SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q08636

- NTPA_ENTHA

UniProt

Q08636 - NTPA_ENTHA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

V-type sodium ATPase catalytic subunit A

Gene
ntpA, EHR_08260
Organism
Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in ATP-driven sodium extrusion.UniRule annotation

Catalytic activityi

ATP + H2O + Na+(In) = ADP + phosphate + Na+(Out).UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi232 – 2398ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-HAMAP

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
  2. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP
  3. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Sodium

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14146.

Protein family/group databases

TCDBi3.A.2.2.2. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type sodium ATPase catalytic subunit A (EC:3.6.3.15)
Alternative name(s):
Na(+)-translocating ATPase subunit A
V-type sodium pump catalytic subunit A
Gene namesi
Name:ntpA
Ordered Locus Names:EHR_08260
OrganismiEnterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Taxonomic identifieri768486 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000002895: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. proton-transporting two-sector ATPase complex, catalytic domain Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593V-type sodium ATPase catalytic subunit AUniRule annotationPRO_0000144622Add
BLAST

Expressioni

Inductioni

By increasing intracellular Na+ concentration.UniRule annotation

Interactioni

Protein-protein interaction databases

DIPiDIP-60125N.

Structurei

Secondary structure

1
593
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 107
Beta strandi13 – 186
Beta strandi27 – 304
Turni31 – 344
Beta strandi35 – 439
Beta strandi46 – 538
Beta strandi63 – 664
Beta strandi68 – 769
Helixi91 – 988
Beta strandi100 – 1023
Beta strandi118 – 1225
Beta strandi129 – 1313
Beta strandi135 – 1395
Beta strandi142 – 1443
Beta strandi147 – 1504
Beta strandi157 – 1626
Beta strandi165 – 1673
Beta strandi174 – 1785
Beta strandi181 – 1855
Beta strandi189 – 1924
Beta strandi200 – 2034
Helixi214 – 2196
Beta strandi227 – 2315
Helixi238 – 24811
Beta strandi252 – 26110
Helixi263 – 27210
Turni273 – 2753
Turni279 – 2813
Beta strandi282 – 2843
Helixi285 – 2884
Beta strandi289 – 2957
Helixi300 – 31819
Turni319 – 3213
Beta strandi323 – 3297
Helixi331 – 34414
Helixi351 – 3533
Helixi358 – 3669
Beta strandi369 – 3735
Beta strandi381 – 39010
Beta strandi393 – 3953
Beta strandi397 – 3993
Helixi400 – 4067
Beta strandi410 – 4123
Helixi417 – 4204
Turni421 – 4233
Turni430 – 4323
Helixi438 – 44912
Helixi453 – 47624
Helixi479 – 4813
Helixi484 – 49916
Beta strandi505 – 5073
Turni508 – 5114
Helixi515 – 53622
Turni537 – 5393
Helixi542 – 5487
Helixi550 – 5578
Helixi559 – 5613
Helixi564 – 5674
Helixi568 – 5714
Helixi573 – 58614

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VR2X-ray2.80A/B/C1-593[»]
3VR3X-ray3.40A/B/C1-593[»]
3VR4X-ray2.17A/B/C1-593[»]
3VR5X-ray3.90A/B/C1-593[»]
3VR6X-ray2.68A/B/C1-593[»]
ProteinModelPortaliQ08636.
SMRiQ08636. Positions 59-589.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK02117.

Family and domain databases

Gene3Di1.10.1140.10. 2 hits.
3.40.50.300. 1 hit.
HAMAPiMF_00309. ATP_synth_A_arch.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08636-1 [UniParc]FASTAAdd to Basket

