SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q08638

- BGLA_THEMA

UniProt

Q08638 - BGLA_THEMA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Beta-glucosidase A
Gene
bglA
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei166 – 1661Proton donor Reviewed prediction
Active sitei351 – 3511Nucleophile By similarity

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-glucosidase A (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase
Cellobiase
Gentiobiase
Gene namesi
Name:bglA
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Beta-glucosidase A
PRO_0000063879Add
BLAST

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi11 – 155
Helixi18 – 214
Helixi27 – 293
Helixi34 – 396
Helixi46 – 483
Beta strandi51 – 533
Helixi57 – 7014
Beta strandi75 – 795
Helixi82 – 854
Beta strandi89 – 913
Helixi95 – 11016
Beta strandi114 – 1229
Helixi126 – 1294
Turni130 – 1323
Helixi133 – 1353
Helixi139 – 15416
Turni155 – 1573
Beta strandi160 – 1656
Helixi167 – 1759
Helixi187 – 21125
Beta strandi216 – 23116
Helixi233 – 24614
Helixi249 – 2579
Helixi262 – 2687
Helixi269 – 2713
Helixi276 – 2794
Helixi280 – 2834
Beta strandi288 – 30215
Helixi307 – 3093
Beta strandi310 – 3134
Beta strandi321 – 3244
Helixi329 – 34214
Beta strandi347 – 3526
Helixi369 – 38719
Beta strandi392 – 3987
Helixi406 – 4116
Beta strandi416 – 4194
Turni421 – 4233
Beta strandi426 – 4283
Helixi430 – 44112

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OD0X-ray2.11A/B2-446[»]
1OIFX-ray2.12A/B2-446[»]
1OIMX-ray2.15A/B2-446[»]
1OINX-ray2.15A/B2-446[»]
1UZ1X-ray2.00A/B2-446[»]
1W3JX-ray2.00A/B2-446[»]
2CBUX-ray1.85A/B2-446[»]
2CBVX-ray1.95A/B2-446[»]
2CESX-ray2.15A/B2-446[»]
2CETX-ray1.97A/B2-446[»]
2J75X-ray1.85A/B2-446[»]
2J77X-ray2.10A/B2-446[»]
2J78X-ray1.65A/B2-446[»]
2J79X-ray1.94A/B2-446[»]
2J7BX-ray1.87A/B2-446[»]
2J7CX-ray2.09A/B2-446[»]
2J7DX-ray2.24A/B2-446[»]
2J7EX-ray2.19A/B2-446[»]
2J7FX-ray2.28A/B2-446[»]
2J7GX-ray1.91A/B2-446[»]
2J7HX-ray1.95A/B2-446[»]
2JALX-ray1.90A/B2-446[»]
2VRJX-ray1.90A/B2-446[»]
2WBGX-ray1.85A/B/C/D2-446[»]
2WC3X-ray2.00A/B/C/D2-446[»]
2WC4X-ray1.70A/B/C/D2-446[»]
4GXPX-ray3.00A/B/C1-446[»]
ProteinModelPortaliQ08638.
SMRiQ08638. Positions 2-445.

Miscellaneous databases

EvolutionaryTraceiQ08638.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR017736. Glyco_hydro_1_beta-glucosidase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR03356. BGL. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08638-1 [UniParc]FASTAAdd to Basket

« Hide

MNVKKFPEGF LWGVATASYQ IEGSPLADGA GMSIWHTFSH TPGNVKNGDT    50
GDVACDHYNR WKEDIEIIEK LGVKAYRFSI SWPRILPEGT GRVNQKGLDF 100
YNRIIDTLLE KGITPFVTIY HWDLPFALQL KGGWANREIA DWFAEYSRVL 150
FENFGDRVKN WITLNEPWVV AIVGHLYGVH APGMRDIYVA FRAVHNLLRA 200
HARAVKVFRE TVKDGKIGIV FNNGYFEPAS EKEEDIRAVR FMHQFNNYPL 250
FLNPIYRGDY PELVLEFARE YLPENYKDDM SEIQEKIDFV GLNYYSGHLV 300
KFDPDAPAKV SFVERDLPKT AMGWEIVPEG IYWILKKVKE EYNPPEVYIT 350
ENGAAFDDVV SEDGRVHDQN RIDYLKAHIG QAWKAIQEGV PLKGYFVWSL 400
LDNFEWAEGY SKRFGIVYVD YSTQKRIVKD SGYWYSNVVK NNGLED 446
Length:446
Mass (Da):51,548
Last modified:October 1, 1994 - v1
Checksum:i2E5B06E72BF84C01
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74163 Genomic DNA. Translation: CAA52276.1.
PIRiS41561. S34570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74163 Genomic DNA. Translation: CAA52276.1 .
PIRi S41561. S34570.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OD0 X-ray 2.11 A/B 2-446 [» ]
1OIF X-ray 2.12 A/B 2-446 [» ]
1OIM X-ray 2.15 A/B 2-446 [» ]
1OIN X-ray 2.15 A/B 2-446 [» ]
1UZ1 X-ray 2.00 A/B 2-446 [» ]
1W3J X-ray 2.00 A/B 2-446 [» ]
2CBU X-ray 1.85 A/B 2-446 [» ]
2CBV X-ray 1.95 A/B 2-446 [» ]
2CES X-ray 2.15 A/B 2-446 [» ]
2CET X-ray 1.97 A/B 2-446 [» ]
2J75 X-ray 1.85 A/B 2-446 [» ]
2J77 X-ray 2.10 A/B 2-446 [» ]
2J78 X-ray 1.65 A/B 2-446 [» ]
2J79 X-ray 1.94 A/B 2-446 [» ]
2J7B X-ray 1.87 A/B 2-446 [» ]
2J7C X-ray 2.09 A/B 2-446 [» ]
2J7D X-ray 2.24 A/B 2-446 [» ]
2J7E X-ray 2.19 A/B 2-446 [» ]
2J7F X-ray 2.28 A/B 2-446 [» ]
2J7G X-ray 1.91 A/B 2-446 [» ]
2J7H X-ray 1.95 A/B 2-446 [» ]
2JAL X-ray 1.90 A/B 2-446 [» ]
2VRJ X-ray 1.90 A/B 2-446 [» ]
2WBG X-ray 1.85 A/B/C/D 2-446 [» ]
2WC3 X-ray 2.00 A/B/C/D 2-446 [» ]
2WC4 X-ray 1.70 A/B/C/D 2-446 [» ]
4GXP X-ray 3.00 A/B/C 1-446 [» ]
ProteinModelPortali Q08638.
SMRi Q08638. Positions 2-445.
ModBasei Search...

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00696 .

Miscellaneous databases

EvolutionaryTracei Q08638.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR017736. Glyco_hydro_1_beta-glucosidase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
TIGRFAMsi TIGR03356. BGL. 1 hit.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative amino acid sequence analysis of Thermotoga maritima beta-glucosidase (BglA) deduced from the nucleotide sequence of the gene indicates distant relationship between beta-glucosidases of the BGA family and other families of beta-1,4-glycosyl hydrolases."
    Liebl W., Gabelsberger J., Schleifer K.H.
    Mol. Gen. Genet. 242:111-115(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiBGLA_THEMA
AccessioniPrimary (citable) accession number: Q08638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

As the DNA coding for this protein is not found in the complete genome of T.maritima. It could have originated from another bacterial species.

Keywords - Technical termi

3D-structure

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi