Reviewed, UniProtKB/Swiss-Prot Q08623 (HDD1A_HUMAN)

Names and origin

Protein names

Recommended name:
    Haloacid dehalogenase-like hydrolase domain-containing protein 1A
      Short name=GS1 protein

Gene names

Name:	HDHD1A
Synonyms:	DXF68S1E, FAM16AX, GS1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. CbbY/cbbZ/gph/yieH family.

Ontologies

Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 214	214	Haloacid dehalogenase-like hydrolase domain-containing protein 1A		PRO_0000108068
Experimental info
	Sequence conflict	74	1	T → M in AAA58622. Ref.1
	Sequence conflict	102	1	G → R in AAH12494. Ref.3
	Sequence conflict	139	1	D → G in BAD97125. Ref.2
	Sequence conflict	177	1	V → A in AAA58622. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q08623-1 [UniParc]. Last modified August 30, 2005. Version 2. Checksum: 93F74475D96423F1	FASTA	214	23,730
	10 20 30 40 50 60 MDGLLLDTER LYSVVFQEIC NRYDKKYSWD VKSLVMGKKA LEAAQIIIDV LQLPMSKEEL 70 80 90 100 110 120 VEESQTKLKE VFPTAALMPG AEKLIIHLRK HGIPFALATS SGSASFDMKT SRHKEFFSLF 130 140 150 160 170 180 SHIVLGDDPE VQHGKPDPDI FLACAKRFSP PPAMEKCLVF EDAPNGVEAA LAAGMQVVMV 190 200 210 PDGNLSRDLT TKATLVLNSL QDFQPELFGL PSYE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a new gene from the distal short arm of the human X chromosome that escapes X-inactivation." Yen P.H., Ellison J., Salido E.C., Mohandas T., Shapiro L. Hum. Mol. Genet. 1:47-52(1992) [PubMed: 1284467] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver cancer.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M86934 mRNA. Translation: AAA58622.1. AK223405 mRNA. Translation: BAD97125.1. BC012494 mRNA. Translation: AAH12494.1.
RefSeq	NP_036212.3.
UniGene	Hs.185910
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q08623.
Genome annotation databases
Ensembl	ENSG00000130021. Homo sapiens. [Contig view]
GeneID	8226.
KEGG	hsa:8226.
NMPDR	fig|9606.3.peg.32410.
Organism-specific databases
HGNC	HGNC:16818. HDHD1A.
MIM	306480. gene.
PharmGKB	PA128394539.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q08623.
HOVERGEN	Q08623.
Gene expression databases
ArrayExpress	Q08623.
CleanEx	HS_HDHD1A.
GermOnline	ENSG00000130021. Homo sapiens.
Family and domain databases
InterPro	IPR005834. Dehalogen-like_hydro. IPR006402. HAD-SF_hydro_IA_v3. [Graphical view]
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01509. HAD-SF-IA-v3. 1 hit.
ProtoNet	Search...
Other Resources
LinkHub	Q08623.
NextBio	30966.
SOURCE	Search...

Entry information

Entry name

HDD1A_HUMAN

Accession

Primary (citable) accession number: Q08623
Secondary accession number(s): Q53F84, Q96EB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	August 30, 2005
Last modified:	November 25, 2008
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)