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Q08579

- THI72_YEAST

UniProt

Q08579 - THI72_YEAST

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Protein

Thiamine transporter THI72

Gene

THI72

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Low affinity thiamine transporter responsible for intake of thiamine. It is possible that the primary function is the uptake of closely related compounds and that thiamine transport is a secondary activity of these proteins.1 Publication

GO - Molecular functioni

  1. 5-amino-1-ribofuranosylimidazole-4-carboxamide transporter activity Source: SGD
  2. nucleobase transmembrane transporter activity Source: InterPro
  3. transporter activity Source: SGD

GO - Biological processi

  1. 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport Source: SGD
  2. thiamine transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33701-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine transporter THI72
Gene namesi
Name:THI72
Ordered Locus Names:YOR192C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR192c.
SGDiS000005718. THI72.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599Thiamine transporter THI72PRO_0000197928Add
BLAST

Proteomic databases

PaxDbiQ08579.

Expressioni

Inductioni

Induced by limited extracellular thiamine levels.1 Publication

Gene expression databases

GenevestigatoriQ08579.

Interactioni

Protein-protein interaction databases

BioGridi34587. 34 interactions.
DIPiDIP-7926N.
IntActiQ08579. 2 interactions.
MINTiMINT-2493622.
STRINGi4932.YOR192C.

Structurei

3D structure databases

ProteinModelPortaliQ08579.
SMRiQ08579. Positions 27-445.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221HelicalSequence AnalysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence AnalysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence AnalysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST
Transmembranei280 – 30021HelicalSequence AnalysisAdd
BLAST
Transmembranei333 – 35321HelicalSequence AnalysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence AnalysisAdd
BLAST
Transmembranei395 – 41521HelicalSequence AnalysisAdd
BLAST
Transmembranei447 – 46721HelicalSequence AnalysisAdd
BLAST
Transmembranei484 – 50421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the purine-cytosine permease family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1953.
GeneTreeiENSGT00530000065049.
HOGENOMiHOG000066000.
InParanoidiQ08579.
OMAiICCGLSE.
OrthoDBiEOG7C2R9F.

Family and domain databases

InterProiIPR001248. Cyt_pur_permease.
IPR012681. NCS1.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00800. ncs1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08579-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFGTRISRA LRFLEIPVKN RASVNFLRNP DLQPIKSVNQ TWGFWSNFAY
60 70 80 90 100
WGVLSFNVGM WIGGSSALTV GLSYSETIGA FIIADLLTIL FALANSCPGY
110 120 130 140 150
DWKVGFTLAQ RFVFGIYGSA LGIIIRILMS IVYYGSNAWL GGLCVNMILD
160 170 180 190 200
SWSHHYLHLP NTLSSKVAMT TKELIGFIIF HILTAFCYFM KPYHMNYILI
210 220 230 240 250
WSCVGTFFAM LGMVIYLTKS AHGVGDLFTS THSTVTGSKK AWAWVYTISY
260 270 280 290 300
WYGSVSPGCT NQSDFSRFGS SNCAIWTGTI VALLIPATLI PVFGIIGASA
310 320 330 340 350
CEKLYGQTFW MPMDIFDNWL TTNYSAGARA ATFFCGFCFV MSQISYTISN
360 370 380 390 400
CGFASGMDLA GLLPKYVDIK RGAIFAACVS WACLPWNFYN SSSTFLTVMS
410 420 430 440 450
SFGVVMTPII TVMICDNFLI RKRQYSVTNA FVLKGEYYFT KGVNWRAIVA
460 470 480 490 500
WVCGMAPGLP GIAWEVNNDY FHNTGIINFF YGDSFFSFLI SFFVYWGLCL
510 520 530 540 550
LFPFKITVKH DDKDYYGAFT DEEARKKGMV PYSEISEEEI RAYTLGECFT
560 570 580 590
SGHEYKPESS DDELPELTKT SSENTKVFEI VHQKDNEKES STSSEKQIA
Length:599
Mass (Da):67,186
Last modified:November 1, 1996 - v1
Checksum:i43872C34C352A2AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z75100 Genomic DNA. Translation: CAA99401.1.
BK006948 Genomic DNA. Translation: DAA10964.1.
PIRiS67084.
RefSeqiNP_014835.3. NM_001183611.3.

Genome annotation databases

EnsemblFungiiYOR192C; YOR192C; YOR192C.
GeneIDi854364.
KEGGisce:YOR192C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z75100 Genomic DNA. Translation: CAA99401.1 .
BK006948 Genomic DNA. Translation: DAA10964.1 .
PIRi S67084.
RefSeqi NP_014835.3. NM_001183611.3.

3D structure databases

ProteinModelPortali Q08579.
SMRi Q08579. Positions 27-445.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34587. 34 interactions.
DIPi DIP-7926N.
IntActi Q08579. 2 interactions.
MINTi MINT-2493622.
STRINGi 4932.YOR192C.

Proteomic databases

PaxDbi Q08579.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOR192C ; YOR192C ; YOR192C .
GeneIDi 854364.
KEGGi sce:YOR192C.

Organism-specific databases

CYGDi YOR192c.
SGDi S000005718. THI72.

Phylogenomic databases

eggNOGi COG1953.
GeneTreei ENSGT00530000065049.
HOGENOMi HOG000066000.
InParanoidi Q08579.
OMAi ICCGLSE.
OrthoDBi EOG7C2R9F.

Enzyme and pathway databases

BioCyci YEAST:G3O-33701-MONOMER.

Miscellaneous databases

NextBioi 976479.

Gene expression databases

Genevestigatori Q08579.

Family and domain databases

InterProi IPR001248. Cyt_pur_permease.
IPR012681. NCS1.
[Graphical view ]
Pfami PF02133. Transp_cyt_pur. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00800. ncs1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Isolation and characterization of a thiamin transport gene, THI10, from Saccharomyces cerevisiae."
    Enjo F., Nosaka K., Ogata M., Iwashima A., Nishimura H.
    J. Biol. Chem. 272:19165-19170(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae."
    Nosaka K., Onozuka M., Konno H., Kawasaki Y., Nishimura H., Sano M., Akaji K.
    Mol. Microbiol. 58:467-479(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiTHI72_YEAST
AccessioniPrimary (citable) accession number: Q08579
Secondary accession number(s): D6W2P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3