRDIYVA FRAVHNLLRA
210 220 230 240 250
HARAVKVFRE TVKDGKIGIV FNNGYFEPAS EKEEDIRAVR FMHQFNNYPL
260 270 280 290 300
FLNPIYRGDY PELVLEFARE YLPENYKDDM SEIQEKIDFV GLNYYSGHLV
310 320 330 340 350
KFDPDAPAKV SFVERDLPKT AMGWEIVPEG IYWILKKVKE EYNPPEVYIT
360 370 380 390 400
ENGAAFDDVV SEDGRVHDQN RIDYLKAHIG QAWKAIQEGV PLKGYFVWSL
410 420 430 440
LDNFEWAEGY SKRFGIVYVD YSTQKRIVKD SGYWYSNVVK NNGLED
Length:446
Mass (Da):51,548
Last modified:October 1, 1994 - v1
Checksum:i2E5B06E72BF84C01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74163 Genomic DNA. Translation: CAA52276.1.
PIRiS41561. S34570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74163 Genomic DNA. Translation: CAA52276.1 .
PIRi S41561. S34570.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OD0 X-ray 2.11 A/B 2-446 [» ]
1OIF X-ray 2.12 A/B 2-446 [» ]
1OIM X-ray 2.15 A/B 2-446 [» ]
1OIN X-ray 2.15 A/B 2-446 [» ]
1UZ1 X-ray 2.00 A/B 2-446 [» ]
1W3J X-ray 2.00 A/B 2-446 [» ]
2CBU X-ray 1.85 A/B 2-446 [» ]
2CBV X-ray 1.95 A/B 2-446 [» ]
2CES X-ray 2.15 A/B 2-446 [» ]
2CET X-ray 1.97 A/B 2-446 [» ]
2J75 X-ray 1.85 A/B 2-446 [» ]
2J77 X-ray 2.10 A/B 2-446 [» ]
2J78 X-ray 1.65 A/B 2-446 [» ]
2J79 X-ray 1.94 A/B 2-446 [» ]
2J7B X-ray 1.87 A/B 2-446 [» ]
2J7C X-ray 2.09 A/B 2-446 [» ]
2J7D X-ray 2.24 A/B 2-446 [» ]
2J7E X-ray 2.19 A/B 2-446 [» ]
2J7F X-ray 2.28 A/B 2-446 [» ]
2J7G X-ray 1.91 A/B 2-446 [» ]
2J7H X-ray 1.95 A/B 2-446 [» ]
2JAL X-ray 1.90 A/B 2-446 [» ]
2VRJ X-ray 1.90 A/B 2-446 [» ]
2WBG X-ray 1.85 A/B/C/D 2-446 [» ]
2WC3 X-ray 2.00 A/B/C/D 2-446 [» ]
2WC4 X-ray 1.70 A/B/C/D 2-446 [» ]
4GXP X-ray 3.00 A/B/C 1-446 [» ]
ProteinModelPortali Q08638.
SMRi Q08638. Positions 2-445.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00696 .

Miscellaneous databases

EvolutionaryTracei Q08638.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR017736. Glyco_hydro_1_beta-glucosidase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
TIGRFAMsi TIGR03356. BGL. 1 hit.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative amino acid sequence analysis of Thermotoga maritima beta-glucosidase (BglA) deduced from the nucleotide sequence of the gene indicates distant relationship between beta-glucosidases of the BGA family and other families of beta-1,4-glycosyl hydrolases."
    Liebl W., Gabelsberger J., Schleifer K.H.
    Mol. Gen. Genet. 242:111-115(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiBGLA_THEMA
AccessioniPrimary (citable) accession number: Q08638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 26, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

As the DNA coding for this protein is not found in the complete genome of T.maritima. It could have originated from another bacterial species.Curated

Keywords - Technical termi

3D-structure

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3