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Q08624 (HXC4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-C4
Alternative name(s):
Homeobox protein Hox-3.5
Gene names
Name:Hoxc4
Synonyms:Hox-3.5, Hoxc-4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family. Deformed subfamily.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 264264Homeobox protein Hox-C4
PRO_0000200165

Regions

DNA binding156 – 21560Homeobox
Motif135 – 1406Antp-type hexapeptide
Compositional bias54 – 607Poly-Pro
Compositional bias183 – 1864Poly-Arg

Experimental info

Sequence conflict801A → G in CAA48784. Ref.2
Sequence conflict961P → S in CAA48784. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q08624 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 35B0FA34B45BF30C

FASTA26429,865
        10         20         30         40         50         60 
MIMSSYLMDS NYIDPKFPPC EEYSQNSYIP EHSPEYYGRT RESGFQHHHQ ELYPPPPPRP 

        70         80         90        100        110        120 
SYPERQYSCT SLQGPGNSRA HGPAQAGHHH PEKSQPLCEP APLSGTSASP SPAPPACSQP 

       130        140        150        160        170        180 
APDHPSSAAS KQPIVYPWMK KIHVSTVNPN YNGGEPKRSR TAYTRQQVLE LEKEFHYNRY 

       190        200        210        220        230        240 
LTRRRRIEIA HSLCLSERQI KIWFQNRRMK WKKDHRLPNT KVRSAPPAGA APSTLSAATP 

       250        260 
GTSEDHSQSA TPPEQQRAED ITRL 

« Hide

References

[1]"Organization and expression of mouse Hox3 cluster genes."
Goto J., Miyabayashi T., Wakamatsu Y., Takahashi N., Muramatsu M.-A.
Mol. Gen. Genet. 239:41-48(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
Tissue: Liver.
[2]"Sequence and embryonic expression of the murine Hox-3.5 gene."
Geada A.M.C., Gaunt S.J., Azzawi M., Shimeld S.M., Pearce J., Sharpe P.T.
Development 116:497-506(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
[3]"Detection of homeobox genes in development and evolution."
Murtha M.T., Leckman J.F., Ruddle F.H.
Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 177-201.
Strain: C57BL/6.
Tissue: Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D11328 Genomic DNA. Translation: BAA01947.1.
S62287 Genomic DNA. Translation: AAB27153.1.
X69019 mRNA. Translation: CAA48784.1.
M81660 Genomic DNA. Translation: AAA63313.1.
CCDSCCDS27897.1.
PIRS35219.
RefSeqNP_038581.2. NM_013553.2.
XP_006520524.1. XM_006520461.1.
XP_006520525.1. XM_006520462.1.
XP_006520526.1. XM_006520463.1.
UniGeneMm.1351.

3D structure databases

ProteinModelPortalQ08624.
SMRQ08624. Positions 163-216.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200386. 6 interactions.

PTM databases

PhosphoSiteQ08624.

Proteomic databases

PRIDEQ08624.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000100164; ENSMUSP00000097740; ENSMUSG00000075394.
GeneID15423.
KEGGmmu:15423.
UCSCuc007xxg.1. mouse.

Organism-specific databases

CTD3221.
MGIMGI:96195. Hoxc4.

Phylogenomic databases

eggNOGNOG314883.
GeneTreeENSGT00750000117269.
HOGENOMHOG000231179.
HOVERGENHBG016849.
InParanoidQ08624.
KOK09304.
OMAERQYNCA.
PhylomeDBQ08624.
TreeFamTF352857.

Gene expression databases

BgeeQ08624.
CleanExMM_HOXC4.
GenevestigatorQ08624.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288166.
PROQ08624.
SOURCESearch...

Entry information

Entry nameHXC4_MOUSE
AccessionPrimary (citable) accession number: Q08624
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries