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Q08636 (NTPA_ENTHA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
V-type sodium ATPase catalytic subunit A

EC=3.6.3.15
Alternative name(s):
Na(+)-translocating ATPase subunit A
V-type sodium pump catalytic subunit A
Gene names
Name:ntpA
Ordered Locus Names:EHR_08260
OrganismEnterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258) [Complete proteome] [HAMAP]
Taxonomic identifier768486 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus

Protein attributes

Sequence length593 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in ATP-driven sodium extrusion. HAMAP-Rule MF_00309

Catalytic activity

ATP + H2O + Na+(In) = ADP + phosphate + Na+(Out). HAMAP-Rule MF_00309

Induction

By increasing intracellular Na+ concentration. HAMAP-Rule MF_00309

Sequence similarities

Belongs to the ATPase alpha/beta chains family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 593593V-type sodium ATPase catalytic subunit A HAMAP-Rule MF_00309
PRO_0000144622

Regions

Nucleotide binding232 – 2398ATP By similarity

Secondary structure

............................................................................................................. 593
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q08636 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 3E209C2D8687B48A

FASTA59365,770
        10         20         30         40         50         60 
MQIGKIIKVS GPLVMAENMS EASIQDMCLV GDLGVIGEII EMRQDVASIQ VYEETSGIGP 

        70         80         90        100        110        120 
GEPVRSTGEA LSVELGPGII SQMFDGIQRP LDTFMEVTQS NFLGRGVQLP ALDHEKQWWF 

       130        140        150        160        170        180 
EATIEEGTEV SAGDIIGYVD ETKIIQHKIM VPNGIKGTVQ KIESGSFTID DPICVIETEQ 

       190        200        210        220        230        240 
GLKELTMMQK WPVRRGRPIK QKLNPDVPMI TGQRVIDTFF PVTKGGAAAV PGPFGAGKTV 

       250        260        270        280        290        300 
VQHQIAKWSD VDLVVYVGCG ERGNEMTDVV NEFPELIDPN TGESLMERTV LIANTSNMPV 

       310        320        330        340        350        360 
AAREASIYTG ITIAEYFRDM GYDVAIMADS TSRWAEALRE MSGRLEEMPG DEGYPAYLGS 

       370        380        390        400        410        420 
RLAEYYERSG RVIALGSDQR EGSITAISAV SPSGGDISEP VTQNTLRVVK VFWGLDSSLA 

       430        440        450        460        470        480 
QKRHFPSINW IQSYSLYSTE VGRYMDQILQ QDWSDMVTEG MRILQEEEQL NEIVRLVGID 

       490        500        510        520        530        540 
SLSDNDRLTL EVAKSIREDY LQQNAFDDVD TFTSREKQFN MLKVILTFGK EARKALSLGA 

       550        560        570        580        590 
YFNEIMEGTV AVRERISRSK YIPEEELAKI SSINEEIKET IQLIVSEGGM TDD 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequencing of the genes coding for the A and B subunits of vacuolar-type Na(+)-ATPase from Enterococcus hirae. Coexistence of vacuolar- and F0F1-type ATPases in one bacterial cell."
Takase K., Yamato I., Kakinuma Y.
J. Biol. Chem. 268:11610-11616(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-20; 345-359 AND 381-407.
Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
[2]"Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790, a model organism for the study of ion transport, bioenergetics, and copper homeostasis."
Gaechter T., Wunderlin C., Schmidheini T., Solioz M.
J. Bacteriol. 194:5126-5127(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
[3]"Operon of vacuolar-type Na(+)-ATPase of Enterococcus hirae."
Solioz M., Davies K.
J. Biol. Chem. 269:9453-9459(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-187.
Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D13816 Genomic DNA. Translation: BAA02969.1.
D17462 Genomic DNA. Translation: BAA04275.1.
CP003504 Genomic DNA. Translation: AFM70579.1.
X76913 Genomic DNA. Translation: CAA54241.1.
PIRA46733.
RefSeqYP_006487470.1. NC_018081.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3VR2X-ray2.80A/B/C1-593[»]
3VR3X-ray3.40A/B/C1-593[»]
3VR4X-ray2.17A/B/C1-593[»]
3VR5X-ray3.90A/B/C1-593[»]
3VR6X-ray2.68A/B/C1-593[»]
ProteinModelPortalQ08636.
SMRQ08636. Positions 59-589.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-60125N.

Protein family/group databases

TCDB3.A.2.2.2. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFM70579; AFM70579; EHR_08260.
GeneID13177593.
KEGGehr:EHR_08260.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK02117.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-14146.

Family and domain databases

Gene3D1.10.1140.10. 2 hits.
3.40.50.300. 1 hit.
HAMAPMF_00309. ATP_synth_A_arch.
InterProIPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view]
PfamPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SUPFAMSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTPA_ENTHA
AccessionPrimary (citable) accession number: Q08636
Secondary accession number(s): I6TB93
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references