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Q08535

- SECR_MOUSE

UniProt

Q08535 - SECR_MOUSE

Protein

Secretin

Gene

Sct

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.

    GO - Biological processi

    1. dentate gyrus development Source: MGI
    2. negative regulation of neuron apoptotic process Source: MGI
    3. neuronal stem cell maintenance Source: MGI
    4. visual learning Source: MGI

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secretin
    Gene namesi
    Name:Sct
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:99466. Sct.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Propeptidei23 – 308By similarityPRO_0000011426
    Peptidei32 – 5827SecretinBy similarityPRO_0000011427Add
    BLAST
    Propeptidei62 – 13372By similarityPRO_0000011428Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei58 – 581Valine amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Proteomic databases

    PRIDEiQ08535.

    Expressioni

    Gene expression databases

    ArrayExpressiQ08535.
    BgeeiQ08535.
    CleanExiMM_SCT.
    GenevestigatoriQ08535.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08535.
    SMRiQ08535. Positions 32-59.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucagon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG329190.
    HOVERGENiHBG017786.
    InParanoidiQ08535.
    KOiK05263.
    PhylomeDBiQ08535.

    Family and domain databases

    InterProiIPR000532. Glucagon_GIP_secretin_VIP.
    IPR015675. Prosecretin.
    [Graphical view]
    PANTHERiPTHR17378. PTHR17378. 1 hit.
    PfamiPF00123. Hormone_2. 1 hit.
    [Graphical view]
    SMARTiSM00070. GLUCA. 1 hit.
    [Graphical view]
    PROSITEiPS00260. GLUCAGON. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q08535-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPPLPTPML LLLLLLLSSS AALPAPPRTP RHSDGMFTSE LSRLQDSARL    50
    QRLLQGLVGK RSEQDTENIP ENSLARSKPL EDQLCLLWSN TQTLQDWLLP 100
    RLSLDGSLSL WLPPGPRSAV DRSEWTETTR PPR 133
    Length:133
    Mass (Da):14,914
    Last modified:October 1, 1994 - v1
    Checksum:i9B69CBCF74CA9709
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07568 Unassigned DNA. Translation: AAA18453.1.
    X73580 mRNA. Translation: CAA51982.1.
    CCDSiCCDS40184.1.
    PIRiJC2202.
    RefSeqiNP_035458.1. NM_011328.3.
    UniGeneiMm.4723.

    Genome annotation databases

    EnsembliENSMUST00000167790; ENSMUSP00000128729; ENSMUSG00000038580.
    GeneIDi20287.
    KEGGimmu:20287.
    UCSCiuc009kkl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07568 Unassigned DNA. Translation: AAA18453.1 .
    X73580 mRNA. Translation: CAA51982.1 .
    CCDSi CCDS40184.1.
    PIRi JC2202.
    RefSeqi NP_035458.1. NM_011328.3.
    UniGenei Mm.4723.

    3D structure databases

    ProteinModelPortali Q08535.
    SMRi Q08535. Positions 32-59.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q08535.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000167790 ; ENSMUSP00000128729 ; ENSMUSG00000038580 .
    GeneIDi 20287.
    KEGGi mmu:20287.
    UCSCi uc009kkl.1. mouse.

    Organism-specific databases

    CTDi 6343.
    MGIi MGI:99466. Sct.

    Phylogenomic databases

    eggNOGi NOG329190.
    HOVERGENi HBG017786.
    InParanoidi Q08535.
    KOi K05263.
    PhylomeDBi Q08535.

    Miscellaneous databases

    NextBioi 297991.
    PROi Q08535.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q08535.
    Bgeei Q08535.
    CleanExi MM_SCT.
    Genevestigatori Q08535.

    Family and domain databases

    InterProi IPR000532. Glucagon_GIP_secretin_VIP.
    IPR015675. Prosecretin.
    [Graphical view ]
    PANTHERi PTHR17378. PTHR17378. 1 hit.
    Pfami PF00123. Hormone_2. 1 hit.
    [Graphical view ]
    SMARTi SM00070. GLUCA. 1 hit.
    [Graphical view ]
    PROSITEi PS00260. GLUCAGON. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiSECR_MOUSE
    AccessioniPrimary (citable) accession number: Q08535
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3