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Q08580 (PEX27_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisomal membrane protein PEX27
Alternative name(s):
Peroxin-27
Gene names
Name:PEX27
Ordered Locus Names:YOR193W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for regulation of peroxisome size and number. Also promotes peroxisome division and biogenesis. Ref.4 Ref.5 Ref.8

Subunit structure

Homooligomer. Interacts with PEX25 and PEX34. Ref.4 Ref.5 Ref.8

Subcellular location

Peroxisome membrane; Peripheral membrane protein Ref.4 Ref.5 Ref.6.

Miscellaneous

Present with 382 molecules/cell in log phase SD medium.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Peroxisomal membrane protein PEX27
PRO_0000270569

Regions

Compositional bias130 – 1389Poly-Leu

Sequences

Sequence LengthMass (Da)Tools
Q08580 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 976FDBCA43AB4F80

FASTA37644,131
        10         20         30         40         50         60 
MTSDPVNTNI SSPTLTDRNA DESWELLKRE FNTLFSNLKT DSKEEGNFTD NKGVIAKKPI 

        70         80         90        100        110        120 
VLQDNDDSDF TQNQGKVATA TSTTSDRSFK RTLGSIEMKK RYVKKNCQAK FVFNTLEGKE 

       130        140        150        160        170        180 
VCSKILQHTL GLLSLLLLTR KIRLLNFSSK LRLVIQQLSL FRYYLRFGNF AINLYKIIKR 

       190        200        210        220        230        240 
FRWLREMKKL HYKDQSILFY FKNFRFFDII EAFYNLTDEL ILFHKLQSMF GKKNTSHANT 

       250        260        270        280        290        300 
NRLMTFVKEQ HYILWEVLNI LAINKNIEQW RQLIRDEIYL SIYNTSGNAI KEYELKYKLP 

       310        320        330        340        350        360 
TNDKVNLELR KNNITLDFYK IILNLLSNLI NIKGKRDKYN SELAYEIISV GSGVTELLKL 

       370 
WNRAKVTSAN EHTSAV 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. expand/collapse author list , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Pex11-related proteins in peroxisome dynamics: a role for the novel peroxin Pex27p in controlling peroxisome size and number in Saccharomyces cerevisiae."
Tam Y.Y.C., Torres-Guzman J.C., Vizeacoumar F.J., Smith J.J., Marelli M., Aitchison J.D., Rachubinski R.A.
Mol. Biol. Cell 14:4089-4102(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT, INTERACTION WITH PEX25, SUBCELLULAR LOCATION.
[5]"Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis."
Rottensteiner H., Stein K., Sonnenhol E., Erdmann R.
Mol. Biol. Cell 14:4316-4328(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT, INTERACTION WITH PEX25, SUBCELLULAR LOCATION.
[6]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast."
Tower R.J., Fagarasanu A., Aitchison J.D., Rachubinski R.A.
Mol. Biol. Cell 22:1727-1738(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH PEX34.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z75101 Genomic DNA. Translation: CAA99406.1.
AY723869 Genomic DNA. Translation: AAU09786.1.
BK006948 Genomic DNA. Translation: DAA10968.1.
PIRS67085.
RefSeqNP_014836.3. NM_001183612.3.

3D structure databases

ProteinModelPortalQ08580.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34591. 14 interactions.
IntActQ08580. 1 interaction.
MINTMINT-2494218.
STRING4932.YOR193W.

Protein family/group databases

TCDB3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBQ08580.
PaxDbQ08580.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYOR193W; YOR193W; YOR193W.
GeneID854368.
KEGGsce:YOR193W.

Organism-specific databases

CYGDYOR193w.
SGDS000005719. PEX27.

Phylogenomic databases

eggNOGNOG40921.
OMAKNTSHAN.
OrthoDBEOG7C2RB2.

Enzyme and pathway databases

BioCycYEAST:G3O-33702-MONOMER.

Gene expression databases

GenevestigatorQ08580.

Family and domain databases

ProtoNetSearch...

Other

NextBio976490.

Entry information

Entry namePEX27_YEAST
AccessionPrimary (citable) accession number: Q08580
Secondary accession number(s): D6W2Q2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XV

Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD