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Protein

V-type sodium ATPase catalytic subunit A

Gene

ntpA

Organism
Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in ATP-driven sodium extrusion.

Catalytic activityi

ATP + H2O + Na+(In) = ADP + phosphate + Na+(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi232 – 239ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processIon transport, Sodium transport, Transport
LigandATP-binding, Nucleotide-binding, Sodium

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14146.

Protein family/group databases

TCDBi3.A.2.2.2. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type sodium ATPase catalytic subunit A (EC:3.6.3.15)
Alternative name(s):
Na(+)-translocating ATPase subunit A
V-type sodium pump catalytic subunit A
Gene namesi
Name:ntpA
Ordered Locus Names:EHR_08260
OrganismiEnterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Taxonomic identifieri768486 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000002895 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001446221 – 593V-type sodium ATPase catalytic subunit AAdd BLAST593

Expressioni

Inductioni

By increasing intracellular Na+ concentration.

Interactioni

Protein-protein interaction databases

DIPiDIP-60125N.

Structurei

Secondary structure

1593
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 10Combined sources7
Beta strandi13 – 18Combined sources6
Beta strandi27 – 30Combined sources4
Turni31 – 34Combined sources4
Beta strandi35 – 43Combined sources9
Beta strandi46 – 53Combined sources8
Beta strandi63 – 66Combined sources4
Beta strandi68 – 76Combined sources9
Helixi91 – 98Combined sources8
Beta strandi100 – 102Combined sources3
Beta strandi118 – 122Combined sources5
Beta strandi129 – 131Combined sources3
Beta strandi135 – 139Combined sources5
Beta strandi142 – 144Combined sources3
Beta strandi147 – 150Combined sources4
Beta strandi157 – 162Combined sources6
Beta strandi165 – 167Combined sources3
Beta strandi169 – 171Combined sources3
Beta strandi174 – 178Combined sources5
Beta strandi181 – 185Combined sources5
Beta strandi189 – 192Combined sources4
Beta strandi200 – 203Combined sources4
Helixi214 – 219Combined sources6
Beta strandi227 – 231Combined sources5
Helixi238 – 248Combined sources11
Beta strandi252 – 261Combined sources10
Helixi263 – 272Combined sources10
Turni273 – 275Combined sources3
Turni279 – 281Combined sources3
Beta strandi282 – 284Combined sources3
Helixi285 – 288Combined sources4
Beta strandi289 – 295Combined sources7
Helixi300 – 318Combined sources19
Turni319 – 321Combined sources3
Beta strandi323 – 329Combined sources7
Helixi331 – 344Combined sources14
Helixi351 – 353Combined sources3
Helixi358 – 366Combined sources9
Beta strandi369 – 373Combined sources5
Beta strandi381 – 390Combined sources10
Beta strandi393 – 395Combined sources3
Beta strandi397 – 399Combined sources3
Helixi400 – 406Combined sources7
Beta strandi410 – 412Combined sources3
Helixi417 – 420Combined sources4
Turni421 – 423Combined sources3
Turni430 – 432Combined sources3
Helixi438 – 449Combined sources12
Helixi453 – 476Combined sources24
Helixi479 – 481Combined sources3
Helixi484 – 499Combined sources16
Beta strandi505 – 507Combined sources3
Turni508 – 511Combined sources4
Helixi515 – 536Combined sources22
Turni537 – 539Combined sources3
Helixi542 – 548Combined sources7
Helixi550 – 557Combined sources8
Helixi559 – 561Combined sources3
Helixi564 – 567Combined sources4
Helixi568 – 571Combined sources4
Helixi573 – 586Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VR2X-ray2.80A/B/C1-593[»]
3VR3X-ray3.40A/B/C1-593[»]
3VR4X-ray2.17A/B/C1-593[»]
3VR5X-ray3.90A/B/C1-593[»]
3VR6X-ray2.68A/B/C1-593[»]
5KNBX-ray3.25A/B/C1-593[»]
5KNCX-ray3.02A/B/C1-593[»]
5KNDX-ray2.89A/B/C1-593[»]
ProteinModelPortaliQ08636.
SMRiQ08636.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

