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Q08624

- HXC4_MOUSE

UniProt

Q08624 - HXC4_MOUSE

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Protein

Homeobox protein Hox-C4

Gene

Hoxc4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi156 – 21560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. HMG box domain binding Source: UniProtKB
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. cartilage development Source: MGI
  3. embryonic organ morphogenesis Source: MGI
  4. skeletal system development Source: MGI
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C4
Alternative name(s):
Homeobox protein Hox-3.5
Gene namesi
Name:Hoxc4
Synonyms:Hox-3.5, Hoxc-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:96195. Hoxc4.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Homeobox protein Hox-C4PRO_0000200165Add
BLAST

Proteomic databases

PRIDEiQ08624.

PTM databases

PhosphoSiteiQ08624.

Expressioni

Gene expression databases

BgeeiQ08624.
CleanExiMM_HOXC4.
ExpressionAtlasiQ08624. baseline and differential.
GenevestigatoriQ08624.

Interactioni

Protein-protein interaction databases

BioGridi200386. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ08624.
SMRiQ08624. Positions 163-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi135 – 1406Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi54 – 607Poly-Pro
Compositional biasi183 – 1864Poly-Arg

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314883.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiQ08624.
KOiK09304.
OMAiERQYNCA.
PhylomeDBiQ08624.
TreeFamiTF352857.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08624-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIMSSYLMDS NYIDPKFPPC EEYSQNSYIP EHSPEYYGRT RESGFQHHHQ
60 70 80 90 100
ELYPPPPPRP SYPERQYSCT SLQGPGNSRA HGPAQAGHHH PEKSQPLCEP
110 120 130 140 150
APLSGTSASP SPAPPACSQP APDHPSSAAS KQPIVYPWMK KIHVSTVNPN
160 170 180 190 200
YNGGEPKRSR TAYTRQQVLE LEKEFHYNRY LTRRRRIEIA HSLCLSERQI
210 220 230 240 250
KIWFQNRRMK WKKDHRLPNT KVRSAPPAGA APSTLSAATP GTSEDHSQSA
260
TPPEQQRAED ITRL
Length:264
Mass (Da):29,865
Last modified:October 1, 1994 - v1
Checksum:i35B0FA34B45BF30C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 801A → G in CAA48784. (PubMed:1363091)Curated
Sequence conflicti96 – 961P → S in CAA48784. (PubMed:1363091)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D11328 Genomic DNA. Translation: BAA01947.1.
S62287 Genomic DNA. Translation: AAB27153.1.
X69019 mRNA. Translation: CAA48784.1.
M81660 Genomic DNA. Translation: AAA63313.1.
CCDSiCCDS27897.1.
PIRiS35219.
RefSeqiNP_038581.2. NM_013553.2.
XP_006520524.1. XM_006520461.1.
XP_006520525.1. XM_006520462.1.
XP_006520526.1. XM_006520463.1.
UniGeneiMm.1351.

Genome annotation databases

EnsembliENSMUST00000100164; ENSMUSP00000097740; ENSMUSG00000075394.
GeneIDi15423.
KEGGimmu:15423.
UCSCiuc007xxg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D11328 Genomic DNA. Translation: BAA01947.1 .
S62287 Genomic DNA. Translation: AAB27153.1 .
X69019 mRNA. Translation: CAA48784.1 .
M81660 Genomic DNA. Translation: AAA63313.1 .
CCDSi CCDS27897.1.
PIRi S35219.
RefSeqi NP_038581.2. NM_013553.2.
XP_006520524.1. XM_006520461.1.
XP_006520525.1. XM_006520462.1.
XP_006520526.1. XM_006520463.1.
UniGenei Mm.1351.

3D structure databases

ProteinModelPortali Q08624.
SMRi Q08624. Positions 163-216.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200386. 6 interactions.

PTM databases

PhosphoSitei Q08624.

Proteomic databases

PRIDEi Q08624.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000100164 ; ENSMUSP00000097740 ; ENSMUSG00000075394 .
GeneIDi 15423.
KEGGi mmu:15423.
UCSCi uc007xxg.1. mouse.

Organism-specific databases

CTDi 3221.
MGIi MGI:96195. Hoxc4.

Phylogenomic databases

eggNOGi NOG314883.
GeneTreei ENSGT00760000118945.
HOGENOMi HOG000231179.
HOVERGENi HBG016849.
InParanoidi Q08624.
KOi K09304.
OMAi ERQYNCA.
PhylomeDBi Q08624.
TreeFami TF352857.

Miscellaneous databases

NextBioi 288166.
PROi Q08624.
SOURCEi Search...

Gene expression databases

Bgeei Q08624.
CleanExi MM_HOXC4.
ExpressionAtlasi Q08624. baseline and differential.
Genevestigatori Q08624.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Organization and expression of mouse Hox3 cluster genes."
    Goto J., Miyabayashi T., Wakamatsu Y., Takahashi N., Muramatsu M.-A.
    Mol. Gen. Genet. 239:41-48(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Liver.
  2. "Sequence and embryonic expression of the murine Hox-3.5 gene."
    Geada A.M.C., Gaunt S.J., Azzawi M., Shimeld S.M., Pearce J., Sharpe P.T.
    Development 116:497-506(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  3. "Detection of homeobox genes in development and evolution."
    Murtha M.T., Leckman J.F., Ruddle F.H.
    Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 177-201.
    Strain: C57BL/6.
    Tissue: Spleen.

Entry informationi

Entry nameiHXC4_MOUSE
AccessioniPrimary (citable) accession number: Q08624
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 29, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3