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Protein

Testican-1

Gene

SPOCK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • cysteine-type endopeptidase inhibitor activity Source: UniProtKB
  • metalloendopeptidase inhibitor activity Source: UniProtKB
  • serine-type endopeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

  • cell adhesion Source: UniProtKB
  • central nervous system neuron differentiation Source: UniProtKB
  • negative regulation of cell-substrate adhesion Source: UniProtKB
  • negative regulation of endopeptidase activity Source: UniProtKB
  • negative regulation of neuron projection development Source: UniProtKB
  • nervous system development Source: UniProtKB
  • neurogenesis Source: UniProtKB
  • neuron migration Source: UniProtKB
  • regulation of cell growth Source: UniProtKB
  • signal transduction Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152377-MONOMER.

Protein family/group databases

MEROPSiI31.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Testican-1
Alternative name(s):
Protein SPOCK
Gene namesi
Name:SPOCK1
Synonyms:SPOCK, TIC1, TICN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:11251. SPOCK1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular space Source: UniProtKB
  • neuromuscular junction Source: UniProtKB
  • node of Ranvier Source: UniProtKB
  • postsynaptic density Source: UniProtKB
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
  • sarcoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6695.
OpenTargetsiENSG00000152377.
PharmGKBiPA36081.

Polymorphism and mutation databases

BioMutaiSPOCK1.
DMDMi24212472.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002669922 – 439Testican-1Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi86 ↔ 97By similarity
Disulfide bondi91 ↔ 107By similarity
Disulfide bondi136 ↔ 166By similarity
Disulfide bondi139 ↔ 159By similarity
Disulfide bondi148 ↔ 180By similarity
Glycosylationi228O-linked (GalNAc...)1 Publication1
Disulfide bondi313 ↔ 337By similarity
Disulfide bondi348 ↔ 355By similarity
Disulfide bondi357 ↔ 376By similarity
Glycosylationi383O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1
Glycosylationi388O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1

Post-translational modificationi

O-glycosylated. Glycosaminoglycan that contains chondroitin sulfate and heparan sulfate.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Heparan sulfate, Proteoglycan

Proteomic databases

EPDiQ08629.
MaxQBiQ08629.
PaxDbiQ08629.
PeptideAtlasiQ08629.
PRIDEiQ08629.
TopDownProteomicsiQ08629.

PTM databases

iPTMnetiQ08629.
PhosphoSitePlusiQ08629.
UniCarbKBiQ08629.

Expressioni

Gene expression databases

BgeeiENSG00000152377.
CleanExiHS_SPOCK1.
ExpressionAtlasiQ08629. baseline and differential.
GenevisibleiQ08629. HS.

Organism-specific databases

HPAiHPA007450.
HPA026770.

Interactioni

Protein-protein interaction databases

BioGridi112573. 2 interactors.
IntActiQ08629. 2 interactors.
STRINGi9606.ENSP00000282223.

Structurei

3D structure databases

ProteinModelPortaliQ08629.
SMRiQ08629.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 182Kazal-likePROSITE-ProRule annotationAdd BLAST53
Domaini310 – 376Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3555. Eukaryota.
ENOG410Y6A8. LUCA.
GeneTreeiENSGT00510000046429.
HOGENOMiHOG000293295.
HOVERGENiHBG026595.
InParanoidiQ08629.
KOiK08136.
OMAiTACTDKE.
OrthoDBiEOG091G086I.
PhylomeDBiQ08629.
TreeFamiTF317779.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002350. Kazal_dom.
IPR019577. SPARC/Testican_Ca-bd-dom.
IPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF07648. Kazal_2. 1 hit.
PF10591. SPARC_Ca_bdg. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08629-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAIAVLAAA AAAWCFLQVE SRHLDALAGG AGPNHGNFLD NDQWLSTVSQ
60 70 80 90 100
YDRDKYWNRF RDDDYFRNWN PNKPFDQALD PSKDPCLKVK CSPHKVCVTQ
110 120 130 140 150
DYQTALCVSR KHLLPRQKKG NVAQKHWVGP SNLVKCKPCP VAQSAMVCGS
160 170 180 190 200
DGHSYTSKCK LEFHACSTGK SLATLCDGPC PCLPEPEPPK HKAERSACTD
210 220 230 240 250
KELRNLASRL KDWFGALHED ANRVIKPTSS NTAQGRFDTS ILPICKDSLG
260 270 280 290 300
WMFNKLDMNY DLLLDPSEIN AIYLDKYEPC IKPLFNSCDS FKDGKLSNNE
310 320 330 340 350
WCYCFQKPGG LPCQNEMNRI QKLSKGKSLL GAFIPRCNEE GYYKATQCHG
360 370 380 390 400
STGQCWCVDK YGNELAGSRK QGAVSCEEEQ ETSGDFGSGG SVVLLDDLEY
410 420 430
ERELGPKDKE GKLRVHTRAV TEDDEDEDDD KEDEVGYIW
Length:439
Mass (Da):49,124
Last modified:November 1, 1996 - v1
Checksum:i1971601D90F1D0AD
GO