KOiK02117.
OrthoDBiPOG091H1U8M.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
HAMAPiMF_00309. ATP_synth_A_arch. 1 hit.
InterProiView protein in InterPro
IPR031686. ATP-synth_a_Xtn.
IPR020003. ATPase_a/bsu_AS.
IPR004100. ATPase_F1/V1/A1_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR024034. ATPase_F1/V1_b/a_C.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
PANTHERiPTHR43607. PTHR43607. 1 hit.
PfamiView protein in Pfam
PF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
PF16886. ATP-synt_ab_Xtn. 1 hit.
SUPFAMiSSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00152. ATPASE_ALPHA_BETA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIGKIIKVS GPLVMAENMS EASIQDMCLV GDLGVIGEII EMRQDVASIQ
60 70 80 90 100
VYEETSGIGP GEPVRSTGEA LSVELGPGII SQMFDGIQRP LDTFMEVTQS
110 120 130 140 150
NFLGRGVQLP ALDHEKQWWF EATIEEGTEV SAGDIIGYVD ETKIIQHKIM
160 170 180 190 200
VPNGIKGTVQ KIESGSFTID DPICVIETEQ GLKELTMMQK WPVRRGRPIK
210 220 230 240 250
QKLNPDVPMI TGQRVIDTFF PVTKGGAAAV PGPFGAGKTV VQHQIAKWSD
260 270 280 290 300
VDLVVYVGCG ERGNEMTDVV NEFPELIDPN TGESLMERTV LIANTSNMPV
310 320 330 340 350
AAREASIYTG ITIAEYFRDM GYDVAIMADS TSRWAEALRE MSGRLEEMPG
360 370 380 390 400
DEGYPAYLGS RLAEYYERSG RVIALGSDQR EGSITAISAV SPSGGDISEP
410 420 430 440 450
VTQNTLRVVK VFWGLDSSLA QKRHFPSINW IQSYSLYSTE VGRYMDQILQ
460 470 480 490 500
QDWSDMVTEG MRILQEEEQL NEIVRLVGID SLSDNDRLTL EVAKSIREDY
510 520 530 540 550
LQQNAFDDVD TFTSREKQFN MLKVILTFGK EARKALSLGA YFNEIMEGTV
560 570 580 590
AVRERISRSK YIPEEELAKI SSINEEIKET IQLIVSEGGM TDD
Length:593
Mass (Da):65,770
Last modified:November 1, 1995 - v1
Checksum:i3E209C2D8687B48A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13816 Genomic DNA. Translation: BAA02969.1.
D17462 Genomic DNA. Translation: BAA04275.1.
CP003504 Genomic DNA. Translation: AFM70579.1.
X76913 Genomic DNA. Translation: CAA54241.1.
PIRiA46733.
RefSeqiWP_010718637.1. NZ_KB946231.1.

Genome annotation databases

EnsemblBacteriaiAFM70579; AFM70579; EHR_08260.
GeneIDi13177593.
KEGGiehr:EHR_08260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13816 Genomic DNA. Translation: BAA02969.1.
D17462 Genomic DNA. Translation: BAA04275.1.
CP003504 Genomic DNA. Translation: AFM70579.1.
X76913 Genomic DNA. Translation: CAA54241.1.
PIRiA46733.
RefSeqiWP_010718637.1. NZ_KB946231.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VR2X-ray2.80A/B/C1-593[»]
3VR3X-ray3.40A/B/C1-593[»]
3VR4X-ray2.17A/B/C1-593[»]
3VR5X-ray3.90A/B/C1-593[»]
3VR6X-ray2.68A/B/C1-593[»]
5KNBX-ray3.25A/B/C1-593[»]
5KNCX-ray3.02A/B/C1-593[»]
5KNDX-ray2.89A/B/C1-593[»]
ProteinModelPortaliQ08636.
SMRiQ08636.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60125N.

Protein family/group databases

TCDBi3.A.2.2.2. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFM70579; AFM70579; EHR_08260.
GeneIDi13177593.
KEGGiehr:EHR_08260.

Phylogenomic databases

KOiK02117.
OrthoDBiPOG091H1U8M.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14146.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
HAMAPiMF_00309. ATP_synth_A_arch. 1 hit.
InterProiView protein in InterPro
IPR031686. ATP-synth_a_Xtn.
IPR020003. ATPase_a/bsu_AS.
IPR004100. ATPase_F1/V1/A1_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR024034. ATPase_F1/V1_b/a_C.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
PANTHERiPTHR43607. PTHR43607. 1 hit.
PfamiView protein in Pfam
PF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
PF16886. ATP-synt_ab_Xtn. 1 hit.
SUPFAMiSSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00152. ATPASE_ALPHA_BETA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNTPA_ENTHA
AccessioniPrimary (citable) accession number: Q08636
Secondary accession number(s): I6TB93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 12, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.