Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP-dependent helicase ULS1

Gene

ULS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent helicase involved mating type switching and in silencing interference through its interaction with the silencing regulator SIR4. Cooperates with UBC4 and UBC5 to mediate ubiquitination of SUMO conjugates.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi969 – 9768ATPPROSITE-ProRule annotation
Zinc fingeri1330 – 138657RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA-dependent ATPase activity Source: SGD
  • helicase activity Source: UniProtKB-KW
  • SUMO binding Source: SGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • chromatin assembly or disassembly Source: SGD
  • mating type switching Source: SGD
  • negative regulation of double-strand break repair via nonhomologous end joining Source: SGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Helicase, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-33700-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent helicase ULS1 (EC:3.6.4.-)
Alternative name(s):
Role in silencing protein 1
Ubiquitin ligase for SUMO conjugates protein 1
Gene namesi
Name:ULS1
Synonyms:DIS1, RIS1, TID4
Ordered Locus Names:YOR191W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR191W.
SGDiS000005717. ULS1.

Subcellular locationi

GO - Cellular componenti

  • condensed nuclear chromosome kinetochore Source: SGD
  • nucleolus Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16191619ATP-dependent helicase ULS1PRO_0000268702Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei121 – 1211PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ08562.

PTM databases

iPTMnetiQ08562.

Interactioni

Subunit structurei

Interacts with CDC3, CDC11, EBP2, SIR4, UBC4 and SUMO/SMT3.3 Publications

GO - Molecular functioni

  • SUMO binding Source: SGD

Protein-protein interaction databases

BioGridi34586. 123 interactions.
DIPiDIP-996N.
IntActiQ08562. 5 interactions.
MINTiMINT-426553.

Structurei

3D structure databases

ProteinModelPortaliQ08562.
SMRiQ08562. Positions 943-1205, 1437-1597.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini956 – 1157202Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1447 – 1606160Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi7 – 104SUMO interacting motif; type a 1
Motifi371 – 3788SUMO interacting motif; type b 1
Motifi470 – 4734SUMO interacting motif; type a 2
Motifi543 – 5508SUMO interacting motif; type b 2

