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Q08580

- PEX27_YEAST

UniProt

Q08580 - PEX27_YEAST

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Protein
Peroxisomal membrane protein PEX27
Gene
PEX27, YOR193W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Required for regulation of peroxisome size and number. Also promotes peroxisome division and biogenesis.3 Publications

GO - Biological processi

  1. peroxisome fission Source: UniProtKB
  2. peroxisome organization Source: SGD
  3. regulation of peroxisome size Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-33702-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX27
Alternative name(s):
Peroxin-27
Gene namesi
Name:PEX27
Ordered Locus Names:YOR193W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR193w.
SGDiS000005719. PEX27.

Subcellular locationi

Peroxisome membrane; Peripheral membrane protein 3 Publications

GO - Cellular componenti

  1. peroxisomal membrane Source: SGD
  2. peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Peroxisomal membrane protein PEX27
PRO_0000270569Add
BLAST

Proteomic databases

MaxQBiQ08580.
PaxDbiQ08580.

Expressioni

Gene expression databases

GenevestigatoriQ08580.

Interactioni

Subunit structurei

Homooligomer. Interacts with PEX25 and PEX34.3 Publications

Protein-protein interaction databases

BioGridi34591. 14 interactions.
IntActiQ08580. 1 interaction.
MINTiMINT-2494218.
STRINGi4932.YOR193W.

Structurei

3D structure databases

ProteinModelPortaliQ08580.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi130 – 1389Poly-Leu

Phylogenomic databases

eggNOGiNOG40921.
OMAiKNTSHAN.
OrthoDBiEOG7C2RB2.

Sequencei

Sequence statusi: Complete.

Q08580-1 [UniParc]FASTAAdd to Basket

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MTSDPVNTNI SSPTLTDRNA DESWELLKRE FNTLFSNLKT DSKEEGNFTD    50
NKGVIAKKPI VLQDNDDSDF TQNQGKVATA TSTTSDRSFK RTLGSIEMKK 100
RYVKKNCQAK FVFNTLEGKE VCSKILQHTL GLLSLLLLTR KIRLLNFSSK 150
LRLVIQQLSL FRYYLRFGNF AINLYKIIKR FRWLREMKKL HYKDQSILFY 200
FKNFRFFDII EAFYNLTDEL ILFHKLQSMF GKKNTSHANT NRLMTFVKEQ 250
HYILWEVLNI LAINKNIEQW RQLIRDEIYL SIYNTSGNAI KEYELKYKLP 300
TNDKVNLELR KNNITLDFYK IILNLLSNLI NIKGKRDKYN SELAYEIISV 350
GSGVTELLKL WNRAKVTSAN EHTSAV 376
Length:376
Mass (Da):44,131
Last modified:November 1, 1996 - v1
Checksum:i976FDBCA43AB4F80
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z75101 Genomic DNA. Translation: CAA99406.1.
AY723869 Genomic DNA. Translation: AAU09786.1.
BK006948 Genomic DNA. Translation: DAA10968.1.
PIRiS67085.
RefSeqiNP_014836.3. NM_001183612.3.

Genome annotation databases

EnsemblFungiiYOR193W; YOR193W; YOR193W.
GeneIDi854368.
KEGGisce:YOR193W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z75101 Genomic DNA. Translation: CAA99406.1 .
AY723869 Genomic DNA. Translation: AAU09786.1 .
BK006948 Genomic DNA. Translation: DAA10968.1 .
PIRi S67085.
RefSeqi NP_014836.3. NM_001183612.3.

3D structure databases

ProteinModelPortali Q08580.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34591. 14 interactions.
IntActi Q08580. 1 interaction.
MINTi MINT-2494218.
STRINGi 4932.YOR193W.

Protein family/group databases

TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBi Q08580.
PaxDbi Q08580.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOR193W ; YOR193W ; YOR193W .
GeneIDi 854368.
KEGGi sce:YOR193W.

Organism-specific databases

CYGDi YOR193w.
SGDi S000005719. PEX27.

Phylogenomic databases

eggNOGi NOG40921.
OMAi KNTSHAN.
OrthoDBi EOG7C2RB2.

Enzyme and pathway databases

BioCyci YEAST:G3O-33702-MONOMER.

Miscellaneous databases

NextBioi 976490.

Gene expression databases

Genevestigatori Q08580.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Pex11-related proteins in peroxisome dynamics: a role for the novel peroxin Pex27p in controlling peroxisome size and number in Saccharomyces cerevisiae."
    Tam Y.Y.C., Torres-Guzman J.C., Vizeacoumar F.J., Smith J.J., Marelli M., Aitchison J.D., Rachubinski R.A.
    Mol. Biol. Cell 14:4089-4102(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INTERACTION WITH PEX25, SUBCELLULAR LOCATION.
  5. "Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis."
    Rottensteiner H., Stein K., Sonnenhol E., Erdmann R.
    Mol. Biol. Cell 14:4316-4328(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INTERACTION WITH PEX25, SUBCELLULAR LOCATION.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast."
    Tower R.J., Fagarasanu A., Aitchison J.D., Rachubinski R.A.
    Mol. Biol. Cell 22:1727-1738(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PEX34.

Entry informationi

Entry nameiPEX27_YEAST
AccessioniPrimary (citable) accession number: Q08580
Secondary accession number(s): D6W2Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 382 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3

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