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Q08579

- THI72_YEAST

UniProt

Q08579 - THI72_YEAST

Protein

Thiamine transporter THI72

Gene

THI72

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Low affinity thiamine transporter responsible for intake of thiamine. It is possible that the primary function is the uptake of closely related compounds and that thiamine transport is a secondary activity of these proteins.1 Publication

    GO - Molecular functioni

    1. 5-amino-1-ribofuranosylimidazole-4-carboxamide transporter activity Source: SGD
    2. nucleobase transmembrane transporter activity Source: InterPro
    3. transporter activity Source: SGD

    GO - Biological processi

    1. 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport Source: SGD
    2. thiamine transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33701-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thiamine transporter THI72
    Gene namesi
    Name:THI72
    Ordered Locus Names:YOR192C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XV

    Organism-specific databases

    CYGDiYOR192c.
    SGDiS000005718. THI72.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 599599Thiamine transporter THI72PRO_0000197928Add
    BLAST

    Proteomic databases

    PaxDbiQ08579.

    Expressioni

    Inductioni

    Induced by limited extracellular thiamine levels.1 Publication

    Gene expression databases

    GenevestigatoriQ08579.

    Interactioni

    Protein-protein interaction databases

    BioGridi34587. 34 interactions.
    DIPiDIP-7926N.
    IntActiQ08579. 2 interactions.
    MINTiMINT-2493622.
    STRINGi4932.YOR192C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08579.
    SMRiQ08579. Positions 27-445.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei112 – 13221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei174 – 19421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei280 – 30021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei333 – 35321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei372 – 39221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei395 – 41521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei447 – 46721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei484 – 50421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the purine-cytosine permease family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1953.
    GeneTreeiENSGT00530000065049.
    HOGENOMiHOG000066000.
    OMAiICCGLSE.
    OrthoDBiEOG7C2R9F.

    Family and domain databases

    InterProiIPR001248. Cyt_pur_permease.
    IPR012681. NCS1.
    [Graphical view]
    PfamiPF02133. Transp_cyt_pur. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00800. ncs1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q08579-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFGTRISRA LRFLEIPVKN RASVNFLRNP DLQPIKSVNQ TWGFWSNFAY    50
    WGVLSFNVGM WIGGSSALTV GLSYSETIGA FIIADLLTIL FALANSCPGY 100
    DWKVGFTLAQ RFVFGIYGSA LGIIIRILMS IVYYGSNAWL GGLCVNMILD 150
    SWSHHYLHLP NTLSSKVAMT TKELIGFIIF HILTAFCYFM KPYHMNYILI 200
    WSCVGTFFAM LGMVIYLTKS AHGVGDLFTS THSTVTGSKK AWAWVYTISY 250
    WYGSVSPGCT NQSDFSRFGS SNCAIWTGTI VALLIPATLI PVFGIIGASA 300
    CEKLYGQTFW MPMDIFDNWL TTNYSAGARA ATFFCGFCFV MSQISYTISN 350
    CGFASGMDLA GLLPKYVDIK RGAIFAACVS WACLPWNFYN SSSTFLTVMS 400
    SFGVVMTPII TVMICDNFLI RKRQYSVTNA FVLKGEYYFT KGVNWRAIVA 450
    WVCGMAPGLP GIAWEVNNDY FHNTGIINFF YGDSFFSFLI SFFVYWGLCL 500
    LFPFKITVKH DDKDYYGAFT DEEARKKGMV PYSEISEEEI RAYTLGECFT 550
    SGHEYKPESS DDELPELTKT SSENTKVFEI VHQKDNEKES STSSEKQIA 599
    Length:599
    Mass (Da):67,186
    Last modified:November 1, 1996 - v1
    Checksum:i43872C34C352A2AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z75100 Genomic DNA. Translation: CAA99401.1.
    BK006948 Genomic DNA. Translation: DAA10964.1.
    PIRiS67084.
    RefSeqiNP_014835.3. NM_001183611.3.

    Genome annotation databases

    EnsemblFungiiYOR192C; YOR192C; YOR192C.
    GeneIDi854364.
    KEGGisce:YOR192C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z75100 Genomic DNA. Translation: CAA99401.1 .
    BK006948 Genomic DNA. Translation: DAA10964.1 .
    PIRi S67084.
    RefSeqi NP_014835.3. NM_001183611.3.

    3D structure databases

    ProteinModelPortali Q08579.
    SMRi Q08579. Positions 27-445.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34587. 34 interactions.
    DIPi DIP-7926N.
    IntActi Q08579. 2 interactions.
    MINTi MINT-2493622.
    STRINGi 4932.YOR192C.

    Proteomic databases

    PaxDbi Q08579.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YOR192C ; YOR192C ; YOR192C .
    GeneIDi 854364.
    KEGGi sce:YOR192C.

    Organism-specific databases

    CYGDi YOR192c.
    SGDi S000005718. THI72.

    Phylogenomic databases

    eggNOGi COG1953.
    GeneTreei ENSGT00530000065049.
    HOGENOMi HOG000066000.
    OMAi ICCGLSE.
    OrthoDBi EOG7C2R9F.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33701-MONOMER.

    Miscellaneous databases

    NextBioi 976479.

    Gene expression databases

    Genevestigatori Q08579.

    Family and domain databases

    InterProi IPR001248. Cyt_pur_permease.
    IPR012681. NCS1.
    [Graphical view ]
    Pfami PF02133. Transp_cyt_pur. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00800. ncs1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
      Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
      , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
      Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Isolation and characterization of a thiamin transport gene, THI10, from Saccharomyces cerevisiae."
      Enjo F., Nosaka K., Ogata M., Iwashima A., Nishimura H.
      J. Biol. Chem. 272:19165-19170(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae."
      Nosaka K., Onozuka M., Konno H., Kawasaki Y., Nishimura H., Sano M., Akaji K.
      Mol. Microbiol. 58:467-479(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiTHI72_YEAST
    AccessioniPrimary (citable) accession number: Q08579
    Secondary accession number(s): D6W2P8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    External Data

    Dasty 3