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Protein

V-type sodium ATPase subunit B

Gene

ntpB

Organism
Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in ATP-driven sodium extrusion.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14147

Protein family/group databases

TCDBi3.A.2.2.2 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type sodium ATPase subunit B
Alternative name(s):
Na(+)-translocating ATPase subunit B
V-type sodium pump subunit B
Gene namesi
Name:ntpB
Ordered Locus Names:EHR_08265
OrganismiEnterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Taxonomic identifieri768486 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000002895 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001446851 – 458V-type sodium ATPase subunit BAdd BLAST458

Proteomic databases

PRIDEiQ08637

Expressioni

Inductioni

By increasing intracellular Na+ concentration.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ntpAQ086363EBI-16032937,EBI-16032906

Protein-protein interaction databases

DIPiDIP-60126N
IntActiQ08637, 1 interactor

Structurei

Secondary structure

1458
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 12Combined sources5
Beta strandi15 – 20Combined sources6
Beta strandi29 – 33Combined sources5
Beta strandi35 – 37Combined sources3
Beta strandi39 – 56Combined sources18
Turni65 – 67Combined sources3
Beta strandi69 – 72Combined sources4
Beta strandi78 – 81Combined sources4
Helixi83 – 85Combined sources3
Beta strandi88 – 91Combined sources4
Beta strandi92 – 94Combined sources3
Beta strandi96 – 98Combined sources3
Beta strandi106 – 112Combined sources7
Turni118 – 120Combined sources3
Beta strandi127 – 129Combined sources3
Helixi133 – 136Combined sources4
Turni137 – 139Combined sources3
Beta strandi149 – 151Combined sources3
Helixi157 – 167Combined sources11
Beta strandi169 – 173Combined sources5
Beta strandi177 – 186Combined sources10
Helixi188 – 201Combined sources14
Helixi203 – 206Combined sources4
Beta strandi207 – 213Combined sources7
Helixi218 – 237Combined sources20
Beta strandi242 – 248Combined sources7
Helixi250 – 263Combined sources14
Helixi270 – 272Combined sources3
Helixi277 – 285Combined sources9
Beta strandi289 – 291Combined sources3
Beta strandi297 – 305Combined sources9
Helixi307 – 309Combined sources3
Beta strandi311 – 313Combined sources3
Helixi314 – 322Combined sources9
Beta strandi323 – 329Combined sources7
Helixi331 – 335Combined sources5
Turni344 – 346Combined sources3
Helixi352 – 354Combined sources3
Turni358 – 360Combined sources3
Helixi365 – 389Combined sources25
Helixi391 – 393Combined sources3
Helixi396 – 411Combined sources16
Helixi423 – 434Combined sources12
Turni439 – 441Combined sources3
Helixi447 – 453Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VR2X-ray2.80D/E/F1-458[»]
3VR3X-ray3.40D/E/F1-458[»]
3VR4X-ray2.17D/E/F1-458[»]
3VR5X-ray3.90D/E/F1-458[»]
3VR6X-ray2.68D/E/F1-458[»]
5KNBX-ray3.25D/E/F1-458[»]
5KNCX-ray3.02D/E/F1-458[»]
5KNDX-ray2.89D/E/F1-458[»]
ProteinModelPortaliQ08637
SMRiQ08637
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

KOiK02118
OrthoDBiPOG091H03NZ

Family and domain databases

HAMAPiMF_00310 ATP_synth_B_arch, 1 hit
InterProiView protein in InterPro
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR027417 P-loop_NTPase
IPR022879 V-ATPase_su_B/beta
PANTHERiPTHR43389 PTHR43389, 1 hit
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039114 V-ATPsynth_beta/V-ATPase_B, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Q08637-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKEYRTIKE VVGPLMAVEK VSGVKYEELI EVRMQNGEIR RGQVLEVQED
60 70 80 90 100
KAMVQIFEGT SGINLKNSSV RFLGHPLQLG VSEDMIGRVF DGLGRPKDNG
110 120 130 140 150
PEILPEKYLD INGEVINPIA RDYPDEFIQT GISAIDHLNT LVRGQKLPVF
160 170 180 190 200
SGSGLPHKEL AAQIARQATV LDSSDDFAVV FAAIGITFEE AEFFMEDFRQ
210 220 230 240 250
TGAIDRSVMF MNLANDPAIE RIATPRMALT AAEYLAYEKG MHVLVIMTDM
260 270 280 290 300
TNYAEALREI SAARREVPGR RGYPGYLYTN LATLFERAGR IRGLKGSVTQ
310 320 330 340 350
IPILTMPEDD KTHPIPDLTG YITEGQIILT RELYKSGIQP PIDVLPSLSR
360 370 380 390 400
LKDKGTGAGK TREDHAATMN QLFAAYAQGK QAKELAVVLG ESALSDIDKI
410 420 430 440 450
YAKFAERFEN EYVNQGFYTN RTITETLDLG WELLAMLPRT ELKRIKDDLL

DKYLPEGK
Length:458
Mass (Da):51,142
Last modified:November 1, 1995 - v1
Checksum:iD89D8F2F58B65262
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13816 Genomic DNA Translation: BAA02970.1
D17462 Genomic DNA Translation: BAA04276.1
CP003504 Genomic DNA Translation: AFM70580.1
PIRiB46733
RefSeqiWP_010718636.1, NZ_KB946231.1

Genome annotation databases

EnsemblBacteriaiAFM70580; AFM70580; EHR_08265
GeneIDi13177594
KEGGiehr:EHR_08265

Similar proteinsi

Entry informationi

Entry nameiNTPB_ENTHA
AccessioniPrimary (citable) accession number: Q08637
Secondary accession number(s): I6S1L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health