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Protein

Thiamine transporter THI72

Gene

THI72

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Low affinity thiamine transporter responsible for intake of thiamine. It is possible that the primary function is the uptake of closely related compounds and that thiamine transport is a secondary activity of these proteins.1 Publication

GO - Molecular functioni

  • 5-amino-1-ribofuranosylimidazole-4-carboxamide transporter activity Source: SGD
  • nucleobase transmembrane transporter activity Source: GO_Central
  • transporter activity Source: SGD

GO - Biological processi

  • 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport Source: SGD
  • nucleobase transport Source: GO_Central
  • thiamine transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33701-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine transporter THI72
Gene namesi
Name:THI72
Ordered Locus Names:YOR192C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR192C.
SGDiS000005718. THI72.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: SGD
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001979281 – 599Thiamine transporter THI72Add BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei560PhosphoserineBy similarity1
Modified residuei572PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ08579.
PRIDEiQ08579.

Expressioni

Inductioni

Induced by limited extracellular thiamine levels.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi34587. 34 interactors.
DIPiDIP-7926N.
IntActiQ08579. 2 interactors.
MINTiMINT-2493622.

Structurei

3D structure databases

ProteinModelPortaliQ08579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000065049.
HOGENOMiHOG000066000.
InParanoidiQ08579.
OMAiIGASACE.
OrthoDBiEOG092C1JZY.

Family and domain databases

InterProiIPR012681. NCS1.
IPR001248. Pur-cyt_permease.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00800. ncs1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFGTRISRA LRFLEIPVKN RASVNFLRNP DLQPIKSVNQ TWGFWSNFAY
60 70 80 90 100
WGVLSFNVGM WIGGSSALTV GLSYSETIGA FIIADLLTIL FALANSCPGY
110 120 130 140 150
DWKVGFTLAQ RFVFGIYGSA LGIIIRILMS IVYYGSNAWL GGLCVNMILD
160 170 180 190 200
SWSHHYLHLP NTLSSKVAMT TKELIGFIIF HILTAFCYFM KPYHMNYILI
210 220 230 240 250
WSCVGTFFAM LGMVIYLTKS AHGVGDLFTS THSTVTGSKK AWAWVYTISY
260 270 280 290 300
WYGSVSPGCT NQSDFSRFGS SNCAIWTGTI VALLIPATLI PVFGIIGASA
310 320 330 340 350
CEKLYGQTFW MPMDIFDNWL TTNYSAGARA ATFFCGFCFV MSQISYTISN
360 370 380 390 400
CGFASGMDLA GLLPKYVDIK RGAIFAACVS WACLPWNFYN SSSTFLTVMS
410 420 430 440 450
SFGVVMTPII TVMICDNFLI RKRQYSVTNA FVLKGEYYFT KGVNWRAIVA
460 470 480 490 500
WVCGMAPGLP GIAWEVNNDY FHNTGIINFF YGDSFFSFLI SFFVYWGLCL
510 520 530 540 550
LFPFKITVKH DDKDYYGAFT DEEARKKGMV PYSEISEEEI RAYTLGECFT
560 570 580 590
SGHEYKPESS DDELPELTKT SSENTKVFEI VHQKDNEKES STSSEKQIA
Length:599
Mass (Da):67,186
Last modified:November 1, 1996 - v1
Checksum:i43872C34C352A2AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75100 Genomic DNA. Translation: CAA99401.1.
BK006948 Genomic DNA. Translation: DAA10964.1.
PIRiS67084.
RefSeqiNP_014835.3. NM_001183611.3.

Genome annotation databases

EnsemblFungiiYOR192C; YOR192C; YOR192C.
GeneIDi854364.
KEGGisce:YOR192C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75100 Genomic DNA. Translation: CAA99401.1.
BK006948 Genomic DNA. Translation: DAA10964.1.
PIRiS67084.
RefSeqiNP_014835.3. NM_001183611.3.

3D structure databases

ProteinModelPortaliQ08579.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34587. 34 interactors.
DIPiDIP-7926N.
IntActiQ08579. 2 interactors.
MINTiMINT-2493622.

Proteomic databases

MaxQBiQ08579.
PRIDEiQ08579.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR192C; YOR192C; YOR192C.
GeneIDi854364.
KEGGisce:YOR192C.

Organism-specific databases

EuPathDBiFungiDB:YOR192C.
SGDiS000005718. THI72.

Phylogenomic databases

GeneTreeiENSGT00530000065049.
HOGENOMiHOG000066000.
InParanoidiQ08579.
OMAiIGASACE.
OrthoDBiEOG092C1JZY.

Enzyme and pathway databases

BioCyciYEAST:G3O-33701-MONOMER.

Miscellaneous databases

PROiQ08579.

Family and domain databases

InterProiIPR012681. NCS1.
IPR001248. Pur-cyt_permease.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00800. ncs1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTHI72_YEAST
AccessioniPrimary (citable) accession number: Q08579
Secondary accession number(s): D6W2P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.