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Q085C9

- LPXB_SHEFN

UniProt

Q085C9 - LPXB_SHEFN

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Shewanella frigidimarina (strain NCIMB 400)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciSFRI318167:GIXS-1335-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:Sfri_1283
    OrganismiShewanella frigidimarina (strain NCIMB 400)
    Taxonomic identifieri318167 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000000684: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382Lipid-A-disaccharide synthasePRO_1000049415Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi318167.Sfri_1283.

    Structurei

    3D structure databases

    ProteinModelPortaliQ085C9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q085C9-1 [UniParc]FASTAAdd to Basket

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    MTNSPSKVFA IVAGEISGDI LGAGLVNSLK KRYPDARFIG IGGPRMQALG    50
    FESLFPMEEL SIMGLVEVLS HLPRLLHIRS SLVKQITELA PDCFIGIDAP 100
    DFNIGVELKL KAKGIKTVHY VSPSVWAWRP KRIFKIAKAT NMVLSLLPFE 150
    KAFYDQHQVP CTFVGHTLAD DIPMHSDKLA ARQLLGLDPN AEYLAVLPGS 200
    RGGELKQLAE PFVKAAQLVK QTFPDIKFVT PVVNDARRQQ FLAALEEFAP 250
    DLEVTIVEGQ SREVMAAADC ILLASGTATL EAMLVKRPMV VSYRVSPITY 300
    AIAIKMMKIK NYSLPNLLAN DTIVPELMQA NCQPQLIADA IIKQLNQDFA 350
    PLNTRFEELH QLLKCNASER AADAVVALLQ TP 382
    Length:382
    Mass (Da):41,995
    Last modified:October 31, 2006 - v1
    Checksum:iDC29E1DC52415B81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000447 Genomic DNA. Translation: ABI71136.1.
    RefSeqiYP_749974.1. NC_008345.1.

    Genome annotation databases

    EnsemblBacteriaiABI71136; ABI71136; Sfri_1283.
    GeneIDi4278394.
    KEGGisfr:Sfri_1283.
    PATRICi23496455. VBISheFri14343_1327.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000447 Genomic DNA. Translation: ABI71136.1 .
    RefSeqi YP_749974.1. NC_008345.1.

    3D structure databases

    ProteinModelPortali Q085C9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 318167.Sfri_1283.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI71136 ; ABI71136 ; Sfri_1283 .
    GeneIDi 4278394.
    KEGGi sfr:Sfri_1283.
    PATRICi 23496455. VBISheFri14343_1327.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci SFRI318167:GIXS-1335-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCIMB 400.

    Entry informationi

    Entry nameiLPXB_SHEFN
    AccessioniPrimary (citable) accession number: Q085C9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3