Q08624 (HXC4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-C4

Alternative name(s):
Homeobox protein Hox-3.5

Gene names

Name:	Hoxc4
Synonyms:	Hox-3.5, Hoxc-4

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Deformed subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from mutant phenotype PubMed 8626021PubMed 8660891. Source: MGI cartilage development Inferred from mutant phenotype PubMed 8626021. Source: MGI embryonic organ morphogenesis Inferred from mutant phenotype PubMed 8660891. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Homeobox protein Hox-C4		PRO_0000200165
Regions
	DNA binding	156 – 215	60	Homeobox
	Motif	135 – 140	6	Antp-type hexapeptide
	Compositional bias	54 – 60	7	Poly-Pro
	Compositional bias	183 – 186	4	Poly-Arg
Experimental info
	Sequence conflict	80	1	A → G in CAA48784. Ref.2
	Sequence conflict	96	1	P → S in CAA48784. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q08624 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 35B0FA34B45BF30C	FASTA	264	29,865
	10 20 30 40 50 60 MIMSSYLMDS NYIDPKFPPC EEYSQNSYIP EHSPEYYGRT RESGFQHHHQ ELYPPPPPRP 70 80 90 100 110 120 SYPERQYSCT SLQGPGNSRA HGPAQAGHHH PEKSQPLCEP APLSGTSASP SPAPPACSQP 130 140 150 160 170 180 APDHPSSAAS KQPIVYPWMK KIHVSTVNPN YNGGEPKRSR TAYTRQQVLE LEKEFHYNRY 190 200 210 220 230 240 LTRRRRIEIA HSLCLSERQI KIWFQNRRMK WKKDHRLPNT KVRSAPPAGA APSTLSAATP 250 260 GTSEDHSQSA TPPEQQRAED ITRL

References

[1]	"Organization and expression of mouse Hox3 cluster genes." Goto J., Miyabayashi T., Wakamatsu Y., Takahashi N., Muramatsu M.-A. Mol. Gen. Genet. 239:41-48(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c. Tissue: Liver.
[2]	"Sequence and embryonic expression of the murine Hox-3.5 gene." Geada A.M.C., Gaunt S.J., Azzawi M., Shimeld S.M., Pearce J., Sharpe P.T. Development 116:497-506(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo.
[3]	"Detection of homeobox genes in development and evolution." Murtha M.T., Leckman J.F., Ruddle F.H. Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 177-201. Strain: C57BL/6. Tissue: Spleen.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D11328 Genomic DNA. Translation: BAA01947.1. S62287 Genomic DNA. Translation: AAB27153.1. X69019 mRNA. Translation: CAA48784.1. M81660 Genomic DNA. Translation: AAA63313.1.
IPI	IPI00122942.
PIR	S35219.
RefSeq	NP_038581.2. NM_013553.2.
UniGene	Mm.1351.
3D structure databases
ProteinModelPortal	Q08624.
SMR	Q08624. Positions 163-216.
ModBase	Search...
PTM databases
PhosphoSite	Q08624.
Proteomic databases
PRIDE	Q08624.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000100164; ENSMUSP00000097740; ENSMUSG00000075394.
GeneID	15423.
KEGG	mmu:15423.
UCSC	uc007xxg.1. mouse.
Organism-specific databases
CTD	3221.
MGI	MGI:96195. Hoxc4.
Phylogenomic databases
eggNOG	NOG314883.
GeneTree	ENSGT00700000104090.
HOGENOM	HOG000231179.
HOVERGEN	HBG016849.
InParanoid	Q08624.
KO	K09304.
OMA	ERQYNCA.
OrthoDB	EOG4GTKF7.
Gene expression databases
ArrayExpress	Q08624.
Bgee	Q08624.
CleanEx	MM_HOXC4.
Genevestigator	Q08624.
GermOnline	ENSMUSG00000075394. Mus musculus.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	288166.
SOURCE	Search...

Entry information

Entry name

HXC4_MOUSE

Accession

Primary (citable) accession number: Q08624

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	April 3, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program