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Q08619 (IFI5B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon-activable protein 205-B

Short name=Ifi-205-B
Alternative name(s):
Interferon-inducible protein p205-B
Myeloid cell nuclear differentiation antigen
Protein D3
Gene names
Name:Ifi205b
Synonyms:Mnda
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a transcriptional regulator in the myeloid lineage. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways. Ref.2 Ref.5

Subunit structure

Interacts with TP53, RB1, CDK1, CDK2 and HOXB2. Ref.5

Subcellular location

Nucleus Ref.2.

Tissue specificity

Mononuclear phagocytes. Ref.1

Induction

By lipopolysaccharides (LPS). Ref.1

Sequence similarities

Belongs to the HIN-200 family.

Contains 1 DAPIN domain.

Contains 1 HIN-200 domain.

Sequence caution

The sequence BAE31364.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CDK2P249412EBI-8064290,EBI-375096From a different organism.
TP53P046372EBI-8064290,EBI-366083From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425Interferon-activable protein 205-B
PRO_0000153722

Regions

Domain1 – 8888DAPIN
Repeat129 – 13571
Repeat136 – 14272
Repeat143 – 14973
Repeat150 – 15674
Domain213 – 413201HIN-200
Region129 – 177494 X 7 AA tandem repeats of T-S-T-A-Q-A-[GR]

Experimental info

Sequence conflict671E → A in BAE29634. Ref.3
Sequence conflict1421G → R in BAE29634. Ref.3
Sequence conflict1421G → R in BAE38635. Ref.3
Sequence conflict1481A → E in BAE38635. Ref.3
Sequence conflict1581S → I in BAE29634. Ref.3
Sequence conflict1871M → R in BAE29634. Ref.3
Sequence conflict2041L → P in BAE29634. Ref.3
Sequence conflict2761K → E in BAE31415. Ref.3
Sequence conflict2771F → S in BAE38635. Ref.3
Sequence conflict3501K → N in BAE38635. Ref.3
Sequence conflict3661S → R in AAB26880. Ref.1

Secondary structure

................ 425
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q08619 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: 4CC601557C946E2B

FASTA42546,977
        10         20         30         40         50         60 
MVNEYKRIVL LRGLECINKH YFSLFKSLLA RDLNLERDNQ EQYTTIQIAN MMEEKFPADS 

        70         80         90        100        110        120 
GLGKLIEFCE EVPALRKRAE ILKKERSEVT GETSLEKNGQ EAGPATPTST TSHMLASERG 

       130        140        150        160        170        180 
ETSATQEETS TAQAGTSTAQ AGTSTAQAGT STAQKRKSMR EEETGVKKSK AAKEPDQPPC 

       190        200        210        220        230        240 
CEEPTAMCQS PILHSSSSAS SNILSAKNQK SQPQNQNIPR GAVLHSEPLT VMVLTATDPF 

       250        260        270        280        290        300 
EYESPEHEVK NMFHATVATV SQYFHVKVFN IDLKEKFTKN NFITISNYFE SKGILEINET 

       310        320        330        340        350        360 
SSVLEAAPKQ MIEVPNCITR NANASPKICD IQKGTSGTVF YGVFTLHKKK VKTQNTSYEI 

       370        380        390        400        410        420 
KDGSGSIEVV GSGQWHNINC KEGDKLHLFC FHLKRERGQP KLVCGDHSFV KVTKAGKKKE 


ASTVQ 

« Hide

References

« Hide 'large scale' references
[1]"A lipopolysaccharide-inducible macrophage gene (D3) is a new member of an interferon-inducible gene cluster and is selectively expressed in mononuclear phagocytes."
Tannenbaum C.S., Major J., Ohmori Y., Hamilton T.A.
J. Leukoc. Biol. 53:563-568(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
Tissue: Macrophage.
[2]"Inhibition of growth by p205: a nuclear protein and putative tumor suppressor expressed during myeloid cell differentiation."
Dermott J.M., Gooya J.M., Asefa B., Weiler S.R., Smith M., Keller J.R.
Stem Cells 22:832-848(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow macrophage, Cerebellum and Mammary gland.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation."
Asefa B., Dermott J.M., Kaldis P., Stefanisko K., Garfinkel D.J., Keller J.R.
FEBS Lett. 580:1205-1214(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH TP53; RB1; CDK1; CDK2 AND HOXB2.
[6]"Solution structures of the PAAD_DAPIN domain of Mus musculus interferon-activatable protein 205."
RIKEN structural genomics initiative (RSGI)
Submitted (FEB-2008) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 8-88.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S62227 mRNA. Translation: AAB26880.1.
AK152621 mRNA. Translation: BAE31364.1. Different initiation.
AK080485 mRNA. Translation: BAC37930.1.
AK150522 mRNA. Translation: BAE29634.1.
AK152683 mRNA. Translation: BAE31415.1.
AK152786 mRNA. Translation: BAE31495.1.
AK166217 mRNA. Translation: BAE38635.1.
BC132314 mRNA. Translation: AAI32315.1.
BC132316 mRNA. Translation: AAI32317.1.
RefSeqNP_001028622.1. NM_001033450.3.
NP_032355.2. NM_008329.2.
UniGeneMm.261270.
Mm.490248.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2YU0NMR-A8-88[»]
ProteinModelPortalQ08619.
SMRQ08619. Positions 8-88, 216-411.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200523. 2 interactions.
IntActQ08619. 11 interactions.
MINTMINT-1781852.

PTM databases

PhosphoSiteQ08619.

Proteomic databases

PaxDbQ08619.
PRIDEQ08619.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000009340; ENSMUSP00000009340; ENSMUSG00000026536.
GeneID15951.
381308.
KEGGmmu:15951.
mmu:381308.
UCSCuc007dsa.1. mouse.

Organism-specific databases

CTD15951.
4332.
MGIMGI:3041120. Mnda.

Phylogenomic databases

eggNOGNOG81691.
GeneTreeENSGT00390000013296.
HOVERGENHBG006122.
InParanoidQ08619.
OrthoDBEOG7ZD1V8.
PhylomeDBQ08619.
TreeFamTF337385.

Gene expression databases

BgeeQ08619.
GenevestigatorQ08619.

Family and domain databases

Gene3D2.40.50.140. 2 hits.
InterProIPR004020. DAPIN.
IPR004021. HIN200/IF120x.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF02760. HIN. 1 hit.
PF02758. PYRIN. 1 hit.
[Graphical view]
PROSITEPS50824. DAPIN. 1 hit.
PS50834. HIN_200. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ08619.
NextBio288690.
PROQ08619.
SOURCESearch...

Entry information

Entry nameIFI5B_MOUSE
AccessionPrimary (citable) accession number: Q08619
Secondary accession number(s): Q3TM07 expand/collapse secondary AC list , Q3U776, Q3U7F4, Q3U7K5, Q3UCH9, Q8C4X3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot