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Q08619

- IFI5B_MOUSE

UniProt

Q08619 - IFI5B_MOUSE

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Protein
Interferon-activable protein 205-B
Gene
Ifi205b, Mnda
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May act as a transcriptional regulator in the myeloid lineage. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways.2 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_196447. IRF3-mediated induction of type I IFN.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-activable protein 205-B
Short name:
Ifi-205-B
Alternative name(s):
Interferon-inducible protein p205-B
Myeloid cell nuclear differentiation antigen
Protein D3
Gene namesi
Name:Ifi205b
Synonyms:Mnda
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:3041120. Mnda.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Interferon-activable protein 205-B
PRO_0000153722Add
BLAST

Proteomic databases

MaxQBiQ08619.
PaxDbiQ08619.
PRIDEiQ08619.

PTM databases

PhosphoSiteiQ08619.

Expressioni

Tissue specificityi

Mononuclear phagocytes.1 Publication

Inductioni

By lipopolysaccharides (LPS).1 Publication

Gene expression databases

BgeeiQ08619.
GenevestigatoriQ08619.

Interactioni

Subunit structurei

Interacts with TP53, RB1, CDK1, CDK2 and HOXB2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CDK2P249412EBI-8064290,EBI-375096From a different organism.
TP53P046372EBI-8064290,EBI-366083From a different organism.

Protein-protein interaction databases

BioGridi200523. 2 interactions.
IntActiQ08619. 11 interactions.
MINTiMINT-1781852.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni10 – 167
Helixi19 – 3012
Turni31 – 333
Beta strandi40 – 423
Helixi45 – 5511
Turni57 – 615
Helixi62 – 7110
Turni73 – 753
Helixi76 – 8611

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YU0NMR-A8-88[»]
ProteinModelPortaliQ08619.
SMRiQ08619. Positions 8-88, 220-411.

Miscellaneous databases

EvolutionaryTraceiQ08619.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8888DAPIN
Add
BLAST
Repeati129 – 13571
Repeati136 – 14272
Repeati143 – 14973
Repeati150 – 15674
Domaini213 – 413201HIN-200
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 177494 X 7 AA tandem repeats of T-S-T-A-Q-A-[GR]
Add
BLAST

Sequence similaritiesi

Belongs to the HIN-200 family.
Contains 1 DAPIN domain.
Contains 1 HIN-200 domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG81691.
GeneTreeiENSGT00390000013296.
HOVERGENiHBG006122.
InParanoidiQ08619.
OMAiCEEPTAM.
OrthoDBiEOG7ZD1V8.
PhylomeDBiQ08619.
TreeFamiTF337385.

Family and domain databases

Gene3Di2.40.50.140. 2 hits.
InterProiIPR004020. DAPIN.
IPR004021. HIN200/IF120x.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF02760. HIN. 1 hit.
PF02758. PYRIN. 1 hit.
[Graphical view]
PROSITEiPS50824. DAPIN. 1 hit.
PS50834. HIN_200. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08619-1 [UniParc]FASTAAdd to Basket

« Hide

MVNEYKRIVL LRGLECINKH YFSLFKSLLA RDLNLERDNQ EQYTTIQIAN    50
MMEEKFPADS GLGKLIEFCE EVPALRKRAE ILKKERSEVT GETSLEKNGQ 100
EAGPATPTST TSHMLASERG ETSATQEETS TAQAGTSTAQ AGTSTAQAGT 150
STAQKRKSMR EEETGVKKSK AAKEPDQPPC CEEPTAMCQS PILHSSSSAS 200
SNILSAKNQK SQPQNQNIPR GAVLHSEPLT VMVLTATDPF EYESPEHEVK 250
NMFHATVATV SQYFHVKVFN IDLKEKFTKN NFITISNYFE SKGILEINET 300
SSVLEAAPKQ MIEVPNCITR NANASPKICD IQKGTSGTVF YGVFTLHKKK 350
VKTQNTSYEI KDGSGSIEVV GSGQWHNINC KEGDKLHLFC FHLKRERGQP 400
KLVCGDHSFV KVTKAGKKKE ASTVQ 425
Length:425
Mass (Da):46,977
Last modified:January 15, 2008 - v2
Checksum:i4CC601557C946E2B
GO

