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Protein

Thiamine transporter THI72

Gene

THI72

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Low affinity thiamine transporter responsible for intake of thiamine. It is possible that the primary function is the uptake of closely related compounds and that thiamine transport is a secondary activity of these proteins.1 Publication

GO - Molecular functioni

  • 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity Source: SGD
  • nucleobase transmembrane transporter activity Source: GO_Central
  • transporter activity Source: SGD

GO - Biological processi

  • 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport Source: SGD
  • nucleobase transport Source: GO_Central
  • thiamine transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-33701-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine transporter THI72
Gene namesi
Name:THI72
Ordered Locus Names:YOR192C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR192C
SGDiS000005718 THI72

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001979281 – 599Thiamine transporter THI72Add BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei560PhosphoserineBy similarity1
Modified residuei572PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ08579
PaxDbiQ08579
PRIDEiQ08579

Expressioni

Inductioni

Induced by limited extracellular thiamine levels.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi34587, 60 interactors
DIPiDIP-7926N
IntActiQ08579, 3 interactors
MINTiQ08579
STRINGi4932.YOR192C

Structurei

3D structure databases

ProteinModelPortaliQ08579
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000065049
HOGENOMiHOG000066000
InParanoidiQ08579
OrthoDBiEOG092C1JZY

Family and domain databases

Gene3Di1.10.4160.10, 1 hit
InterProiView protein in InterPro
IPR012681 NCS1
IPR001248 Pur-cyt_permease
IPR038271 Pur-cyt_permease_sf
PfamiView protein in Pfam
PF02133 Transp_cyt_pur, 1 hit
TIGRFAMsiTIGR00800 ncs1, 1 hit

Sequencei

Sequence statusi: Complete.

Q08579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFGTRISRA LRFLEIPVKN RASVNFLRNP DLQPIKSVNQ TWGFWSNFAY
60 70 80 90 100
WGVLSFNVGM WIGGSSALTV GLSYSETIGA FIIADLLTIL FALANSCPGY
110 120 130 140 150
DWKVGFTLAQ RFVFGIYGSA LGIIIRILMS IVYYGSNAWL GGLCVNMILD
160 170 180 190 200
SWSHHYLHLP NTLSSKVAMT TKELIGFIIF HILTAFCYFM KPYHMNYILI
210 220 230 240 250
WSCVGTFFAM LGMVIYLTKS AHGVGDLFTS THSTVTGSKK AWAWVYTISY
260 270 280 290 300
WYGSVSPGCT NQSDFSRFGS SNCAIWTGTI VALLIPATLI PVFGIIGASA
310 320 330 340 350
CEKLYGQTFW MPMDIFDNWL TTNYSAGARA ATFFCGFCFV MSQISYTISN
360 370 380 390 400
CGFASGMDLA GLLPKYVDIK RGAIFAACVS WACLPWNFYN SSSTFLTVMS
410 420 430 440 450
SFGVVMTPII TVMICDNFLI RKRQYSVTNA FVLKGEYYFT KGVNWRAIVA
460 470 480 490 500
WVCGMAPGLP GIAWEVNNDY FHNTGIINFF YGDSFFSFLI SFFVYWGLCL
510 520 530 540 550
LFPFKITVKH DDKDYYGAFT DEEARKKGMV PYSEISEEEI RAYTLGECFT
560 570 580 590
SGHEYKPESS DDELPELTKT SSENTKVFEI VHQKDNEKES STSSEKQIA
Length:599
Mass (Da):67,186
Last modified:November 1, 1996 - v1
Checksum:i43872C34C352A2AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75100 Genomic DNA Translation: CAA99401.1
BK006948 Genomic DNA Translation: DAA10964.1
PIRiS67084
RefSeqiNP_014835.3, NM_001183611.3

Genome annotation databases

EnsemblFungiiYOR192C; YOR192C; YOR192C
GeneIDi854364
KEGGisce:YOR192C

Similar proteinsi

Entry informationi

Entry nameiTHI72_YEAST
AccessioniPrimary (citable) accession number: Q08579
Secondary accession number(s): D6W2P8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health