Q08513 (NTP1_SWPVK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleoside triphosphatase I
EC=3.6.1.15

Alternative name(s):
Nucleoside triphosphate phosphohydrolase I
Short name=NPH I

Gene names

Name:

NPH1

Organism

Swinepox virus (strain Kasza) (SWPV)

Taxonomic identifier

10277 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Suipoxvirus

Virus host

Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length	89 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Serves two roles in transcription; it acts in concert with viral termination factor/capping enzyme to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex, and it acts by itself as a polymerase elongation factor to facilitate readthrough of intrinsic pause sites By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate.
Sequence similarities	Belongs to the helicase family. NPH I subfamily.

Ontologies

Keywords
Biological process	Transcription
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›89	›89	Nucleoside triphosphatase I		PRO_0000099097
Regions
	Domain	42 – ›89	›48	Helicase ATP-binding
	Nucleotide binding	55 – 62	8	ATP By similarity
Experimental info
	Non-terminal residue	89	1

Sequences

	Sequence		Length	Mass (Da)
	Q08513 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: F550027F762EEDE6	FASTA	89	10,240
	10 20 30 40 50 60 MSSYHAAYID YELRVTESMT DTMGTDTEIT LKPYQHFVAS VFLGLDKMHS LLLFHDTGVG 70 80 KTITTTFIIK QLKNIYTNWS ILLLVKKHL

References

[1]

"DNA sequence analysis of conserved and unique regions of swinepox virus: identification of genetic elements supporting phenotypic observations including a novel G protein-coupled receptor homologue." Massung R.F., Jayarama V., Moyer R.W. Virology 197:511-528(1993) [PubMed: 8249275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L22012 Unassigned DNA. Translation: AAA16175.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000330. SNF2_N. [Graphical view]
Pfam	PF00176. SNF2_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NTP1_SWPVK

Accession

Primary (citable) accession number: Q08513

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	May 31, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program