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Protein

Transcriptional regulatory protein btr

Gene

btr

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May regulate gene expression in response to changes in oxygen levels or to changes in the redox potential of the bacterial environment.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi191 – 21020H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBPER257313:BP1197-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein btr
Gene namesi
Name:btr
Ordered Locus Names:BP1197
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000002676 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Transcriptional regulatory protein btrPRO_0000100143Add
BLAST

Proteomic databases

PRIDEiQ08530.

Interactioni

Protein-protein interaction databases

STRINGi257313.BP1197.

Structurei

3D structure databases

ProteinModelPortaliQ08530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini158 – 23174HTH crp-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000186461.
KOiK01420.
OMAiESGPTHR.
OrthoDBiEOG6RVFWF.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08530-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRRVPLSPD AAHCSSCMLG HVCVPVGMPA NEVEKLDELV KERVRVERGK
60 70 80 90 100
TLYELDDPLD AVYGVRFGSL KTQLEDSSGQ LQITGFHLPG EIVGLDGMIE
110 120 130 140 150
SKHVSSAVAL EDSEVCVIRL PEIDRVSTQL PSLQQQFRRL MSREITRSHQ
160 170 180 190 200
MLATVGAMRS EQRLAAFLLN LSQRYAALGY SSTEFVLRMS REEIGNYLGL
210 220 230 240
TLETVSRLFS RFGREGLIRI NQREVRLIDL PGLKQLIGQE SC
Length:242
Mass (Da):27,130
Last modified:September 19, 2003 - v2
Checksum:iCD07103C2AFDAC12
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 6438GMPAN…DAVYG → ACLPTKSRNWTNSSRRPCAW SAAKRSTNSTIPWSRLR in AAC36850 (PubMed:7693656).CuratedAdd
BLAST
Sequence conflicti96 – 961D → V in AAC36850 (PubMed:7693656).Curated
Sequence conflicti174 – 18714RYAAL…TEFVL → ATRRSAIRRPNSCV in AAC36850 (PubMed:7693656).CuratedAdd
BLAST
Sequence conflicti223 – 2231R → A in AAC36850 (PubMed:7693656).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20602 Unassigned DNA. Translation: AAC36850.1.
BX640414 Genomic DNA. Translation: CAE41493.1.
PIRiA49926.
RefSeqiNP_879971.1. NC_002929.2.
WP_010930241.1. NC_002929.2.

Genome annotation databases

EnsemblBacteriaiCAE41493; CAE41493; BP1197.
GeneIDi2667591.
KEGGibpe:BP1197.
PATRICi21155580. VBIBorPer7866_1289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20602 Unassigned DNA. Translation: AAC36850.1.
BX640414 Genomic DNA. Translation: CAE41493.1.
PIRiA49926.
RefSeqiNP_879971.1. NC_002929.2.
WP_010930241.1. NC_002929.2.

3D structure databases

ProteinModelPortaliQ08530.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257313.BP1197.

Proteomic databases

PRIDEiQ08530.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE41493; CAE41493; BP1197.
GeneIDi2667591.
KEGGibpe:BP1197.
PATRICi21155580. VBIBorPer7866_1289.

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000186461.
KOiK01420.
OMAiESGPTHR.
OrthoDBiEOG6RVFWF.

Enzyme and pathway databases

BioCyciBPER257313:BP1197-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of btr, a Bordetella pertussis gene encoding an FNR-like transcriptional regulator."
    Bannan J.D., Moran M.J., Macinnnes J.I., Soltes G.A., Friedman R.L.
    J. Bacteriol. 175:7228-7235(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BP504.
  2. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Entry informationi

Entry nameiBTR_BORPE
AccessioniPrimary (citable) accession number: Q08530
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: September 19, 2003
Last modified: July 22, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.