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1330 – 138657RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00830000128384.
HOGENOMiHOG000065999.
InParanoidiQ08562.
OMAiIMLRRSK.
OrthoDBiEOG092C0TGB.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 3 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08562-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVPTIDLT LADSDNEDIF HSFSSSTSVD KIDIRKENGK LRMAGLEVAQ
60 70 80 90 100
SNDDAARQAF HVFKTNISNN ETFDTILSKS KTITDSTFNN EKSSNEVKQQ
110 120 130 140 150
QVLKEETMGS SNDEKKTQES SPSAEMIKLF YENDDVPLSD SFKQKEEGKR
160 170 180 190 200
INQDEQVKEN ICGISSSYVS KDYDGVEDDF EPNTCQDSNL DFQEEKLNLN
210 220 230 240 250
NKPSQQQFSD PETKDNSLKS ENKDQIKGVT TTSYRDLPIE SSAFQDSETQ
260 270 280 290 300
NNSKNTIPNI VNEKRTPALP SNLSSVESSL KNETAKVEGK TTVRLPGLQN
310 320 330 340 350
NVALLEQEQS ELFKHFSEQP VDISDFGRKI KRKHSGDFAD NKILKRPILP
360 370 380 390 400
SKNMDHTTHN SHDSEQKNSS IIILSDEDES GAGINDIESP LKVSEPNTAD
410 420 430 440 450
ALRSSVPEVI SLLDLPNIDL NNSVIKEASG SNSIPTSETD AQSSSSSVLQ
460 470 480 490 500
GTIMTEQATQ SSQHECNSSL DTLKKNHQKL LKDLNSRESE LRNALSCCKT
510 520 530 540 550
NSEILRRKLS RREKEVSDAE KHWQLLLTSM ARGGRTISST QQILVDEAEN
560 570 580 590 600
QLNKLKEKRQ LTKSKLDSIN LKMYNYNEQW KSFVHSKNIN LQKSLAALER
610 620 630 640 650
SARDSKASAT VNKRNECLAE KEKLDQMLKE GTLSFSTYKQ LTGEIQQKLN
660 670 680 690 700
DLKLGDQRTT DINSVLPIVR QPLAKRDLFI KSIDTAKDLL AKNTSRTEMT
710 720 730 740 750
KRILYRHLDN LVSYKNFFED GRSLIDINRR HVAHESAQIL FTNGVKMPIV
760 770 780 790 800
FETLQDYGIK FSNPAIVNPD RRAQYFKSIE VARDLISKST RSEDAKRKIT
810 820 830 840 850
RFLNIIEEFR KDIDTGFPPT PLKREGVGKA VVGLRQQGLK MDRLYENLRR
860 870 880 890 900
YKIPITSEEL LQQSYLFPVN ADQRPPSNWN IVENTEDTSS TANDLSMQDE
910 920 930 940 950
FHISNMHAAE DQEQIRALLE NVKQSESIID GEALTPEDMT VNLLKHQRLG
960 970 980 990 1000
LHWLLQVENS AKKGGLLADD MGLGKTIQAI ALMLANRSEE SKCKTNLIVA
1010 1020 1030 1040 1050
PVSVLRVWKG ELETKVKKRA KFTTFIFGGS GNGKVKHWRD LARYDAVLVS
1060 1070 1080 1090 1100
YQTLANEFKK HWPKKLDGEQ NQLPAVPHIQ ALNRLKTSNE YYSPFFCNDS
1110 1120 1130 1140 1150
TFYRILLDEG QNIKNKNTRA SKACCTINGM YRWVLSGTPI QNSMDELYSL
1160 1170 1180 1190 1200
IRFLRIPPYH KEQRFKLDIG RFFQRNKQYQ YDNEDRKNAL RKVRVLLNAI
1210 1220 1230 1240 1250
MLRRSKADKI DGKPLLELPP KIVEVDESRL KGEELKFYTA LESKNQALAK
1260 1270 1280 1290 1300
KLLNNSTRGS YSSVLTLLLR LRQACCHSEL VVMGEKKAEG TKVANGKSFE
1310 1320 1330 1340 1350
DDWLRLYYKI THMSGEAQAQ VITSMNSMTC FWCMEQLEPE AMSVLTGCGH
1360 1370 1380 1390 1400
LICDTCIEPF IEESSMLPQA KKTKGGAFAI PCKDCQRLTN EKDIVSHKLY
1410 1420 1430 1440 1450
DQVINQGFTE EDLHAEYLSE MEKQKIQQKN VYVPNFESLE PSTKIEQCIQ
1460 1470 1480 1490 1500
VIQRVFDESA TEKIIIFSQF TTFFEILEHF LKNKLNFPYL KYIGSMNAQR
1510 1520 1530 1540 1550
RSDVINEFYR DPEKRILLIS MKAGNSGLTL TCANHVVIVD PFWNPYVEEQ
1560 1570 1580 1590 1600
AQDRCYRISQ TKKVQVHKLF IKDSVEDRIS ELQKRKKEMV DSAMDPGKIK
1610
EVNSLGRREL GFLFGLNAL
Length:1,619
Mass (Da):184,406
Last modified:November 1, 1996 - v1
Checksum:iFCE20374085B0605
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75099 Genomic DNA. Translation: CAA99400.1.
BK006948 Genomic DNA. Translation: DAA10963.1.
PIRiS67083.
RefSeqiNP_014834.1. NM_001183610.1.

Genome annotation databases

EnsemblFungiiYOR191W; YOR191W; YOR191W.
GeneIDi854363.
KEGGisce:YOR191W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75099 Genomic DNA. Translation: CAA99400.1.
BK006948 Genomic DNA. Translation: DAA10963.1.
PIRiS67083.
RefSeqiNP_014834.1. NM_001183610.1.

3D structure databases

ProteinModelPortaliQ08562.
SMRiQ08562. Positions 943-1205, 1437-1597.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34586. 123 interactions.
DIPiDIP-996N.
IntActiQ08562. 5 interactions.
MINTiMINT-426553.

PTM databases

iPTMnetiQ08562.

Proteomic databases

MaxQBiQ08562.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR191W; YOR191W; YOR191W.
GeneIDi854363.
KEGGisce:YOR191W.

Organism-specific databases

EuPathDBiFungiDB:YOR191W.
SGDiS000005717. ULS1.

Phylogenomic databases

GeneTreeiENSGT00830000128384.
HOGENOMiHOG000065999.
InParanoidiQ08562.
OMAiIMLRRSK.
OrthoDBiEOG092C0TGB.

Enzyme and pathway databases

BioCyciYEAST:G3O-33700-MONOMER.

Miscellaneous databases

PROiQ08562.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 3 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiULS1_YEAST
AccessioniPrimary (citable) accession number: Q08562
Secondary accession number(s): D6W2P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.