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Q08624

- HXC4_MOUSE

UniProt

Q08624 - HXC4_MOUSE

Protein

Homeobox protein Hox-C4

Gene

Hoxc4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi156 – 21560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. HMG box domain binding Source: UniProtKB
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. cartilage development Source: MGI
    3. embryonic organ morphogenesis Source: MGI
    4. skeletal system development Source: MGI
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-C4
    Alternative name(s):
    Homeobox protein Hox-3.5
    Gene namesi
    Name:Hoxc4
    Synonyms:Hox-3.5, Hoxc-4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:96195. Hoxc4.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 264264Homeobox protein Hox-C4PRO_0000200165Add
    BLAST

    Proteomic databases

    PRIDEiQ08624.

    PTM databases

    PhosphoSiteiQ08624.

    Expressioni

    Gene expression databases

    BgeeiQ08624.
    CleanExiMM_HOXC4.
    GenevestigatoriQ08624.

    Interactioni

    Protein-protein interaction databases

    BioGridi200386. 6 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08624.
    SMRiQ08624. Positions 163-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi135 – 1406Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi54 – 607Poly-Pro
    Compositional biasi183 – 1864Poly-Arg

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG314883.
    GeneTreeiENSGT00750000117269.
    HOGENOMiHOG000231179.
    HOVERGENiHBG016849.
    InParanoidiQ08624.
    KOiK09304.
    OMAiERQYNCA.
    PhylomeDBiQ08624.
    TreeFamiTF352857.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q08624-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIMSSYLMDS NYIDPKFPPC EEYSQNSYIP EHSPEYYGRT RESGFQHHHQ    50
    ELYPPPPPRP SYPERQYSCT SLQGPGNSRA HGPAQAGHHH PEKSQPLCEP 100
    APLSGTSASP SPAPPACSQP APDHPSSAAS KQPIVYPWMK KIHVSTVNPN 150
    YNGGEPKRSR TAYTRQQVLE LEKEFHYNRY LTRRRRIEIA HSLCLSERQI 200
    KIWFQNRRMK WKKDHRLPNT KVRSAPPAGA APSTLSAATP GTSEDHSQSA 250
    TPPEQQRAED ITRL 264
    Length:264
    Mass (Da):29,865
    Last modified:October 1, 1994 - v1
    Checksum:i35B0FA34B45BF30C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti80 – 801A → G in CAA48784. (PubMed:1363091)Curated
    Sequence conflicti96 – 961P → S in CAA48784. (PubMed:1363091)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D11328 Genomic DNA. Translation: BAA01947.1.
    S62287 Genomic DNA. Translation: AAB27153.1.
    X69019 mRNA. Translation: CAA48784.1.
    M81660 Genomic DNA. Translation: AAA63313.1.
    CCDSiCCDS27897.1.
    PIRiS35219.
    RefSeqiNP_038581.2. NM_013553.2.
    XP_006520524.1. XM_006520461.1.
    XP_006520525.1. XM_006520462.1.
    XP_006520526.1. XM_006520463.1.
    UniGeneiMm.1351.

    Genome annotation databases

    EnsembliENSMUST00000100164; ENSMUSP00000097740; ENSMUSG00000075394.
    GeneIDi15423.
    KEGGimmu:15423.
    UCSCiuc007xxg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D11328 Genomic DNA. Translation: BAA01947.1 .
    S62287 Genomic DNA. Translation: AAB27153.1 .
    X69019 mRNA. Translation: CAA48784.1 .
    M81660 Genomic DNA. Translation: AAA63313.1 .
    CCDSi CCDS27897.1.
    PIRi S35219.
    RefSeqi NP_038581.2. NM_013553.2.
    XP_006520524.1. XM_006520461.1.
    XP_006520525.1. XM_006520462.1.
    XP_006520526.1. XM_006520463.1.
    UniGenei Mm.1351.

    3D structure databases

    ProteinModelPortali Q08624.
    SMRi Q08624. Positions 163-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200386. 6 interactions.

    PTM databases

    PhosphoSitei Q08624.

    Proteomic databases

    PRIDEi Q08624.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000100164 ; ENSMUSP00000097740 ; ENSMUSG00000075394 .
    GeneIDi 15423.
    KEGGi mmu:15423.
    UCSCi uc007xxg.1. mouse.

    Organism-specific databases

    CTDi 3221.
    MGIi MGI:96195. Hoxc4.

    Phylogenomic databases

    eggNOGi NOG314883.
    GeneTreei ENSGT00750000117269.
    HOGENOMi HOG000231179.
    HOVERGENi HBG016849.
    InParanoidi Q08624.
    KOi K09304.
    OMAi ERQYNCA.
    PhylomeDBi Q08624.
    TreeFami TF352857.

    Miscellaneous databases

    NextBioi 288166.
    PROi Q08624.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q08624.
    CleanExi MM_HOXC4.
    Genevestigatori Q08624.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Organization and expression of mouse Hox3 cluster genes."
      Goto J., Miyabayashi T., Wakamatsu Y., Takahashi N., Muramatsu M.-A.
      Mol. Gen. Genet. 239:41-48(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
      Tissue: Liver.
    2. "Sequence and embryonic expression of the murine Hox-3.5 gene."
      Geada A.M.C., Gaunt S.J., Azzawi M., Shimeld S.M., Pearce J., Sharpe P.T.
      Development 116:497-506(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    3. "Detection of homeobox genes in development and evolution."
      Murtha M.T., Leckman J.F., Ruddle F.H.
      Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 177-201.
      Strain: C57BL/6.
      Tissue: Spleen.

    Entry informationi

    Entry nameiHXC4_MOUSE
    AccessioniPrimary (citable) accession number: Q08624
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3