Reviewed,
UniProtKB/Swiss-Prot Q08623 (HDD1A_HUMAN)
Last modified
June 16, 2009.
Version 66.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Haloacid dehalogenase-like hydrolase domain-containing protein 1A Alternative name(s): Protein GS1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 214 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Sequence similarities | Belongs to the HAD-like hydrolase superfamily. CbbY/cbbZ/gph/yieH family. |
Ontologies
| Gene Ontology (GO) | |
|---|---|
| Biological process | metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | catalytic activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 214 | 214 | Haloacid dehalogenase-like hydrolase domain-containing protein 1A | PRO_0000108068 | |||||
Experimental info | |||||||||
| Sequence conflict | 74 | 1 | T → M in AAA58622. Ref.1 | ||||||
| Sequence conflict | 102 | 1 | G → R in AAH12494. Ref.4 | ||||||
| Sequence conflict | 139 | 1 | D → G in BAD97125. Ref.3 | ||||||
| Sequence conflict | 177 | 1 | V → A in AAA58622. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation of a new gene from the distal short arm of the human X chromosome that escapes X-inactivation." Yen P.H., Ellison J., Salido E.C., Mohandas T., Shapiro L. Hum. Mol. Genet. 1:47-52(1992) [PubMed: 1284467] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.  Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [3] | Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver cancer. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| [5] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| M86934 mRNA. Translation: AAA58622.1. AK313155 mRNA. Translation: BAG35973.1. AK223405 mRNA. Translation: BAD97125.1. BC012494 mRNA. Translation: AAH12494.1. | |
| IPI | IPI00302436. |
| RefSeq | NP_001129037.1. NP_036212.3. |
| UniGene | Hs.185910 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q08623. |
Proteomic databases | |
| PRIDE | Q08623. |
Genome annotation databases | |
| Ensembl | ENSG00000130021. Homo sapiens. [Contig view] |
| GeneID | 8226. |
| NMPDR | fig|9606.3.peg.32410. |
Organism-specific databases | |
| GeneCards | GC0XM006976. |
| HGNC | HGNC:16818. HDHD1A. |
| MIM | 306480. gene. |
| PharmGKB | PA128394539. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q08623. |
| HOVERGEN | Q08623. |
Gene expression databases | |
| ArrayExpress | Q08623. |
| Bgee | Q08623. |
| CleanEx | HS_HDHD1A. |
| GermOnline | ENSG00000130021. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR005834. Dehalogen-like_hydro. IPR006402. HAD-SF_hydro_IA_v3. [Graphical view] |
| Pfam | PF00702. Hydrolase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01509. HAD-SF-IA-v3. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 30966. |
| SOURCE | Search... |
Entry information
| Entry name | HDD1A_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q08623 Secondary accession number(s): B2R7X6, Q53F84, Q96EB8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |
