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Protein

Secretin

Gene

Sct

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.

GO - Biological processi

  1. dentate gyrus development Source: MGI
  2. negative regulation of neuron apoptotic process Source: MGI
  3. neuronal stem cell maintenance Source: MGI
  4. visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_313192. G alpha (s) signalling events.
REACT_339920. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretin
Gene namesi
Name:Sct
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:99466. Sct.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Propeptidei23 – 308By similarityPRO_0000011426
Peptidei32 – 5827SecretinBy similarityPRO_0000011427Add
BLAST
Propeptidei62 – 13372By similarityPRO_0000011428Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581Valine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PRIDEiQ08535.

Expressioni

Gene expression databases

BgeeiQ08535.
CleanExiMM_SCT.
ExpressionAtlasiQ08535. baseline and differential.
GenevestigatoriQ08535.

Structurei

3D structure databases

ProteinModelPortaliQ08535.
SMRiQ08535. Positions 32-59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG329190.
HOVERGENiHBG017786.
InParanoidiQ08535.
KOiK05263.
PhylomeDBiQ08535.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015675. Prosecretin.
[Graphical view]
PANTHERiPTHR17378. PTHR17378. 1 hit.
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08535-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPLPTPML LLLLLLLSSS AALPAPPRTP RHSDGMFTSE LSRLQDSARL
60 70 80 90 100
QRLLQGLVGK RSEQDTENIP ENSLARSKPL EDQLCLLWSN TQTLQDWLLP
110 120 130
RLSLDGSLSL WLPPGPRSAV DRSEWTETTR PPR
Length:133
Mass (Da):14,914
Last modified:October 1, 1994 - v1
Checksum:i9B69CBCF74CA9709
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07568 Unassigned DNA. Translation: AAA18453.1.
X73580 mRNA. Translation: CAA51982.1.
CCDSiCCDS40184.1.
PIRiJC2202.
RefSeqiNP_035458.1. NM_011328.3.
UniGeneiMm.4723.

Genome annotation databases

EnsembliENSMUST00000167790; ENSMUSP00000128729; ENSMUSG00000038580.
GeneIDi20287.
KEGGimmu:20287.
UCSCiuc009kkl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07568 Unassigned DNA. Translation: AAA18453.1.
X73580 mRNA. Translation: CAA51982.1.
CCDSiCCDS40184.1.
PIRiJC2202.
RefSeqiNP_035458.1. NM_011328.3.
UniGeneiMm.4723.

3D structure databases

ProteinModelPortaliQ08535.
SMRiQ08535. Positions 32-59.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ08535.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167790; ENSMUSP00000128729; ENSMUSG00000038580.
GeneIDi20287.
KEGGimmu:20287.
UCSCiuc009kkl.1. mouse.

Organism-specific databases

CTDi6343.
MGIiMGI:99466. Sct.

Phylogenomic databases

eggNOGiNOG329190.
HOVERGENiHBG017786.
InParanoidiQ08535.
KOiK05263.
PhylomeDBiQ08535.

Enzyme and pathway databases

ReactomeiREACT_313192. G alpha (s) signalling events.
REACT_339920. Glucagon-type ligand receptors.

Miscellaneous databases

NextBioi297991.
PROiQ08535.
SOURCEiSearch...

Gene expression databases

BgeeiQ08535.
CleanExiMM_SCT.
ExpressionAtlasiQ08535. baseline and differential.
GenevestigatoriQ08535.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015675. Prosecretin.
[Graphical view]
PANTHERiPTHR17378. PTHR17378. 1 hit.
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSECR_MOUSE
AccessioniPrimary (citable) accession number: Q08535
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 1, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.