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Q08579

- THI72_YEAST

UniProt

Q08579 - THI72_YEAST

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Protein
Thiamine transporter THI72
Gene
THI72, YOR192C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Low affinity thiamine transporter responsible for intake of thiamine. It is possible that the primary function is the uptake of closely related compounds and that thiamine transport is a secondary activity of these proteins.1 Publication

GO - Molecular functioni

  1. nucleobase transmembrane transporter activity Source: InterPro
  2. transporter activity Source: SGD
Complete GO annotation...

GO - Biological processi

  1. thiamine transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33701-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine transporter THI72
Gene namesi
Name:THI72
Ordered Locus Names:YOR192C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR192c.
SGDiS000005718. THI72.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221Helical; Reviewed prediction
Add
BLAST
Transmembranei78 – 9821Helical; Reviewed prediction
Add
BLAST
Transmembranei112 – 13221Helical; Reviewed prediction
Add
BLAST
Transmembranei174 – 19421Helical; Reviewed prediction
Add
BLAST
Transmembranei197 – 21721Helical; Reviewed prediction
Add
BLAST
Transmembranei280 – 30021Helical; Reviewed prediction
Add
BLAST
Transmembranei333 – 35321Helical; Reviewed prediction
Add
BLAST
Transmembranei372 – 39221Helical; Reviewed prediction
Add
BLAST
Transmembranei395 – 41521Helical; Reviewed prediction
Add
BLAST
Transmembranei447 – 46721Helical; Reviewed prediction
Add
BLAST
Transmembranei484 – 50421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599Thiamine transporter THI72
PRO_0000197928Add
BLAST

Proteomic databases

PaxDbiQ08579.

Expressioni

Inductioni

Induced by limited extracellular thiamine levels.1 Publication

Gene expression databases

GenevestigatoriQ08579.

Interactioni

Protein-protein interaction databases

BioGridi34587. 34 interactions.
DIPiDIP-7926N.
IntActiQ08579. 2 interactions.
MINTiMINT-2493622.
STRINGi4932.YOR192C.

Structurei

3D structure databases

ProteinModelPortaliQ08579.
SMRiQ08579. Positions 27-445.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1953.
GeneTreeiENSGT00530000065049.
HOGENOMiHOG000066000.
OMAiICCGLSE.
OrthoDBiEOG7C2R9F.

Family and domain databases

InterProiIPR001248. Cyt_pur_permease.
IPR012681. NCS1.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00800. ncs1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08579-1 [UniParc]FASTAAdd to Basket

« Hide

MSFGTRISRA LRFLEIPVKN RASVNFLRNP DLQPIKSVNQ TWGFWSNFAY    50
WGVLSFNVGM WIGGSSALTV GLSYSETIGA FIIADLLTIL FALANSCPGY 100
DWKVGFTLAQ RFVFGIYGSA LGIIIRILMS IVYYGSNAWL GGLCVNMILD 150
SWSHHYLHLP NTLSSKVAMT TKELIGFIIF HILTAFCYFM KPYHMNYILI 200
WSCVGTFFAM LGMVIYLTKS AHGVGDLFTS THSTVTGSKK AWAWVYTISY 250
WYGSVSPGCT NQSDFSRFGS SNCAIWTGTI VALLIPATLI PVFGIIGASA 300
CEKLYGQTFW MPMDIFDNWL TTNYSAGARA ATFFCGFCFV MSQISYTISN 350
CGFASGMDLA GLLPKYVDIK RGAIFAACVS WACLPWNFYN SSSTFLTVMS 400
SFGVVMTPII TVMICDNFLI RKRQYSVTNA FVLKGEYYFT KGVNWRAIVA 450
WVCGMAPGLP GIAWEVNNDY FHNTGIINFF YGDSFFSFLI SFFVYWGLCL 500
LFPFKITVKH DDKDYYGAFT DEEARKKGMV PYSEISEEEI RAYTLGECFT 550
SGHEYKPESS DDELPELTKT SSENTKVFEI VHQKDNEKES STSSEKQIA 599
Length:599
Mass (Da):67,186
Last modified:November 1, 1996 - v1
Checksum:i43872C34C352A2AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z75100 Genomic DNA. Translation: CAA99401.1.
BK006948 Genomic DNA. Translation: DAA10964.1.
PIRiS67084.
RefSeqiNP_014835.3. NM_001183611.3.

Genome annotation databases

EnsemblFungiiYOR192C; YOR192C; YOR192C.
GeneIDi854364.
KEGGisce:YOR192C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z75100 Genomic DNA. Translation: CAA99401.1 .
BK006948 Genomic DNA. Translation: DAA10964.1 .
PIRi S67084.
RefSeqi NP_014835.3. NM_001183611.3.

3D structure databases

ProteinModelPortali Q08579.
SMRi Q08579. Positions 27-445.
ModBasei Search...

Protein-protein interaction databases

BioGridi 34587. 34 interactions.
DIPi DIP-7926N.
IntActi Q08579. 2 interactions.
MINTi MINT-2493622.
STRINGi 4932.YOR192C.

Proteomic databases

PaxDbi Q08579.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOR192C ; YOR192C ; YOR192C .
GeneIDi 854364.
KEGGi sce:YOR192C.

Organism-specific databases

CYGDi YOR192c.
SGDi S000005718. THI72.

Phylogenomic databases

eggNOGi COG1953.
GeneTreei ENSGT00530000065049.
HOGENOMi HOG000066000.
OMAi ICCGLSE.
OrthoDBi EOG7C2R9F.

Enzyme and pathway databases

BioCyci YEAST:G3O-33701-MONOMER.

Miscellaneous databases

NextBioi 976479.

Gene expression databases

Genevestigatori Q08579.

Family and domain databases

InterProi IPR001248. Cyt_pur_permease.
IPR012681. NCS1.
[Graphical view ]
Pfami PF02133. Transp_cyt_pur. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00800. ncs1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Isolation and characterization of a thiamin transport gene, THI10, from Saccharomyces cerevisiae."
    Enjo F., Nosaka K., Ogata M., Iwashima A., Nishimura H.
    J. Biol. Chem. 272:19165-19170(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae."
    Nosaka K., Onozuka M., Konno H., Kawasaki Y., Nishimura H., Sano M., Akaji K.
    Mol. Microbiol. 58:467-479(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiTHI72_YEAST
AccessioniPrimary (citable) accession number: Q08579
Secondary accession number(s): D6W2P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3

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