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Protein

Peroxisomal membrane protein PEX27

Gene

PEX27

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for regulation of peroxisome size and number. Also promotes peroxisome division and biogenesis.3 Publications

GO - Biological processi

  1. peroxisome fission Source: UniProtKB
  2. peroxisome organization Source: SGD
  3. regulation of peroxisome size Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-33702-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX27
Alternative name(s):
Peroxin-27
Gene namesi
Name:PEX27
Ordered Locus Names:YOR193W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XV

Organism-specific databases

CYGDiYOR193w.
EuPathDBiFungiDB:YOR193W.
SGDiS000005719. PEX27.

Subcellular locationi

  1. Peroxisome membrane 3 Publications; Peripheral membrane protein 3 Publications

GO - Cellular componenti

  1. peroxisomal membrane Source: SGD
  2. peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Peroxisomal membrane protein PEX27PRO_0000270569Add
BLAST

Proteomic databases

MaxQBiQ08580.
PaxDbiQ08580.

Expressioni

Gene expression databases

GenevestigatoriQ08580.

Interactioni

Subunit structurei

Homooligomer. Interacts with PEX25 and PEX34.3 Publications

Protein-protein interaction databases

BioGridi34591. 14 interactions.
IntActiQ08580. 1 interaction.
MINTiMINT-2494218.
STRINGi4932.YOR193W.

Structurei

3D structure databases

ProteinModelPortaliQ08580.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi130 – 1389Poly-Leu

Phylogenomic databases

eggNOGiNOG40921.
OrthoDBiEOG7C2RB2.

Sequencei

Sequence statusi: Complete.

Q08580-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSDPVNTNI SSPTLTDRNA DESWELLKRE FNTLFSNLKT DSKEEGNFTD
60 70 80 90 100
NKGVIAKKPI VLQDNDDSDF TQNQGKVATA TSTTSDRSFK RTLGSIEMKK
110 120 130 140 150
RYVKKNCQAK FVFNTLEGKE VCSKILQHTL GLLSLLLLTR KIRLLNFSSK
160 170 180 190 200
LRLVIQQLSL FRYYLRFGNF AINLYKIIKR FRWLREMKKL HYKDQSILFY
210 220 230 240 250
FKNFRFFDII EAFYNLTDEL ILFHKLQSMF GKKNTSHANT NRLMTFVKEQ
260 270 280 290 300
HYILWEVLNI LAINKNIEQW RQLIRDEIYL SIYNTSGNAI KEYELKYKLP
310 320 330 340 350
TNDKVNLELR KNNITLDFYK IILNLLSNLI NIKGKRDKYN SELAYEIISV
360 370
GSGVTELLKL WNRAKVTSAN EHTSAV
Length:376
Mass (Da):44,131
Last modified:November 1, 1996 - v1
Checksum:i976FDBCA43AB4F80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75101 Genomic DNA. Translation: CAA99406.1.
AY723869 Genomic DNA. Translation: AAU09786.1.
BK006948 Genomic DNA. Translation: DAA10968.1.
PIRiS67085.
RefSeqiNP_014836.3. NM_001183612.3.

Genome annotation databases

EnsemblFungiiYOR193W; YOR193W; YOR193W.
GeneIDi854368.
KEGGisce:YOR193W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75101 Genomic DNA. Translation: CAA99406.1.
AY723869 Genomic DNA. Translation: AAU09786.1.
BK006948 Genomic DNA. Translation: DAA10968.1.
PIRiS67085.
RefSeqiNP_014836.3. NM_001183612.3.

3D structure databases

ProteinModelPortaliQ08580.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34591. 14 interactions.
IntActiQ08580. 1 interaction.
MINTiMINT-2494218.
STRINGi4932.YOR193W.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBiQ08580.
PaxDbiQ08580.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR193W; YOR193W; YOR193W.
GeneIDi854368.
KEGGisce:YOR193W.

Organism-specific databases

CYGDiYOR193w.
EuPathDBiFungiDB:YOR193W.
SGDiS000005719. PEX27.

Phylogenomic databases

eggNOGiNOG40921.
OrthoDBiEOG7C2RB2.

Enzyme and pathway databases

BioCyciYEAST:G3O-33702-MONOMER.

Miscellaneous databases

NextBioi976490.
PROiQ08580.

Gene expression databases

GenevestigatoriQ08580.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Pex11-related proteins in peroxisome dynamics: a role for the novel peroxin Pex27p in controlling peroxisome size and number in Saccharomyces cerevisiae."
    Tam Y.Y.C., Torres-Guzman J.C., Vizeacoumar F.J., Smith J.J., Marelli M., Aitchison J.D., Rachubinski R.A.
    Mol. Biol. Cell 14:4089-4102(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INTERACTION WITH PEX25, SUBCELLULAR LOCATION.
  5. "Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis."
    Rottensteiner H., Stein K., Sonnenhol E., Erdmann R.
    Mol. Biol. Cell 14:4316-4328(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INTERACTION WITH PEX25, SUBCELLULAR LOCATION.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast."
    Tower R.J., Fagarasanu A., Aitchison J.D., Rachubinski R.A.
    Mol. Biol. Cell 22:1727-1738(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PEX34.

Entry informationi

Entry nameiPEX27_YEAST
AccessioniPrimary (citable) accession number: Q08580
Secondary accession number(s): D6W2Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: April 29, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 382 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.