UniProtKB - Q08558 (DCI1_YEAST)
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Protein
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase
Gene
DCI1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Converts 3,5-dienoyl-CoAs to the corresponding 2,4-dienoyl-CoAs. Involved in fatty acid metabolism. Required for ECI1 to be peroxisomal located.3 Publications
: fatty acid beta-oxidation Pathwayi
This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 120 | Substrate; via amide nitrogenBy similarity | 1 | |
Active sitei | 152 | Proton donor/acceptorBy similarity | 1 |
GO - Molecular functioni
- dodecenoyl-CoA delta-isomerase activity Source: SGD
GO - Biological processi
- fatty acid beta-oxidation Source: SGD
Keywordsi
Molecular function | Isomerase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Enzyme and pathway databases
BioCyci | MetaCyc:YOR180C-MONOMER. YEAST:YOR180C-MONOMER. |
Reactomei | R-SCE-390247. Beta-oxidation of very long chain fatty acids. R-SCE-70895. Branched-chain amino acid catabolism. R-SCE-77310. Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA. R-SCE-77346. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA. R-SCE-77348. Beta oxidation of octanoyl-CoA to hexanoyl-CoA. R-SCE-77350. Beta oxidation of hexanoyl-CoA to butanoyl-CoA. R-SCE-77352. Beta oxidation of butanoyl-CoA to acetyl-CoA. |
UniPathwayi | UPA00659. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:DCI1 Synonyms:ECI2, EHD2 Ordered Locus Names:YOR180C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YOR180C. |
SGDi | S000005706. DCI1. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000232996 | 1 – 271 | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomeraseAdd BLAST | 271 |
Proteomic databases
PaxDbi | Q08558. |
PRIDEi | Q08558. |
Expressioni
Inductioni
By oleate, through the binding of the OAF1-PIP2 transcriptional activator complex to its promoter ORE element. Expression is also induced during ammonia pulses in yeast colonies, at the beginning of detectable ammonia production.4 Publications
Interactioni
Subunit structurei
Interacts with ECI1.1 Publication
Protein-protein interaction databases
BioGridi | 34575. 67 interactors. |
DIPi | DIP-4132N. |
IntActi | Q08558. 3 interactors. |
MINTi | Q08558. |
STRINGi | 4932.YOR180C. |
Structurei
3D structure databases
ProteinModelPortali | Q08558. |
SMRi | Q08558. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 62 – 66 | Substrate bindingBy similarity | 5 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 269 – 271 | Microbody targeting signalSequence analysis | 3 |
Sequence similaritiesi
Belongs to the enoyl-CoA hydratase/isomerase family.Curated
Phylogenomic databases
GeneTreei | ENSGT00890000139344. |
HOGENOMi | HOG000027948. |
InParanoidi | Q08558. |
OMAi | ATENLHV. |
OrthoDBi | EOG092C431D. |
Family and domain databases
InterProi | View protein in InterPro IPR029045. ClpP/crotonase-like_dom_sf. IPR001753. Enoyl-CoA_hydra/iso. |
Pfami | View protein in Pfam PF00378. ECH_1. 1 hit. |
SUPFAMi | SSF52096. SSF52096. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q08558-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSRVCYHIN GPFFIIKLID PKHLNSLTFE DFVYIALLLH KANDIDSVLF
60 70 80 90 100
TVLQSSGKYF SSGGKFSAVN KLNDGDVTSE VEKVSKLVSA ISSPNIFVAN
110 120 130 140 150
AFAIHKKVLV CCLNGPAIGL SASLVALCDI VYSQNDSVFL LFPFSNLGFV
160 170 180 190 200
AEVGTSVTLT QKLGINSANE HMIFSTPVLF KELIGTIITK NYQLTNTETF
210 220 230 240 250
NEKVLQDIKQ NLEGLYPKSV LGMKELLHSE MKQKLIKAQA METNGTLPFW
260 270
ASGEPFKRFK QLQEGNRRHK L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z75088 Genomic DNA. Translation: CAA99389.1. AY558432 Genomic DNA. Translation: AAS56758.1. BK006948 Genomic DNA. Translation: DAA10952.1. |
PIRi | S67072. |
RefSeqi | NP_014823.3. NM_001183599.3. |
Genome annotation databases
EnsemblFungii | YOR180C; YOR180C; YOR180C. |
GeneIDi | 854352. |
KEGGi | sce:YOR180C. |
Similar proteinsi
Entry informationi
Entry namei | DCI1_YEAST | |
Accessioni | Q08558Primary (citable) accession number: Q08558 Secondary accession number(s): D6W2N6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | March 28, 2018 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |