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Q08637

- NTPB_ENTHA

UniProt

Q08637 - NTPB_ENTHA

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Protein

V-type sodium ATPase subunit B

Gene

ntpB

Organism
Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in ATP-driven sodium extrusion.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-HAMAP

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
  2. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP
  3. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14147.

Protein family/group databases

TCDBi3.A.2.2.2. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type sodium ATPase subunit B
Alternative name(s):
Na(+)-translocating ATPase subunit B
V-type sodium pump subunit B
Gene namesi
Name:ntpB
Ordered Locus Names:EHR_08265
OrganismiEnterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Taxonomic identifieri768486 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000002895: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. proton-transporting two-sector ATPase complex, catalytic domain Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458V-type sodium ATPase subunit BPRO_0000144685Add
BLAST

Expressioni

Inductioni

By increasing intracellular Na+ concentration.

Interactioni

Protein-protein interaction databases

DIPiDIP-60126N.

Structurei

Secondary structure

1
458
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 125
Beta strandi15 – 206
Beta strandi29 – 335
Beta strandi39 – 5618
Turni65 – 673
Beta strandi69 – 724
Beta strandi78 – 814
Helixi83 – 853
Beta strandi88 – 914
Beta strandi96 – 983
Beta strandi106 – 1127
Turni118 – 1203
Beta strandi127 – 1293
Helixi133 – 1364
Turni137 – 1393
Beta strandi149 – 1513
Helixi157 – 16711
Beta strandi169 – 1735
Beta strandi177 – 18610
Helixi188 – 20114
Helixi203 – 2064
Beta strandi207 – 2137
Helixi218 – 23720
Beta strandi242 – 2487
Helixi250 – 26314
Helixi270 – 2723
Helixi277 – 2859
Beta strandi289 – 2913
Beta strandi297 – 3059
Helixi307 – 3093
Helixi314 – 3229
Beta strandi323 – 3297
Helixi331 – 3355
Turni344 – 3463
Helixi352 – 3543
Turni358 – 3603
Helixi365 – 38925
Helixi391 – 3933
Helixi396 – 41116
Helixi423 – 43412
Turni439 – 4413
Helixi447 – 4537

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VR2X-ray2.80D/E/F1-458[»]
3VR3X-ray3.40D/E/F1-458[»]
3VR4X-ray2.17D/E/F1-458[»]
3VR5X-ray3.90D/E/F1-458[»]
3VR6X-ray2.68D/E/F1-458[»]
ProteinModelPortaliQ08637.
SMRiQ08637. Positions 13-456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

KOiK02118.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00310. ATP_synth_B_arch.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR027417. P-loop_NTPase.
IPR022879. V-ATPase_su_B/beta.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08637-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKEYRTIKE VVGPLMAVEK VSGVKYEELI EVRMQNGEIR RGQVLEVQED
60 70 80 90 100
KAMVQIFEGT SGINLKNSSV RFLGHPLQLG VSEDMIGRVF DGLGRPKDNG
110 120 130 140 150
PEILPEKYLD INGEVINPIA RDYPDEFIQT GISAIDHLNT LVRGQKLPVF
160 170 180 190 200
SGSGLPHKEL AAQIARQATV LDSSDDFAVV FAAIGITFEE AEFFMEDFRQ
210 220 230 240 250
TGAIDRSVMF MNLANDPAIE RIATPRMALT AAEYLAYEKG MHVLVIMTDM
260 270 280 290 300
TNYAEALREI SAARREVPGR RGYPGYLYTN LATLFERAGR IRGLKGSVTQ
310 320 330 340 350
IPILTMPEDD KTHPIPDLTG YITEGQIILT RELYKSGIQP PIDVLPSLSR
360 370 380 390 400
LKDKGTGAGK TREDHAATMN QLFAAYAQGK QAKELAVVLG ESALSDIDKI
410 420 430 440 450
YAKFAERFEN EYVNQGFYTN RTITETLDLG WELLAMLPRT ELKRIKDDLL

DKYLPEGK
Length:458
Mass (Da):51,142
Last modified:November 1, 1995 - v1
Checksum:iD89D8F2F58B65262
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13816 Genomic DNA. Translation: BAA02970.1.
D17462 Genomic DNA. Translation: BAA04276.1.
CP003504 Genomic DNA. Translation: AFM70580.1.
PIRiB46733.
RefSeqiYP_006487471.1. NC_018081.1.

Genome annotation databases

EnsemblBacteriaiAFM70580; AFM70580; EHR_08265.
GeneIDi13177594.
KEGGiehr:EHR_08265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13816 Genomic DNA. Translation: BAA02970.1 .
D17462 Genomic DNA. Translation: BAA04276.1 .
CP003504 Genomic DNA. Translation: AFM70580.1 .
PIRi B46733.
RefSeqi YP_006487471.1. NC_018081.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3VR2 X-ray 2.80 D/E/F 1-458 [» ]
3VR3 X-ray 3.40 D/E/F 1-458 [» ]
3VR4 X-ray 2.17 D/E/F 1-458 [» ]
3VR5 X-ray 3.90 D/E/F 1-458 [» ]
3VR6 X-ray 2.68 D/E/F 1-458 [» ]
ProteinModelPortali Q08637.
SMRi Q08637. Positions 13-456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60126N.

Protein family/group databases

TCDBi 3.A.2.2.2. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFM70580 ; AFM70580 ; EHR_08265 .
GeneIDi 13177594.
KEGGi ehr:EHR_08265.

Phylogenomic databases

KOi K02118.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-14147.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00310. ATP_synth_B_arch.
InterProi IPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR027417. P-loop_NTPase.
IPR022879. V-ATPase_su_B/beta.
[Graphical view ]
Pfami PF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47917. SSF47917. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of the genes coding for the A and B subunits of vacuolar-type Na(+)-ATPase from Enterococcus hirae. Coexistence of vacuolar- and F0F1-type ATPases in one bacterial cell."
    Takase K., Yamato I., Kakinuma Y.
    J. Biol. Chem. 268:11610-11616(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-25.
    Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
  2. "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790, a model organism for the study of ion transport, bioenergetics, and copper homeostasis."
    Gaechter T., Wunderlin C., Schmidheini T., Solioz M.
    J. Bacteriol. 194:5126-5127(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.

Entry informationi

Entry nameiNTPB_ENTHA
AccessioniPrimary (citable) accession number: Q08637
Secondary accession number(s): I6S1L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3