« Hide

MQIGKIIKVS GPLVMAENMS EASIQDMCLV GDLGVIGEII EMRQDVASIQ    50
VYEETSGIGP GEPVRSTGEA LSVELGPGII SQMFDGIQRP LDTFMEVTQS 100
NFLGRGVQLP ALDHEKQWWF EATIEEGTEV SAGDIIGYVD ETKIIQHKIM 150
VPNGIKGTVQ KIESGSFTID DPICVIETEQ GLKELTMMQK WPVRRGRPIK 200
QKLNPDVPMI TGQRVIDTFF PVTKGGAAAV PGPFGAGKTV VQHQIAKWSD 250
VDLVVYVGCG ERGNEMTDVV NEFPELIDPN TGESLMERTV LIANTSNMPV 300
AAREASIYTG ITIAEYFRDM GYDVAIMADS TSRWAEALRE MSGRLEEMPG 350
DEGYPAYLGS RLAEYYERSG RVIALGSDQR EGSITAISAV SPSGGDISEP 400
VTQNTLRVVK VFWGLDSSLA QKRHFPSINW IQSYSLYSTE VGRYMDQILQ 450
QDWSDMVTEG MRILQEEEQL NEIVRLVGID SLSDNDRLTL EVAKSIREDY 500
LQQNAFDDVD TFTSREKQFN MLKVILTFGK EARKALSLGA YFNEIMEGTV 550
AVRERISRSK YIPEEELAKI SSINEEIKET IQLIVSEGGM TDD 593
Length:593
Mass (Da):65,770
Last modified:November 1, 1995 - v1
Checksum:i3E209C2D8687B48A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13816 Genomic DNA. Translation: BAA02969.1.
D17462 Genomic DNA. Translation: BAA04275.1.
CP003504 Genomic DNA. Translation: AFM70579.1.
X76913 Genomic DNA. Translation: CAA54241.1.
PIRiA46733.
RefSeqiYP_006487470.1. NC_018081.1.

Genome annotation databases

EnsemblBacteriaiAFM70579; AFM70579; EHR_08260.
GeneIDi13177593.
KEGGiehr:EHR_08260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13816 Genomic DNA. Translation: BAA02969.1 .
D17462 Genomic DNA. Translation: BAA04275.1 .
CP003504 Genomic DNA. Translation: AFM70579.1 .
X76913 Genomic DNA. Translation: CAA54241.1 .
PIRi A46733.
RefSeqi YP_006487470.1. NC_018081.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3VR2 X-ray 2.80 A/B/C 1-593 [» ]
3VR3 X-ray 3.40 A/B/C 1-593 [» ]
3VR4 X-ray 2.17 A/B/C 1-593 [» ]
3VR5 X-ray 3.90 A/B/C 1-593 [» ]
3VR6 X-ray 2.68 A/B/C 1-593 [» ]
ProteinModelPortali Q08636.
SMRi Q08636. Positions 59-589.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60125N.

Protein family/group databases

TCDBi 3.A.2.2.2. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFM70579 ; AFM70579 ; EHR_08260 .
GeneIDi 13177593.
KEGGi ehr:EHR_08260.

Phylogenomic databases

KOi K02117.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-14146.

Family and domain databases

Gene3Di 1.10.1140.10. 2 hits.
3.40.50.300. 1 hit.
HAMAPi MF_00309. ATP_synth_A_arch.
InterProi IPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view ]
Pfami PF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of the genes coding for the A and B subunits of vacuolar-type Na(+)-ATPase from Enterococcus hirae. Coexistence of vacuolar- and F0F1-type ATPases in one bacterial cell."
    Takase K., Yamato I., Kakinuma Y.
    J. Biol. Chem. 268:11610-11616(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-20; 345-359 AND 381-407.
    Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
  2. "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790, a model organism for the study of ion transport, bioenergetics, and copper homeostasis."
    Gaechter T., Wunderlin C., Schmidheini T., Solioz M.
    J. Bacteriol. 194:5126-5127(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
  3. "Operon of vacuolar-type Na(+)-ATPase of Enterococcus hirae."
    Solioz M., Davies K.
    J. Biol. Chem. 269:9453-9459(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-187.
    Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.

Entry informationi

Entry nameiNTPA_ENTHA
AccessioniPrimary (citable) accession number: Q08636
Secondary accession number(s): I6TB93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi