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Q08638

- BGLA_THEMA

UniProt

Q08638 - BGLA_THEMA

Protein

Beta-glucosidase A

Gene

bglA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei166 – 1661Proton donorSequence Analysis
    Active sitei351 – 3511NucleophilePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    UniPathwayiUPA00696.

    Protein family/group databases

    CAZyiGH1. Glycoside Hydrolase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-glucosidase A (EC:3.2.1.21)
    Alternative name(s):
    Beta-D-glucoside glucohydrolase
    Cellobiase
    Gentiobiase
    Gene namesi
    Name:bglA
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Beta-glucosidase APRO_0000063879Add
    BLAST

    Structurei

    Secondary structure

    1
    446
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi11 – 155
    Helixi18 – 214
    Helixi27 – 293
    Helixi34 – 396
    Helixi46 – 483
    Beta strandi51 – 533
    Helixi57 – 7014
    Beta strandi75 – 795
    Helixi82 – 854
    Beta strandi89 – 913
    Helixi95 – 11016
    Beta strandi114 – 1229
    Helixi126 – 1294
    Turni130 – 1323
    Helixi133 – 1353
    Helixi139 – 15416
    Turni155 – 1573
    Beta strandi160 – 1656
    Helixi167 – 1759
    Helixi187 – 21125
    Beta strandi216 – 23116
    Helixi233 – 24614
    Helixi249 – 2579
    Helixi262 – 2687
    Helixi269 – 2713
    Helixi276 – 2794
    Helixi280 – 2834
    Beta strandi288 – 30215
    Helixi307 – 3093
    Beta strandi310 – 3134
    Beta strandi321 – 3244
    Helixi329 – 34214
    Beta strandi347 – 3526
    Helixi369 – 38719
    Beta strandi392 – 3987
    Helixi406 – 4116
    Beta strandi416 – 4194
    Turni421 – 4233
    Beta strandi426 – 4283
    Helixi430 – 44112

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OD0X-ray2.11A/B2-446[»]
    1OIFX-ray2.12A/B2-446[»]
    1OIMX-ray2.15A/B2-446[»]
    1OINX-ray2.15A/B2-446[»]
    1UZ1X-ray2.00A/B2-446[»]
    1W3JX-ray2.00A/B2-446[»]
    2CBUX-ray1.85A/B2-446[»]
    2CBVX-ray1.95A/B2-446[»]
    2CESX-ray2.15A/B2-446[»]
    2CETX-ray1.97A/B2-446[»]
    2J75X-ray1.85A/B2-446[»]
    2J77X-ray2.10A/B2-446[»]
    2J78X-ray1.65A/B2-446[»]
    2J79X-ray1.94A/B2-446[»]
    2J7BX-ray1.87A/B2-446[»]
    2J7CX-ray2.09A/B2-446[»]
    2J7DX-ray2.24A/B2-446[»]
    2J7EX-ray2.19A/B2-446[»]
    2J7FX-ray2.28A/B2-446[»]
    2J7GX-ray1.91A/B2-446[»]
    2J7HX-ray1.95A/B2-446[»]
    2JALX-ray1.90A/B2-446[»]
    2VRJX-ray1.90A/B2-446[»]
    2WBGX-ray1.85A/B/C/D2-446[»]
    2WC3X-ray2.00A/B/C/D2-446[»]
    2WC4X-ray1.70A/B/C/D2-446[»]
    4GXPX-ray3.00A/B/C1-446[»]
    ProteinModelPortaliQ08638.
    SMRiQ08638. Positions 2-445.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ08638.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 1 family.Curated