Sequence cautioni

The sequence BAE31364.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671E → A in BAE29634. 1 Publication
Sequence conflicti142 – 1421G → R in BAE29634. 1 Publication
Sequence conflicti142 – 1421G → R in BAE38635. 1 Publication
Sequence conflicti148 – 1481A → E in BAE38635. 1 Publication
Sequence conflicti158 – 1581S → I in BAE29634. 1 Publication
Sequence conflicti187 – 1871M → R in BAE29634. 1 Publication
Sequence conflicti204 – 2041L → P in BAE29634. 1 Publication
Sequence conflicti276 – 2761K → E in BAE31415. 1 Publication
Sequence conflicti277 – 2771F → S in BAE38635. 1 Publication
Sequence conflicti350 – 3501K → N in BAE38635. 1 Publication
Sequence conflicti366 – 3661S → R in AAB26880. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S62227 mRNA. Translation: AAB26880.1.
AK152621 mRNA. Translation: BAE31364.1. Different initiation.
AK080485 mRNA. Translation: BAC37930.1.
AK150522 mRNA. Translation: BAE29634.1.
AK152683 mRNA. Translation: BAE31415.1.
AK152786 mRNA. Translation: BAE31495.1.
AK166217 mRNA. Translation: BAE38635.1.
BC132314 mRNA. Translation: AAI32315.1.
BC132316 mRNA. Translation: AAI32317.1.
CCDSiCCDS15532.1.
RefSeqiNP_001028622.1. NM_001033450.3.
NP_032355.2. NM_008329.2.
UniGeneiMm.261270.
Mm.490248.

Genome annotation databases

EnsembliENSMUST00000009340; ENSMUSP00000009340; ENSMUSG00000026536.
GeneIDi15951.
381308.
KEGGimmu:15951.
mmu:381308.
UCSCiuc007dsa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S62227 mRNA. Translation: AAB26880.1 .
AK152621 mRNA. Translation: BAE31364.1 . Different initiation.
AK080485 mRNA. Translation: BAC37930.1 .
AK150522 mRNA. Translation: BAE29634.1 .
AK152683 mRNA. Translation: BAE31415.1 .
AK152786 mRNA. Translation: BAE31495.1 .
AK166217 mRNA. Translation: BAE38635.1 .
BC132314 mRNA. Translation: AAI32315.1 .
BC132316 mRNA. Translation: AAI32317.1 .
CCDSi CCDS15532.1.
RefSeqi NP_001028622.1. NM_001033450.3.
NP_032355.2. NM_008329.2.
UniGenei Mm.261270.
Mm.490248.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YU0 NMR - A 8-88 [» ]
ProteinModelPortali Q08619.
SMRi Q08619. Positions 8-88, 220-411.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200523. 2 interactions.
IntActi Q08619. 11 interactions.
MINTi MINT-1781852.

PTM databases

PhosphoSitei Q08619.

Proteomic databases

MaxQBi Q08619.
PaxDbi Q08619.
PRIDEi Q08619.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000009340 ; ENSMUSP00000009340 ; ENSMUSG00000026536 .
GeneIDi 15951.
381308.
KEGGi mmu:15951.
mmu:381308.
UCSCi uc007dsa.1. mouse.

Organism-specific databases

CTDi 15951.
4332.
MGIi MGI:3041120. Mnda.

Phylogenomic databases

eggNOGi NOG81691.
GeneTreei ENSGT00390000013296.
HOVERGENi HBG006122.
InParanoidi Q08619.
OMAi CEEPTAM.
OrthoDBi EOG7ZD1V8.
PhylomeDBi Q08619.
TreeFami TF337385.

Enzyme and pathway databases

Reactomei REACT_196447. IRF3-mediated induction of type I IFN.

Miscellaneous databases

EvolutionaryTracei Q08619.
NextBioi 288690.
PROi Q08619.
SOURCEi Search...

Gene expression databases

Bgeei Q08619.
Genevestigatori Q08619.

Family and domain databases

Gene3Di 2.40.50.140. 2 hits.
InterProi IPR004020. DAPIN.
IPR004021. HIN200/IF120x.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF02760. HIN. 1 hit.
PF02758. PYRIN. 1 hit.
[Graphical view ]
PROSITEi PS50824. DAPIN. 1 hit.
PS50834. HIN_200. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A lipopolysaccharide-inducible macrophage gene (D3) is a new member of an interferon-inducible gene cluster and is selectively expressed in mononuclear phagocytes."
    Tannenbaum C.S., Major J., Ohmori Y., Hamilton T.A.
    J. Leukoc. Biol. 53:563-568(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Tissue: Macrophage.
  2. "Inhibition of growth by p205: a nuclear protein and putative tumor suppressor expressed during myeloid cell differentiation."
    Dermott J.M., Gooya J.M., Asefa B., Weiler S.R., Smith M., Keller J.R.
    Stem Cells 22:832-848(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow macrophage, Cerebellum and Mammary gland.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation."
    Asefa B., Dermott J.M., Kaldis P., Stefanisko K., Garfinkel D.J., Keller J.R.
    FEBS Lett. 580:1205-1214(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TP53; RB1; CDK1; CDK2 AND HOXB2.
  6. "Solution structures of the PAAD_DAPIN domain of Mus musculus interferon-activatable protein 205."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2008) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 8-88.

Entry informationi

Entry nameiIFI5B_MOUSE
AccessioniPrimary (citable) accession number: Q08619
Secondary accession number(s): Q3TM07
, Q3U776, Q3U7F4, Q3U7K5, Q3UCH9, Q8C4X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 15, 2008
Last modified: September 3, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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