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Q08637

- NTPB_ENTHA

UniProt

Q08637 - NTPB_ENTHA

Protein

V-type sodium ATPase subunit B

Gene

ntpB

Organism
Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Involved in ATP-driven sodium extrusion.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-HAMAP

    GO - Biological processi

    1. ATP hydrolysis coupled proton transport Source: InterPro
    2. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP
    3. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-14147.

    Protein family/group databases

    TCDBi3.A.2.2.2. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type sodium ATPase subunit B
    Alternative name(s):
    Na(+)-translocating ATPase subunit B
    V-type sodium pump subunit B
    Gene namesi
    Name:ntpB
    Ordered Locus Names:EHR_08265
    OrganismiEnterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
    Taxonomic identifieri768486 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
    ProteomesiUP000002895: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. proton-transporting two-sector ATPase complex, catalytic domain Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 458458V-type sodium ATPase subunit BPRO_0000144685Add
    BLAST

    Expressioni

    Inductioni

    By increasing intracellular Na+ concentration.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-60126N.

    Structurei

    Secondary structure

    1
    458
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi8 – 125
    Beta strandi15 – 206
    Beta strandi29 – 335
    Beta strandi39 – 5618
    Turni65 – 673
    Beta strandi69 – 724
    Beta strandi78 – 814
    Helixi83 – 853
    Beta strandi88 – 914
    Beta strandi96 – 983
    Beta strandi106 – 1127
    Turni118 – 1203
    Beta strandi127 – 1293
    Helixi133 – 1364
    Turni137 – 1393
    Beta strandi149 – 1513
    Helixi157 – 16711
    Beta strandi169 – 1735
    Beta strandi177 – 18610
    Helixi188 – 20114
    Helixi203 – 2064
    Beta strandi207 – 2137
    Helixi218 – 23720
    Beta strandi242 – 2487
    Helixi250 – 26314
    Helixi270 – 2723
    Helixi277 – 2859
    Beta strandi289 – 2913
    Beta strandi297 – 3059
    Helixi307 – 3093
    Helixi314 – 3229
    Beta strandi323 – 3297
    Helixi331 – 3355
    Turni344 – 3463
    Helixi352 – 3543
    Turni358 – 3603
    Helixi365 – 38925
    Helixi391 – 3933
    Helixi396 – 41116
    Helixi423 – 43412
    Turni439 – 4413
    Helixi447 – 4537

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3VR2X-ray2.80D/E/F1-458[»]
    3VR3X-ray3.40D/E/F1-458[»]
    3VR4X-ray2.17D/E/F1-458[»]
    3VR5X-ray3.90D/E/F1-458[»]
    3VR6X-ray2.68D/E/F1-458[»]
    ProteinModelPortaliQ08637.
    SMRiQ08637. Positions 13-456.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATPase alpha/beta chains family.Curated

    Phylogenomic databases

    KOiK02118.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00310. ATP_synth_B_arch.
    InterProiIPR020003. ATPase_a/bsu_AS.
    IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR004100. ATPase_F1_a/bsu_N.
    IPR027417. P-loop_NTPase.
    IPR022879. V-ATPase_su_B/beta.
    [Graphical view]
    PfamiPF00006. ATP-synt_ab. 1 hit.
    PF00306. ATP-synt_ab_C. 1 hit.
    PF02874. ATP-synt_ab_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47917. SSF47917. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q08637-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKEYRTIKE VVGPLMAVEK VSGVKYEELI EVRMQNGEIR RGQVLEVQED    50
    KAMVQIFEGT SGINLKNSSV RFLGHPLQLG VSEDMIGRVF DGLGRPKDNG 100
    PEILPEKYLD INGEVINPIA RDYPDEFIQT GISAIDHLNT LVRGQKLPVF 150
    SGSGLPHKEL AAQIARQATV LDSSDDFAVV FAAIGITFEE AEFFMEDFRQ 200
    TGAIDRSVMF MNLANDPAIE RIATPRMALT AAEYLAYEKG MHVLVIMTDM 250
    TNYAEALREI SAARREVPGR RGYPGYLYTN LATLFERAGR IRGLKGSVTQ 300
    IPILTMPEDD KTHPIPDLTG YITEGQIILT RELYKSGIQP PIDVLPSLSR 350
    LKDKGTGAGK TREDHAATMN QLFAAYAQGK QAKELAVVLG ESALSDIDKI 400
    YAKFAERFEN EYVNQGFYTN RTITETLDLG WELLAMLPRT ELKRIKDDLL 450
    DKYLPEGK 458
    Length:458
    Mass (Da):51,142
    Last modified:November 1, 1995 - v1
    Checksum:iD89D8F2F58B65262
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13816 Genomic DNA. Translation: BAA02970.1.
    D17462 Genomic DNA. Translation: BAA04276.1.
    CP003504 Genomic DNA. Translation: AFM70580.1.
    PIRiB46733.
    RefSeqiYP_006487471.1. NC_018081.1.

    Genome annotation databases

    EnsemblBacteriaiAFM70580; AFM70580; EHR_08265.
    GeneIDi13177594.
    KEGGiehr:EHR_08265.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13816 Genomic DNA. Translation: BAA02970.1 .
    D17462 Genomic DNA. Translation: BAA04276.1 .
    CP003504 Genomic DNA. Translation: AFM70580.1 .
    PIRi B46733.
    RefSeqi YP_006487471.1. NC_018081.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3VR2 X-ray 2.80 D/E/F 1-458 [» ]
    3VR3 X-ray 3.40 D/E/F 1-458 [» ]
    3VR4 X-ray 2.17 D/E/F 1-458 [» ]
    3VR5 X-ray 3.90 D/E/F 1-458 [» ]
    3VR6 X-ray 2.68 D/E/F 1-458 [» ]
    ProteinModelPortali Q08637.
    SMRi Q08637. Positions 13-456.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60126N.

    Protein family/group databases

    TCDBi 3.A.2.2.2. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFM70580 ; AFM70580 ; EHR_08265 .
    GeneIDi 13177594.
    KEGGi ehr:EHR_08265.

    Phylogenomic databases

    KOi K02118.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-14147.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00310. ATP_synth_B_arch.
    InterProi IPR020003. ATPase_a/bsu_AS.
    IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR004100. ATPase_F1_a/bsu_N.
    IPR027417. P-loop_NTPase.
    IPR022879. V-ATPase_su_B/beta.
    [Graphical view ]
    Pfami PF00006. ATP-synt_ab. 1 hit.
    PF00306. ATP-synt_ab_C. 1 hit.
    PF02874. ATP-synt_ab_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47917. SSF47917. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of the genes coding for the A and B subunits of vacuolar-type Na(+)-ATPase from Enterococcus hirae. Coexistence of vacuolar- and F0F1-type ATPases in one bacterial cell."
      Takase K., Yamato I., Kakinuma Y.
      J. Biol. Chem. 268:11610-11616(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-25.
      Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
    2. "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790, a model organism for the study of ion transport, bioenergetics, and copper homeostasis."
      Gaechter T., Wunderlin C., Schmidheini T., Solioz M.
      J. Bacteriol. 194:5126-5127(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.

    Entry informationi

    Entry nameiNTPB_ENTHA
    AccessioniPrimary (citable) accession number: Q08637
    Secondary accession number(s): I6S1L8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3