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Q08619

- IFI5B_MOUSE

UniProt

Q08619 - IFI5B_MOUSE

Protein

Interferon-activable protein 205-B

Gene

Ifi205b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    May act as a transcriptional regulator in the myeloid lineage. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_196447. IRF3-mediated induction of type I IFN.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon-activable protein 205-B
    Short name:
    Ifi-205-B
    Alternative name(s):
    Interferon-inducible protein p205-B
    Myeloid cell nuclear differentiation antigen
    Protein D3
    Gene namesi
    Name:Ifi205b
    Synonyms:Mnda
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:3041120. Mnda.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Interferon-activable protein 205-BPRO_0000153722Add
    BLAST

    Proteomic databases

    MaxQBiQ08619.
    PaxDbiQ08619.
    PRIDEiQ08619.

    PTM databases

    PhosphoSiteiQ08619.

    Expressioni

    Tissue specificityi

    Mononuclear phagocytes.1 Publication

    Inductioni

    By lipopolysaccharides (LPS).1 Publication

    Gene expression databases

    BgeeiQ08619.
    GenevestigatoriQ08619.

    Interactioni

    Subunit structurei

    Interacts with TP53, RB1, CDK1, CDK2 and HOXB2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDK2P249412EBI-8064290,EBI-375096From a different organism.
    TP53P046372EBI-8064290,EBI-366083From a different organism.

    Protein-protein interaction databases

    BioGridi200523. 2 interactions.
    IntActiQ08619. 11 interactions.
    MINTiMINT-1781852.

    Structurei

    Secondary structure

    1
    425
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni10 – 167
    Helixi19 – 3012
    Turni31 – 333
    Beta strandi40 – 423
    Helixi45 – 5511
    Turni57 – 615
    Helixi62 – 7110
    Turni73 – 753
    Helixi76 – 8611

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YU0NMR-A8-88[»]
    ProteinModelPortaliQ08619.
    SMRiQ08619. Positions 8-88, 220-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ08619.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8888DAPINPROSITE-ProRule annotationAdd
    BLAST
    Repeati129 – 13571
    Repeati136 – 14272
    Repeati143 – 14973
    Repeati150 – 15674
    Domaini213 – 413201HIN-200PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni129 – 177494 X 7 AA tandem repeats of T-S-T-A-Q-A-[GR]Add
    BLAST

    Sequence similaritiesi

    Belongs to the HIN-200 family.Curated
    Contains 1 DAPIN domain.PROSITE-ProRule annotation
    Contains 1 HIN-200 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG81691.
    GeneTreeiENSGT00390000013296.
    HOVERGENiHBG006122.
    InParanoidiQ08619.
    OMAiCEEPTAM.
    OrthoDBiEOG7ZD1V8.
    PhylomeDBiQ08619.
    TreeFamiTF337385.

    Family and domain databases

    Gene3Di2.40.50.140. 2 hits.
    InterProiIPR004020. DAPIN.
    IPR004021. HIN200/IF120x.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF02760. HIN. 1 hit.
    PF02758. PYRIN. 1 hit.
    [Graphical view]
    PROSITEiPS50824. DAPIN. 1 hit.
    PS50834. HIN_200. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q08619-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNEYKRIVL LRGLECINKH YFSLFKSLLA RDLNLERDNQ EQYTTIQIAN    50
    MMEEKFPADS GLGKLIEFCE EVPALRKRAE ILKKERSEVT GETSLEKNGQ 100
    EAGPATPTST TSHMLASERG ETSATQEETS TAQAGTSTAQ AGTSTAQAGT 150
    STAQKRKSMR EEETGVKKSK AAKEPDQPPC CEEPTAMCQS PILHSSSSAS 200
    SNILSAKNQK SQPQNQNIPR GAVLHSEPLT VMVLTATDPF EYESPEHEVK 250
    NMFHATVATV SQYFHVKVFN IDLKEKFTKN NFITISNYFE SKGILEINET 300
    SSVLEAAPKQ MIEVPNCITR NANASPKICD IQKGTSGTVF YGVFTLHKKK 350
    VKTQNTSYEI KDGSGSIEVV GSGQWHNINC KEGDKLHLFC FHLKRERGQP 400
    KLVCGDHSFV KVTKAGKKKE ASTVQ 425
    Length:425
    Mass (Da):46,977
    Last modified:January 15, 2008 - v2
    Checksum:i4CC601557C946E2B
    GO

