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Q08636

- NTPA_ENTHA

UniProt

Q08636 - NTPA_ENTHA

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Protein

V-type sodium ATPase catalytic subunit A

Gene

ntpA

Organism
Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in ATP-driven sodium extrusion.

Catalytic activityi

ATP + H2O + Na+(In) = ADP + phosphate + Na+(Out).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi232 – 2398ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-HAMAP

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
  2. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP
  3. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Sodium

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14146.

Protein family/group databases

TCDBi3.A.2.2.2. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type sodium ATPase catalytic subunit A (EC:3.6.3.15)
Alternative name(s):
Na(+)-translocating ATPase subunit A
V-type sodium pump catalytic subunit A
Gene namesi
Name:ntpA
Ordered Locus Names:EHR_08260
OrganismiEnterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Taxonomic identifieri768486 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000002895: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. proton-transporting two-sector ATPase complex, catalytic domain Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593V-type sodium ATPase catalytic subunit APRO_0000144622Add
BLAST

Expressioni

Inductioni

By increasing intracellular Na+ concentration.

Interactioni

Protein-protein interaction databases

DIPiDIP-60125N.

Structurei

Secondary structure

1
593
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 107Combined sources
Beta strandi13 – 186Combined sources
Beta strandi27 – 304Combined sources
Turni31 – 344Combined sources
Beta strandi35 – 439Combined sources
Beta strandi46 – 538Combined sources
Beta strandi63 – 664Combined sources
Beta strandi68 – 769Combined sources
Helixi91 – 988Combined sources
Beta strandi100 – 1023Combined sources
Beta strandi118 – 1225Combined sources
Beta strandi129 – 1313Combined sources
Beta strandi135 – 1395Combined sources
Beta strandi142 – 1443Combined sources
Beta strandi147 – 1504Combined sources
Beta strandi157 – 1626Combined sources
Beta strandi165 – 1673Combined sources
Beta strandi174 – 1785Combined sources
Beta strandi181 – 1855Combined sources
Beta strandi189 – 1924Combined sources
Beta strandi200 – 2034Combined sources
Helixi214 – 2196Combined sources
Beta strandi227 – 2315Combined sources
Helixi238 – 24811Combined sources
Beta strandi252 – 26110Combined sources
Helixi263 – 27210Combined sources
Turni273 – 2753Combined sources
Turni279 – 2813Combined sources
Beta strandi282 – 2843Combined sources
Helixi285 – 2884Combined sources
Beta strandi289 – 2957Combined sources
Helixi300 – 31819Combined sources
Turni319 – 3213Combined sources
Beta strandi323 – 3297Combined sources
Helixi331 – 34414Combined sources
Helixi351 – 3533Combined sources
Helixi358 – 3669Combined sources
Beta strandi369 – 3735Combined sources
Beta strandi381 – 39010Combined sources
Beta strandi393 – 3953Combined sources
Beta strandi397 – 3993Combined sources
Helixi400 – 4067Combined sources
Beta strandi410 – 4123Combined sources
Helixi417 – 4204Combined sources
Turni421 – 4233Combined sources
Turni430 – 4323Combined sources
Helixi438 – 44912Combined sources
Helixi453 – 47624Combined sources
Helixi479 – 4813Combined sources
Helixi484 – 49916Combined sources
Beta strandi505 – 5073Combined sources
Turni508 – 5114Combined sources
Helixi515 – 53622Combined sources
Turni537 – 5393Combined sources
Helixi542 – 5487Combined sources
Helixi550 – 5578Combined sources
Helixi559 – 5613Combined sources
Helixi564 – 5674Combined sources
Helixi568 – 5714Combined sources
Helixi573 – 58614Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VR2X-ray2.80A/B/C1-593[»]
3VR3X-ray3.40A/B/C1-593[»]
3VR4X-ray2.17A/B/C1-593[»]
3VR5X-ray3.90A/B/C1-593[»]
3VR6X-ray2.68A/B/C1-593[»]
ProteinModelPortaliQ08636.
SMRiQ08636. Positions 59-589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

KOiK02117.

Family and domain databases

Gene3Di1.10.1140.10. 2 hits.
3.40.50.300. 1 hit.
HAMAPiMF_00309. ATP_synth_A_arch.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08636-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQIGKIIKVS GPLVMAENMS EASIQDMCLV GDLGVIGEII EMRQDVASIQ
60 70 80 90 100
VYEETSGIGP GEPVRSTGEA LSVELGPGII SQMFDGIQRP LDTFMEVTQS
110 120 130 140 150
NFLGRGVQLP ALDHEKQWWF EATIEEGTEV SAGDIIGYVD ETKIIQHKIM
160 170 180 190 200
VPNGIKGTVQ KIESGSFTID DPICVIETEQ GLKELTMMQK WPVRRGRPIK
210 220 230 240 250
QKLNPDVPMI TGQRVIDTFF PVTKGGAAAV PGPFGAGKTV VQHQIAKWSD
260 270 280 290 300
VDLVVYVGCG ERGNEMTDVV NEFPELIDPN TGESLMERTV LIANTSNMPV
310 320 330 340 350
AAREASIYTG ITIAEYFRDM GYDVAIMADS TSRWAEALRE MSGRLEEMPG
360 370 380 390 400
DEGYPAYLGS RLAEYYERSG RVIALGSDQR EGSITAISAV SPSGGDISEP
410 420 430 440 450
VTQNTLRVVK VFWGLDSSLA QKRHFPSINW IQSYSLYSTE VGRYMDQILQ
460 470 480 490 500
QDWSDMVTEG MRILQEEEQL NEIVRLVGID SLSDNDRLTL EVAKSIREDY
510 520 530 540 550
LQQNAFDDVD TFTSREKQFN MLKVILTFGK EARKALSLGA YFNEIMEGTV
560 570 580 590
AVRERISRSK YIPEEELAKI SSINEEIKET IQLIVSEGGM TDD
Length:593
Mass (Da):65,770
Last modified:November 1, 1995 - v1
Checksum:i3E209C2D8687B48A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13816 Genomic DNA. Translation: BAA02969.1.
D17462 Genomic DNA. Translation: BAA04275.1.
CP003504 Genomic DNA. Translation: AFM70579.1.
X76913 Genomic DNA. Translation: CAA54241.1.
PIRiA46733.
RefSeqiWP_010718637.1. NZ_KB946231.1.
YP_006487470.1. NC_018081.1.

Genome annotation databases

EnsemblBacteriaiAFM70579; AFM70579; EHR_08260.
GeneIDi13177593.
KEGGiehr:EHR_08260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13816 Genomic DNA. Translation: BAA02969.1 .
D17462 Genomic DNA. Translation: BAA04275.1 .
CP003504 Genomic DNA. Translation: AFM70579.1 .
X76913 Genomic DNA. Translation: CAA54241.1 .
PIRi A46733.
RefSeqi WP_010718637.1. NZ_KB946231.1.
YP_006487470.1. NC_018081.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3VR2 X-ray 2.80 A/B/C 1-593 [» ]
3VR3 X-ray 3.40 A/B/C 1-593 [» ]
3VR4 X-ray 2.17 A/B/C 1-593 [» ]
3VR5 X-ray 3.90 A/B/C 1-593 [» ]
3VR6 X-ray 2.68 A/B/C 1-593 [» ]
ProteinModelPortali Q08636.
SMRi Q08636. Positions 59-589.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60125N.

Protein family/group databases

TCDBi 3.A.2.2.2. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFM70579 ; AFM70579 ; EHR_08260 .
GeneIDi 13177593.
KEGGi ehr:EHR_08260.

Phylogenomic databases

KOi K02117.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-14146.

Family and domain databases

Gene3Di 1.10.1140.10. 2 hits.
3.40.50.300. 1 hit.
HAMAPi MF_00309. ATP_synth_A_arch.
InterProi IPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view ]
Pfami PF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of the genes coding for the A and B subunits of vacuolar-type Na(+)-ATPase from Enterococcus hirae. Coexistence of vacuolar- and F0F1-type ATPases in one bacterial cell."
    Takase K., Yamato I., Kakinuma Y.
    J. Biol. Chem. 268:11610-11616(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-20; 345-359 AND 381-407.
    Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
  2. "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790, a model organism for the study of ion transport, bioenergetics, and copper homeostasis."
    Gaechter T., Wunderlin C., Schmidheini T., Solioz M.
    J. Bacteriol. 194:5126-5127(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
  3. "Operon of vacuolar-type Na(+)-ATPase of Enterococcus hirae."
    Solioz M., Davies K.
    J. Biol. Chem. 269:9453-9459(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-187.
    Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.

Entry informationi

Entry nameiNTPA_ENTHA
AccessioniPrimary (citable) accession number: Q08636
Secondary accession number(s): I6TB93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3