Q08580 (PEX27_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peroxisomal membrane protein PEX27

Alternative name(s):
Peroxin-27

Gene names

Name:	PEX27
Ordered Locus Names:	YOR193W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for regulation of peroxisome size and number. Also promotes peroxisome division and biogenesis. Ref.4 Ref.5 Ref.8
Subunit structure	Homooligomer. Interacts with PEX25 and PEX34. Ref.4 Ref.5 Ref.8
Subcellular location	Peroxisome membrane; Peripheral membrane protein Ref.4 Ref.5 Ref.6.
Miscellaneous	Present with 382 molecules/cell in log phase SD medium.

Ontologies

Keywords
Biological process	Peroxisome biogenesis
Cellular component	Membrane Peroxisome
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peroxisome fission Inferred from direct assay PubMed 20826455. Source: UniProtKB regulation of peroxisome size Inferred from direct assay PubMed 20826455. Source: UniProtKB
Cellular_component	peroxisomal membrane Inferred from direct assay Ref.4. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Peroxisomal membrane protein PEX27		PRO_0000270569
Regions
	Compositional bias	130 – 138	9	Poly-Leu

Sequences

	Sequence		Length	Mass (Da)
	Q08580 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 976FDBCA43AB4F80	FASTA	376	44,131
	10 20 30 40 50 60 MTSDPVNTNI SSPTLTDRNA DESWELLKRE FNTLFSNLKT DSKEEGNFTD NKGVIAKKPI 70 80 90 100 110 120 VLQDNDDSDF TQNQGKVATA TSTTSDRSFK RTLGSIEMKK RYVKKNCQAK FVFNTLEGKE 130 140 150 160 170 180 VCSKILQHTL GLLSLLLLTR KIRLLNFSSK LRLVIQQLSL FRYYLRFGNF AINLYKIIKR 190 200 210 220 230 240 FRWLREMKKL HYKDQSILFY FKNFRFFDII EAFYNLTDEL ILFHKLQSMF GKKNTSHANT 250 260 270 280 290 300 NRLMTFVKEQ HYILWEVLNI LAINKNIEQW RQLIRDEIYL SIYNTSGNAI KEYELKYKLP 310 320 330 340 350 360 TNDKVNLELR KNNITLDFYK IILNLLSNLI NIKGKRDKYN SELAYEIISV GSGVTELLKL 370 WNRAKVTSAN EHTSAV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K. Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Pex11-related proteins in peroxisome dynamics: a role for the novel peroxin Pex27p in controlling peroxisome size and number in Saccharomyces cerevisiae." Tam Y.Y.C., Torres-Guzman J.C., Vizeacoumar F.J., Smith J.J., Marelli M., Aitchison J.D., Rachubinski R.A. Mol. Biol. Cell 14:4089-4102(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBUNIT, INTERACTION WITH PEX25, SUBCELLULAR LOCATION.
[5]	"Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis." Rottensteiner H., Stein K., Sonnenhol E., Erdmann R. Mol. Biol. Cell 14:4316-4328(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBUNIT, INTERACTION WITH PEX25, SUBCELLULAR LOCATION.
[6]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast." Tower R.J., Fagarasanu A., Aitchison J.D., Rachubinski R.A. Mol. Biol. Cell 22:1727-1738(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH PEX34.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z75101 Genomic DNA. Translation: CAA99406.1. AY723869 Genomic DNA. Translation: AAU09786.1. BK006948 Genomic DNA. Translation: DAA10968.1.
PIR	S67085.
RefSeq	NP_014836.3. NM_001183612.3.
3D structure databases
ProteinModelPortal	Q08580.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q08580. 1 interaction.
MINT	MINT-2494218.
STRING	4932.YOR193W.
Proteomic databases
PaxDb	Q08580.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YOR193W; YOR193W; YOR193W.
GeneID	854368.
KEGG	sce:YOR193W. sce:YOR195W.
Organism-specific databases
CYGD	YOR193w.
SGD	S000005719. PEX27.
Phylogenomic databases
eggNOG	NOG40921.
GeneTree	ENSGT00530000068471.
KO	K12575.
Gene expression databases
Genevestigator	Q08580.
Family and domain databases
ProtoNet	Search...
Other
NextBio	976490.

Entry information

Entry name

PEX27_YEAST

Accession

Primary (citable) accession number: Q08580
Secondary accession number(s): D6W2Q2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program