    Sequence cautioni

    The sequence BAE31364.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 671E → A in BAE29634. (PubMed:16141072)Curated
    Sequence conflicti142 – 1421G → R in BAE29634. (PubMed:16141072)Curated
    Sequence conflicti142 – 1421G → R in BAE38635. (PubMed:16141072)Curated
    Sequence conflicti148 – 1481A → E in BAE38635. (PubMed:16141072)Curated
    Sequence conflicti158 – 1581S → I in BAE29634. (PubMed:16141072)Curated
    Sequence conflicti187 – 1871M → R in BAE29634. (PubMed:16141072)Curated
    Sequence conflicti204 – 2041L → P in BAE29634. (PubMed:16141072)Curated
    Sequence conflicti276 – 2761K → E in BAE31415. (PubMed:16141072)Curated
    Sequence conflicti277 – 2771F → S in BAE38635. (PubMed:16141072)Curated
    Sequence conflicti350 – 3501K → N in BAE38635. (PubMed:16141072)Curated
    Sequence conflicti366 – 3661S → R in AAB26880. (PubMed:7684766)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S62227 mRNA. Translation: AAB26880.1.
    AK152621 mRNA. Translation: BAE31364.1. Different initiation.
    AK080485 mRNA. Translation: BAC37930.1.
    AK150522 mRNA. Translation: BAE29634.1.
    AK152683 mRNA. Translation: BAE31415.1.
    AK152786 mRNA. Translation: BAE31495.1.
    AK166217 mRNA. Translation: BAE38635.1.
    BC132314 mRNA. Translation: AAI32315.1.
    BC132316 mRNA. Translation: AAI32317.1.
    CCDSiCCDS15532.1.
    RefSeqiNP_001028622.1. NM_001033450.3.
    NP_032355.2. NM_008329.2.
    UniGeneiMm.261270.
    Mm.490248.

    Genome annotation databases

    EnsembliENSMUST00000009340; ENSMUSP00000009340; ENSMUSG00000026536.
    GeneIDi15951.
    381308.
    KEGGimmu:15951.
    mmu:381308.
    UCSCiuc007dsa.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S62227 mRNA. Translation: AAB26880.1 .
    AK152621 mRNA. Translation: BAE31364.1 . Different initiation.
    AK080485 mRNA. Translation: BAC37930.1 .
    AK150522 mRNA. Translation: BAE29634.1 .
    AK152683 mRNA. Translation: BAE31415.1 .
    AK152786 mRNA. Translation: BAE31495.1 .
    AK166217 mRNA. Translation: BAE38635.1 .
    BC132314 mRNA. Translation: AAI32315.1 .
    BC132316 mRNA. Translation: AAI32317.1 .
    CCDSi CCDS15532.1.
    RefSeqi NP_001028622.1. NM_001033450.3.
    NP_032355.2. NM_008329.2.
    UniGenei Mm.261270.
    Mm.490248.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YU0 NMR - A 8-88 [» ]
    ProteinModelPortali Q08619.
    SMRi Q08619. Positions 8-88, 220-411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200523. 2 interactions.
    IntActi Q08619. 11 interactions.
    MINTi MINT-1781852.

    PTM databases

    PhosphoSitei Q08619.

    Proteomic databases

    MaxQBi Q08619.
    PaxDbi Q08619.
    PRIDEi Q08619.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000009340 ; ENSMUSP00000009340 ; ENSMUSG00000026536 .
    GeneIDi 15951.
    381308.
    KEGGi mmu:15951.
    mmu:381308.
    UCSCi uc007dsa.1. mouse.

    Organism-specific databases

    CTDi 15951.
    4332.
    MGIi MGI:3041120. Mnda.

    Phylogenomic databases

    eggNOGi NOG81691.
    GeneTreei ENSGT00390000013296.
    HOVERGENi HBG006122.
    InParanoidi Q08619.
    OMAi CEEPTAM.
    OrthoDBi EOG7ZD1V8.
    PhylomeDBi Q08619.
    TreeFami TF337385.

    Enzyme and pathway databases

    Reactomei REACT_196447. IRF3-mediated induction of type I IFN.

    Miscellaneous databases

    EvolutionaryTracei Q08619.
    NextBioi 288690.
    PROi Q08619.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q08619.
    Genevestigatori Q08619.

    Family and domain databases

    Gene3Di 2.40.50.140. 2 hits.
    InterProi IPR004020. DAPIN.
    IPR004021. HIN200/IF120x.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF02760. HIN. 1 hit.
    PF02758. PYRIN. 1 hit.
    [Graphical view ]
    PROSITEi PS50824. DAPIN. 1 hit.
    PS50834. HIN_200. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A lipopolysaccharide-inducible macrophage gene (D3) is a new member of an interferon-inducible gene cluster and is selectively expressed in mononuclear phagocytes."
      Tannenbaum C.S., Major J., Ohmori Y., Hamilton T.A.
      J. Leukoc. Biol. 53:563-568(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
      Tissue: Macrophage.
    2. "Inhibition of growth by p205: a nuclear protein and putative tumor suppressor expressed during myeloid cell differentiation."
      Dermott J.M., Gooya J.M., Asefa B., Weiler S.R., Smith M., Keller J.R.
      Stem Cells 22:832-848(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow macrophage, Cerebellum and Mammary gland.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation."
      Asefa B., Dermott J.M., Kaldis P., Stefanisko K., Garfinkel D.J., Keller J.R.
      FEBS Lett. 580:1205-1214(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TP53; RB1; CDK1; CDK2 AND HOXB2.
    6. "Solution structures of the PAAD_DAPIN domain of Mus musculus interferon-activatable protein 205."
      RIKEN structural genomics initiative (RSGI)
      Submitted (FEB-2008) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 8-88.

    Entry informationi

    Entry nameiIFI5B_MOUSE
    AccessioniPrimary (citable) accession number: Q08619
    Secondary accession number(s): Q3TM07
    , Q3U776, Q3U7F4, Q3U7K5, Q3UCH9, Q8C4X3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3