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Protein

Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase

Gene

DCI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts 3,5-dienoyl-CoAs to the corresponding 2,4-dienoyl-CoAs. Involved in fatty acid metabolism. Required for ECI1 to be peroxisomal located.3 Publications

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei120Substrate; via amide nitrogenBy similarity1
Active sitei152Proton donor/acceptorBy similarity1

GO - Molecular functioni

  • dodecenoyl-CoA delta-isomerase activity Source: SGD

GO - Biological processi

  • fatty acid beta-oxidation Source: SGD

Keywordsi

Molecular functionIsomerase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:YOR180C-MONOMER
YEAST:YOR180C-MONOMER
ReactomeiR-SCE-390247 Beta-oxidation of very long chain fatty acids
R-SCE-70895 Branched-chain amino acid catabolism
R-SCE-77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
R-SCE-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
R-SCE-77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA
R-SCE-77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA
R-SCE-77352 Beta oxidation of butanoyl-CoA to acetyl-CoA
R-SCE-9033241 Peroxisomal protein import
UniPathwayiUPA00659

Names & Taxonomyi

Protein namesi
Recommended name:
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase (EC:5.3.3.-)
Gene namesi
Name:DCI1
Synonyms:ECI2, EHD2
Ordered Locus Names:YOR180C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR180C
SGDiS000005706 DCI1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002329961 – 271Delta(3,5)-Delta(2,4)-dienoyl-CoA isomeraseAdd BLAST271

Proteomic databases

PaxDbiQ08558
PRIDEiQ08558

Expressioni

Inductioni

By oleate, through the binding of the OAF1-PIP2 transcriptional activator complex to its promoter ORE element. Expression is also induced during ammonia pulses in yeast colonies, at the beginning of detectable ammonia production.4 Publications

Interactioni

Subunit structurei

Interacts with ECI1.1 Publication

Protein-protein interaction databases

BioGridi34575, 67 interactors
DIPiDIP-4132N
IntActiQ08558, 2 interactors
MINTiQ08558
STRINGi4932.YOR180C

Structurei

3D structure databases

ProteinModelPortaliQ08558
SMRiQ08558
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 66Substrate bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi269 – 271Microbody targeting signalSequence analysis3

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00890000139344
HOGENOMiHOG000027948
InParanoidiQ08558
KOiK22587
OMAiATENLHV
OrthoDBiEOG092C431D

Family and domain databases

InterProiView protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR001753 Enoyl-CoA_hydra/iso
PfamiView protein in Pfam
PF00378 ECH_1, 1 hit
SUPFAMiSSF52096 SSF52096, 1 hit

Sequencei

Sequence statusi: Complete.

Q08558-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRVCYHIN GPFFIIKLID PKHLNSLTFE DFVYIALLLH KANDIDSVLF
60 70 80 90 100
TVLQSSGKYF SSGGKFSAVN KLNDGDVTSE VEKVSKLVSA ISSPNIFVAN
110 120 130 140 150
AFAIHKKVLV CCLNGPAIGL SASLVALCDI VYSQNDSVFL LFPFSNLGFV
160 170 180 190 200
AEVGTSVTLT QKLGINSANE HMIFSTPVLF KELIGTIITK NYQLTNTETF
210 220 230 240 250
NEKVLQDIKQ NLEGLYPKSV LGMKELLHSE MKQKLIKAQA METNGTLPFW
260 270
ASGEPFKRFK QLQEGNRRHK L
Length:271
Mass (Da):30,058
Last modified:November 1, 1996 - v1
Checksum:i0AA0BF3A981F733F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75088 Genomic DNA Translation: CAA99389.1
AY558432 Genomic DNA Translation: AAS56758.1
BK006948 Genomic DNA Translation: DAA10952.1
PIRiS67072
RefSeqiNP_014823.3, NM_001183599.3

Genome annotation databases

EnsemblFungiiYOR180C; YOR180C; YOR180C
GeneIDi854352
KEGGisce:YOR180C

Similar proteinsi

Entry informationi

Entry nameiDCI1_YEAST
AccessioniPrimary (citable) accession number: Q08558
Secondary accession number(s): D6W2N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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