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Q08535 (SECR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Secretin
Gene names
Name:Sct
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length133 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.

Subcellular location

Secreted.

Sequence similarities

Belongs to the glucagon family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Propeptide23 – 308 By similarity
PRO_0000011426
Peptide32 – 5827Secretin By similarity
PRO_0000011427
Propeptide62 – 13372 By similarity
PRO_0000011428

Amino acid modifications

Modified residue581Valine amide By similarity

Sequences

Sequence LengthMass (Da)Tools
Q08535 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 9B69CBCF74CA9709

FASTA13314,914
        10         20         30         40         50         60 
MEPPLPTPML LLLLLLLSSS AALPAPPRTP RHSDGMFTSE LSRLQDSARL QRLLQGLVGK 

        70         80         90        100        110        120 
RSEQDTENIP ENSLARSKPL EDQLCLLWSN TQTLQDWLLP RLSLDGSLSL WLPPGPRSAV 

       130 
DRSEWTETTR PPR 

« Hide

References

[1]"cDNA sequence and genomic organization of mouse secretin."
Lan M.S., Kajiyama W., Donadel G., Lu J., Notkins A.L.
Biochem. Biophys. Res. Commun. 200:1066-1071(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U07568 Unassigned DNA. Translation: AAA18453.1.
X73580 mRNA. Translation: CAA51982.1.
CCDSCCDS40184.1.
PIRJC2202.
RefSeqNP_035458.1. NM_011328.3.
UniGeneMm.4723.

3D structure databases

ProteinModelPortalQ08535.
SMRQ08535. Positions 32-59.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ08535.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000167790; ENSMUSP00000128729; ENSMUSG00000038580.
GeneID20287.
KEGGmmu:20287.
UCSCuc009kkl.1. mouse.

Organism-specific databases

CTD6343.
MGIMGI:99466. Sct.

Phylogenomic databases

eggNOGNOG329190.
HOVERGENHBG017786.
InParanoidQ08535.
KOK05263.
PhylomeDBQ08535.

Gene expression databases

ArrayExpressQ08535.
BgeeQ08535.
CleanExMM_SCT.
GenevestigatorQ08535.

Family and domain databases

InterProIPR000532. Glucagon_GIP_secretin_VIP.
IPR015675. Prosecretin.
[Graphical view]
PANTHERPTHR17378. PTHR17378. 1 hit.
PfamPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEPS00260. GLUCAGON. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio297991.
PROQ08535.
SOURCESearch...

Entry information

Entry nameSECR_MOUSE
AccessionPrimary (citable) accession number: Q08535
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot