Reviewed, UniProtKB/Swiss-Prot Q08513 (NTP1_SWPVK)

Names and origin

Protein names

Recommended name:
    Nucleoside triphosphatase I
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase I
      Short name=NPH I

Gene names

Name:

NPH1

Organism

Swinepox virus (strain Kasza) (SWPV)

Taxonomic identifier

10277 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Suipoxvirus

Virus host

Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length	89 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serves two roles in transcription; it acts in concert with viral termination factor/capping enzyme to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex, and it acts by itself as a polymerase elongation factor to facilitate readthrough of intrinsic pause sites By similarity.
Catalytic activity	NTP + H(2)O = NDP + phosphate.
Sequence similarities	Belongs to the helicase family. NPH I subfamily.

Ontologies

Keywords
Biological process	Transcription
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›89	›89	Nucleoside triphosphatase I		PRO_0000099097
Regions
	Domain	42 – ›89	›48	Helicase ATP-binding
	Nucleotide binding	55 – 62	8	ATP By similarity
Experimental info
	Non-terminal residue	89	1

Sequences

	Sequence		Length	Mass (Da)
	Q08513-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: F550027F762EEDE6	FASTA	89	10,240
	10 20 30 40 50 60 MSSYHAAYID YELRVTESMT DTMGTDTEIT LKPYQHFVAS VFLGLDKMHS LLLFHDTGVG 70 80 KTITTTFIIK QLKNIYTNWS ILLLVKKHL

References

[1]

"DNA sequence analysis of conserved and unique regions of swinepox virus: identification of genetic elements supporting phenotypic observations including a novel G protein-coupled receptor homologue." Massung R.F., Jayarama V., Moyer R.W. Virology 197:511-528(1993) [PubMed: 8249275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	L22012 Unassigned DNA. Translation: AAA16175.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR000330. SNF2_N. [Graphical view]
Pfam	PF00176. SNF2_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NTP1_SWPVK

Accession

Primary (citable) accession number: Q08513

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	November 25, 2008
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)