Sequence cautioni

The sequence BAD92938 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62D → DEVE in BAD92938 (Ref. 4) Curated1
Sequence conflicti77Q → K in AAH30691 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73608 mRNA. Translation: CAA51999.1.
AF231124 mRNA. Translation: AAF43687.1.
AK094489 mRNA. Translation: BAG52875.1.
AB209701 mRNA. Translation: BAD92938.1. Different initiation.
AC005213 Genomic DNA. Translation: AAC24945.1.
AC091818 Genomic DNA. No translation available.
AC106746 Genomic DNA. No translation available.
AC106809 Genomic DNA. No translation available.
BC030691 mRNA. Translation: AAH30691.1.
CCDSiCCDS4191.1.
PIRiS33293.
RefSeqiNP_004589.1. NM_004598.3.
UniGeneiHs.596136.

Genome annotation databases

EnsembliENST00000394945; ENSP00000378401; ENSG00000152377.
GeneIDi6695.
KEGGihsa:6695.
UCSCiuc003lbp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73608 mRNA. Translation: CAA51999.1.
AF231124 mRNA. Translation: AAF43687.1.
AK094489 mRNA. Translation: BAG52875.1.
AB209701 mRNA. Translation: BAD92938.1. Different initiation.
AC005213 Genomic DNA. Translation: AAC24945.1.
AC091818 Genomic DNA. No translation available.
AC106746 Genomic DNA. No translation available.
AC106809 Genomic DNA. No translation available.
BC030691 mRNA. Translation: AAH30691.1.
CCDSiCCDS4191.1.
PIRiS33293.
RefSeqiNP_004589.1. NM_004598.3.
UniGeneiHs.596136.

3D structure databases

ProteinModelPortaliQ08629.
SMRiQ08629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112573. 2 interactors.
IntActiQ08629. 2 interactors.
STRINGi9606.ENSP00000282223.

Protein family/group databases

MEROPSiI31.006.

PTM databases

iPTMnetiQ08629.
PhosphoSitePlusiQ08629.
UniCarbKBiQ08629.

Polymorphism and mutation databases

BioMutaiSPOCK1.
DMDMi24212472.

Proteomic databases

EPDiQ08629.
MaxQBiQ08629.
PaxDbiQ08629.
PeptideAtlasiQ08629.
PRIDEiQ08629.
TopDownProteomicsiQ08629.

Protocols and materials databases

DNASUi6695.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394945; ENSP00000378401; ENSG00000152377.
GeneIDi6695.
KEGGihsa:6695.
UCSCiuc003lbp.4. human.

Organism-specific databases

CTDi6695.
DisGeNETi6695.
GeneCardsiSPOCK1.
HGNCiHGNC:11251. SPOCK1.
HPAiHPA007450.
HPA026770.
MIMi602264. gene.
neXtProtiNX_Q08629.
OpenTargetsiENSG00000152377.
PharmGKBiPA36081.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3555. Eukaryota.
ENOG410Y6A8. LUCA.
GeneTreeiENSGT00510000046429.
HOGENOMiHOG000293295.
HOVERGENiHBG026595.
InParanoidiQ08629.
KOiK08136.
OMAiTACTDKE.
OrthoDBiEOG091G086I.
PhylomeDBiQ08629.
TreeFamiTF317779.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152377-MONOMER.

Miscellaneous databases

ChiTaRSiSPOCK1. human.
GeneWikiiSPOCK1.
GenomeRNAii6695.
PROiQ08629.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152377.
CleanExiHS_SPOCK1.
ExpressionAtlasiQ08629. baseline and differential.
GenevisibleiQ08629. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002350. Kazal_dom.
IPR019577. SPARC/Testican_Ca-bd-dom.
IPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF07648. Kazal_2. 1 hit.
PF10591. SPARC_Ca_bdg. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTICN1_HUMAN
AccessioniPrimary (citable) accession number: Q08629
Secondary accession number(s): B3KSW3
, Q59EW0, Q8N630, Q9UCL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.