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Q08580

- PEX27_YEAST

UniProt

Q08580 - PEX27_YEAST

Protein

Peroxisomal membrane protein PEX27

Gene

PEX27

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Required for regulation of peroxisome size and number. Also promotes peroxisome division and biogenesis.3 Publications

    GO - Biological processi

    1. peroxisome fission Source: UniProtKB
    2. peroxisome organization Source: SGD
    3. regulation of peroxisome size Source: UniProtKB

    Keywords - Biological processi

    Peroxisome biogenesis

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33702-MONOMER.

    Protein family/group databases

    TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal membrane protein PEX27
    Alternative name(s):
    Peroxin-27
    Gene namesi
    Name:PEX27
    Ordered Locus Names:YOR193W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XV

    Organism-specific databases

    CYGDiYOR193w.
    SGDiS000005719. PEX27.

    Subcellular locationi

    Peroxisome membrane 3 Publications; Peripheral membrane protein 3 Publications

    GO - Cellular componenti

    1. peroxisomal membrane Source: SGD
    2. peroxisome Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Peroxisomal membrane protein PEX27PRO_0000270569Add
    BLAST

    Proteomic databases

    MaxQBiQ08580.
    PaxDbiQ08580.

    Expressioni

    Gene expression databases

    GenevestigatoriQ08580.

    Interactioni

    Subunit structurei

    Homooligomer. Interacts with PEX25 and PEX34.3 Publications

    Protein-protein interaction databases

    BioGridi34591. 14 interactions.
    IntActiQ08580. 1 interaction.
    MINTiMINT-2494218.
    STRINGi4932.YOR193W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08580.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi130 – 1389Poly-Leu

    Phylogenomic databases

    eggNOGiNOG40921.
    OMAiKNTSHAN.
    OrthoDBiEOG7C2RB2.

    Sequencei

    Sequence statusi: Complete.

    Q08580-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSDPVNTNI SSPTLTDRNA DESWELLKRE FNTLFSNLKT DSKEEGNFTD    50
    NKGVIAKKPI VLQDNDDSDF TQNQGKVATA TSTTSDRSFK RTLGSIEMKK 100
    RYVKKNCQAK FVFNTLEGKE VCSKILQHTL GLLSLLLLTR KIRLLNFSSK 150
    LRLVIQQLSL FRYYLRFGNF AINLYKIIKR FRWLREMKKL HYKDQSILFY 200
    FKNFRFFDII EAFYNLTDEL ILFHKLQSMF GKKNTSHANT NRLMTFVKEQ 250
    HYILWEVLNI LAINKNIEQW RQLIRDEIYL SIYNTSGNAI KEYELKYKLP 300
    TNDKVNLELR KNNITLDFYK IILNLLSNLI NIKGKRDKYN SELAYEIISV 350
    GSGVTELLKL WNRAKVTSAN EHTSAV 376
    Length:376
    Mass (Da):44,131
    Last modified:November 1, 1996 - v1
    Checksum:i976FDBCA43AB4F80
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z75101 Genomic DNA. Translation: CAA99406.1.
    AY723869 Genomic DNA. Translation: AAU09786.1.
    BK006948 Genomic DNA. Translation: DAA10968.1.
    PIRiS67085.
    RefSeqiNP_014836.3. NM_001183612.3.

    Genome annotation databases

    EnsemblFungiiYOR193W; YOR193W; YOR193W.
    GeneIDi854368.
    KEGGisce:YOR193W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z75101 Genomic DNA. Translation: CAA99406.1 .
    AY723869 Genomic DNA. Translation: AAU09786.1 .
    BK006948 Genomic DNA. Translation: DAA10968.1 .
    PIRi S67085.
    RefSeqi NP_014836.3. NM_001183612.3.

    3D structure databases

    ProteinModelPortali Q08580.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34591. 14 interactions.
    IntActi Q08580. 1 interaction.
    MINTi MINT-2494218.
    STRINGi 4932.YOR193W.

    Protein family/group databases

    TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Proteomic databases

    MaxQBi Q08580.
    PaxDbi Q08580.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YOR193W ; YOR193W ; YOR193W .
    GeneIDi 854368.
    KEGGi sce:YOR193W.

    Organism-specific databases

    CYGDi YOR193w.
    SGDi S000005719. PEX27.

    Phylogenomic databases

    eggNOGi NOG40921.
    OMAi KNTSHAN.
    OrthoDBi EOG7C2RB2.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33702-MONOMER.

    Miscellaneous databases

    NextBioi 976490.

    Gene expression databases

    Genevestigatori Q08580.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
      Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
      , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
      Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Pex11-related proteins in peroxisome dynamics: a role for the novel peroxin Pex27p in controlling peroxisome size and number in Saccharomyces cerevisiae."
      Tam Y.Y.C., Torres-Guzman J.C., Vizeacoumar F.J., Smith J.J., Marelli M., Aitchison J.D., Rachubinski R.A.
      Mol. Biol. Cell 14:4089-4102(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, INTERACTION WITH PEX25, SUBCELLULAR LOCATION.
    5. "Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis."
      Rottensteiner H., Stein K., Sonnenhol E., Erdmann R.
      Mol. Biol. Cell 14:4316-4328(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, INTERACTION WITH PEX25, SUBCELLULAR LOCATION.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast."
      Tower R.J., Fagarasanu A., Aitchison J.D., Rachubinski R.A.
      Mol. Biol. Cell 22:1727-1738(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PEX34.

    Entry informationi

    Entry nameiPEX27_YEAST
    AccessioniPrimary (citable) accession number: Q08580
    Secondary accession number(s): D6W2Q2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 382 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    External Data

    Dasty 3