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Q08530

- BTR_BORPE

UniProt

Q08530 - BTR_BORPE

Protein

Transcriptional regulatory protein btr

Gene

btr

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (19 Sep 2003)
      Previous versions | rss
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    Functioni

    May regulate gene expression in response to changes in oxygen levels or to changes in the redox potential of the bacterial environment.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi191 – 21020H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciBPER257313:BP1197-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional regulatory protein btr
    Gene namesi
    Name:btr
    Ordered Locus Names:BP1197
    OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
    Taxonomic identifieri257313 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000002676: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 242242Transcriptional regulatory protein btrPRO_0000100143Add
    BLAST

    Proteomic databases

    PRIDEiQ08530.

    Interactioni

    Protein-protein interaction databases

    STRINGi257313.BP1197.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08530.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini158 – 23174HTH crp-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000186461.
    KOiK01420.
    OMAiVREHGVM.
    OrthoDBiEOG6RVFWF.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00325. Crp. 1 hit.
    [Graphical view]
    PRINTSiPR00034. HTHCRP.
    SMARTiSM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    PROSITEiPS00042. HTH_CRP_1. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q08530-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRRVPLSPD AAHCSSCMLG HVCVPVGMPA NEVEKLDELV KERVRVERGK    50
    TLYELDDPLD AVYGVRFGSL KTQLEDSSGQ LQITGFHLPG EIVGLDGMIE 100
    SKHVSSAVAL EDSEVCVIRL PEIDRVSTQL PSLQQQFRRL MSREITRSHQ 150
    MLATVGAMRS EQRLAAFLLN LSQRYAALGY SSTEFVLRMS REEIGNYLGL 200
    TLETVSRLFS RFGREGLIRI NQREVRLIDL PGLKQLIGQE SC 242
    Length:242
    Mass (Da):27,130
    Last modified:September 19, 2003 - v2
    Checksum:iCD07103C2AFDAC12
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 6438GMPAN…DAVYG → ACLPTKSRNWTNSSRRPCAW SAAKRSTNSTIPWSRLR in AAC36850. (PubMed:7693656)CuratedAdd
    BLAST
    Sequence conflicti96 – 961D → V in AAC36850. (PubMed:7693656)Curated
    Sequence conflicti174 – 18714RYAAL…TEFVL → ATRRSAIRRPNSCV in AAC36850. (PubMed:7693656)CuratedAdd
    BLAST
    Sequence conflicti223 – 2231R → A in AAC36850. (PubMed:7693656)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L20602 Unassigned DNA. Translation: AAC36850.1.
    BX640414 Genomic DNA. Translation: CAE41493.1.
    PIRiA49926.
    RefSeqiNP_879971.1. NC_002929.2.

    Genome annotation databases

    EnsemblBacteriaiCAE41493; CAE41493; BP1197.
    GeneIDi2667591.
    KEGGibpe:BP1197.
    PATRICi21155580. VBIBorPer7866_1289.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L20602 Unassigned DNA. Translation: AAC36850.1 .
    BX640414 Genomic DNA. Translation: CAE41493.1 .
    PIRi A49926.
    RefSeqi NP_879971.1. NC_002929.2.

    3D structure databases

    ProteinModelPortali Q08530.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257313.BP1197.

    Proteomic databases

    PRIDEi Q08530.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE41493 ; CAE41493 ; BP1197 .
    GeneIDi 2667591.
    KEGGi bpe:BP1197.
    PATRICi 21155580. VBIBorPer7866_1289.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000186461.
    KOi K01420.
    OMAi VREHGVM.
    OrthoDBi EOG6RVFWF.

    Enzyme and pathway databases

    BioCyci BPER257313:BP1197-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00325. Crp. 1 hit.
    [Graphical view ]
    PRINTSi PR00034. HTHCRP.
    SMARTi SM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    PROSITEi PS00042. HTH_CRP_1. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of btr, a Bordetella pertussis gene encoding an FNR-like transcriptional regulator."
      Bannan J.D., Moran M.J., Macinnnes J.I., Soltes G.A., Friedman R.L.
      J. Bacteriol. 175:7228-7235(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BP504.
    2. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
      Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
      , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
      Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

    Entry informationi

    Entry nameiBTR_BORPE
    AccessioniPrimary (citable) accession number: Q08530
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: September 19, 2003
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3