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR017736. Glyco_hydro_1_beta-glucosidase.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10353. PTHR10353. 1 hit.
    PfamiPF00232. Glyco_hydro_1. 1 hit.
    [Graphical view]
    PRINTSiPR00131. GLHYDRLASE1.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    TIGRFAMsiTIGR03356. BGL. 1 hit.
    PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q08638-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNVKKFPEGF LWGVATASYQ IEGSPLADGA GMSIWHTFSH TPGNVKNGDT    50
    GDVACDHYNR WKEDIEIIEK LGVKAYRFSI SWPRILPEGT GRVNQKGLDF 100
    YNRIIDTLLE KGITPFVTIY HWDLPFALQL KGGWANREIA DWFAEYSRVL 150
    FENFGDRVKN WITLNEPWVV AIVGHLYGVH APGMRDIYVA FRAVHNLLRA 200
    HARAVKVFRE TVKDGKIGIV FNNGYFEPAS EKEEDIRAVR FMHQFNNYPL 250
    FLNPIYRGDY PELVLEFARE YLPENYKDDM SEIQEKIDFV GLNYYSGHLV 300
    KFDPDAPAKV SFVERDLPKT AMGWEIVPEG IYWILKKVKE EYNPPEVYIT 350
    ENGAAFDDVV SEDGRVHDQN RIDYLKAHIG QAWKAIQEGV PLKGYFVWSL 400
    LDNFEWAEGY SKRFGIVYVD YSTQKRIVKD SGYWYSNVVK NNGLED 446
    Length:446
    Mass (Da):51,548
    Last modified:October 1, 1994 - v1
    Checksum:i2E5B06E72BF84C01
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74163 Genomic DNA. Translation: CAA52276.1.
    PIRiS41561. S34570.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74163 Genomic DNA. Translation: CAA52276.1 .
    PIRi S41561. S34570.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OD0 X-ray 2.11 A/B 2-446 [» ]
    1OIF X-ray 2.12 A/B 2-446 [» ]
    1OIM X-ray 2.15 A/B 2-446 [» ]
    1OIN X-ray 2.15 A/B 2-446 [» ]
    1UZ1 X-ray 2.00 A/B 2-446 [» ]
    1W3J X-ray 2.00 A/B 2-446 [» ]
    2CBU X-ray 1.85 A/B 2-446 [» ]
    2CBV X-ray 1.95 A/B 2-446 [» ]
    2CES X-ray 2.15 A/B 2-446 [» ]
    2CET X-ray 1.97 A/B 2-446 [» ]
    2J75 X-ray 1.85 A/B 2-446 [» ]
    2J77 X-ray 2.10 A/B 2-446 [» ]
    2J78 X-ray 1.65 A/B 2-446 [» ]
    2J79 X-ray 1.94 A/B 2-446 [» ]
    2J7B X-ray 1.87 A/B 2-446 [» ]
    2J7C X-ray 2.09 A/B 2-446 [» ]
    2J7D X-ray 2.24 A/B 2-446 [» ]
    2J7E X-ray 2.19 A/B 2-446 [» ]
    2J7F X-ray 2.28 A/B 2-446 [» ]
    2J7G X-ray 1.91 A/B 2-446 [» ]
    2J7H X-ray 1.95 A/B 2-446 [» ]
    2JAL X-ray 1.90 A/B 2-446 [» ]
    2VRJ X-ray 1.90 A/B 2-446 [» ]
    2WBG X-ray 1.85 A/B/C/D 2-446 [» ]
    2WC3 X-ray 2.00 A/B/C/D 2-446 [» ]
    2WC4 X-ray 1.70 A/B/C/D 2-446 [» ]
    4GXP X-ray 3.00 A/B/C 1-446 [» ]
    ProteinModelPortali Q08638.
    SMRi Q08638. Positions 2-445.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH1. Glycoside Hydrolase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00696 .

    Miscellaneous databases

    EvolutionaryTracei Q08638.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR017736. Glyco_hydro_1_beta-glucosidase.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10353. PTHR10353. 1 hit.
    Pfami PF00232. Glyco_hydro_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00131. GLHYDRLASE1.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    TIGRFAMsi TIGR03356. BGL. 1 hit.
    PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative amino acid sequence analysis of Thermotoga maritima beta-glucosidase (BglA) deduced from the nucleotide sequence of the gene indicates distant relationship between beta-glucosidases of the BGA family and other families of beta-1,4-glycosyl hydrolases."
      Liebl W., Gabelsberger J., Schleifer K.H.
      Mol. Gen. Genet. 242:111-115(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

    Entry informationi

    Entry nameiBGLA_THEMA
    AccessioniPrimary (citable) accession number: Q08638
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    As the DNA coding for this protein is not found in the complete genome of T.maritima. It could have originated from another bacterial species.Curated

    Keywords - Technical termi

    3D-structure

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3