DCI1

Functionⁱ

Converts 3,5-dienoyl-CoAs to the corresponding 2,4-dienoyl-CoAs. Involved in fatty acid metabolism. Required for ECI1 to be peroxisomal located.3 Publications

Pathwayⁱ: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	120	Substrate; via amide nitrogenBy similarity		1
Active siteⁱ	152	Proton donor/acceptorBy similarity		1

GO - Molecular functionⁱ

dodecenoyl-CoA delta-isomerase activity
Source: SGD
Inferred from direct assayⁱ
- 10455114

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fatty acid beta-oxidation
Source: SGD
Inferred from mutant phenotypeⁱ
- 10381339

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Fatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BioCycⁱ	MetaCyc:YOR180C-MONOMER YEAST:YOR180C-MONOMER
Reactomeⁱ	R-SCE-390247 Beta-oxidation of very long chain fatty acids R-SCE-70895 Branched-chain amino acid catabolism R-SCE-77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-SCE-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-SCE-77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-SCE-77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-SCE-77352 Beta oxidation of butanoyl-CoA to acetyl-CoA R-SCE-9033241 Peroxisomal protein import
UniPathwayⁱ	UPA00659

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase (EC:5.3.3.-)
Gene namesⁱ	Name:DCI1 Synonyms:ECI2, EHD2 Ordered Locus Names:YOR180C
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome XV

Organism-specific databases

EuPathDBⁱ	FungiDB:YOR180C
Saccharomyces Genome Database More...SGDⁱ	S000005706 DCI1

Keywords - Cellular componentⁱ

Peroxisome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000232996	1 – 271	Delta(3,5)-Delta(2,4)-dienoyl-CoA isomeraseAdd BLAST		271

Proteomic databases

PaxDbⁱ	Q08558
PRIDEⁱ	Q08558

Expressionⁱ

Inductionⁱ

By oleate, through the binding of the OAF1-PIP2 transcriptional activator complex to its promoter ORE element. Expression is also induced during ammonia pulses in yeast colonies, at the beginning of detectable ammonia production.4 Publications

Interactionⁱ

Subunit structureⁱ

Interacts with ECI1.1 Publication

Protein-protein interaction databases

BioGridⁱ	34575, 67 interactors
Database of interacting proteins More...DIPⁱ	DIP-4132N
IntActⁱ	Q08558, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q08558
STRINGⁱ	4932.YOR180C

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q08558
SMRⁱ	Q08558
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	62 – 66	Substrate bindingBy similarity		5

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	269 – 271	Microbody targeting signalSequence analysis		3

Sequence similaritiesⁱ

Belongs to the enoyl-CoA hydratase/isomerase family.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139344
HOGENOMⁱ	HOG000027948
InParanoidⁱ	Q08558
KEGG Orthology (KO) More...KOⁱ	K22587
OMAⁱ	ATENLHV
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C431D

Family and domain databases

InterProⁱ	View protein in InterPro IPR029045 ClpP/crotonase-like_dom_sf IPR001753 Enoyl-CoA_hydra/iso
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00378 ECH_1, 1 hit
SUPFAMⁱ	SSF52096 SSF52096, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q08558-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSRVCYHIN GPFFIIKLID PKHLNSLTFE DFVYIALLLH KANDIDSVLF 
        60         70         80         90        100
TVLQSSGKYF SSGGKFSAVN KLNDGDVTSE VEKVSKLVSA ISSPNIFVAN 
       110        120        130        140        150
AFAIHKKVLV CCLNGPAIGL SASLVALCDI VYSQNDSVFL LFPFSNLGFV 
       160        170        180        190        200
AEVGTSVTLT QKLGINSANE HMIFSTPVLF KELIGTIITK NYQLTNTETF 
       210        220        230        240        250
NEKVLQDIKQ NLEGLYPKSV LGMKELLHSE MKQKLIKAQA METNGTLPFW 
       260        270 
ASGEPFKRFK QLQEGNRRHK L

Length:271

Mass (Da):30,058

Last modified:November 1, 1996 - v1

Checksum:ⁱ0AA0BF3A981F733F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z75088 Genomic DNA Translation: CAA99389.1 AY558432 Genomic DNA Translation: AAS56758.1 BK006948 Genomic DNA Translation: DAA10952.1
PIRⁱ	S67072
NCBI Reference Sequences More...RefSeqⁱ	NP_014823.3, NM_001183599.3

Genome annotation databases

EnsemblFungiⁱ	YOR180C; YOR180C; YOR180C
GeneIDⁱ	854352
KEGGⁱ	sce:YOR180C

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q08558	K7_Dci1p		YEASK		271
Dci1p		YEAS8		271
Dci1p		YEASC		271
Dci1p		YEAS2		271
Dci1p		YEASL		100
+9

Protein	Similar proteins		Species	Score	Length
Q08558	K7_Dci1p		YEASK		271
Dci1p		YEAS8		271
Dci1p		YEASC		271
Dci1p		YEAS2		271
Dci1p		YEASL		100
+20

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z75088 Genomic DNA Translation: CAA99389.1 AY558432 Genomic DNA Translation: AAS56758.1 BK006948 Genomic DNA Translation: DAA10952.1
PIRⁱ	S67072
NCBI Reference Sequences More...RefSeqⁱ	NP_014823.3, NM_001183599.3

3D structure databases

ProteinModelPortalⁱ	Q08558
SMRⁱ	Q08558
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	34575, 67 interactors
Database of interacting proteins More...DIPⁱ	DIP-4132N
IntActⁱ	Q08558, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q08558
STRINGⁱ	4932.YOR180C

Proteomic databases

PaxDbⁱ	Q08558
PRIDEⁱ	Q08558

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YOR180C; YOR180C; YOR180C
GeneIDⁱ	854352
KEGGⁱ	sce:YOR180C

Organism-specific databases

EuPathDBⁱ	FungiDB:YOR180C
Saccharomyces Genome Database More...SGDⁱ	S000005706 DCI1

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139344
HOGENOMⁱ	HOG000027948
InParanoidⁱ	Q08558
KEGG Orthology (KO) More...KOⁱ	K22587
OMAⁱ	ATENLHV
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C431D

Enzyme and pathway databases

UniPathwayⁱ	UPA00659
BioCycⁱ	MetaCyc:YOR180C-MONOMER YEAST:YOR180C-MONOMER
Reactomeⁱ	R-SCE-390247 Beta-oxidation of very long chain fatty acids R-SCE-70895 Branched-chain amino acid catabolism R-SCE-77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-SCE-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-SCE-77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-SCE-77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-SCE-77352 Beta oxidation of butanoyl-CoA to acetyl-CoA R-SCE-9033241 Peroxisomal protein import

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q08558

PROⁱ

PR:Q08558

Family and domain databases

InterProⁱ	View protein in InterPro IPR029045 ClpP/crotonase-like_dom_sf IPR001753 Enoyl-CoA_hydra/iso
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00378 ECH_1, 1 hit
SUPFAMⁱ	SSF52096 SSF52096, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DCI1_YEAST
Accessionⁱ	Q08558Primary (citable) accession number: Q08558 Secondary accession number(s): D6W2N6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
	Last sequence update:	November 1, 1996
	Last modified:	June 20, 2018
	This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q08558 (DCI1_YEAST)

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Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid beta-oxidation

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Peroxisome

Peroxisome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: fatty acid beta-oxidation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